DysfunctionDisordersTumorsInflammatoryAxisCentral hypothyroidismInflammationDeficiencyDiabetes MellitusHormoneNeurodegenerationSigns of hypothalamicDiagnosis of hypothalamicSyndromesHormonesDisorderEndocrine diseasesSymptomsChronic obstrucNeurodegenerative DiseasesAutoimmuneMetabolicSyndromeOccurManifestationsCraniopharyngiomaGeneticMetabolismLIMBIC SYSTEMClinicalNucleiAlterationsAlzheimer'sHuntington'sInfectious DiseaseComplicationsSupraoptic nucleusEnergy homeostasisInvolvementHypopituitarismPatientsFunctionalParkinson's
- doi:10.1016/B0-12-475570-4/00714-9 MedlinePlus Encyclopedia Hypothalamic dysfunction Rehan, K. (2011). (wikipedia.org)
- These early metabolic and lipid alterations are likely prodromal signs of hypothalamic dysfunction. (uantwerpen.be)
- Rapid-onset obesity with hypoventilation, hypothalamic dysfunction, and autonomic dysregulation (ROHHAD) is a rare disease. (pedinfect.com)
- Finally, based on the rapid weight gain, hypoventilation, hypothalamic dysfunction, and signs of autonomic dysregulation, the patient was diagnosed with ROHHAD syndrome. (pedinfect.com)
- In children with rapid and early-onset obesity associated with hypothalamic-pituitary endocrine dysfunction, ROHHAD syndrome should be considered in the differential diagnosis. (pedinfect.com)
- Rapid-onset obesity with hypoventilation, hypothalamic dysfunction, and autonomic dysregulation (ROHHAD) syndrome is a very rare disease that was first reported in a 3-year-old boy in 1965 ( 1 ). (pedinfect.com)
- Over the following months and years, other manifestations will develop, including alveolar hypoventilation, hypothalamic dysfunction, and autonomic dysregulation ( 3 , 5 ). (pedinfect.com)
- These Reviews also discuss how inflammation can lead to other aspects of metabolic syndrome, including hyperphagia, reduced energy expenditure, β cell dysfunction, and liver disease, and summarize the status of therapeutic interventions that target inflammation in the context of metabolic syndrome. (jci.org)
- This Primer by Platt and colleagues provides an overview of the LSDs, including how lysosomal dysfunction gives rise to disease and how these disorders are diagnosed and treated. (nature.com)
- Dietary intake of isoflavones and polyunsaturated fatty acids associated with a Japanese diet reduce lung dysfunction, breathlessness and the prevalence of chronic obstructive pulmonary disease. (greenmedinfo.com)
- Hypothalamic dysfunction is a problem with part of the brain called the hypothalamus . (medlineplus.gov)
- There are many causes of hypothalamic dysfunction. (medlineplus.gov)
- Many causes of hypothalamic dysfunction are treatable. (medlineplus.gov)
- Complications of hypothalamic dysfunction depend on the cause. (medlineplus.gov)
- Investigation of suspected hypothalamic, pituitary or gonadal dysfunction. (southend.nhs.uk)
- Hypothalamic disease is a disorder presenting primarily in the hypothalamus, which may be caused by damage resulting from malnutrition, including anorexia and bulimia eating disorders, genetic disorders, radiation, surgery, head trauma, lesion, tumour or other physical injury to the hypothalamus. (wikipedia.org)
- Hypopituitarism, neurogenic diabetes insipidus, tertiary hypothyroidism, and developmental disorders are examples of precipitating conditions caused by hypothalamic disease. (wikipedia.org)
- This book presents the state of the art in the pathophysiology, diagnosis, and therapy of hypothalamic and pituitary disorders. (worldcat.org)
- After an introduction devoted to the physiology of the neuroendocrine control of the hypothalamic-pituitary unit, the diverse disorders involving hormonal excess or deficiency are systematically addressed axis by axis. (worldcat.org)
- Though hypothalamic hamartomas can occur in patients with certain genetic disorders (such as Pallister-Hall syndrome ), the majority of cases are sporadic. (cdc.gov)
- The causes of SIAD comprise a wide variety of diseases, including malignancy, drugs, respiratory and central nervous system disorders among others. (springer.com)
- The Journal of Huntington's Disease is an international multidisciplinary journal to facilitate progress in understanding the genetics, molecular correlates, pathogenesis, pharmacology, diagnosis and treatment of Huntington's disease and related disorders. (iospress.com)
- The journal is dedicated to providing an open forum for original research in basic science, translational research and clinical medicine that will expedite our fundamental understanding and improve treatment of Huntington's disease and related disorders. (iospress.com)
- Hypothalamic and pituitary diseases that may cause decreased testicular function include tumours and cysts of the hypothalamus , nonsecreting and prolactin-secreting pituitary tumours , trauma, hemochromatosis (excess iron storage), infections, and nonendocrine disorders, such as chronic illness and malnutrition. (britannica.com)
- Men with hypogonadism who have increased serum gonadotropin concentrations are said to have hypergonadotropic hypogonadism, and their evaluation should be focused on the causes of testicular disease, including chromosomal disorders. (britannica.com)
- Lipid-storage diseases are a group of disorders characterized by excessive accumulation of lipids due to inherited abnormalities in lipid metabolism. (nature.com)
- Lysosomal storage diseases (LSDs) are a diverse group of disorders that can manifest at any stage of life. (nature.com)
- 21.4 Other neuroimmunological hypothalamic disorders and lesions. (elsevier.com)
- 25. Hypothalamic lesions following trauma and iatrogenic disorders. (elsevier.com)
- 26. Hypothalamic involvement in psychiatric disorders. (elsevier.com)
- The present invention is also directed to uses of the pyrazole, triazole, and tetrazole compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. (patents.com)
- To formulate clinical practice guidelines for the endocrine treatment of hypothalamic-pituitary and growth disorders in survivors of childhood cancer. (medscape.com)
- However, by virtue of their disease and its treatments, childhood cancer survivors are at increased risk for a wide range of serious health conditions, including disorders of the endocrine system. (medscape.com)
- The following guideline addresses the diagnosis and treatment of hypothalamic-pituitary and growth disorders commonly encountered in childhood cancer survivors. (medscape.com)
- Adrenal disease-including disorders such as congenital adrenal hyperplasia (CAH), Addison disease, Cushing syndrome, pheochromocytoma , and primary hyperaldosteronism-can reduce female fertility or severely impact maternal and fetal health during pregnancy. (medscape.com)
- There are many different disorders that can involve the suprasellar cistern including benign and malignant tumors, metastatic disease, cysts, abscesses, infiltrative and inflammatory processes, aneurysms, harmatomas and an ectopic posterior pituitary. (tuftsmedicalcenter.org)
- The Neuroendocrine and Endocrine Neoplasia Clinic at Tufts Medical Center in Boston provides care for patients with hypothalamic, suprasellar and pituitary disorders. (tuftsmedicalcenter.org)
- Definition of neurology: a science involved in the study of the nervous systems, especially of the diseases and disorders affecting them. (neurosciencenews.com)
- Global, regional, and national burden of neurological disorders during 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. (edu.au)
- However, recent breakthroughs in the understanding of the neurobiology of the organism's response to acute and chronic stress, and the evolving understanding of elaborate brain-gut interactions and their modulation in health and disease, are beginning to require a reassessment of chronic stress in the pathophysiology and management not only of functional but also of "organic" gastrointestinal disorders. (bmj.com)
- Certain stressful life events have been associated with the onset or symptom exacerbation in some of the most common chronic disorders of the digestive system, including functional gastrointestinal disorders (FGD), inflammatory bowel disease (IBD), gastro-oesophageal reflux disease (GORD), and peptic ulcer disease (PUD). (bmj.com)
- Barrow receives referrals from all over the world and is internationally recognized for the treatment of disorders such as cerebrovascular aneurysms, hypothalamic hamartomas and other brain tumors, complex spinal disorders, stroke and Parkinson's disease at the Muhammad Ali Parkinson Center. (wikipedia.org)
- Other causes for hypothalamic obesity include other rare tumors, head trauma, swelling in the brain and being born with a brain malformation. (cdc.gov)
- 19.1 Symptoms due to hypothalamic tumors. (elsevier.com)
- RATIONALE: Gathering information about patients with central nervous system tumors over time may help doctors learn more about the disease and find better methods of treatment and on-going. (bioportfolio.com)
- This activation of hypothalamic inflammatory pathways results in the uncoupling of caloric intake and energy expenditure, fostering overeating and further weight gain. (jci.org)
- An understanding of the contributions of different neuronal and non-neuronal cell types to hypothalamic inflammatory processes, and delineation of the differences and similarities between acute and chronic activation of these inflammatory pathways, will be critical for the development of novel therapeutic strategies for the treatment of obesity and metabolic syndrome. (jci.org)
- Chronic rhinosinusitis (CRS) is a complex inflammatory disease that is treated primarily with sinus surgery and the long-term use of topical steroid therapy. (clinicaltrials.gov)
- CRS is an inflammatory disease of the paranasal sinuses that is difficult to treat. (clinicaltrials.gov)
- Systemic disease, e.g. undiagnosed and untreated coeliac disease (which often occurs without gastrointestinal symptoms), inflammatory bowel disease (principally Crohn's disease), chronic renal failure. (wikipedia.org)
- We investigated the hypothalamic-pituitary-adrenal (HPA) axis activity, functionality, and reactivity for up to 6 weeks after an intracerebroventricular injection of amyloid-β(25-35) peptide (Aβ(25-35)) in rat, a validated acute model of AD. (nih.gov)
- Sundowning Syndrome and Hypothalamic-Pituitary-Adrenal Axis Dysregulation in Individuals with Alzheimer's Disease: Is There an Association? (wiley.com)
- Background The diagnostic value of tests used in assessing hypothalamic-pituitary-adrenal axis (HPA) in children remains controversial. (bmj.com)
- However, the effects of budesonide irrigation on the hypothalamic-pituitary-adrenal (HPA) axis in patients with CRS following sinus surgery, is as of yet not defined. (clinicaltrials.gov)
- The hypothalamic-pituitary-gonadal axis (HPG axis) functions normally at birth and well into adult life, giving normal puberty and normal reproductive function. (wikipedia.org)
- Functional hypothalamic amenorrhoea is seen in females where the HPG axis is suppressed in response to physical or psychological stress or malnutrition but is reversible with the removal of the stressor. (wikipedia.org)
- The hypothalamic-pituitary-adrenal axis ( HPA axis or HTPA axis ) is a complex set of direct influences and feedback interactions among three components: the hypothalamus , the pituitary gland (a pea-shaped structure located below the thalamus), and the adrenal (also called "suprarenal") glands (small, conical organs on top of the kidneys). (wikipedia.org)
- The HPA axis, HPG axis , HPT axis , and the hypothalamic-neurohypophyseal system are the four major neuroendocrine systems through which the hypothalamus and pituitary direct neuroendocrine function. (wikipedia.org)
- Long-term treatment with inhaled steroids (ICS), especially fluticasone that developed lately, may suppress the hypothalamic-pituitary-adrenal (HPA) axis. (bvsalud.org)
- Among women with fibromyalgia, pain symptoms early in the day are associated with variations in function of the hypothalamic-pituitary-adrenal axis (e.g. high cortisol). (greenmedinfo.com)
- Persons with fibromyalgia and rheumatoid arthritis may have a hypothalamic-pituitary-adrenal axis disturbance (e.g. high cortisol). (greenmedinfo.com)
- Systemic corticosteroid use suppresses the hypothalamic-pituitary-adrenal-axis in patients with acute exacerbation of chronic obstructive pulmonary disease. (greenmedinfo.com)
- The hypothalamic-pituitary-thyroid axis in subjects with subclinical thyroid diseases: the impact of the negative feedback mechanism. (nel.edu)
- Falaschi P, Martocchia A, Proietti A, D'Urso R, Gargano S, Culasso F, Rocco A. The hypothalamic-pituitary-thyroid axis in subjects with subclinical thyroid diseases: the impact of the negative feedback mechanism. (nel.edu)
- The somatotropic axis is overactive even in patients with early disease, and could be related to the weight loss seen in HD patients. (plos.org)
- The three glands and the hormones they produce make up the "Hypothalamic - Pituitary - Thyroid axis. (thyroid.ca)
- In healthy individuals and in those with goitre, the hypothalamic - pituitary - thyroid axis maintains thyroid hormone production at a finely controlled level and enables the thyroid to respond to situations requiring more or less thyroid hormone production. (thyroid.ca)
- Neurosteroid, GABAergic and hypothalamic pituitary adrenal (HPA) axis regulation: what is the current state of knowledge in humans? (ebscohost.com)
- Assesses the effect of short-term treatment with two different antidepressant medication on hypothalamic-pituitary-adrenal (HPA) axis activity. (ebscohost.com)
- Rationale: Stress activates the hypothalamic-pituitary-adrenal (HPA) axis, and GABAergic neuroactive steroids contribute to homeostatic regulation of this circuitry. (ebscohost.com)
- First, the basics: The body's response to stress is controlled by the hypothalamic-pituitary-adrenal (HPA) axis . (alzforum.org)
- Autoimmune hypothalamic-pituitary-adrenal axis (HPA) diseases induced by checkpoint inhibitors are being increasingly recognized. (medworm.com)
- Hypothalamic hypothyroidism belongs to the group of hypothyroidisms collectively known as central hypothyroidism. (renalandurologynews.com)
- Acquired hypothyroidism can be caused by both thyroid disease (primary hypothyroidism) and hypothalamic-pituitary disease (central hypothyroidism). (wrongdiagnosis.com)
- Over the last years, hypothalamic inflammation has been linked to the development and progression of obesity and its sequelae. (jci.org)
- Over the last years, hypothalamic inflammation has been linked to the development and progression of obesity and its sequelae and has emerged not only as an important driver of impaired energy balance, but also as a contributor to obesity-associated insulin resistance via altered neurocircuit functions. (jci.org)
- Furthermore, early intervention by voluntary exercise normalized hypothalamic inflammation and neurodegeneration as well as glucose metabolism in the 3xtg-AD model. (pubtransformer.com)
- Hypothalamic Inflammation at a Crossroad of Somatic Diseases. (nih.gov)
- In this issue of the JCI , a group of experts have provided reviews that dive deeply into the mechanisms by which obesity-induced inflammation influences metabolic homeostasis, surveying the modes and mechanisms of inflammation in different tissues and how they might contribute to disease. (jci.org)
- There are a few rare genetic inherited conditions that include the symptoms of hypothalamic obesity such as Bardet-Biedl syndrome and leptin deficiency . (cdc.gov)
- Hypothalamic obesity is often complicated in patients with craniopharyngioma due to hypothalamic damage by the tumor itself, treatment modalities, and associated multiple pituitary hormone deficiency. (e-apem.org)
- This causes a deficiency or loss of hypothalamic regulatory hormone input to the pituitary, resulting in loss of anterior pituitary hormone secretion. (medscape.com)
- Hypothalamic obesity causes secondary diseases such as nonalcoholic fatty liver disease (NAFLD) and diabetes mellitus (DM). (e-apem.org)
- As the hypothalamus plays a crucial role in the homeostasis of the synthesis of anterior pituitary hormones [ 3 ], damage to the hypothalamus results in dysregulation of multiple pituitary hormones and subsequent complications such as hypothalamic obesity, nonalcoholic fatty liver disease (NAFLD), and diabetes mellitus (DM). (e-apem.org)
- Hypothalamic disease may cause insufficient or inhibited signalling to the pituitary leading to deficiencies of one or more of the following hormones: thyroid-stimulating hormone, adrenocorticotropic hormone, beta-endorphin, luteinizing hormone, follicle-stimulating hormone, and melanocyte-stimulating hormones. (wikipedia.org)
- T4 and T3 are normally synthesized and released in response to a combined hypothalamic pituitary signal mediated by thyroid stimulating hormone (TSH) from the anterior pituitary and thyrotropin releasing hormone (TRH) from the hypothalamus. (renalandurologynews.com)
- When low thyroid hormone levels are the result of a failure of the hypothalamus to secrete TRH, which, in turn, stimulates the anterior pituitary to produce TSH, the resulting hypothyroidism is hypothalamic hypothyroidism, also known as tertiary hypothyroidism. (renalandurologynews.com)
- Fundamental mechanisms underlying disease pathogenesis are presented to provide the reader with an in-depth understanding of mechanisms subserving both normal and disordered pituitary hormone secretion and action. (elsevier.com)
- Sperm count cannot be increased in men with testicular disease, although it is sometimes possible to increase sperm count in men with hypothalamic or pituitary disease by prolonged administration of gonadotropin-releasing hormone or gonadotropins. (britannica.com)
- This structure has direct connections with the Retina & plays a major role in the 'Circadian Rhythm' of the hypothalamic systems (hormone release, temp. (sporcle.com)
- Relationships between hormone levels and disease severity, including weight-loss severity, were evaluated. (plos.org)
- The effects of exercise on hypothalamic neurodegeneration of Alzheimer's disease mouse model. (pubtransformer.com)
- PMID- 29293568 OWN - NLM STAT- MEDLINE DCOM- 20180206 LR - 20180206 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 13 IP - 1 DP - 2018 TI - The effects of exercise on hypothalamic neurodegeneration of Alzheimer's disease mouse model. (pubtransformer.com)
- There are currently over 1.9 billion people who are obese or overweight, leading to a rise in related health complications, including insulin resistance, type 2 diabetes, cardiovascular disease, liver disease, cancer, and neurodegeneration. (jci.org)
- A study shows that, in a mouse model of neuronopathic Gaucher disease, delivery of a gene therapy into the brains of fetal animals prevents neurodegeneration, ameliorates associated neuroinflammation and promotes survival. (nature.com)
- Patients surviving craniopharyngioma need to be followed up carefully to detect signs of hypothalamic obesity and monitored for the development of other comorbidities such as DM, NAFLD, and hepatopulmonary syndrome. (e-apem.org)
- Interferences may obscure the diagnosis of hypothalamic hypothyroidism or complicate the monitoring of the effectiveness of thyroid replacement therapy. (renalandurologynews.com)
- The diagnosis of hypothalamic obesity is made based on the symptoms which include a sudden onset of excessive hunger and weight gain after trauma or brain surgery. (cdc.gov)
- Certain genetic syndromes also include symptoms of hypothalamic obesity. (cdc.gov)
- A complete medical history, review of systems, growth pattern, and physical examination will reveal most of the systemic diseases and conditions capable of arresting development or delaying puberty, as well as providing clues to some of the recognizable syndromes affecting the reproductive system. (wikipedia.org)
- Many of these hypothalamic hormones act on the pituitary gland. (wikipedia.org)
- The principal aim of this prospective study is to evaluate the variability of hypothalamic-pituitary hormones and clinical effects in children and adults after ETV in order to plan a multicentric study. (clinicaltrials.gov)
- Delay of puberty may also occur due to malnutrition, many forms of systemic disease, or to defects of the reproductive system (hypogonadism) or the body's responsiveness to sex hormones. (wikipedia.org)
- We conducted detailed hypothalamic proteome analyses and also measured circulating levels of various metabolic hormones and lipids in pre-symptomatic and symptomatic animals. (uantwerpen.be)
- It synthesizes and secretes certain neurohormones , called releasing hormones or hypothalamic hormones, and these in turn stimulate or inhibit the secretion of hormones from the pituitary gland. (wikipedia.org)
- Graves' disease (thyrotoxicosis) is due to a unique antibody called "thyroid stimulating antibody" which stimulates the thyroid cells to grow larger and to produce excessive amounts of thyroid hormones. (thyroid.ca)
- In hypothyroidism due to a hypothalamic disorder, free T4 is decreased. (renalandurologynews.com)
- Alzheimer's disease is a neurodegenerative disorder that affects the central nervous system. (pubtransformer.com)
- PG - e0190205 LID - 10.1371/journal.pone.0190205 [doi] AB - Alzheimer's disease is a neurodegenerative disorder that affects the central nervous system. (pubtransformer.com)
- Huntington's disease (HD) is a neurodegenerative disorder, which is characterized by progressive motor impairment and cognitive alterations. (uantwerpen.be)
- Huntington's disease (HD) is a neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin gene. (iospress.com)
- Men with hypogonadism caused by a hypothalamic disorder, pituitary disorder, or testicular disorder are treated with testosterone. (britannica.com)
- REM sleep behavior disorder is related to enteric neuropathology in Parkinson disease. (amedeo.com)
- Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder characterized by late-onset motor, psychiatric, and cognitive deficits. (jneurosci.org)
- Huntington's disease (HD) is a severe inherited neurodegenerative disorder characterized, in addition to neurological impairment, by weight loss suggesting endocrine disturbances. (plos.org)
- Huntington's disease (HD) is a rare, autosomal dominant, neurodegenerative disorder resulting from expansion of a CAG repeat within the IT15 huntingtin (htt) gene on chromosome 4p . (plos.org)
- Erdheim-Chester disease (ECD) is a rare multi-system, non-Langerhans cell histiocytic disorder (NLCHD) with only a few hundred cases reported in the literature. (springer.com)
- In Editor-in-Chief: Luciano Martini (Ed.), Encyclopedia of endocrine diseases (pp. 678-687). (wikipedia.org)
- The symptoms of hypothalamic obesity vary by the cause and include uncontrollable hunger, rapid, excessive weight gain, and a low metabolic rate. (cdc.gov)
- Signs and symptoms of hypothalamic obesity include excessive appetite, inability to feel 'full', and rapid weight gain. (cdc.gov)
- When this tumor is removed, the hypothalamus can get damaged leading to the symptoms of hypothalamic obesity. (cdc.gov)
- Prader-Willi syndrome also shares symptoms with hypothalamic obesity, but it is not generally inherited in families. (cdc.gov)
- Both the type and severity of symptoms vary greatly among patients with hypothalamic hamartomas. (cdc.gov)
- This table lists symptoms that people with this disease may have. (cdc.gov)
- For most diseases, symptoms will vary from person to person. (cdc.gov)
- People with the same disease may not have all the symptoms listed. (cdc.gov)
- Do you have more information about symptoms of this disease? (cdc.gov)
- Short stature, delayed growth in height and weight, and/or delayed puberty may be the only clinical manifestations of coeliac disease, in absence of any other symptoms. (wikipedia.org)
- Because the hypothalamus controls so many different functions, hypothalamic disease can have many different symptoms, depending on the cause. (medlineplus.gov)
- and decreased hearing are symptoms usually expressed later in the course of the disease. (oncologynurseadvisor.com)
- Symptoms of 'Cushing's Disease' (excess ACTH) are what? (sporcle.com)
- Oral chinese herbal medicines appear to improve the quality of life in patients with stable chronic obstructive pulmonary disease. (greenmedinfo.com)
- Dietary Omega-3 fatty acids may protect smokers against chronic obstructive pulmonary disease. (greenmedinfo.com)
- Echinacea purpurea along with zinc, selenium and vitamin C alleviate exacerbations of chronic obstructive pulmonary disease. (greenmedinfo.com)
- Dr. Cuervo is professor of developmental and molecular biology , of anatomy and structural biology , and of medicine and holds the Robert and Renee Belfer Chair for the Study of Neurodegenerative Diseases. (yu.edu)
- This lateral hypothalamic abnormality would be expected to affect the function of most of the pituitary axes (as shown in other neurodegenerative diseases where neuroendocrine alterations occur ), potentially modifying the basal levels of GH, TSH, ACTH, LH, FSH, and prolactin, at least at late in the course of HD. (plos.org)
- That the limitations and side unaware of observations of dementia or other neurodegenerative diseases that also look like Ken. (reed-electronics.com)
- Evidence against screening includes the observation that factors such as some medications, autoimmune diseases, or assay variations, may explain abnormal TSH levels, and studies show those abnormalities will commonly normalize on their own in subsequent testing. (medscape.com)
- Gaining a greater understanding of the hypothalamic and metabolic alterations that occur in HD, could lead to the development of novel therapeutics for early interventional treatment of HD. (uantwerpen.be)
- The different functions of white, brown and beige fat might yield new targets in the fight against obesity and metabolic disease. (nature.com)
- We report a 19-year-old female who was diagnosed with craniopharyngioma, developed hypothalamic obesity after tumor resection, and progressed to hepatopulmonary syndrome. (e-apem.org)
- We describe a case of hepatopulmonary syndrome complicated with hypothalamic obesity, NAFLD, and type 2 DM after craniopharyngioma resection. (e-apem.org)
- We designed a prospective nonrandomized study aiming at assessing the impact of continuous positive airway pressure (CPAP) after a new diagnosis of obstructive sleep apnea syndrome (OSAS) in patients with coronary artery disease (CAD). (biomedsearch.com)
- Almost always the endocrine manifestations occur in a patient with widespread disease involving the lungs, skin or liver. (bmj.com)
- Hypothalamic hamartomas (HH) are rare, tumor -like malformations that occur during fetal development and are present at birth. (cdc.gov)
- In fact, recent studies using postmortem tissue, magnetic resonance imaging and positron emission tomography have shown that hypothalamic and limbic system changes occur early in clinical HD. (iospress.com)
- Neurologic manifestations of hypothalamic disease. (wikipedia.org)
- Clinical manifestations of the anti-IgLON5 disease. (amedeo.com)
- Medical management of motor manifestations of Huntington disease. (edu.au)
- Up to 52% of pediatric craniopharyngioma patients develop hypothalamic obesity after tumor resection and most patients manifest obesity-related morbidities and low quality of life. (e-apem.org)
- A recent study of craniopharyngioma patients with hypothalamic involvement showed a 50% incidence of NAFLD [ 5 ], raising the need for liver function monitoring in patients with hypothalamic injuries. (e-apem.org)
- Making a diagnosis for a genetic or rare disease can often be challenging. (cdc.gov)
- Hashimoto's disease during interferon-alpha therapy in a patient with pre-treatment negative anti-thyroid autoantibodies and with the specific genetic susceptibility to the thyroid disease. (nel.edu)
- Martocchia A, Labbadia G, Paoletti V, Gargano S, Grossi A, Trabace S, Musca A, Falaschi P. Hashimoto's disease during interferon-alpha therapy in a patient with pre-treatment negative anti-thyroid autoantibodies and with the specific genetic susceptibility to the thyroid disease. (nel.edu)
- Huntington disease: The complexities of making and disclosing a clinical diagnosis after premanifest genetic testing. (edu.au)
- Jeffrey Pessin, Ph.D., director of Einstein's Diabetes Research Center , and Christopher Newgard, Ph.D., of Duke University School of Medicine, will co-chair the panel on metabolism and how making it more efficient could help fight age-related diseases processes. (yu.edu)
- This review summarizes the current state of knowledge in this area based on clinical studies as well as experiments in animal models of the disease and establishes that hypothalamic and limbic system changes are part of the HD pathology. (iospress.com)
- A case is reported of central nervous system (CNS) sarcoidosis with no other clinical, biochemical or histological evidence of the disease. (bmj.com)
- Today, the clinical diagnosis of the disease requires unequivocal signs of typical motor disturbances, which is thought to be due to pathology in the striatum of the basal ganglia. (iospress.com)
- Consensus guidelines for the diagnosis and clinical management of Erdheim-Chester disease. (springer.com)
- A cross section of the monkey hypothalamus displays 2 of the major hypothalamic nuclei on either side of the fluid-filled 3rd ventricle. (wikipedia.org)
- This newly described regulatory center is extensively connected with other feeding control circuits via projections to other hypothalamic nuclei. (sciencemag.org)
- Our results demonstrate that there are significant alterations in HD rat hypothalamic protein expression such as glial fibrillary acidic protein (GFAP), heat shock protein-70, the oxidative damage protein glutathione peroxidase (Gpx4), glycogen synthase1 (Gys1) and the lipid synthesis enzyme acylglycerol-3-phosphate O-acyltransferase 1 (Agpat1). (uantwerpen.be)
- There is morphological evidence for differential alterations in striatal medium-sized spiny neurons (MSNs) giving rise to the direct and indirect output pathways in Huntington's disease (HD). (iospress.com)
- In the past, little attention has been paid to the significance of alterations in skin thickness in disease. (annals.org)
- Elevated cortisol evidence in Alzheimer's disease (AD) patients prompted the hypothesis that stress and glucocorticoids are involved in the development and/or maintenance of AD. (nih.gov)
- The data, taken as a whole, suggests a hypothalamic-mediated mechanism where exercise prevents the progression of dementia and of Alzheimer's disease. (pubtransformer.com)
- Exposure to a single immobilization or lipopolysaccharide challenge increases expression of genes implicated in the development of Alzheimer's disease in the mice brain cortex. (nih.gov)
- Morphometric measurements of MRI findings in patients with Alzheimer's disease. (semanticscholar.org)
- Does stress increase the risk of developing Alzheimer's disease, or worsen dementia? (alzforum.org)
- Although the disease today known as Huntington's was described as early as the mid-19th century, knowledgeable physicians despaired of finding successful therapies and affected families largely kept it hidden. (iospress.com)
- The Journal of Huntington's Disease is a welcome new resource in this effort. (iospress.com)
- Huntington's disease (HD) mouse models that express N-terminal huntingtin fragments show rapid disease progression and have been used for developing therapeutics. (jneurosci.org)
- To elucidate the pathogenic mechanisms in Huntington's disease (HD) elicited by expression of full-length human mutant huntingtin (fl-mhtt), a bacterial artificial chromosome (BAC)-mediated transgenic mouse model (BACHD) was developed expressing fl-mhtt with 97 glutamine repeats under the control of endogenous htt regulatory machinery on the BAC. (jneurosci.org)
- What do we know about late onset Huntington's disease? (edu.au)
- Journal of Huntington's Disease , 6(2), 95-103. (edu.au)
- Most commonly, trauma or infectious disease cause the change from compensated to decompensated disease. (medscape.com)
- Severe obesity can lead to complications such as diabetes, heart disease, and stroke. (cdc.gov)
- This disease occurs upon destruction of the 'Supraoptic Nucleus & Paraventricular Nucleus', causing lowered Vasopressin (ADH) production. (sporcle.com)
- Hypothalamic control of energy homeostasis. (jci.org)
- Spontaneous periodic hypothermia in Parkinson disease with hypothalamic involvement. (nih.gov)
- CNS involvement and treatment with interferon-alpha are independent prognostic factors in Erdheim-Chester disease: a multicenter survival analysis of 53 patients. (springer.com)
- Erdheim-Chester disease presenting with cutaneous involvement: a case report and literature review. (springer.com)
- Cerebral, facial, and orbital involvement in Erdheim-Chester disease: CT and MR imaging findings. (springer.com)
- Pituitary defects and diseases e.g. hypopituitarism. (wikipedia.org)
- We used the HD transgenic (tg) rat model bearing 51 CAG repeats, which exhibits similar HD symptomology as HD patients to investigate hypothalamic function. (uantwerpen.be)
- The high prevalence of cardiorespiratory arrest in ROHHAD patients, a lack of medical awareness about the disease, and delay in diagnosis and treatment can lead to poor therapeutic outcomes ( 6 , 7 ). (pedinfect.com)
- Studies of PCNSL in patients with rheumatic diseases are lacking. (bioportfolio.com)
- Association between human leukocyte antigen (HLA) and interferon- induced thyroid diseases in four patients with HCV-related chronic hepatitis. (nel.edu)
- Reduced cognitive function in patients with Parkinson disease and obstructive sleep apnea. (amedeo.com)
- Patients with adult-onset HD experience symptom onset around age 40 and death usually occurs 10-20 years after disease onset. (jneurosci.org)
- Immunohistochemical evidence of a cytokine and chemokine network in three patients with Erdheim-Chester disease: implications for pathogenesis. (springer.com)
- Systemic perturbation of cytokine and chemokine networks in Erdheim-Chester disease: a single-center series of 37 patients. (springer.com)
- Studies in adults with hypothalamopituitary disconnection (functional pituitary stalk transection), show GHRP-6-mediated GH release to be completely blocked, indicating a main action at the hypothalamic rather than the pituitary level. (curehunter.com)
- NLRP3 expression in mesencephalic neurons and characterization of a rare NLRP3 polymorphism associated with decreased risk of Parkinson's disease. (nih.gov)