• Patients surviving craniopharyngioma need to be followed up carefully to detect signs of hypothalamic obesity and monitored for the development of other comorbidities such as DM, NAFLD, and hepatopulmonary syndrome. (e-apem.org)
  • Evidence against screening includes the observation that factors such as some medications, autoimmune diseases, or assay variations, may explain abnormal TSH levels, and studies show those abnormalities will commonly normalize on their own in subsequent testing. (medscape.com)
  • We report a 19-year-old female who was diagnosed with craniopharyngioma, developed hypothalamic obesity after tumor resection, and progressed to hepatopulmonary syndrome. (e-apem.org)
  • We describe a case of hepatopulmonary syndrome complicated with hypothalamic obesity, NAFLD, and type 2 DM after craniopharyngioma resection. (e-apem.org)
  • We designed a prospective nonrandomized study aiming at assessing the impact of continuous positive airway pressure (CPAP) after a new diagnosis of obstructive sleep apnea syndrome (OSAS) in patients with coronary artery disease (CAD). (biomedsearch.com)
  • Jeffrey Pessin, Ph.D., director of Einstein's Diabetes Research Center , and Christopher Newgard, Ph.D., of Duke University School of Medicine, will co-chair the panel on metabolism and how making it more efficient could help fight age-related diseases processes. (yu.edu)
  • This review summarizes the current state of knowledge in this area based on clinical studies as well as experiments in animal models of the disease and establishes that hypothalamic and limbic system changes are part of the HD pathology. (iospress.com)
  • Our results demonstrate that there are significant alterations in HD rat hypothalamic protein expression such as glial fibrillary acidic protein (GFAP), heat shock protein-70, the oxidative damage protein glutathione peroxidase (Gpx4), glycogen synthase1 (Gys1) and the lipid synthesis enzyme acylglycerol-3-phosphate O-acyltransferase 1 (Agpat1). (uantwerpen.be)
  • There is morphological evidence for differential alterations in striatal medium-sized spiny neurons (MSNs) giving rise to the direct and indirect output pathways in Huntington's disease (HD). (iospress.com)
  • In the past, little attention has been paid to the significance of alterations in skin thickness in disease. (annals.org)
  • Although the disease today known as Huntington's was described as early as the mid-19th century, knowledgeable physicians despaired of finding successful therapies and affected families largely kept it hidden. (iospress.com)
  • The Journal of Huntington's Disease is a welcome new resource in this effort. (iospress.com)
  • Huntington's disease (HD) mouse models that express N-terminal huntingtin fragments show rapid disease progression and have been used for developing therapeutics. (jneurosci.org)
  • To elucidate the pathogenic mechanisms in Huntington's disease (HD) elicited by expression of full-length human mutant huntingtin (fl-mhtt), a bacterial artificial chromosome (BAC)-mediated transgenic mouse model (BACHD) was developed expressing fl-mhtt with 97 glutamine repeats under the control of endogenous htt regulatory machinery on the BAC. (jneurosci.org)
  • What do we know about late onset Huntington's disease? (edu.au)
  • Journal of Huntington's Disease , 6(2), 95-103. (edu.au)
  • This disease occurs upon destruction of the 'Supraoptic Nucleus & Paraventricular Nucleus', causing lowered Vasopressin (ADH) production. (sporcle.com)
  • Studies in adults with hypothalamopituitary disconnection (functional pituitary stalk transection), show GHRP-6-mediated GH release to be completely blocked, indicating a main action at the hypothalamic rather than the pituitary level. (curehunter.com)
  • NLRP3 expression in mesencephalic neurons and characterization of a rare NLRP3 polymorphism associated with decreased risk of Parkinson's disease. (nih.gov)