Ocular hypertensionProstaglandinShockEpisodesPatientsEffectVitroAllergicClonidineSystemicArterialEffectivenessMechanismsEffectsEvaluateRabbitsBloodActivityAllergic and Hypotensive ReactionsTopical ocular hypotensive medicationsAcute Hypotensive Transfusion ReactionsEFFECTAnaesthesiaPregnancyHemodynamicsTraumaAgentsAgentResponseEpisodeInjuryHigh

Ocular hypertension2

• To evaluate the ocular hypotensive efficacy of 0.05%, 0.1% and 0.25% AR-12286 Ophthalmic Solutions in patients diagnosed with ocular hypertension or glaucoma. (entokey.com)
• AR-12286 was well tolerated and provided clinically and statistically significant ocular hypotensive efficacy in patients with ocular hypertension and glaucoma. (entokey.com)

Prostaglandin1

• Use of ocular hypotensive prostaglandin analogues in patients with uveitis: does their use increase anterior uveitis and cystoid macular oedema? (bmj.com)

Shock6

• Some patients with COVID-19 will become critically ill and may develop hypotensive shock, but there is uncertainty about the most beneficial way to treat this. (paho.org)
• Vasopressors have shown evidence of benefit in hypotensive shock, probably because of their ability to raise blood pressure. (paho.org)
• Their effects for patients with hypotensive shock caused by other factors might indicate their effects in patients with COVID-19. (paho.org)
• In this Cochrane systematic review, the authors searched for randomized trials comparing different vasopressor regimens on mortality in critically ill patients with hypotensive shock. (paho.org)
• This was a single-center study including less than 100 hypotensive patients (only ~20 of whom had septic shock), and was by its nature unblinded, so consider it far from definitive. (pulmccm.org)
• BACKGROUND: The aim of our study was to evaluate the effect of lactate level (LL) and shock index (SI) on the outcome in nontraumatic hypotensive patients in the emergency department, and also to show the significance of the combined usage of these two parameters. (uaeu.ac.ae)

Episodes2

• The duration of hypotensive episodes induced by Lys-des-Arg9-BK was increased in rabbits pretreated with either captopril, an ACE inhibitor, or the aminopeptidase M inhibitor amastatin, consistent with the prolonged effect of metabolically protected analogs. (aspetjournals.org)
• Number of severe hypotensive episodes. (who.int)

Patients3

• Our objective was to study hypotensive therapy efficiency at early periods of observation of patients with arterial hypertension associated with type II diabetes mellitus depending on the type of left ventricular remodelling. (eco-vector.com)
• No dependence between hypotensive effect and the geometry type of the left ventricle in patients with arterial hypertension associated with type II diabetes mellitus was detected. (eco-vector.com)
• In hypotensive and normotensive patients, use etomidate. (medscape.com)

Effect4

• Both analogs were found to elicit a biphasic response consisting of a brief hypotensive effect followed by a prolonged hypotensive state. (aspetjournals.org)
• Peptides with molecular weights below 3 kDa from the hydrolysis of olive seed proteins with Thermolysin (OS-3 kDa) have demonstrated a high in vitro hypotensive effect. (uah.es)
• Objectives: To determine the effect of an escalating dose of droxidopa (100, 200, and 400mg) compared with placebo on seated blood pressure (BP) in hypotensive individuals with spinal cord injury (SCI). (mssm.edu)
• There has been detected a direct correlation between the hypotensive effect and the myocardium mass of the left ventricle and a negative correlation between the relative ventricle wall thickness and the index of the area of diastolic blood pressure. (eco-vector.com)

Vitro2

• In anesthetized male Wistar rats, this peptide exhibited hypotensive actions similar to those of bradykinin (BK) when administered intravenously (i.v.), and was found to be metabolized both in vitro and in vivo by several peptidases, including the angiotensin-converting enzyme (ACE). (nih.gov)
• In addition, Lys-des-Arg9-BK is hydrolyzed in vitro by aminopeptidase M. Therefore, we tested the hypotensive effects of Lys-des-Arg9-BK analogs selectively protected against ACE activity (Lys-[D-Phe8]des-Arg9-BK) or against both ACE and aminopeptidase M (Sar-[D-Phe8]des-Arg9-BK). (aspetjournals.org)

Allergic1

• The SHOT team are excited to announce our final Webinar of 2020 covering the Febrile, Allergic and Hypotensive Reactions (FAHR) chapter of the Annual SHOT Report 2019 along with a 7-year trend analysis. (mhra.gov.uk)

Clonidine2

• Hypotensive agents (e.g., reserpine, MAO inhibitors, clonidine) may increase the risk of hypotension and/or severe bradycardia. (nih.gov)
• Clonidine is in a class of medications called centrally acting alpha-agonist hypotensive agents. (medlineplus.gov)

Systemic2

• The objectives of this study were to evaluate the ocular hypotensive efficacy along with the ocular and systemic safety of AR-12286 ophthalmic solutions. (entokey.com)
• These findings drew attention to the systemic effects of topical hypotensive drug treatment. (nyu.edu)

Arterial1

• When an arterial catheter isn't feasible for whatever reason (obesity, operator skill, etc.), noninvasive blood pressure cuffs appear to be effective at answering the most important question: whether a patient is hypotensive. (pulmccm.org)

Effectiveness2

• The hypotensive effectiveness of defatted crude ethanolic extract, ethyl acetate and butanolic fractions of Cassytha filiformis L. have been compared on anesthesized prednisone-saline-induced (PN) and Prednisone-saline-LNAME -induced (PNL) hypertensive rats. (yoriyuliandra.com)
• These results indicated that the hypotensive effectiveness of the defatted ethanolic extract of Cassytha filiformis is better as compared to its ethyl acetate and butanolic fractions and these effects are greater on oxidative stress related hypertensive rats. (yoriyuliandra.com)

Mechanisms2

• BDNF downregulates β-adrenergic receptor-mediated hypotensive mechanisms in the paraventricular nucleus of the hypothalamus. (atsbio.com)
• Thorsdottir D, Cruickshank NC, Einwag Z, Hennig GW, Erdos B (2019) BDNF downregulates β-adrenergic receptor-mediated hypotensive mechanisms in the paraventricular nucleus of the hypothalamus. (atsbio.com)

Effects2

• Hypotensive effects of hemopressin and bradykinin in rabbits, rats and mice. (nih.gov)
• Hypotensive effects of Lys-des-Arg9-bradykinin and metabolically protected agonists of B1 receptors for kinins. (aspetjournals.org)

Evaluate1

• This study highlights the need for future prospective studies to evaluate several outcomes following intravenous fluid therapy in hypotensive cats. (veteducation.com.au)

Rabbits1

• An infusion of the B1 agonist Sar-[D-Phe8]des-Arg9-BK (1 microgram/min) in lipopolysaccharide-pretreated rabbits led to a very important and persistent hypotensive state that was not prevented by indomethacin. (aspetjournals.org)

Blood5

• A Hypotensive transfusion reaction or HTR is a rare condition that presents with low blood pressure associated with administration of blood products. (wikipedia.org)
• Objective: To determine whether BDNF increases blood pressure in part by diminishing inhibitory hypotensive input from nucleus of the solitary tract (NTS) catecholaminergic neurons projecting to the PVN. (atsbio.com)
• Summary: BDNF, a key hypothalamic regulator of blood pressure, disrupts catecholaminergic signaling between the NTS and the PVN by reducing the responsiveness of PVN neurons to inhibitory hypotensive β-adrenergic input from the NTS. (atsbio.com)
• After the second dose, the patient suddenly became hypotensive (blood pressure 60/35 mm Hg). (medscape.com)
• HA and NA were found to be strong hypotensive agents which dilate blood vessels by direct smooth muscle action. (cdc.gov)

Activity1

• A prostamide analogue with ocular hypotensive activity. (medscape.com)

Allergic and Hypotensive Reactions1

• The SHOT team are excited to announce our final Webinar of 2020 covering the Febrile, Allergic and Hypotensive Reactions (FAHR) chapter of the Annual SHOT Report 2019 along with a 7-year trend analysis. (mhra.gov.uk)

Topical ocular hypotensive medications1

• With all topical ocular hypotensive medications, pregnant and breastfeeding patients should be advised to perform nasolacrimal occlusion during eyedrop instillation. (aao.org)

Acute Hypotensive Transfusion Reactions3

• Acute hypotensive transfusion reactions (AHTRs) are characterized by early and abrupt onset of hypotension as the predominant clinical manifestation. (medscape.com)
• A fifth type of reaction has been characterized as being almost solely hypotensive in nature, termed acute hypotensive transfusion reactions. (medscape.com)
• Cite this: Acute Hypotensive Transfusion Reactions - Medscape - Sep 01, 2006. (medscape.com)

EFFECT4

• This amine may stimulate the same central alpha-adrenergic receptors as those activated by clonidine, which will result in a hypotensive effect. (nih.gov)
• whereas hypotensive effect of holamide and pubscinine were not modified by atropine. (hilarispublisher.com)
• CaCl 2 alone produced marked positive inotropic and renal vasodilatory effects which contributed to maintenance of the hypotensive effect of V. (tau.ac.il)
• Objectives: To determine the effect of an escalating dose of droxidopa (100, 200, and 400mg) compared with placebo on seated blood pressure (BP) in hypotensive individuals with spinal cord injury (SCI). (mssm.edu)

Anaesthesia2

• The potential use of hypotensive anaesthesia for maxillofacial surgery was first noted in the 1950s. (nationalelfservice.net)
• Since then a number of studies have been reported on the effects of hypotensive anaesthesia in relation to blood loss operating time and surgical field quality producing conflicting results. (nationalelfservice.net)

Pregnancy1

• The decision as to whether to continue ocular hypotensive therapy during pregnancy, and what agents to use, should be made in collaboration with the patient and her obstetrician. (aao.org)

Hemodynamics1

• Observation and Results: We have observed stable hemodynamics in group D as compare to group E. We have also observed significant less time for eye opening, less requirement of muscle relaxants and inhalational agent and other hypotensive agent. (journalcra.com)

Trauma1

• The results indicate that, even in a geographically large urban EMS system, the time factor involved in managing and transporting hypotensive penetrating injury victims directly to a regional trauma center does not appear to be related to an adverse outcome, at least during the first hour after injury. (elsevierpure.com)

Agents2

• Hypotensive agents (e.g., reserpine, MAO inhibitors, clonidine) may increase the risk of hypotension and/or severe bradycardia. (nih.gov)
• HA and NA were found to be strong hypotensive agents which dilate blood vessels by direct smooth muscle action. (cdc.gov)

Agent1

• They were also observed for surgical field, time to eye-opening and requirement of another hypotensive agent. (journalcra.com)

Response2

• We conclude that although both treatments had a similar hypotensive response only the modified diet beneficially influenced other cardiovascular risk factors. (eurekamag.com)
• These data indicate that the steroidal alkaloids i.e. holamide and pubscinine from Holarrhena pubescens mediated hypotensive response through a mechanism different to that of acetylcholine. (hilarispublisher.com)

Episode1

• Did participant/subject experience hypotensive episode? (nih.gov)

Injury1

• Any idea on how long someone can go with inadequate urine output until there is irreparable damage such as a situation where you're playing the hypotensive resuscitation game due to a non-compressible injury? (prolongedfieldcare.org)

High1

• The high affinity of this endopeptidase for bradykinin (Km = 10 µM) and for atrial natriuretic peptide (Km = 5 µM) suggests that it may play a physiological role in the inactivation of these circulating hypotensive peptide hormones. (scielo.br)