OrthostaticBradycardiaHypertensionInsulinDehydrationHepatic impairmentMetabolicTardive dyskinesiaSyncopeHypoxiaRespiratory depressionSymptomsReactionsCautionDoseCardiacSystemicSeptic shockMicrovascularTraumatic brainCerebrovascular diseaseSepsisComplicationsPatientsManifestationsDeficiencyGlucoseSensitivityMyocardial contractilityCellularDiabetesNeutropeniaAnginaDecreaseHarmChronicDiureticReductionModerate
Orthostatic4
- Caution with other CNS drugs, alcohol, drugs that may cause orthostatic hypotension. (empr.com)
- Orthostatic hypotension may occur with alcohol, barbiturates and narcotics. (medicscientist.com)
- Caution patient to avoid sudden position changes to prevent orthostatic hypotension. (medicscientist.com)
- Diabetic autonomic neuropathy (DAN) occurs when widespread involvement of autonomic unmyelinated fibers occurs, and patients can be incapacitated with orthostatic hypotension as well as neurogenic bladder and bowel involvement. (elsevierpure.com)
Bradycardia4
- failed verification] Xylazine was also studied for use in human beings, but due to hazardous side-effects, including hypotension and bradycardia, it was not approved by the Food and Drug Administration (FDA) for human use. (wikipedia.org)
- It can cause hypotension or low blood pressure, bradycardia or a heart rate of under 60 beats per minute. (naturalpedia.com)
- Bradycardia, hypotension, worsening heart failure/fluid retention may occur. (coregcr.com)
- Severe bradycardia (unless permanent pacemaker in place). (coregcr.com)
Hypertension5
- Diuretics such as chlorthalidone are indicated in the management of hypertension either as the sole therapeutic agent or to enhance the effect of other antihypertensive drugs in the more severe forms of hypertension. (nih.gov)
- Side-effects in animals include transient hypertension, hypotension, and respiratory depression. (wikipedia.org)
- Elevated systolic or diastolic pressure causes increased cardiovascular risk, and the absolute risk increase per mmHg is greater at higher blood pressures, so that even modest reductions of severe hypertension can provide substantial benefit. (globalrph.com)
- May increase pressor response, resulting in severe hypertension. (medicscientist.com)
- May cause severe, persistent hypertension. (medicscientist.com)
Insulin5
- Although many patients with HHS respond to fluids alone, IV insulin in dosages similar to those used in DKA can facilitate correction of hyperglycemia. (medscape.com)
- Further, the decrease of tissue sensitivity to insulin leads to xylazine-induced hyperglycemia and a reduction of tissue glucose uptake and utilization. (wikipedia.org)
- No net uptake of glucose to the cells occurred during the two 1-h measurement periods despite insulin administration in the intervening time period. (springeropen.com)
- The severely hyperglycemic patient is always dehydrated, and insulin might aggravate the situation by relocating extracellular fluid (ECF) to the cells, whereby hemodynamic collapse can occur. (springeropen.com)
- Diabetes mellitus is impaired insulin secretion and variable degrees of peripheral insulin resistance leading to hyperglycemia. (msdmanuals.com)
Dehydration4
- HHS is characterized by hyperglycemia, hyperosmolarity, and dehydration without significant ketoacidosis. (medscape.com)
- Most patients present with severe dehydration and focal or global neurologic deficits. (medscape.com)
- Conditions that predispose to hypotension (eg, dehydration, hypovolemia). (empr.com)
- Our hypothesis was that the calculations would enhance knowledge about the severity of the dehydration and the degree of fluid shifts that occur in the treatment of hyperglycemia. (springeropen.com)
Hepatic impairment3
- Severe hepatic impairment. (empr.com)
- Licensed product information recommends caution in patients with severe hepatic impairment as clinical data are lacking in this patient group. (pocketdrugguide.com)
- In the absence of pharmacokinetic studies in patients with stable severe hepatic impairment (Child Pugh grade C) without decompensation, caution should be exercised when ritonavir is used as a pharmacokinetic enhancer as increased levels of the co-administered protease inhibitor may occur. (who.int)
Metabolic3
- Hyperosmolar hyperglycemic state (HHS) is one of two serious metabolic derangements that occur in patients with diabetes mellitus (DM). (medscape.com)
- Toxicity occurs with repeated administration, given that the metabolic clearance of the drug is usually calculated as 7-9 times the half-life, which is 4 to 5 days for the clearance of xylazine. (wikipedia.org)
- DKA is characterized by hyperglycemia, metabolic acidosis and ketosis. (lww.com)
Tardive dyskinesia1
- Consider discontinuation if tardive dyskinesia occurs. (empr.com)
Syncope2
- When switching from higher doses of immediate-release carvedilol to COREG CR®, a lower starting dose should be considered to reduce the risk of hypotension and syncope. (coregcr.com)
- a When switching from carvedilol 12.5 mg or 25 mg twice daily, a starting dose of COREG CR 20 mg or 40 mg once daily, respectively, may be warranted for elderly patients or those at increased risk of hypotension, dizziness, or syncope. (coregcr.com)
Hypoxia1
- While primary brain injury is unpredictable and irreversible, the sequelae of secondary brain injury may be modified by prevention or minimization of recognized exacerbating systemic insults, such as hypotension, hypoxia, and hyperglycemia ( 2 ). (frontiersin.org)
Respiratory depression2
- This includes patients with significant respiratory depression (in unmonitored settings or the absence of resuscitative equipment) and patients with acute or severe bronchial asthma or hypercarbia. (prescriptiondrugs.com)
- Serious adverse reactions that may be associated with oxycodone hydrochloride tablets therapy in clinical use are those observed with other opioid analgesics and include: respiratory depression, respiratory arrest, circulatory depression, cardiac arrest, hypotension, and/or shock (see OVERDOSAGE and WARNINGS ). (prescriptiondrugs.com)
Symptoms4
- While we have had Xylazine in the area previously, at this time there are new and very serious adverse effects that are occurring such as stroke like symptoms where people may seem okay one moment and then have severe symptoms thereafter. (bloodtribe.org)
- The diagnosis of thyroid storm is based on the presence of severe and life-threatening symptoms such as hyperpyrexia, cardiovascular dysfunction, and/or altered mentation along with biochemical evidence of hyperthyroidism (elevation of free T4 and/or T3 and suppression of TSH). (your-doctor.net)
- Early symptoms are related to hyperglycemia and include polydipsia, polyphagia, polyuria, and blurred vision. (msdmanuals.com)
- Chronic use of mefenamic acid can result in gastritis, ulceration with or without GI perforation, and/or GI bleeding, which can occur at any time, often without preceding symptoms. (pdr.net)
Reactions1
- Sensitivity reactions may occur in patients with a history of allergy or bronchial asthma. (nih.gov)
Caution1
- Chlorthalidone should be used with caution in severe renal disease. (nih.gov)
Dose1
- Discontinue diuretics 2-3 days before initiation of an ACE inhibitor to reduce the likelihood of 1st dose hypotension. (medicscientist.com)
Cardiac1
- adjunct in treatment of cardiac arrest and profound hypotension. (medicscientist.com)
Systemic2
- Increases in systemic glucose are associated with impaired cerebrovasular autoregulation after severe pediatric TBI. (frontiersin.org)
- Hyperglycemia (79%), fever (62%), systemic inflammatory response syndrome (60%), and hypotension requiring vasopressors (42%) were the four most common medical ICU-COMPL. (umassmed.edu)
Septic shock2
- There is a continuum of clinical manifestations from SIRS to sepsis to severe sepsis to septic shock to Multiple Organ Dysfunction Syndrome (MODS). (atsu.edu)
- Treatment was started with intravenous cefazolin and betamethasone for lung maturation, oral nifedipine, and magnesium sulfate to prevent preterm labor and fetal neuronal protection, evolving with sustained hypotension and septic shock. (bvsalud.org)
Microvascular2
- Complications of Diabetes Mellitus In patients with diabetes mellitus, years of poorly controlled hyperglycemia lead to multiple, primarily vascular, complications that affect small vessels (microvascular), large vessels (macrovascular). (msdmanuals.com)
- The main causative mechanism is hyperglycemia, although microvascular involvement, hypertriglyceridemia, as well as genetic and immune mechanisms may be contributory. (elsevierpure.com)
Traumatic brain2
- A strong association exists between hyperglycemia and outcome in pediatric traumatic brain injury (TBI). (frontiersin.org)
- Hyperglycemia occurs frequently in the pediatric traumatic brain injury (TBI) population and the occurrence of elevated blood glucose values has been linked to increased mortality and worse neurological outcomes ( 3 - 6 ). (frontiersin.org)
Cerebrovascular disease1
- Target organ diseases occur in the heart (hypertensive heart disease), brain (cerebrovascular disease), peripheral vasculature (peripheral vascular disease), kidney (nephrosclerosis), and eyes (retinal damage). (surenapps.com)
Sepsis1
- Epidemiology of severe sepsis in the United States: analysis of incidence, outcome and associated costs of care. (atsu.edu)
Complications1
- It is also reported that blue-grey skin color occurs and an increase of wound development and non-healing wounds are occurring leading to complications. (bloodtribe.org)
Patients8
- The new equation was applied to plasma and urinary concentrations of sodium and chloride measured before and 30 min after a 30-min infusion of 1 L of 0.9% saline on two consecutive days in 14 patients with severe hyperglycemia (mean age 50 years). (springeropen.com)
- However, few details are known about the fluid shifts that actually occur when treating severely hyperglycemic patients [ 3 ]. (springeropen.com)
- Atrioventricular block can occur in patients without preexisting conduction defects. (drugs.com)
- These patients present with proximal weakness of a subacute onset, often with severe pain and some autonomic failure. (elsevierpure.com)
- A retrospective analysis was performed on pediatric severe TBI patients admitted to Addenbrookes Hospital Paediatric Intensive Care Unit (PICU) between January 2001 and December 2013. (frontiersin.org)
- BACKGROUND: Known predictors of adverse outcomes in patients with moderate-severe TBI (msTBI) explain only a relatively small proportion of patient-related outcomes. (umassmed.edu)
- Most fatal GI events occur in older or debilitated patients. (pdr.net)
- L'objectif de ce travail était de décrire le profi l des manifestations cardiovasculaires chez les patients vivants avec le VIH en le comparant à celui de patients séronégatifs. (bvsalud.org)
Manifestations3
- higher BG levels increase serum osmolality and produce more severe neurologic manifestations such as somnolence, coma, seizures, hemiparesis, and aphasia. (diabetestalk.net)
- Thyroid storm is a rare, life-threatening condition characterized by severe clinical manifestations of thyrotoxicosis. (your-doctor.net)
- Manifestations of severe retinal damage include blurring of vision, retinal hemorrhage, and loss of vision. (surenapps.com)
Deficiency1
- It can also cause one to have leukopenia, which is the deficiency of white blood cells in the blood, and hyperglycemia, or the abnormally high level og blood glucose in the body, which is a precursor to diabetes. (naturalpedia.com)
Glucose2
- 4. The major high blood glucose complication of type 2 diabetes mellitus is hyperosmolar hyperglycemia. (diabetestalk.net)
- While it is not entirely clear whether this association is due to a direct deleterious effect of hyperglycemia or simply a marker of illness severity, there is an increasing body evidence from the adult TBI population that ascribe a putative pathological role to raised blood glucose ( 2 ). (frontiersin.org)
Sensitivity1
- Sensitivity analysis revealed that UTI occurred later, suggesting a non-causal association with survival. (umassmed.edu)
Myocardial contractility2
- Coronary vasodilation occurs secondary to enhanced myocardial contractility. (medicscientist.com)
- Beta-blockade carries a potential hazard of further depressing myocardial contractility and precipitating more severe failure. (druglib.com)
Cellular3
- Bipolar I and II disorders are severe mental health conditions that affect approximately 11 million adults in the U.S. and there remains a significant need for more treatment options," said Dr. Sharon Mates, Chairman and CEO of Intra-Cellular Therapies. (biospace.com)
- AIDS or HIV A disease in which there is a severe loss of the body' cellular immunity, greatly lowering the resistance to infection and malignancy. (aszuhaz.hu)
- In the context of trauma, primary brain injury occurs due to cellular and extracellular matrix disruption from direct mechanical forces at the time of the traumatic incident. (frontiersin.org)
Diabetes1
- DKA more commonly occurs among those with type 1 diabetes, yet almost a third of the cases occur among those with type 2 diabetes. (lww.com)
Neutropenia1
- Anaemia and febrile neutropenia may occur. (pocketdrugguide.com)
Angina1
- Angina A condition marked by severe pain in the chest caused by an inadequate blood prostatitis buzzing to the heart. (aszuhaz.hu)
Decrease1
- Taking N-acetyl cysteine by mouth for at least 6 months seems to decrease flare-ups by about 40% in people with moderate to severe COPD. (medlineplus.gov)
Harm2
- Blackout states that last for hours can occur, which leave people vulnerable to harm when they are not aware what is occurring around them. (bloodtribe.org)
- Further studies are required to delineate putative mechanisms of hyperglycemia induced cerebral harm. (frontiersin.org)
Chronic3
- Schizophrenia is a chronic brain disorder that can be severe and disabling. (jnj.com)
- Acid reflux A chronic digestive disease occurring when stomach acid or content flows back into the food pipe prostatitis buzzing the lining of the esophagus. (aszuhaz.hu)
- Arteriosclerosis A chronic disease involving the thickening and hardening of the walls of the arteries, occurring typically in old age. (aszuhaz.hu)
Diuretic1
- The diuretic effect of the drug occurs in approximately 2.6 hours and continues for up to 72 hours. (nih.gov)
Reduction1
- This occurs if HbA1c is rapidly reduced within 3 months, and the likelihood is proportional to the original A1c and the size of the reduction. (elsevierpure.com)
Moderate1
- Oxycodone hydrochloride tablets are an immediate-release oral formulation of oxycodone hydrochloride indicated for the management of moderate to severe pain where the use of an opioid analgesic is appropriate. (prescriptiondrugs.com)