• The first treatment of its kind, donislecel (Lantidra) is indicated for adults with type 1 diabetes who, owing to current, repeated episodes of severe hypoglycemia, have been unable to approach target HbA1c, even with intensive diabetes management and education. (medscape.com)
  • In this study, we aimed to determine whether hypoglycemic episodes are associated with higher mortality in diabetic patients hospitalized in the general ward. (diabetesjournals.org)
  • The associations between the number and severity of hypoglycemic (≤50 mg/dl) episodes and inpatient mortality, length of stay (LOS), and mortality within 1 year after discharge were evaluated. (diabetesjournals.org)
  • Background: Poor glycaemic control with erratic blood glucose levels manifesting as recurrent hyperglycaemia with unpredictable episodes of hypoglycaemia is problem still faced today in daily practice. (endocrine-abstracts.org)
  • People with T1DM have an average of two bouts of symptomatic hypoglycemia every week, which amounts to thousands of episodes over the course of a lifetime with diabetes. (paleorecipediet.com)
  • If taking too much insulin, those with diabetes may suffer hypoglycemic episodes. (americanmedical-id.com)
  • To avoid hypoglycemic episodes, the patients should be instructed to eat within 30 minutes prior to administration. (picmonic.com)
  • Because of the frequency of hypoglycemic events with altered levels of consciousness (at least 30 episodes documented per month) the patient's driver's license was revoked, and he sought an early retirement from his job as an electrical engineer. (silverchair.com)
  • Two months after receiving his new meter, K.A. reported that he was no longer experiencing any hypoglycemic episodes and was feeling so well on his insulin pump that he began to work part-time and hoped to have his driving privileges re-instated. (silverchair.com)
  • Medication Adjustments: Collaborate with your healthcare team to review and adjust your diabetes medication dosages, meal timing, or even the exercise routine to prevent future hypoglycemic episodes. (healththoroughfare.com)
  • Studies have suggested that the benefits of tight glycemic control may be at least partially offset by the increased risk of hypoglycemia ( 2 , 3 ). (diabetesjournals.org)
  • In patients with diabetes, treatment with an (Selective serotonin reuptake inhibitors) SSRI may alter glycemic control (hypoglycemia or hyperglycemia). (dvago.pk)
  • The CGMS test was repeated and showed no hypoglycemic events and improved overall glycemic control. (silverchair.com)
  • alcohol may decrease endogenous glucose production (increased hypoglycemia risk) or worsen glycemic control by adding calories. (medscape.com)
  • In sensitivity analyses, we studied whether any association with outcome was different in patients with iatrogenic or spontaneous/recurrent hypoglycemia. (biomedcentral.com)
  • Impaired executive functions were most pronounced in patients with spontaneous or recurrent hypoglycemia. (biomedcentral.com)
  • Critically ill children exposed to hypoglycemia in PICU were at higher risk of impaired executive functions after 4 years, especially in cases of spontaneous/recurrent hypoglycemia. (biomedcentral.com)
  • Hypoglycemia is common in diabetic patients hospitalized in the general ward. (diabetesjournals.org)
  • Diabetic hypoglycemia occurs when a person with diabetes has insufficient glucose (sugar) in his or her blood. (paleorecipediet.com)
  • Hypoglycemia may result by taking an excessive amount of insulin or oral diabetic medications. (paleorecipediet.com)
  • His diabetic disorder was based on a delayed insulin secretory response to hyperglycaemia and daily excessive intake of glucose from a high caloric diet and soft drinks. (bmj.com)
  • During Ramadan, a devout diabetic who fasts increases his risk of hypoglycemic coma, seizures, sudden death. (jparksmd.com)
  • Insulin and/or oral hypoglycaemic dosage may need to be adjusted. (gov.sa)
  • The association between chronic hyperglycemia and increased risk of microvascular complications in patients with type 1 DM was demonstrated in the Diabetes Control and Complications Trial (DCCT). (medscape.com)
  • Importantly, these advances saw a major improvement in glucose control and appreciation of the role of hyperglycemia in the development of diabetes complications. (jdrf.org)
  • Frequency of hypoglycaemic/ hyperglycaemic complications and severity of adverse drug reactions. (who.int)
  • The article outlines a seven-stage protocol developed from practice-based evidence to be used in an inpatient setting to minimize the requirement for insulin or other hypoglycemic medications and to normalize markers of T2DM in patients with this condition. (openaccessjournals.com)
  • Low-carbohydrate diets are therapeutic interventions that clinicians can use to help patients discontinue medications for hyperglycemia and achieve remission of T2DM [ 9 , 10 ]. (openaccessjournals.com)
  • He was successfully treated by diet and exercise therapy without any hypoglycaemic medications or insulin. (bmj.com)
  • Repalglinide (Prandin) and nateglinide (Starlix) are oral hypoglycemic medications classified as meglitinides or "glinides. (picmonic.com)
  • Repaglinide and nateglinide are meglitinides that act as oral hypoglycemic medications. (picmonic.com)
  • You should consistently monitor your blood sugar levels, adhere to prescribed medications, and adopt a healthy lifestyle to effectively manage hyperglycemia and hypoglycemia. (healththoroughfare.com)
  • In contrast, hypoglycemia unrelated to exogenous insulin therapy is an uncommon clinical syndrome caused by various disorders or medications. (msdmanuals.com)
  • In two nonrandomized, single-arm studies that together evaluated the safety and effectiveness of donislecel in a total of 30 adults with type 1 diabetes and hypoglycemic unawareness, 21 participants needed no posttreatment insulin intake for at least a year. (medscape.com)
  • In the ensuing 5 years, he had developed hypoglycemic unawareness. (silverchair.com)
  • Hypoglycemia univariably associated with higher mortality in PICU, at 90 days and 4 years after randomization, but not when adjusted for risk factors. (biomedcentral.com)
  • Studies showed that glycated hemoglobin (HbA 1c ) levels and hypoglycemic events can be significantly reduced by frequent use of CGM systems. (degruyter.com)
  • Fear of hypoglycemia often leads to a rethinking of patients in the direction of an acceptance of higher BG levels, and subsequently increased glycated hemoglobin (HbA 1c ) values, to avoid the risk of getting into a state of hypoglycemia. (degruyter.com)
  • Buformin and the other biguanides are not hypoglycemic, but rather antihyperglycemic agents. (wikipedia.org)
  • In patients with diabetes who take insulin or antihyperglycemic treatment, hypoglycemia is common and is defined as a glucose level of ≤ 70 mg/dL. (msdmanuals.com)
  • Hypoglycemia ( low blood glucose ) is the most frequent side effect and it occurs somewhat less frequently with repaglinide than with sulfonylureas such as glyburide and glipizide. (hdkino.org)
  • Measures should be undertaken to decrease the frequency of hypoglycemia in this high-risk patient population. (diabetesjournals.org)
  • Expanded analysis iii of real-world data from Canada demonstrate that higher frequency of scanning is associated with increased time in target glucose range (hours per day spent in between 70-180 mg/dL vii ) and decreased hypoglycemia. (mediaroom.com)
  • Hypoglycemia is a frequent problem in the newborn. (hindawi.com)
  • However, it remains debated whether brief hypoglycemia occurring in the context of critical illness by itself causes harm, since hypoglycemia more frequently occurs in patients with higher illness severity, which introduces potential bias [ 3 ]. (biomedcentral.com)
  • Likewise, a longer duration of stay in the pediatric intensive care unit (PICU), also indicating higher illness severity, prolongs the exposure to glucose control strategies and hence increases the odds of developing a hypoglycemic event. (biomedcentral.com)
  • Although hyperglycemia (aka high blood sugar) and hypoglycemia (aka low blood sugar) are both conditions related to blood sugar levels, they differ in terms of the direction and severity of the imbalance. (healththoroughfare.com)
  • A helpful practical classification is based on clinical status: whether hypoglycemia occurs in patients who appear healthy or ill. (msdmanuals.com)
  • This is known as ketoacidosis, which is related to hyperglycaemia. (stjohnvic.com.au)
  • We considered that insulin supersensitivity might be involved in the pathogenic mechanisms of his clinical normoinsulinaemic hypoglycaemia. (bmj.com)
  • Insulin supersensitivity and normoinsulinaemic hypoglycaemia might play a role in clinical manifestation and pathogenesis of type 2 DM. (bmj.com)
  • Today I will take on the difficult task of comparing the American Association of Clinical Endocrinologists (AACE) algorithms for the treatment of type 2 diabetes [ 1 ] with the position statement of the American Diabetes Association/European Association for the Study of Diabetes (ADA/EASD) for the management of hyperglycemia in type 2 diabetes. (medscape.com)
  • In a retrospective cohort study from October 2012 to March 2013, outcomes (HbA1c, weight, hypoglycaemia and lipohypertrophy) were compared at baseline and 6 months after treatment in 628 patients. (who.int)
  • This difference in HbA1c remained significant after controlling for the effects of age, sex, duration of diabetes, body mass index and hypoglycaemia (-coefficient was -0.18 in favour of BHI30). (who.int)
  • BHI30 achieved better reduction in HbA1c compared with BIAsp30, with less cost, slightly more weight gain and greater reported mild hypoglycaemia. (who.int)
  • Previously, hypoglycemia occurring under tight glucose control in critically ill children receiving early PN did not associate with long-term harm. (biomedcentral.com)
  • We investigated whether hypoglycemia in PICU differentially associates with outcome in the context of withholding early PN, and whether any potential association with outcome may depend on the applied glucose control protocol. (biomedcentral.com)
  • To study whether an association of hypoglycemia with outcome may be affected by the nutritional strategy or center-specific glucose control protocol, we further adjusted the models for the interaction between hypoglycemia and the randomized nutritional strategy, respectively, treatment center. (biomedcentral.com)
  • Further adjustment for the interaction of hypoglycemia with the randomized intervention or treatment center revealed a potential interaction, whereby tight glucose control and withholding early PN may be protective. (biomedcentral.com)
  • The new data show that users of the FreeStyle Libre system have improved glucose control, iii increased time in target glucose range, iii and decreased time in hyperglycemia iv (high glucose levels) and hypoglycemia iv (low glucose levels), as well as reduced HbA1Ci , ii (average glucose levels over a three month period). (mediaroom.com)
  • Patients with hypoglycemia have increased LOS and higher mortality both during and after admission. (diabetesjournals.org)
  • In this secondary analysis of the multicenter PEPaNIC RCT, we studied whether hypoglycemia in PICU associated with mortality ( N = 1440) and 4-years neurodevelopmental outcome ( N = 674) through univariable comparison and multivariable regression analyses adjusting for potential confounders. (biomedcentral.com)
  • In the dexamethasone treatment group, the most commonly reported serious adverse reactions were pneumonia (4%), hyperglycemia (3%), pyrexia, and psychotic disorder (2% each).A total of 145 patients, including 84 (25%) of 331 patients in the bortezomib treatment group and 61 (18%) of 332 patients in the dexamethasone treatment group were discontinued from treatment due to adverse reactions. (drugcentral.org)
  • Among the 332 patients in the dexamethasone group, the most commonly reported adverse reactions leading to treatment discontinuation were psychotic disorder and hyperglycemia (2% each).Four deaths were considered to be bortezomib-related in this relapsed multiple myeloma study: one case each of cardiogenic shock, respiratory insufficiency, congestive heart failure and cardiac arrest. (drugcentral.org)
  • Treatment of hypoglycemia is provision of glucose combined with treatment of the underlying disorder. (msdmanuals.com)
  • After 4 years, critically ill children with hypoglycemia scored significantly worse for certain parent/caregiver-reported executive functions (working memory, planning and organization, metacognition) than patients without hypoglycemia, also when adjusted for risk factors including baseline NSE and S100B. (biomedcentral.com)
  • Weight gain and mild hypoglycaemia was significantly higher with BHI30 than with BIAsp30. (who.int)
  • The underlying mechanism of stress hyperglycemia is a complex network of biological signaling pathways that decrease sensitivity to insulin [5] and increase endogenous glucose production (EGP). (confex.com)
  • Hypoglycemia is associated with adverse outcomes in mixed populations of patients in intensive care units. (diabetesjournals.org)
  • In recent years, there has been an increasing focus on controlling hyperglycemia in hospitalized patients ( 1 ). (diabetesjournals.org)
  • Both pathways are evaluated to determine whether they act individually or concurrently to produce observed insulin resistance and stress hyperglycemia in ICU patients. (confex.com)
  • Data has only been collected from a small subset of patients (n=10), but has shown, as expected, that predictive low glucose suspend can reduce the prevalence of hypoglycemia. (closeconcerns.com)
  • NIPHS is a rare condition in which patients have hyperinsulinemic hypoglycemia with negative localizing imaging studies and no history of bariatric surgery. (msdmanuals.com)
  • RÉSUMÉ En dépit des avantages rapportés en termes de contrôle de la glycémie, les analogues de l'insuline sont coûteux pour les patients des pays en développement. (who.int)
  • La présente étude en Jordanie visait à comparer l'efficacité de l'insuline humaine prémélangée (BHI30) à celle de l'analogue de l'insuline prémélangé (BIAsp30) ainsi que les événements indésirables pour deux substances chez des patients atteints de diabète de type 2. (who.int)
  • The two modeled metabolic regulatory processes involved in dynamic modification of metabolism in the ICU are: (i) the hypoglycemia counterregulatory response and (ii) the acute inflammatory response. (confex.com)
  • In multivariable analysis, each additional day with hypoglycemia was associated with an increase of 85.3% in the odds of inpatient death ( P = 0.009) and 65.8% ( P = 0.0003) in the odds of death within 1 year from discharge. (diabetesjournals.org)
  • Gemfibrozil (Lopid) decreases the metabolism rate of meglitinides and should not be administered to prevent drug accumulation leading to hypoglycemia. (picmonic.com)
  • The hypoglycemic action of the drug is consistent with the existence of an insulin-independent effect of fatty acid oxidation on glucose metabolism in man. (arizona.edu)
  • The most used pharmacological groups were antihypertensive drugs, antilipidemics, drugs to control hypothyroidism and hypoglycemic agents. (bvsalud.org)