• In two nonrandomized, single-arm studies that together evaluated the safety and effectiveness of donislecel in a total of 30 adults with type 1 diabetes and hypoglycemic unawareness, 21 participants needed no posttreatment insulin intake for at least a year. (medscape.com)
  • The article outlines a seven-stage protocol developed from practice-based evidence to be used in an inpatient setting to minimize the requirement for insulin or other hypoglycemic medications and to normalize markers of T2DM in patients with this condition. (openaccessjournals.com)
  • Studies have suggested that the benefits of tight glycemic control may be at least partially offset by the increased risk of hypoglycemia ( 2 , 3 ). (diabetesjournals.org)
  • The first treatment of its kind, donislecel (Lantidra) is indicated for adults with type 1 diabetes who, owing to current, repeated episodes of severe hypoglycemia, have been unable to approach target HbA1c, even with intensive diabetes management and education. (medscape.com)
  • In this study, we aimed to determine whether hypoglycemic episodes are associated with higher mortality in diabetic patients hospitalized in the general ward. (diabetesjournals.org)
  • The associations between the number and severity of hypoglycemic (≤50 mg/dl) episodes and inpatient mortality, length of stay (LOS), and mortality within 1 year after discharge were evaluated. (diabetesjournals.org)
  • Hyperglycemia is associated with adverse clinical outcomes, and randomized controlled trials in intensive care units (ICUs) have shown that aggressive treatment of elevated blood glucose improves outcomes. (diabetesjournals.org)
  • Hormone tests, carried out to explain his resistant hypoglycemia, yielded normal results. (hindawi.com)
  • If unequivocal hyperglycemia is absent, two abnormal test results are required for diagnosis, using the same sample or two separate test samples. (medscape.com)
  • The patient was diagnosed with hypoglycemic convulsion and given phenobarbital, after which he was sent to our clinic and hospitalized. (hindawi.com)
  • Measures should be undertaken to decrease the frequency of hypoglycemia in this high-risk patient population. (diabetesjournals.org)
  • The association between chronic hyperglycemia and increased risk of microvascular complications in patients with type 1 DM was demonstrated in the Diabetes Control and Complications Trial (DCCT). (medscape.com)
  • In particular, hypoglycemia in ICUs has been linked to increased risk of mortality, seizures, and coma ( 4 ). (diabetesjournals.org)
  • To examine the impact of hypoglycaemia in insulin-treated patients in the Lebanese cohort of the Hypoglycaemia Assessment Tool (HAT) study. (who.int)
  • To assess the risks of amputation, blindness, severe kidney failure, hyperglycaemia, and hypoglycaemia in patients with type 2 diabetes associated with prescribed diabetes drugs, particularly newer agents including gliptins or glitazones (thiazolidinediones). (nih.gov)
  • Simultaneously, hyperglycemia can stimulate viral replication and augment cytokine expression, making these patients more vulnerable to severe disease ( 9 ). (silverchair.com)
  • Rates of nocturnal and severe hypoglycaemia were 10.7 (95% CI: 9.1-12.3) and 13.2 (95% CI: 11.5-14.9) events/patient-year for T1DM, and 3.3 (95% CI: 2.8-3.8) and 4.2 events/patient-year (95% CI: 3.6-4.8) for T2DM, respectively. (who.int)
  • Fear of hypoglycaemia was significantly associated with nocturnal and severe hypoglycaemia in both diabetes types (P (who.int)
  • In patients with type 2 diabetes mellitus (T2DM) an association between severe hypoglycaemic episodes and the risk of cardiovascular (CV) morbidity and mortality has been previously established. (biomedcentral.com)
  • There is an association between severe hypoglycaemic episodes (i.e. hypoglycaemia requiring third party assistance) and risk of CV morbidity and mortality has been shown in patients with T2DM. (biomedcentral.com)
  • As reported in that study, 22.6% of the patients with a history of severe hypoglycaemia ( 10 ). (who.int)
  • Selected miRNAs were validated by qRT-PCR in 14 patients with T2DM on metformin monotherapy, without established CV disease and antiplatelet therapy during a stepwise hypoglycaemic clamp experiment and a follow-up 7 days after the clamp event. (biomedcentral.com)
  • The association between chronic hyperglycemia and increased risk of microvascular complications in patients with type 1 DM was demonstrated in the Diabetes Control and Complications Trial (DCCT). (medscape.com)
  • The Diabetes Complications and Controls Trial found that intensive therapy in patients with T1DM caused a 3-fold increase in the number of hypoglycaemic events, compared with those treated less aggressively (7). (who.int)
  • Hypoglycaemia increases the risk of CV complications as it increases pro-atherothrombotic factors [ 2 ]. (biomedcentral.com)
  • As a result, hyperglycemia and long-term complications increase morbidity and premature mortality, and lead to increased costs to health services. (springer.com)
  • Diabetic hypoglycaemia affects medication adherence, patients' productivity and quality of life. (who.int)
  • Hypoglycaemia affects medication adherence, patients' productivity (11), and quality of life at the mental, physical and social functioning levels (12). (who.int)
  • i also heard about hyperglycemia and hypo and it says its different than diabetic and its not easy to detect need to test a couple of times. (medhelp.org)
  • Hypoglycaemia can significantly influence the expression of platelet-enriched miRNAs, with a time trend paralleling the time course of platelet activation. (biomedcentral.com)
  • Hyperglycemia in hospitalized patients with coronavirus disease 2019 (COVID-19) is linked to increased morbidity and mortality. (silverchair.com)
  • Diabetes and hyperglycemia are important risk factors for disease severity, hospitalization, length of stay, intensive care unit (ICU) admissions, morbidity, and mortality ( 2 - 5 ). (silverchair.com)
  • with T1DM caused a 3-fold increase in the number of Diabetes is a worldwide health problem associated with hypoglycaemic events, compared with those treated less serious morbidity, mortality, and considerable econom- aggressively ( 7 ). (who.int)
  • These include reducing the complexity of therapy by fixed-dose combination pills and less frequent dosing regimens, using medications that are associated with fewer adverse events (hypoglycemia or weight gain), educational initiatives with improved patient-healthcare provider communication, reminder systems and social support to help reduce costs. (springer.com)
  • Hypoglycaemia is a common adverse ic burdens ( 1 ). (who.int)
  • Although sugary foods will spike the blood sugar up very quickly which OK initially in a hypoglycaemic attack, it is better to eat slow energy release food. (medhelp.org)
  • Patients presenting with type 2 diabetes mellitus are initially encouraged to maintain a healthy diet and exercise regimen, followed by early medication that generally includes one or more oral hypoglycemic agents and later may include an injectable treatment. (springer.com)
  • The results suggest that the less-advanced healthcare systems in Lebanon are implicated in lower levels of patient knowledge about hypoglycaemia and related preventive measures. (who.int)
  • Circulating levels of miR-106a-5p, miR-15b, miR-15a, miR-16-5p, miR-223 and miR-126 were increased after euglycaemic clamp followed by hypoglycaemic clamp, each with its distinctive time trend. (biomedcentral.com)
  • However, it was previously described that fibrinolytic processes that are mediated by altered levels of coagulation factors might be impaired for up to 1 week following hypoglycaemia [ 5 ]. (biomedcentral.com)
  • Sixty-five patients with COVID-19 and glucocorticoid-induced hyperglycemia admitted after the protocol implementation were matched 1:1 to patients admitted before the treatment protocol rollout for analysis. (silverchair.com)
  • The primary endpoint was the proportion of patients experiencing ≥ 1 hypoglycaemic event during the 4-week follow-up period. (who.int)
  • 95% CI: 42.2-50.2) patients with T2D experienced at least 1 hypoglycaemic event. (who.int)
  • Hyperglycaemia is when there is far too much sugar in the blood stream. (medhelp.org)
  • Hypoglycaemia is when the sugar level in the blood is very low. (medhelp.org)
  • We aimed to investigate the influence of hypoglycaemia on several diabetes-related and platelet-related miRNAs selected based on bioinformatic analysis and literature search, including hsa-miR-16, hsa-miR-34a, hsa-miR-129-2, hsa-miR-15a, hsa-miR-15b, hsa-miR-106a, miR-223, miR-126. (biomedcentral.com)
  • Increased platelet activation in response to acute hypoglycaemia may be the result of the release of counter-regulatory catecholamines [ 6 ]. (biomedcentral.com)
  • If unequivocal hyperglycemia is absent, two abnormal test results are required for diagnosis, using the same sample or two separate test samples. (medscape.com)