A child in whom ingestion of any first-generation sulfonylurea (eg, chlorpropamide, acetohexamide, tolbutamide, tolazamide) is suspected should be admitted to the pediatric ward for at least 24 hours of observation, regardless of initial symptoms. (medscape.com)
Sulfonylureas (tolbutamide) leads to increased mortality due to cardiovascular events, the use of the first generation sulfonylureas (acetohexamide, chlorpropamide, tolbutamide and tolazamide) quickly fell out of favour. (ijpsr.com)
Sulfonylureas2
The exact mechanism of sulfonylureas' hypoglycemic effect remains to be elucidated. (medscape.com)
The authors compared the rates of first occurrence of myocardial infarction (MI), congestive heart failure, and all-cause mortality among people prescribed glitazones, sulfonylureas, metformin and other hypoglycaemic drugs. (centreformedicinesoptimisation.co.uk)
Glipizide2
For example, glyburide has greater hypoglycemic effects than glipizide and glimepiride, particularly in patients with kidney dysfunction and in the elderly. (medscape.com)
Multiple doses of activated charcoal have been suggested in patients with glipizide overdose because this hypoglycemic agent has an enterohepatic circulation. (medscape.com)
Antihyperglycemic agents2
consequently, they are appropriately referred to as antihyperglycemic agents rather than hypoglycemic agents. (medscape.com)
With the exceptions of Insulin, exenatide, liraglutide and pramlintide, all are administered orally and are thus also called oral hypoglycemic agents or oral antihyperglycemic agents. (diabetestalk.net)
Sulfonylurea1
Acetohexamide (trade name Dymelor) is a first-generation sulfonylurea medication used to treat diabetes mellitus type 2, particularly in people whose diabetes cannot be controlled by diet alone. (wikipedia.org)
Insulin1
With the exception of insulin, about GLP receptor agonist ( liraglutide, exenatide, and others ), and pramlintide, all be distribute orally and be thus besides call oral hypoglycemic agent oregon oral antihyperglycemic agent. (glucophagemetformin.com)
Glucose2
Administer intravenous glucose to all patients with hypoglycemic symptoms. (medscape.com)
As we have concluded previously , it remains uncertain whether intensive glucose control (the addition of hypoglycaemic drugs to reduce HbA1c to levels significantly below that of standard treatments) offers any significant benefit in addition to that achievable by successful implementation of other interventions to reduce cardiovascular risk (including smoking cessation, exercise, losing weight, controlling blood pressure, taking statins, etc). (centreformedicinesoptimisation.co.uk)
Exposure2
No racial or sex predilection has been reported in oral hypoglycemic agent exposure. (medscape.com)
The main goal in oral hypoglycemic agent exposure is supportive care, which includes airway, breathing, and circulation. (medscape.com)
Cardiovascular1
Oral hypoglycemic drugs, including acetohexamide, have been associated with increased cardiovascular mortality. (wikipedia.org)
The first generation sulfonylureas include acetohexamide, chlorpropamide, tolazamide and tolbutamide, oral hypoglycemic agents that are used in therapy of type 2 diabetes. (nih.gov)
Tolbutamide was the first oral hypoglycemic agent used in the management of diabetes. (nih.gov)
Although only one drug in the sulfonylurea class (tolbutamide) was included in this study, it is prudent from a safety standpoint to consider that this warning may also apply to other oral hypoglycemic drugs in this class, in view of their close similarities in mode of action and chemical structure. (druginteractionchecker.com)
Tolazamide3
Some patients who are initially responsive to oral hypoglycemic drugs, including tolazamide tablets, may become unresponsive or poorly responsive over time. (nih.gov)
When normal fasting non-diabetic subjects are given a single 500 mg dose of tolazamide orally, a hypoglycemic effect can be noted within 20 minutes after ingestion with a peak hypoglycemic effect occurring in 2 to 4 hours. (nih.gov)
Following a single oral dose of 500 mg tolazamide, a statistically significant hypoglycemic effect was demonstrated in fasted nondiabetic subjects 20 hours after administration. (nih.gov)
Sulfonylurea hypoglycemic3
Extrapancreatic effects may be involved in the mechanism of action of oral sulfonylurea hypoglycemic drugs. (nih.gov)
Glyburide and glipizide, second-generation oral sulfonylurea hypoglycemic agents. (nih.gov)
A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. (nih.gov)
Sulfonylureas3
The exact mechanism of sulfonylureas' hypoglycemic effect remains to be elucidated. (medscape.com)
However, because of their short duration of action, there is a lowered risk of the potential prolonged hypoglycemic periods of the sulfonylureas, with the danger of associated sequelae. (medscape.com)
Drug Interactions The hypoglycemic action of sulfonylureas may be potentiated by certain drugs including nonsteroidal anti-inflammatory agents and other drugs that are highly protein bound, salicylates, sulfonamides, chloramphenicol, probenecid, coumarins, monoamine oxidase inhibitors, and beta adrenergic blocking agents. (druginteractionchecker.com)
Glyburide2
For example, glyburide has greater hypoglycemic effects than glipizide and glimepiride, particularly in patients with kidney dysfunction and in the elderly. (medscape.com)
A possible interaction between glyburide and ciprofloxacin, a fluoroquinolone antibiotic, has been reported, resulting in a potentiation of the hypoglycemic action of glyburide. (druginteractionchecker.com)
Dymelor1
Acetohexamide (trade name Dymelor) is a first-generation sulfonylurea medication used to treat diabetes mellitus type 2, particularly in people whose diabetes cannot be controlled by diet alone. (wikipedia.org)
Associated with increased cardiovascular mortality2
Oral hypoglycemic drugs, including acetohexamide, have been associated with increased cardiovascular mortality. (wikipedia.org)
SPECIAL WARNING ON INCREASED RISK OF CARDIOVASCULAR MORTALITY: The administration of oral hypoglycemic drugs has been reported to be associated with increased cardiovascular mortality as compared to treatment with diet alone or diet plus insulin. (nih.gov)
Oral3
No racial or sex predilection has been reported in oral hypoglycemic agent exposure. (medscape.com)
A potential interaction between oral miconazole and oral hypoglycemic agents leading to severe hypoglycemia has been reported. (druginteractionchecker.com)
Following results were obtained and discussed in relation to hypoglycemic action and uncoupling site of these drugs. (nii.ac.jp)
Overdose1
Two cases of hypoglycemic overdose have been reported with descriptions of drowsiness, fatigue, obtundation, brief coma, and seizures. (medscape.com)
Diabetes1
As hypoglycaemia is a significant cause of morbidity and mortality, treatment regimens for diabetes should minimize the occurrence of hypoglycaemic episodes and be tailored to the patient's individual needs. (diabetestalk.net)
Agents2
consequently, they are appropriately referred to as antihyperglycemic agents rather than hypoglycemic agents. (medscape.com)
If there is concern, monitoring of the breastfed infant's blood glucose is advisable during maternal therapy with hypoglycemic agents. (nih.gov)
Duration1
The duration of maximal hypoglycemic effect in fed diabetic patients is about 10 hours, with the onset occurring at 4 to 6 hours and with the blood glucose levels beginning to rise at 14 to 16 hours. (nih.gov)
Effect2
With fasting diabetic patients, the peak hypoglycemic effect occurs at 4 to 6 hours. (nih.gov)
The effect of several hypoglycemic sulphonylureas upon the oxidative phos- phorylation of intact rat liver mitochondria was examined. (nii.ac.jp)