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  • Adverse
  • Objectives To quantify and compare potential benefits (subjective reports of sleep variables) and risks (adverse events and morning-after psychomotor impairment) of short term treatment with sedative hypnotics in older people with insomnia. (bmj.com)
  • Adverse events that are associated with sedative use, such as ataxia, falls, or memory impairment, are thought to be particularly detrimental for older people. (bmj.com)
  • This meta-analysis aims to study the benefits of sedative use, as determined by subjective reported changes in sleep variables, and the risks, as determined by adverse events. (bmj.com)
  • In older persons with insomnia, short-term treatment with sedative-hypnotics is twice as likely to produce an adverse effect as improve the quality of sleep. (acpjc.org)
  • patients
  • Meta-analysis of 4 trials ( n = 1072) showed that 13 patients (CI 7 to 63) would need to be treated with a sedative for 1 additional patient to have an improvement in sleep quality. (acpjc.org)
  • The surgeon giving his patients VR instead of sedatives BBC In Mexicos most violent state, a surgeon is using virtual reality to relieve the pain and stress of operations when sedatives are not possible. (blogspot.com)
  • mice
  • This study investigated the sedative-hypnotic effect of agarwood essential oil (AEO) using locomotor activity and pentobarbital-induced sleeping assays in mice. (mdpi.com)
  • Single (1-day) and multiple (7- and 14-days) administrations of 60 mg/kg AEO generated significant sedative effect on inhibiting locomotor activity and hypnotic effect on pentobarbital-induced sleeping in mice. (mdpi.com)
  • effect
  • Conclusions Improvements in sleep with sedative use are statistically significant, but the magnitude of effect is small. (bmj.com)