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Saline Solution, HypertonicResuscitationHypertonic SolutionsCardiopulmonary ResuscitationGlucose Solution, HypertonicIsotonic SolutionsHypotonic SolutionsSolutionsOsmolar ConcentrationHeart ArrestOsmosisSucroseOsmotic PressureMannitolShock, HemorrhagicSodium ChlorideRana temporariaTetracaineDiuretics, OsmoticResuscitation OrdersAnuraRana pipiensWater-Electrolyte BalanceTromethaminePotassiumFluid TherapyMusclesMembrane PotentialsHeart MassageSodiumPotassium ChlorideMuscle ContractionCell Membrane PermeabilityTime FactorsChloridesOut-of-Hospital Cardiac ArrestGuinea PigsCaffeineGlycerolEmergency Medical ServicesManikinsDefibrillatorsSulfatesSodium-Potassium-Chloride SymportersCalciumAction PotentialsMyofibrilsNeuromuscular JunctionUreaMuscle, SmoothCell SizeOuabainVentricular FibrillationWaterMedical FutilityElectrophysiology
Hemorrhagic shockNormal salineCrystalloidsCrystalloidColloidIntravenousShockRinger'sNaClHydroxyethyl starchLactateIsotonic salineAcuteIncreasinglyPatientsIntravascular volumeCONCLUSIONSInfusionImmunologicSterileConcentrationSurgeryAdultsVolumeSodiumTraumaFluidsRestorationTissueSurgicalHypotonicIncludeColloidsClinicalSuggestsChlorideEffectPromptLarge amountsEarlyWaterTherapyStrategyStrategiesTypeChoice
Hemorrhagic shock10
  • Because these cells are central to the innate response to bacteria, we hypothesized that hypertonic treatment for hemorrhagic shock might alter the host response to bacterial contamination of the peritoneal cavity and therefore render the host more susceptible to invasive infection. (mcmaster.ca)
  • METHODS: Male Sprague-Dawley rats were subjected to hemorrhagic shock and resuscitated with either lactated Ringer solution (RL) or HTS. (mcmaster.ca)
  • Hypertonic saline resuscitation maintains a more balanced profile of T-lymphocyte subpopulations in a rat model of hemorrhagic shock[J]. Journal of Zhejiang University Science B, 2007, 8(1): 70-75. (zju.edu.cn)
  • Objective: To investigate the potential and early effect of hypertonic saline resuscitation on t-lymphocyte subpopulations in rats with hemorrhagic shock . (zju.edu.cn)
  • Results: In the early stage after hemorrhagic shock , fluid resuscitation and emergency treatment, the CD4 + lymphocytes of peripheral blood in HTS and NS groups markedly increased. (zju.edu.cn)
  • Conclusion: In this model of rat with severe hemorrhagic shock , small volume resuscitation with HTS is more effective than NS in reducing immunologic disorders and promoting a more balanced profile of t-lymphocyte subpopulations regulating network. (zju.edu.cn)
  • Small-volume fluid resuscitation with hypertonic saline prevents inflammation but not mortality in a rat model of hemorrhagic shock. (zju.edu.cn)
  • Hypertonic saline solution resuscitation in hemorrhagic shock dog. (zju.edu.cn)
  • It has been shown to induce renal failure and impair pulmonary function when used for resuscitation in hemorrhagic shock. (brainscape.com)
  • Hypertonic saline with or without colloidal solution has been successfully used for treating hemorrhagic shock in animal experiments and clinical studies. (omeka.net)
Normal saline3
  • INTERVENTIONS: Rats were randomized to five groups: sham, MV-HTN alone, MV-HTN with 4 mL/kg normal saline resuscitation (equal volume), MV-HTN with 33 mL/kg normal saline resuscitation (equal salt), and MV-HTN with 4 mL/kg hypertonic saline. (utmb.edu)
  • The rats were randomly divided into Sham group, HTS group ( hypertonic saline resuscitation group) and NS group (normal saline resuscitation group). (zju.edu.cn)
  • The experts also stressed the poor level of proof to prefer buffered solution to normal saline solution (0.9% of NaCl) in brain-injured patients [ 5 ]. (biomedcentral.com)
Crystalloids5
  • Compared to our previous experience with isotonic saline solution we concluded that better results were achieved with hypertonic crystalloids during the resuscitation period. (medbc.com)
  • Resuscitation strategies recently have focused on concerns regarding the use of Ringer s lactate, the reemergence of the evaluation of hypertonic saline, the use of colloids, the use of alternative crystalloids, and the use of oxygen carrying solutions or hemoglobin solutions. (medicosecuador.com)
  • Background: Crystalloids and different component colloids, used for volume resuscitation, are sometimes associated with various adverse effects. (researchsquare.com)
  • Crystalloids, mineral salts, or other water-soluble molecule solutions have been used for more than 100 years for fluid resuscitation (1,2). (researchsquare.com)
  • A recent consensus statement on fluid management for brain-injured patients suggested the use of crystalloids as the first-line choice for maintenance or resuscitation fluid [ 5 ]. (biomedcentral.com)
Crystalloid4
  • Thus, non-oxygen-carrying fluids (eg, crystalloid or colloid solutions) may be used to restore intravascular volume in mild to moderate blood loss. (merckmanuals.com)
  • Crystalloid solutions for intravascular volume replenishment are typically isotonic (eg, 0.9% saline or Ringer's lactate). (merckmanuals.com)
  • However, colloid solutions offer no major advantage over crystalloid solutions, hydroxyethyl starch increases risk of renal injury, and albumin has been associated with poorer outcomes in patients with traumatic brain injury. (merckmanuals.com)
  • A recent report of the Institute of Medicine raised concerns with crystalloid resuscitation using Ringer s lactate and concerns have been raised regarding colloid resuscitation. (medicosecuador.com)
Colloid1
  • Colloid solutions (eg, hydroxyethyl starch , albumin , dextrans) are also effective for volume replacement during major hemorrhage. (merckmanuals.com)
Intravenous3
  • Hypertonic resuscitation - a concentrated intravenous (IV) dose of saline and dextran, a sugar solution - has the potential to help survivors of blunt trauma by improving blood flow and delivery of oxygen to the injured brain while decreasing high pressure in the brain, a common problem for patients with brain injury. (atlantainjurylawblog.com)
  • Dextran in intravenous solution provides an osmotically neutral fluid that once in the body is digested by cells into glucose and free water. (the-medical-dictionary.com)
  • Options for treating fetal distress include attempting intrauterine resuscitation by changing the mother's position, ensuring the mother is well-hydrated, ensuring the mother is adequately oxygenated, amnioinfusion to alleviate compression of the umbilical cord, tocolysis to stop contraction, or intravenous hypertonic dextrose. (1800nynylaw.com)
Shock2
  • The CD4 + and CD8 + subpopulations of T-lymphocytes in peripheral blood were detected respectively before shock and after resuscitation by double antibody labelling and flow cytometry . (zju.edu.cn)
  • We therefore investigated the hypothesis that infusion of hypertonic saline would further improve O-2 delivery, O-2 extraction, and O-2 uptake in hyperdynamic septic shock patients already stabilized by adequate volume and catecholamine infusion. (omeka.net)
Ringer's2
  • The changes in blood water concentration indicated a mean size of V of 5.9 1 (+/- 0.8, SEM) for Ringer's solution, 2.6 (+/- 0.3) 1 for dextran, and 1.2 (+/- 0.1) 1 for hypertonic saline. (silverchair.com)
  • In the present study, volunteers were given Ringer's solution, dextran, and hypertonic saline, and three markers of blood dilution were followed. (silverchair.com)
NaCl2
  • The authors infused 25 ml/kg of Ringer acetate solution, 5 ml/kg of 6% dextran 70 in 0.9% NaCl, and 3 ml/kg of 7.5% NaCl over 30 min in 8 male volunteers aged from 25 to 36 years (mean, 31 years) and measured the changes in total hemoglobin, serum albumin, and total blood water over time. (silverchair.com)
  • NaCl however is an ideal solution for correcting volume deficits associated with hyponatremia, hypochloremia, and metabolic alkalosis. (brainscape.com)
Hydroxyethyl starch1
  • Twenty-one patients received 2-4 mL/kg body weight of hypertonic saline in hydroxyethyl starch within 15 min. (omeka.net)
Lactate1
  • Without adequate fluid resuscitation, tissue hypoperfusion leads to lactate production and metabolic acidosis. (medscape.com)
Isotonic saline1
  • Treatment strategies for syndrome of inappropriate antidiuretic hormone include fluid restriction to 1 to 1.5 L of free water per day, sodium chloride tablets, isotonic saline along with furosemide or hypertonic saline (2% or 3%) alone, and vasopressin-2 (V2) receptor antagonists (conivaptan and tolvaptan). (mhmedical.com)
Acute7
  • The experimental hypertonic saline/dextran (HSD) solution is more concentrated than the current treatment and may offer potential benefits to victims of blunt trauma, Bulger says, including more rapid improvement of blood pressure, improved blood flow to the injured brain while decreasing the high pressure in the brain, and an altered immune system response which may decrease the risk of infection and acute respiratory distress syndrome. (atlantainjurylawblog.com)
  • We hypothesized that hypertonic saline (7.5%) would reverse these detrimental effects of acute edema. (utmb.edu)
  • Acute hemorrhage is the leading cause of acute life-threatening intravascular volume loss requiring aggressive fluid resuscitation to maintain tissue perfusion until the underlying cause can be corrected. (medscape.com)
  • Disturbances between the intravascular and extravascular volumes or acute blood loss are all indications for fluid resuscitation. (medscape.com)
  • Nebulized hypertonic saline solution for acute bronchiolitis in infants. (thieme-connect.de)
  • For acute correction of symptomatic hypocalcemia, IV calcium gluconate, or calcium chloride (10 mL of a 10% solution) can be administered over 10 minutes. (mhmedical.com)
  • To evaluate if the increase in chloride intake during a continuous infusion of 20% hypertonic saline solution (HSS) is associated with an increase in the incidence of acute kidney injury (AKI) compared to standard of care in traumatic brain injury patients. (biomedcentral.com)
Increasingly2
Patients8
  • Resuscitation aimed at these patients will unlikely be associated with improved outcomes. (medicosecuador.com)
  • This has led to much controversy over fluid resuscitation in injured patients. (medicosecuador.com)
  • The advantages of hypertonic saline resuscitation include its hemodynamic effects, its effects on lowering ICP in brain injured patients, and most recently multiple studies which have suggested benefits in modulating the inflammatory response. (medicosecuador.com)
  • However, they required the greatest resuscitation volume among all fluid types, especially in trauma patients. (researchsquare.com)
  • Fluid resuscitation is one of the most common and important methods in managing critically hypotensive patients. (researchsquare.com)
  • Calcium chloride is contraindicated for cardiac resuscitation in the presence of ventricular fibrillation or in patients with the risk of existing digitalis toxicity. (nih.gov)
  • In these hyperdynamic septic patients, hypertonic saline infusion produced a transient increase in circulation, but no evidence of a substantial increase in O-2 consumption. (omeka.net)
  • These reports raised the question of the impact of hypertonic solutions on kidney function in neuro-intensive care patients. (biomedcentral.com)
Intravascular volume1
  • In the past decades, several colloids, larger insoluble molecular solutions, have been developed to improve intravascular volume more effectively. (researchsquare.com)
CONCLUSIONS2
  • CONCLUSIONS: HTS resuscitation did not impair the host response to bacterial contamination of the peritoneal cavity. (mcmaster.ca)
  • CONCLUSIONS: Hypertonic saline prevented intestinal tissue edema. (utmb.edu)
Infusion1
Immunologic1
  • The discovery of the immunologic properties of hypertonic saline occurred following observations of immunosuppression in in vitro T-cell blastogenesis by high extracellular salt concentrations. (medicosecuador.com)
Sterile2
  • Sputum induction is conducted by inhalation of nebulised sterile saline solution (isotonic or hypertonic) followed by coughing and expectoration of airway secretions. (ersjournals.com)
  • Induction is carried out using a sterile, freshly prepared saline solution. (ersjournals.com)
Concentration4
  • In those with high volume or hypervolemia: Intake of a hypertonic fluid (a fluid with a higher concentration of solutes than the remainder of the body) with restricted free water intake. (wikipedia.org)
  • Current pre-hospital treatment includes two liters of an IV saline solution having a similar concentration to human plasma. (atlantainjurylawblog.com)
  • However, normal (0.9%) and hypertonic (3% or 20%) saline solutions are not devoid of side effects as saline solutions contain a "supra physiological" concentration of chloride that may induce metabolic disturbances [ 6 ]. (biomedcentral.com)
  • pH, the negative logarithm of the hydrogen ion concentration ([H + ]), defines the acidity or alkalinity of solutions or blood. (aneskey.com)
Surgery1
  • Reports vary by where death occurs (in the field, in the hospital, or in the operating room) and it is also difficult to sort out the effects of transport times, the presence of airway control and ventilation, the type and degree of fluid resuscitation or use of MAST suits, and the impact of surgery. (medicosecuador.com)
Adults1
Volume5
  • This is relatively uncommon, though it can occur after a vigorous resuscitation where a patient receives a large volume of a concentrated sodium bicarbonate solution. (wikipedia.org)
  • If significant volume loss is reported, volume resuscitation is likely required regardless of laboratory findings or relatively normal vital signs. (medscape.com)
  • 1,2 ] This approach has been used, for example, to show that Ringer solution increases the blood volume by 20-25% of the given amount of fluid. (silverchair.com)
  • Small volume resuscitation with HTS also induced peripheral CD8 + lymphocytes to a certain extent, whereas NS resuscitation showed no effect in this respect. (zju.edu.cn)
  • Other treatments include furosemide after adequate volume resuscitation is achieved, calcitonin, bisphosphonates (pamidronate and zoledronate), and dialysis. (mhmedical.com)
Sodium4
Trauma2
  • BACKGROUND: Hypertonic saline (HTS) has been proposed as a resuscitation strategy following trauma based on its ability to prevent organ dysfunction by exerting immunosuppressive effects on inflammatory cells, including neutrophils. (mcmaster.ca)
  • When one reviews the development of trauma systems and the effects of fluid resuscitation, it is difficult to evaluate the data. (medicosecuador.com)
Fluids1
  • Hypertonic saline is not recommended for resuscitation because the evidence suggests there is no difference in outcome when compared to isotonic fluids. (merckmanuals.com)
Restoration1
  • Concerns have been raised about the effects of enhanced blood pressure restoration using hypertonic saline and the effect on primary hemostasis. (medicosecuador.com)
Tissue1
  • In addition, hypertonic saline improved intestinal transit, possibly through more efficient transmission of muscle force through stiffer intestinal tissue. (utmb.edu)
Surgical1
  • Canon pointed out the disadvantage fluid resuscitation in 1910 and emphasized that increases in blood pressure prior to surgical hemostasis would pop the clot and increase bleeding with potential exsanguination. (medicosecuador.com)
Hypotonic1
Include1
  • Features include hybrid inpatientoutpatient support, advanced billing, fast healthcare interoperability resources fhir integration, modern cloud offerings, ability to perform quality reporting, lowcost medical devices connectivity, and other commonly requested solutions. (web.app)
Colloids1
Clinical1
Suggests1
  • 6 Recent data suggests in a well designed animal model that retroperitoneal bleeding is less following HTS resuscitation with less percent bleeding. (medicosecuador.com)
Chloride1
  • The pH of 10% Calcium Chloride Injection, USP is 5.5 to 7.5 when diluted with water for injection to make a 5% solution. (nih.gov)
Effect1
  • Hypertonic saline significantly lessened the effect of edema on intestinal transit and prevented the changes in stiffness and residual stress. (utmb.edu)
Prompt1
Large amounts1
  • Premature neonates are particularly at risk because their kidneys are immature, and they require large amounts of calcium and phosphate solutions, which contain aluminum. (nih.gov)
Early1
  • This suggested that early fluid resuscitation for bleeding has to be focused on the earliest outcomes, and that when you bleed enough to die you do so in less than 6 hours. (medicosecuador.com)
Water1
  • Ingesting seawater also causes hypernatremia because seawater is hypertonic and free water is not available. (wikipedia.org)
Therapy1
Strategy1
Strategies1
  • Whereas emigration into the peritoneum activated neutrophils, there was no difference between resuscitation strategies, consistent with the finding that bacterial clearance did not differ between groups. (mcmaster.ca)
Type1
  • Although peritoneal neutrophil sequestration was unaffected by resuscitation type, HTS still was able to prevent lung neutrophil accumulation compared to RL treatment. (mcmaster.ca)
Choice1