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  • Ecstasy
  • An acute and potentially life-threatening complication associated with the recreational use of the 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) is hyperthermia. (aspetjournals.org)
  • There is some uncertainty whether the acute hyperthermia caused by MDMA (ecstasy) plays a significant role in determining the long-term neurotoxic effects on brain 5-HT systems and associated changes in mood and behaviour. (mdma.net)
  • MDMA
  • MDMA (40 mg/kg s.c.) induced a significant increase in thyroxine levels 1 h post-treatment. (aspetjournals.org)
  • The combination of prazosin and cyanopindolol resulted in an abolishment of MDMA-induced hyperthermia. (aspetjournals.org)
  • Although the importance of their elucidation cannot be overstated, the fundamental biological mechanisms involved in heat production and progression to hyperthermia after MDMA exposure are unknown. (aspetjournals.org)
  • Furthermore, we do not understand clearly the associations between hyperthermia and many of the pathological changes induced by MDMA. (aspetjournals.org)
  • In addition to evidence suggesting that MDMA acutely disturbs central nervous system thermoregulatory functions, MDMA-induced activation of the sympathetic nervous system (SNS) and subsequent alterations in vascular hemodynamics may also play an important role in heat production and redistribution. (aspetjournals.org)
  • These results indicate that high-fat feeding regulates MDMA-induced thermogenesis by augmenting the activation of UCP rather than its expression. (pubmedcentralcanada.ca)
  • The present study assessed whether long-term behavioural and cognitive changes seen in MDMA-treated rats are affected by hyperthermia at the time of drug administration. (mdma.net)
  • MDMA treatment caused a clear and consistent hyperthermia at 28 degrees C and hypothermia at 16 degrees C. Months later, rats pre-treated with MDMA at either 16 or 28 degrees C displayed increased anxiety in the social interaction and emergence tests and reduced escape attempts and increased immobility in the forced swim test. (mdma.net)
  • These results indicate that hyperthermia at the time of dosing with MDMA is not necessary to produce subsequent 5-HT depletion and anxiety in rats. (mdma.net)
  • vivo
  • We and others have previously shown that moderate heat treatment (hyperthermia) induces HPV E2 gene mutation and promotes host response in vivo , and induces apoptosis and cell cycle arrest of cervical cancer cells in vitro [ 5 - 8 ]. (ijbs.com)
  • To clarify the function of adenosine A 2A receptors in childhood convulsive disorders associated to hyperthermia, we investigated the in vivo interaction between adenosine A 2A receptors and their ligands in HS in childhood rats. (naver.com)
  • In vivo studies have shown that the method can induce an immune response that is effective against re-challenging, therefore indicating abscopal effect. (intechopen.com)
  • Mechanism
  • However, thermotolerance induced by heme oxygenase-1 (HO-1), a stress-inducible cytoprotective protein, limits the efficacy of hyperthermic therapy, for which the exact mechanism remains unknown. (ijbs.com)
  • Thus, the findings indicate that blockade of HO-1 enhances hyperthermia-induced autophagy, an event resulting in apoptosis of cervical cancer cells through an antiviral mechanism. (ijbs.com)
  • receptors
  • The functional deterioration of adenosine A 1 receptors in the CNS was reported to cause a failure of termination of seizures and to a lower seizure threshold of hyperthermia-induced seizures (HS) in childhood rats, which may contribute to adenosine-related convulsive disorders such as theophylline-associated seizures in childhood patients. (naver.com)
  • physiological
  • In this complex physiological response, cold-induced activation of the SNS leads to noradrenaline release and activation of β -adrenoceptors on brown adipocytes, which in turn initiate the 3′,5′-cyclic adenosine monophosphate (cAMP) and protein kinase A-dependent activation of intracellular lipases and the accumulation of cellular free-fatty acids (FFA). (pubmedcentralcanada.ca)
  • alterations
  • Further research in this area by Nybo and Nielsen (200 1) suggests that alterations in cerebral brain activity may be associated with hyperthermia-induced fatigue during prolonged exercise in the heat. (bl.uk)
  • treatment
  • Hyperthermia has been clinically utilized as an adjuvant therapy in the treatment of cervical carcinoma. (ijbs.com)
  • In the present study, we found that heat treatment induced HO-1 expression and decreased copy number of HPV16 in cervical cancer cells and tissues from cervical cancer and precursor lesions. (ijbs.com)
  • However, cervical carcinomas with the same histologic grade and HPV subtype may have significant differences in response to hyperthermia treatment [ 9 ]. (ijbs.com)
  • outcomes
  • Hyperthermia at 39-45°C is a potent radiosensitiser and has been shown to improve therapeutic outcomes in various tumours through its synergy with chemotherapy. (uzh.ch)
  • study
  • This paper recounts a study of the prevalence of malignant hyperthermia in a population of boars entering the Record of Performance Test Station at New Hamburg, Ontario over a period of ten months. (islandscholar.ca)
  • It was determined in this population of boars that there was a 1.5% prevalence Show more This paper recounts a study of the prevalence of malignant hyperthermia in a population of boars entering the Record of Performance Test Station at New Hamburg, Ontario over a period of ten months. (islandscholar.ca)
  • frequencies
  • The targeted RF absorption enhancers may, in a manner of speaking, add one or more RF absorption frequencies to cells in the target area, which will permit a hyperthermia generating RF signal at that frequency or frequencies to heat the targeted cells. (google.com)
  • activation
  • The activation of the adenosine A 2A receptor might enhance seizures associated to hyperthermia in the childhood human brain, and be involved in the pathogenesis of sudden unexpected death in epilepsy (SUDEP) in childhood patients with convulsive disorders. (naver.com)
  • depression
  • Our previous data indicates that heating immature rat hippocampal slices from 34 to 41°C in an interface chamber induced epileptiform-like population spikes accompanied by a spreading depression (SD). (biomedcentral.com)
  • cause
  • The lethal effects of cocaine are unique among those of other illicit drugs because cocaine has the propensity to cause hyperthermia. (annals.org)
  • signal
  • An RF transceiver for coupling an RF signal through a target area, having a transmission head having a transmission inductor having a first axis directed toward a target area, an RF generator capable of generating a hyperthermia-inducing RF signal having at least one component for transmission via the. (google.de)
  • Given the evidence that RYR1 has retrograde effects on DHPR function, and that this retrograde signal is affected by RYR1 conformation as described above, the question naturally arises of whether malignant hyperthermia (MH)-causing mutations in RYR1 affect DHPR function. (rupress.org)