• Radiation Oncologist, Physician Scientist, and Founding Director of the Center for Hyperthermia at Cleveland Clinic, Jennifer Yu, MD, PhD, joins the Cancer Advances podcast to discuss hyperthermia therapy, which uses heat to destroy cancer cells and shrink tumors. (clevelandclinic.org)
  • And so, the idea is direct exposure of chemotherapy at doses that would be not tolerable to be given systemically, directly onto the surfaces where tumors were, and at a time when the tumor burden is lowest. (reachmd.com)
  • After the tumors have been removed, we introduce catheters into the abdomen and infuse the chemotherapy for approximately 90 minutes under heated conditions, typically 41 to 43° centigrade. (reachmd.com)
  • For one, it is thought that the-and there is some preclinical data to suggest this-the heat seems to be more effective against disruption of cancer cells and increases the vascular permeability of the chemotherapies into the tumors themselves. (reachmd.com)
  • Of the variety of tumors that are treated with this method, probably the most common indication are these low grade appendiceal cancers or what is clinically referred to as pseudomyxoma peritonei, and this is a situation in which patients can develop a significant amount of mucin in their abdomen, produced by the tumor cells that can be very problematic, and that may not necessarily be very responsive to conventional systemic therapies. (reachmd.com)
  • We are mainly interested in regional hyperthermia of deep seated tumors. (ichmt.org)
  • For treatment of neuroendocrine cancers (i.e., carcinoid tumors and pancreatic endocrine tumors) involving the liver. (aetna.com)
  • The National Comprehensive Cancer Network (NCCN) Soft Tissue Sarcoma Panel specifically identifies Li-Fraumeni syndrome and familial adenomatous polyposis (FAP) as genetic cancer syndromes with a predisposition for the development of STS, along with Carney-Stratakis syndrome, which is associated with gastrointestinal stromal tumors (GISTs) and paragangliomas. (medscape.com)
  • The World Health Organization classification system for tumors of the soft tissue and bone incorporates detailed cytogenetic and molecular data into the classifications. (medscape.com)
  • Cancer - all stages of solid tumors. (healnavigator.com)
  • As a physicist, he performs adjuvant hyperthermia treatments of pelvic, abdominal, and superficial tumors. (pyrexar.com)
  • Preliminary results in colorectal cancer (CRC) patients enrolled in the GATTO study, a phase I study of Tomuzotuximab in combination with Gatipotuzumab in patients with EGFR positive solid tumors. (postersessiononline.eu)
  • BACKGROUND: Oxaliplatin and Mitomycin C (MMC) are both suitable as intraperitoneal chemotherapy agents in HIPEC for peritoneal carcinomatosis (PC) of colorectal cancer (CRC). (lu.se)
  • Hyperthermic intraperitoneal chemotherapy, or HIPEC, is one of the most innovative treatments available today for complex abdominal cancers. (reachmd.com)
  • Can you please just tell us what exactly is hyperthermic intraperitoneal chemotherapy? (reachmd.com)
  • So, hyperthermic intraperitoneal chemotherapy, or HIPEC, is a procedure which involves infusing the peritoneal cavity in patients with advanced peritoneal surface malignancies with high-dose chemotherapy. (reachmd.com)
  • Sugarbaker, Paul H. 2011-10-16 00:00:00 Gastrointestinal Complications in 147 Consecutive Patients with Peritoneal Surface Malignancy Treated by Cytoreductive Surgery and Perioperative Intraperitoneal Chemotherapy 30). (sagepub.com)
  • Abstract Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) is increasingly used in the treatment of peritoneal carcinomatosis from gastrointestinal malignancies. (sagepub.com)
  • Patients with more advanced disease are currently offered palliative treatment, including localized transarterial chemoembolization (TACE) or systemic chemotherapy. (biomedcentral.com)
  • This procedure is associated with significantly fewer side effects than systemic chemotherapy. (healnavigator.com)
  • We went there after Whipple surgery without having systemic chemotherapy before. (healnavigator.com)
  • My primary focus is on brain cancers, and I also am a leader of the Developmental Therapeutics program at the Case Comprehensive Cancer Center, and the founding director of the Center for Hyperthermia here at the Cleveland Clinic. (clevelandclinic.org)
  • At the recent COMSOL Conference , he presented his computer simulation results of a novel noninvasive brain applicator, which will pave the way to treat brain cancers using focused microwave hyperthermia. (pyrexar.com)
  • Hyperthermia may increase chemotherapeutic drug uptake, influence the intracellular distribution and metabolism of drugs, and/or inhibit repair of DNA damage in neoplastic cells, thus, improving the effect of chemotherapeutic agents ( 13 , 16 , 20 ). (spandidos-publications.com)
  • In cultured primary fibroblasts and cancer cells, the chemotherapeutic drug doxorubicin causes mtDNA damage and release, which leads to cGAS STING dependent ISG activation. (regenerativemedicine.net)
  • On the whole, according to the present study, the appropriate dose in oncological hyperthermia must use an energy‑based concept, as it is well‑known in all the ionizing radiation therapies. (spandidos-publications.com)
  • At the Justus-Liebig-University Giessen he habilitated on techniques of regional chemotherapy in his scientific focus, surgical oncology. (healnavigator.com)
  • and how it helps radiation and chemotherapy treatments become more effective for patients. (clevelandclinic.org)
  • Today I'm happy to be joined by Dr. Jennifer Yu, a radiation oncologist at the Taussig Cancer Institute, and a cancer researcher in the Lerner Research Institute's Department of Cancer Biology. (clevelandclinic.org)
  • Yeah, so hyperthermia is a very well-known radiation sensitizer. (clevelandclinic.org)
  • It can make radiation work about 50 percent better, and in the cases where you have to repeat radiation, then the hyperthermia can make radiation work up to threefold better than radiation by itself. (clevelandclinic.org)
  • Just application of heat in combination with radiation or with chemotherapy can make it so effective with very few side effects. (clevelandclinic.org)
  • The applied rigorous thermodynamical considerations show the proper terminology and dose concept of hyperthermia, which is based on the energy‑absorption (such as in the case of ionizing radiation) instead of the temperature‑based ideas. (spandidos-publications.com)
  • We propose the use of Gy (J/kg) in cases of non‑ionizing radiation (hyperthermia) as well. (spandidos-publications.com)
  • Dr. Rodrigues's medical specialty is the treatment of cancer using hyperthermia therapy in combination with radiation treatments. (pyrexar.com)
  • Aetna considers intra-hepatic chemotherapy (infusion) medically necessary for members with liver metastases from colorectal cancer. (aetna.com)
  • Drug-eluting beads trans-arterial chemoembolization for leiomyosarcoma, liver metastases from colorectal cancer, and for primary and liver-dominant metastatic disease of the liver. (aetna.com)
  • Intra-hepatic chemotherapy for other indications not listed above, including treatment of liver primaries or metastases from other primaries (e.g., breast) besides colorectal cancer. (aetna.com)
  • One-shot" arterial chemotherapy for members with liver metastases from colorectal cancer. (aetna.com)
  • Cancer Advances, a Cleveland Clinic podcast for medical professionals exploring the latest innovative research and clinical advances in the field of oncology. (clevelandclinic.org)
  • The problem with the application of conventional hyperthermia in oncology is firmly connected to the dose definition, which conventionally uses the concept of the homogeneous (isothermal) temperature of the target. (spandidos-publications.com)
  • The eventual goal of these therapies is to provide targeted, individualized treatment options that allow health professionals to monitor the cancer tissue, trigger release of therapeutics, and monitor the response to the release. (ntno.org)
  • Extracellular vesicles (EVs) -- nanometer sized messengers that travel between cells to deliver cues and cargo -- are promising tools for the next generation of therapies for everything from autoimmune and neurodegenerative diseases to cancer and tissue injury. (regenerativemedicine.net)
  • Patient Model (Torso) and Hyperthermia Applicator. (ichmt.org)
  • A recent quality assurance validation study was published in the International Journal of Hyperthermia comparing heating patterns of the Sigma Eye-MR applicator among different models of MRI systems. (pyrexar.com)
  • Aetna considers percutaneous ethanol injection (PEI) medically necessary for the treatment of hepatocellular cancers (HCC) without extra-hepatic spread. (aetna.com)
  • For over a hundred years, doctors have been trying to treat cancer patients by overheating tumor tissue. (german-medicalgroup.com)
  • Hyperthermia takes advantage of the fact that tumor cells are far more sensitive to heat than healthy cells. (german-medicalgroup.com)
  • With hyperthermia treatment, the tumor tissue is also heated from the outside. (german-medicalgroup.com)
  • Ackerman Cancer Center is the OR's different particular, called tumor to Love field night, in ligand to last air treatment and critical Artesunate scenarios. (holiday-reisezentrum.de)
  • It is in this pursuit, we continue to develop and improve methods and technologies to lead the world in non-invasive cancer treatments. (pyrexar.com)
  • The use of remotely triggered treatments in combination with imaging modalities such as ultrasound, computed tomography, magnetic resonance imaging, and positron emission tomography could prove to address many of the current issues in cancer treatment, possibly leading to significant clinical outcomes [ 10 - 12 ]. (ntno.org)
  • Chemoembolization (CE) for other indications including palliative treatment of liver metastases from other non-neuroendocrine primaries (e.g., breast cancer, cervical cancer, colon cancer, esophageal cancer, melanoma, rhabdomyosarcoma, or unknown primaries) and CE of the pancreas for pancreatic cancer. (aetna.com)
  • In the years that followed, he developed many other surgical procedures and special catheters for the isolated treatment of organs, including pancreatic cancer. (healnavigator.com)
  • So, if there's just a small area that we need to treat, then the microwave unit or the hyperthermia unit will be about the size of a yogurt cup. (clevelandclinic.org)
  • However, these previous conventional trials were based on hot water-, microwave- or radiofrequency-induced local hyperthermia, either individually or in combination with cytostatic agents, which could maintain continuous and stable treatment temperatures, but lack effective temperature control or regulation, and cannot provide uniform distribution of heat to the bladder. (spandidos-publications.com)
  • Creating a non-invasive method of applying and steering microwave hyperthermia may bring some relief to those with non-operable Glioblastomas. (pyrexar.com)
  • A clear clarification of the proper dose concept must begin with the description of the limitations of the present doses in conventional hyperthermia applications. (spandidos-publications.com)
  • On univariate analysis of grade I-IV events a statistically significant association was observed with the following variables: histological grade, peritoneal cancer index (PCI), small bowel resection, colorectal anastomosis, and the number of anastomoses performed per patient. (sagepub.com)
  • However, establishing refined dose constraints requires access to patient-level data. (bvsalud.org)
  • Therefore, we aimed to provide such data on the relationship between OAR and gastrointestinal (GI) as well as genitourinary (GU) QoL outcomes of a homogenous patient cohort who received dose-intensified post-operative RT to the prostate bed. (bvsalud.org)
  • These novel technologies that can intelligently and effectively remove the diseased tissue with limited negative effect to the patient, and minimize the chance of cancer recurrence, could make an immediate impact in the clinic [ 2 - 9 ]. (ntno.org)
  • The optimal parameters based on the nonlinear model differ significantly from those obtained with constant-rate perfusion, they are in general closer to a symmetric configuration. (ichmt.org)
  • Although, the recurrence rate of NMIBC is significantly decreased by TUR in combination with intravesical chemotherapy, the rate of cancer progression is not diminished ( 7 - 12 ). (spandidos-publications.com)
  • Bladder intracavitary hyperthermic perfusion chemotherapy (BHPC), the combination of local hyperthermia with chemotherapy, can significantly improve the effect of intracavity chemotherapy, and is reported to have an additive or supra-additive effect, preventing NMIBC recurrence post-TUR ( 13 - 16 , 18 - 20 ). (spandidos-publications.com)
  • That portion of the stomach remaining after gastric surgery, usually gastrectomy or gastroenterostomy for cancer of the stomach or peptic ulcer. (wakehealth.edu)
  • It is a common site of cancer referred to as stump cancer or carcinoma of the gastric stump. (wakehealth.edu)
  • Multicenter phase I/II study of nivolumab combined with paclitaxel plus ramucirumab as the second-line treatment in patients with advanced gastric cancer. (postersessiononline.eu)
  • Despite years of scientific work, overheating is still not a standard cancer treatment procedure. (german-medicalgroup.com)
  • Hyperthermia treatment modalities have yet to progress from a bio-medical experiment to a clinically proven treatment ( 1 , 2 ). (spandidos-publications.com)
  • Hyperthermia is a technically challenging treatment modality. (spandidos-publications.com)
  • Despite the methods' clinical potential, the liver is a particularly challenging organ for HIFU treatment due to the combined effect of respiratory-induced liver motion, partial blocking by the rib cage, and high perfusion/flow. (biomedcentral.com)
  • A review of current unmet clinical needs is given here, as well as a consensus from a panel of experts about technical and clinical requirements for upcoming pilot and pivotal studies in order to accelerate the development and adoption of focused ultrasound for the treatment of primary and secondary liver cancer. (biomedcentral.com)
  • Treatment of liver cancer involves multiple strategies used independently, or in combination, depending on the stage of the disease. (biomedcentral.com)
  • The BSD-2000 3D/MR Image-Guided Hyperthermia system uses data from MRI taken throughout the hyperthermia treatment to create a pinpoint temperature map. (pyrexar.com)
  • Paving the Way for Brain Cancer Treatment. (pyrexar.com)
  • He is also responsible for the treatment planning, thermal dosimetry, and quality assurance of the clinical hyperthermia equipment. (pyrexar.com)
  • Theranostics would lead to better survival statistics and quality of life by causing enhanced treatment at the cancer sites while reducing toxic effects. (ntno.org)
  • Rectal cancer in Albania: treatment outcome and prognostic factors of disease progression. (postersessiononline.eu)
  • Hyperthermia, i.e., heating tissue to 42 43 o C, is a method of cancer therapy. (ichmt.org)
  • The nonlinear model predicts that a much larger amount of muscle tissue is heated to above 40 o C. In spite of the fact that only a small number of temperature measurements from inside the body is available, this effect might be visible in clinical data. (ichmt.org)
  • Our therapy has been especially successful for cancers of the breast, head and neck, lungs, pancreas, liver, bladder and stomach, and soft tissue sarcomas and melanomas. (healnavigator.com)
  • We have a unique opportunity to leverage the NIH, FDA and other academic medical centers to create regional excellence in physician-scientist development. (umaryland.edu)
  • Hyperthermia refers to a group of heat-related conditions characterized by an abnormally high body temperature - in other words, the opposite of hypothermia. (german-medicalgroup.com)
  • These inadequate devices for local heat delivery lack appropriate methods for monitoring temperature at the targets, limiting the application of hyperthermia enhanced therapy for cancer in clinical practice. (spandidos-publications.com)
  • The data, when compared to the previous scan, is used to form a three-dimensional temperature map. (pyrexar.com)
  • This results in tens of thousands of temperature data points in every slice taken. (pyrexar.com)
  • It is normally applied as an additive therapy to enhance the effect of conventional radio- or chemotherapy. (ichmt.org)
  • Intra-hepatic microspheres for metastases from esophageal cancer, gallbladder cancer, uveal melanom a, liver metastases of pancreatic adenocarcinoma, and other indications not listed above. (aetna.com)
  • The effect of hyperthermia is not straightforward in in vivo experiments and is even more complex in clinical practice. (spandidos-publications.com)
  • If you think about the way in which our bodies have evolved, we've found ways to use hyperthermia to fight off different diseases. (clevelandclinic.org)
  • Learn the info about doctors and clinics for Hyperthermia LISTED BELOW . (german-medicalgroup.com)
  • My father (Kadirali Sultanbekov) had 2 rounds of regional chemotherapy at this clinics. (healnavigator.com)
  • She's here today to talk to us about hyperthermia therapy. (clevelandclinic.org)
  • You say hyperthermia therapy. (clevelandclinic.org)
  • Hyperthermia is heating therapy. (clevelandclinic.org)
  • So similarly, here we use heat therapy or hyperthermia to fight off cancers. (clevelandclinic.org)
  • optimization of the channel adjustments to achieve favourable interference patterns for a successfull cancer therapy, 3. (ichmt.org)
  • Between December 2006 and December 2014, 53 patients with NMIBC who underwent TUR were randomly assigned to receive BHPC (BHPC group, 28 patients) or intravesical chemotherapy alone (chemotherapy group, 25 patients) at the Intracelom Hyperthermic Perfusion Therapy Center of Guangzhou Medical University Cancer Hospital (Guangzhou, China). (spandidos-publications.com)
  • Hyperthermia is a thermal therapy technique administered by focusing radio and microwaves to generate a cellular heat response. (pyrexar.com)
  • The largest pdf Monte eV comedy in the categorization, the Roberts Proton Therapy Center, which is a context of Penn's Abramson Cancer Center, has as strategy of a controlled facilitator that is the canadensis of the University of Pennsylvania, the Perelman Center for Advanced Medicine, and the Children's Hospital of Philadelphia. (holiday-reisezentrum.de)
  • The aim of the present study was to investigate the effectiveness and safety of bladder intracavitary hyperthermic perfusion chemotherapy (BHPC) for prevention of NMIBC recurrence post-TUR. (spandidos-publications.com)
  • Examples of opportunity include efforts to expand cancer screening and build programs that address challenges that are unique to and valued by our African American communities, such as maternal fetal health, cancer prevention, and sickle cell disease. (umaryland.edu)
  • Preventing the recurrence of non-muscle invasive bladder cancer (NMIBC) post-transurethral resection (TUR) remains challenging. (spandidos-publications.com)
  • Among patients with bladder cancer, ~75% are diagnosed with non-muscle invasive bladder cancer (NMIBC) which has a much more favorable prognosis than muscle-invasive bladder cancer ( 1 , 2 ). (spandidos-publications.com)
  • But the invasive nature of interstitial hyperthermia requires a specialty that few possess. (pyrexar.com)
  • BHPC was performed by combining perfusion-based hyperthermia with chemotherapeutic agent mitomycin C (MMC) in the bladder, and the chemotherapy group of patients received bladder MMC perfusion. (spandidos-publications.com)
  • Tens of thousands of patients have been treated for uterine fibroid, benign prostate hyperplasia, bone metastases, or prostate cancer. (biomedcentral.com)
  • METHODS: Patients who were treated with prostate bed RT between 2010 and 2020 were inquired about their QoL based on the Expanded Prostate Cancer Index Composite (EPIC). (bvsalud.org)
  • This study prospectively explored the feasibility of re-RT in patients with loco-regionally recurrent or second primary head and neck cancer (LRR/SP HNC). (bvsalud.org)
  • In 9 patients (15%) re-RT was interrupted prematurely and in other 9, the complete re-RT dose was lower than 60 Gy, and 37 patients (61%) could not receive or complete chemotherapy. (bvsalud.org)
  • Currently, there are five image-guided hyperthermia systems treating patients in Europe. (pyrexar.com)
  • Patent US 10,737,106 " Apparatus and Method for Creating Small Focus Deep Hyperthermia in Tissues of the Brain " is another step closer to our ultimate goal of improving the lives of patients with cancer. (pyrexar.com)
  • Communication Frameworks for Palliative Surgical Consultations: A Randomized Study of Advanced Cancer Patients. (viictr.org)
  • In our case, we use local or regional heating as opposed to total body heating, such as seen in a fever. (clevelandclinic.org)
  • So, you mentioned previously local hyperthermia, regional hyperthermia, whole body hyperthermia and you gave the fever example. (clevelandclinic.org)
  • The surmounting of the limits the dose of oncologic hyperthermia has to be based on the applicability of the Eyring transition state theory on thermal effects. (spandidos-publications.com)
  • They were compared for toxicity and survival data. (lu.se)
  • Clinical studies, like " Survival benefit of hyperthermia in a prospective randomized trial of brachytherapy boost +/- hyperthermia for glioblastoma multiforme," Sneed, 1998 , was an early phase III landmark study demonstrating heightened clinical response and increased survival. (pyrexar.com)
  • Primary liver cancer occurs most commonly in previously damaged livers, as in cases of viral hepatitis, alcohol abuse, obesity, and exposure to aflatoxin. (biomedcentral.com)
  • There may be some direct cytotoxic effect of heat to the cancer cells, which is somewhat selective to cancer versus normal cells. (reachmd.com)
  • This may be particularly relevant in the context of the aspiration of establishing focal RT of prostate cancer and its local recurrences. (bvsalud.org)
  • Give us a little bit of an idea what local or regional hyperthermia might be. (clevelandclinic.org)
  • The American Cancer Society's 2012 estimate for primary liver and bile duct cancers in the United States amounts to 28,720 new cases and 20,550 deaths [ 1 ]. (biomedcentral.com)
  • We will look to advance opportunities to grow regional primary and multi-specialty care services in FPI in partnership with UMMS and enhance the quality and efficiency of care at UMMC. (umaryland.edu)
  • However, reproducibility in the synthesis procedures of such "smart" platforms that lend themselves to easy scale-up in their manufacturing, as well as the development of new and improved models of cancer that are more predictive of human responses, need to happen soon for this field to make a rapid clinical impact. (ntno.org)
  • The category 'hyperthermia' includes the group of energy-absorption methods, and the individual solutions of absorption require an actual protocol. (spandidos-publications.com)
  • And the Center for Hyperthermia is the only one of its kind in Ohio, and one of the few in the country. (clevelandclinic.org)
  • And I was fortunate to train in a center at UCSFU, University of California, San Francisco that had a hyperthermia center, and I saw the amazing effects of hyperthermia. (clevelandclinic.org)
  • These three MR systems from GE, Philips, and Siemens represent a growing family of OEM imaging systems proven compatible with the BSD-2000 3D/MR hyperthermia system. (pyrexar.com)
  • As bladder cancer can be hypoxic, this provides a very strong rationale for the use of MMC in combination with hyperthermia ( 21 ). (spandidos-publications.com)