AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceNamed GroupsHealth Care
Anesthesia, Closed-CircuitSystems TheoryComputer SimulationHypertensionModels, TheoreticalModels, BiologicalNumerical Analysis, Computer-AssistedSystems BiologyHypertension, PulmonaryModels, CardiovascularAlgorithmsBlood VesselsHypertension, RenalBlood PressureCorrosion CastingHypertension, PortalHypertension, RenovascularReproducibility of ResultsAntihypertensive AgentsTime FactorsXylemHypertension, MalignantModels, StatisticalPlant Vascular BundleLymphatic SystemCardiovascular SystemNeovascularization, PhysiologicLymphatic VesselsEndothelium, VascularPulmonary ArteryHypertension, Pregnancy-InducedPhloemLymphangiogenesisArteriesEndothelial CellsVeinsVascular DiseasesOcular HypertensionVascular ResistanceHemodynamicsRisk FactorsKidneyPlant StemsRats, Inbred SHRReninAortaIntracranial HypertensionBlood Pressure DeterminationMuscle, Smooth, VascularPulmonary CirculationNeuropilinsEndothelium, LymphaticRats, Inbred WKYMicroscopy, Electron, ScanningRegional Blood FlowCapillariesSignal TransductionDesoxycorticosteroneDisease Models, AnimalNitric OxideHypertrophy, Right VentricularCardiovascular DiseasesPersistent Hyperplastic Primary VitreousSodium Chloride, DietaryBlood Pressure Monitoring, AmbulatoryVasodilationMonocrotalinePregnancy Complications, CardiovascularPrevalenceAngiotensin IIRats, Sprague-DawleyLymphedemaRenin-Angiotensin SystemPlant LeavesVasoconstrictionYolk SacPregnancyGene Expression Regulation, DevelopmentalNeovascularization, PathologicAldosteroneEphrin-B2In Situ HybridizationHyperaldosteronismReceptor, TIE-2Heart RatePseudotumor CerebriOphthalmic ArteryMicrocirculationVascular Endothelial Growth Factor AHypertrophy, Left VentricularMice, KnockoutSodium, DietaryRNA, MessengerLungCells, CulturedFollow-Up StudiesSystoleBlood Flow VelocityDiet, Sodium-RestrictedVasodilator Agents
AtherosclerosisDiseasesPatients with hypertensionDiseasePulmonary arterial hypInflammationComorbiditiesEndothelial cellsClinicalAngiogenesisRatsAngiotensinStrokeOxidativeMortalityMyocardial infarctionMechanismsLymphaticSystemicDysfunctionNitric oxideRenal vascularCardiac hypertrophyPathogenesisReactivityDevelopment of hypertensionInducesHomeostasisInsulinRiskHuman vascularPromote vascularTissueDeoxycorticosteroneResponsesDementiaResearchPhysiologyDamageArterialHealthEndothelium
Atherosclerosis5
  • I have multiple awards including Research Recognition Award from American Physiological Society, Central Nervous System section and Atherosclerosis, Thrombosis, and Vascular Biology Travel Award for Young Investigators from AHA/ASA. (omicsonline.org)
  • Endothelial dysfunction, as manifested by an attenuation of nitric oxide (NO)-mediated vasodilation, is recognized to be a fundamental abnormality in the genesis of hypertension, atherosclerosis, and coronary artery disease ( 1 ). (diabetesjournals.org)
  • They suggest that vitamin D-3 has the potential to significantly reverse the damage that high blood pressure, diabetes, atherosclerosis, and other diseases inflict on the cardiovascular system. (vita-sy.com)
  • Excess oxidative stress induces endothelial dysfunction and inflammatory reactions in vascular systems, leading to atherosclerosis. (biomedcentral.com)
  • Recent studies in animal models report that UA may have a causal role in the development of atherosclerosis, whereas lowering uric acid levels prevented or reversed the features of the MetS [ 23 ]. (biomedcentral.com)
Diseases13
  • Adrenomedullin is seen as a positive influence in diseases such as hypertension, myocardial infarction, chronic obstructive pulmonary disease and other cardiovascular diseases, whereas it can be seen as a negative factor in potentiating the ability of cancerous cells to extend their blood supply and thereby enable further cell proliferation. (wikipedia.org)
  • What excites you about this field, in particular, and do you see this as the future for treatment of cardiovascular diseases? (escardio.org)
  • Molecular basis of diseases affecting iron, blood and the cardiovascular system. (utoronto.ca)
  • The nanoparticle we developed is a powerful new delivery system for genome editing in vascular endothelial cells, and could be used to treat many diseases, including acute respiratory distress syndrome from severe COVID-19," said senior author Dr. Zhao from Lurie Children's. (eurekalert.org)
  • Endothelial dysfunction is at the root of many diseases, such as coronary artery disease, stroke, bronchopulmonary dysplasia and pulmonary artery hypertension. (eurekalert.org)
  • Elevated levels of homocysteine, termed hyperhomocysteinemia (HHcy), is considered a risk factor for cardiovascular and cerebrovascular diseases [ 7 ]. (biomedcentral.com)
  • The funds from this ARC will be used to 1) initiate collaborative studies in mouse models on mechanisms of obesity-linked cardiovascular diseases and 2) support research where basic science and clinical research labs perform molecular analyses on tissues and cell samples isolated from patient populations. (bu.edu)
  • Obese individuals are at high risk for the development of metabolic disorders, including insulin resistance, type II diabetes mellitus and cardiovascular diseases (CVD). (benthamscience.com)
  • Arterial Stiffness and Risk in Various Cardiovascular Diseases -- 27. (nshealth.ca)
  • RationaleDuring the last decennium t a more focused attention has been directed to the presence of chronic inflammation in cardiovascular diseases (CVD), but mainly to the high impact that this one has in generating and. (medandlife.org)
  • Interplay of infection, immunity, and inflammation in the initiation and progression of atherosclerotic cardiovascular diseases (ASCVD) in people with HIV (PWH). (nih.gov)
  • In this capacity, she has worked across federal and private partners to execute evidence-based strategies to prevent cardiovascular diseases and improve health. (cdc.gov)
  • [ 5 , 7 ] Although the underlying mechanisms are complex, the chronic inflammatory state and microbial burden in people with periodontal disease may predispose them to cardiovascular diseases in ways proposed for other infections. (medscape.com)
Patients with hypertension3
  • The need for novel, effective, and safe combination therapies for patients with hypertension who are not responding to monotherapy is well acknowledged. (ijpsonline.com)
  • In human subjects, studies have shown that endothelial dysfunction, recognized as impairments in flow-mediated dilation or endothelial-dependent vasodilation in response to acetylcholine, is predictive of cardiovascular events in patients with hypertension, coronary artery disease, peripheral artery disease, etc. (bu.edu)
  • Among COVID-19 patients with hypertension, those received either ARBs/ACEIs or non-ARBs/ACEIs had comparable blood pressure. (medrxiv.org)
Disease48
  • ETHNOPHARMACOLOGICAL RELEVANCE: Induced vascular growth in the myocardium has been widely acknowledged as a promising intervention strategy for patients with ischemic coronary artery disease. (bvsalud.org)
  • Racist and discriminatory federal, state, and local housing policies significantly contribute to disparities in cardiovascular disease incidence and mortality for individuals that self-identify as Black or African American. (frontiersin.org)
  • We propose that racial residential segregation and discrimination increases tissue inflammation and cytokine production, resulting in dysregulated immune signaling, which promotes plaque formation and cardiovascular disease. (frontiersin.org)
  • This framework has the power to link structural racism not only to cardiovascular disease, but also to cancer. (frontiersin.org)
  • In this address, the AHA declared structural racism a key cause of premature death from cardiovascular disease ( 3 ) and called for change through strategic goals and increased focus on health equity ( 3 ). (frontiersin.org)
  • There are many drugs which have favourable effects on cardiovascular disease, however, the use of some strong drugs is limited because of side effects or off-target effects. (escardio.org)
  • Animal models and genetic basis of disease. (utoronto.ca)
  • The immune system in disease. (utoronto.ca)
  • The beneficial actions of kinins in renal and cardiovascular disease are largely mediated by nitric oxide and prostaglandins, and extend beyond their recognized role in lowering blood pressure to include cardioprotection and nephroprotection. (nature.com)
  • Metabolic risk factors, such as obesity, insulin resistance, and type 2 diabetes (T2D), can initiate and accelerate endothelial dysfunction leading to cardiovascular disease (CVD) ( 1 ). (diabetesjournals.org)
  • Objective To investigate the association between long term intake of dietary and supplemental calcium and death from all causes and cardiovascular disease. (bmj.com)
  • Main outcome measures Primary outcome measures, identified from registry data, were time to death from all causes (n=11 944) and cause specific cardiovascular disease (n=3862), ischaemic heart disease (n=1932), and stroke (n=1100). (bmj.com)
  • Compared with intakes between 600 and 1000 mg/day, intakes above 1400 mg/day were associated with higher death rates from all causes (hazard ratio 1.40, 95% confidence interval 1.17 to 1.67), cardiovascular disease (1 49, 1.09 to 2.02), and ischaemic heart disease (2.14, 1.48 to 3.09) but not from stroke (0.73, 0.33 to 1.65). (bmj.com)
  • Conclusion High intakes of calcium in women are associated with higher death rates from all causes and cardiovascular disease but not from stroke. (bmj.com)
  • Hypertension is the primary worldwide cause of cardiovascular disease and early death. (cardiometry.net)
  • Objective To develop, validate, and evaluate a new QRISK model to estimate lifetime risk of cardiovascular disease. (bmj.com)
  • Subjects Patients aged 30-84 years who were free of cardiovascular disease and not taking statins between 1 January 1994 and 30 April 2010: 2 343 759 in the derivation dataset, and 1 267 159 in the validation dataset. (bmj.com)
  • Cardiovascular disease is the leading cause of premature death and a major cause of disability in the UK. (bmj.com)
  • 1 National policies now support targeting of interventions to reduce risk of cardiovascular disease among high risk patients. (bmj.com)
  • Vascular dementia is the second most common cause of dementia after Alzheimer's disease (AD). (biomedcentral.com)
  • We used a dietary model of cerebrovascular disease that relies on the induction of hyperhomocysteinemia (HHcy). (biomedcentral.com)
  • HHcy is a significant clinical risk factor for stroke, cardiovascular disease and type 2 diabetes. (biomedcentral.com)
  • These data show that cerebrovascular disease can significantly impact Aβ distribution in the brain, favoring vascular deposition. (biomedcentral.com)
  • Obesity promotes a chronic inflammatory state, which contributes to the development of insulin resistance and cardiovascular disease. (bu.edu)
  • This ARC will coordinate activities of basic science labs and clinical research labs to assess the interrelationship between metabolic dysfunction and vascular disease. (bu.edu)
  • We propose projects to define the molecular mechanisms by which metabolic disease impacts vascular function and vice versa . (bu.edu)
  • The ARC takes a well integrated approach to understand the functional interrelationships between metabolic disease and vascular dysfunction. (bu.edu)
  • Obesity and its comorbidities, including hypertension, hyperlipidemia and type 2 diabetes mellitus, have a devastating impact on vascular function leading to conditions that promote cardiovascular disease. (bu.edu)
  • Due in large part to the increased prevalence of cardiovascular disease, it is estimated that life expectancy declines by 3 years for those with a Body Mass Index (BMI) over 30 and 10 years for those with a BMI over 40. (bu.edu)
  • Any drugs that are discovered to improve brain blood supply may also be able to open a new line of attack in treating Alzheimer's disease, which causes very similar damage to blood vessels as vascular dementia. (hospitalhealthcare.com)
  • Cardiovascular disease causes one-third of deaths worldwide and represents an urgent threat to global health. (nature.com)
  • The scientific, clinical, pharmacological and public health communities have coordinated efforts to prevent, diagnose, treat and cure cardiovascular disease. (nature.com)
  • However, there is only limited evidence on the clinical implications of xanthine oxidase inhibitors on atherosclerotic cardiovascular disease in patients with hyperuricemia. (biomedcentral.com)
  • We designed the PRIZE study to evaluate the effects of febuxostat on a surrogate marker of cardiovascular disease risk, ultrasonography-based intima-media thickness of the carotid artery in patients with hyperuricemia. (biomedcentral.com)
  • Renin-Angiotensin-Aldosterone System and Cardiomyocyte Apoptosis in Hypertensive Heart Disease -- 15. (nshealth.ca)
  • Introduction: Hypertension is a chronic disease, which represents one of the most common public health problems in the world and afflicts about 28% of the North Americans, 44% of the Europeans and 26% of the East Mediterranean. (medandlife.org)
  • Mechanisms of HIV infection related atherosclerotic cardiovascular disease. (nih.gov)
  • Feel more energetic and significantly reduce your risk of chronic conditions like diabetes and cardiovascular disease. (lark.com)
  • Hypertension affects 46% of American adults and is a risk factor for stroke, cardiovascular disease, and other vascular disease [ 1 ]. (lark.com)
  • Hearts is to engage a broad set of stakeholders involved with Cardiovascular disease, including heart disease and stroke, is health and health care, including clinicians, pharmacists, insur- the leading cause of death and disability in the United States. (cdc.gov)
  • States have a heart attack or stroke and, as a result of these prevention and treatment efforts will accelerate translation conditions, approximately 800,000 die from cardiovascular into practice, resulting in decreased burden to society and disease ( 1 ). (cdc.gov)
  • The ongoing complications that result by empowering persons in the United States to make healthy from cardiovascular disease greatly contribute to the economic choices (e.g., avoid tobacco, reduce sodium intake, and reduce burden on the health-care system and to society as a whole. (cdc.gov)
  • 2010, the cost in health-care expenditures and lost productivity who need it through focus on the "ABCS" (i.e., appropriate in the United States from cardiovascular disease amounted to aspirin use for those at risk, blood pressure control, cholesterol nearly $444 billion, and these costs are increasing every year management, and smoking cessation). (cdc.gov)
  • Million Hearts is being implemented through parallel efforts tors for cardiovascular disease (i.e., high blood pressure, high aimed at clinical settings and communities ( 3 ). (cdc.gov)
  • Introduction of Serogroup A Meningococcal ties to reduce cardiovascular disease. (cdc.gov)
  • The calculation is based on individual characteristics: age, sex, and 7 comorbidities including hypertension, diabetes and cardiovascular disease. (cdc.gov)
  • Through of the evaluation for HRV autonomic maneuvers can identify objectively cardiovascular autonomic neuropathy early stages and provide treatment options that based on control of symptoms and prevention of disease progression. (bvsalud.org)
  • Hypertension tion and management of the disease. (who.int)
Pulmonary arterial hyp1
  • Statins are known to improve pulmonary arterial hypertension (PAH) by their anti-inflammatory and anti-proliferative effects in animal models. (escardio.org)
Inflammation4
  • Lastly, we focus on the impact of inflammation on the immune system and the molecular mechanisms by which the inflamed immune microenvironment promotes the formation of atherosclerotic plaques. (frontiersin.org)
  • Additionally, CGRP might be important in processes such as control of fetoplacental vascular tone, regulation of calcium metabolism and insulin secretion, acetylcholine receptor synthesis, peripheral nerve regeneration, and neurogenic inflammation. (bachem.com)
  • 3) Vascular dysfunction within adipose tissue leads to inflammation and metabolic dysfunction. (bu.edu)
  • However, some of the fluid, along with certain cells and cellular debris (eg, from the immune response to local infection, cancer, inflammation) enters the lymphatic system. (msdmanuals.com)
Comorbidities1
  • Pre-clinical and animal models for HIV-associated HLBS comorbidities. (nih.gov)
Endothelial cells2
  • This is the first time that vascular endothelial cells could be reached for genome editing, since the usual way to deliver CRISPR/Cas9 - through a virus - does not work for this cell type. (eurekalert.org)
  • There are not many," Prof. Malinski adds, "if any, known systems which can be used to restore cardiovascular endothelial cells which are already damaged, and vitamin D-3 can do it. (vita-sy.com)
Clinical11
  • The phase III MAX clinical trial randomised patients with metastatic colorectal cancer (mCRC) to receive first-line capecitabine chemotherapy alone or in combination with the anti-VEGF-A antibody bevacizumab (± mitomycin C). We utilised this cohort to examine whether single nucleotide polymorphisms (SNPs) in VEGF-A, VEGFR1, and VEGFR2 are predictive of efficacy outcomes with bevacizumab or the development of hypertension. (bvsalud.org)
  • Since our nanoparticle is relatively nonspecific for the target organ, it is known to be extremely safe, and thus can be the first clinical oriented drug delivery system in the field of cardiology. (escardio.org)
  • Some of these agents are currently under evaluation in clinical trials for treatment of hypertension and diabetes. (frontiersin.org)
  • In clinical trials on healthy, young subjects, CIT supplementation increases L-arginine, NO-dependent signaling, vascular conductance and has the potential to upsurge peripheral tissue oxygenation and dwindle systemic BP[ 6 - 8 ]. (ijpsonline.com)
  • Experimental and clinical evidence implicate an imbalance between endogenous vasoconstrictor and vasodilator systems in the development and maintenance of hypertension. (nature.com)
  • This article is a review of exciting, recently generated genetic, biochemical and clinical data from studies that have examined the importance of the tissue kallikrein-kinin system in protection from hypertension, vascular remodeling and renal fibrosis. (nature.com)
  • This ARC is intended to promote translational research by bringing basic and clinical research laboratories together to study the cardiovascular consequences of obesity and diabetes. (bu.edu)
  • Nature Cardiovascular Research aims to serve this multidisciplinary community by providing a unifying publishing platform that will champion and disseminate original and important advances in basic, translational, clinical and public health research in cardiovascular biology and haematology. (nature.com)
  • A Real-Time Polyp-Detection System with Clinical Application in Colonoscopy Using Deep Convolutional Neural Networks. (cdc.gov)
  • fetArtificial Intelligence in Liver Cancers: Decoding the Impact of Machine Learning Models in Clinical Diagnosis of Primary Liver Cancers and Liver Cancer Metastases. (cdc.gov)
  • Assessment of the statistical optimization strategies and clinical evaluation of an artificial intelligence-based automated diagnostic system for thyroid nodule screening. (cdc.gov)
Angiogenesis3
  • Angiogenesis is the process of new vascular formation, which is derived from various factors. (bvsalud.org)
  • Vascular endothelial growth factor family receptors, including Flt-1, Flk-1 and Flt-4, have been found to play an essential role in regulating angiogenesis. (bvsalud.org)
  • however, platelet factor-4 proved to be a less effective drug of anti-angiogenesis on rat breast carcinoma model. (bvsalud.org)
Rats5
  • Deoxycorticosterone acetate salt (20 mg/kg, s.c.) was administered twice a week in male Wistar rats for 4 w with daily drinking water containing sodium chloride (1 %) and potassium chloride (0.2 %) to develop hypertension. (ijpsonline.com)
  • Aside from Nox … The partnership Topotecan HCl (Hycamtin) between ROS and blood circulation pressure was first recommended in the 1960s (170) nonetheless it was in the first 2000s that association was explored at length when it had Eng been proven that angiotensin II (Ang II)-induced hypertension in rats boosts vascular ROS creation non-phagocytic NADPH oxidase activation (162). (researchassistantresume.com)
  • In two models of partial renal IR with and without ischemia preconditioning (IPC) and using Mas receptor (MasR) blockade, A779 or its vehicle, the renal vascular responses to angiotensin II (Ang II) administration in two-kidney-one-clip (2K1C) hypertensive rats were determined. (hindawi.com)
  • Objective: We examined if renal denervation (RDN) attenuates the progression of aortocaval fistula (ACF)-induced heart failure or improves renal hemodynamics in Ren-2 transgenic rats (TGR), a model of angiotensin II (ANG II)-dependent hypertension. (cas.cz)
  • The present study examined the combined effects of an antihypertensive (S-Amlodipine) and an insulin-sensitizing agent, peroxisome proliferator-activated receptor (PPAR) agonists (Pioglitazone and Ragaglitazar), on cardiovascular risk factors in aged diabetic and insulin-resistant Zucker fa/fa rats. (biomedcentral.com)
Angiotensin12
Stroke3
  • I studied mechanisms of microvascular responses during various inflammatory pathologies such as hypertension, stroke, and others that are associated with enhanced blood content of fibrinogen (Fg) and homocysteine (Hcy). (omicsonline.org)
  • Included in this assortment are stroke, aneurysm, damage due to chronic hypoperfusion and damage due to chronic hypertension. (biomedcentral.com)
  • If this brain blood vessel bursts, it could lead to high blood pressure or uncontrolled hypertension, causing a hemorrhagic stroke. (marijuanadoctors.com)
Oxidative12
  • Treatment effects assessed by measuring non-invasive and invasive blood pressure, body and heart weight, vascular reactivity to catecholamines, acetylcholine-induced vasorelaxation in the isolated artery, and oxidative stress in heart specimens. (ijpsonline.com)
  • Compared to the deoxycorticosterone acetate group, the L-citrulline and spironolactone combination therapy dose-dependently ameliorated the elevated levels of different blood pressure parameters, improved cardiac hypertrophy, vascular reactivity, aorta relaxant responses and attenuated oxidative stress. (ijpsonline.com)
  • There's a paucity of scientific information linked to the systems of oxidative tension and blood circulation pressure elevation and some assays accurately measure ROS straight in sufferers. (researchassistantresume.com)
  • Many experimental types of hypertension display some extent of oxidative tension (48 67 93 95 236 Furthermore mice with minimal antioxidant enzyme systems and the ones lacking in NADPH oxidase possess higher blood stresses than people that have intact systems. (researchassistantresume.com)
  • Predicated on comprehensive experimental data it's been recommended that oxidative tension is causally connected with hypertension at least in pet models. (researchassistantresume.com)
  • In scientific medicine the immediate romantic relationship between ROS and hypertension isn't convincing and there continues to be no definitive evidence that oxidative tension is a primary reason behind hypertension in human beings. (researchassistantresume.com)
  • Included in these are vitiligo neurodegenerative illnesses and progeria (67 99 117 145 172 216 In regards to to scientific hypertension most research examining ROS derive from organizations between plasma or urine markers of oxidative tension and blood circulation pressure. (researchassistantresume.com)
  • Biomarkers of cell harm because of systemic oxidative tension such as for example plasma thiobarbituric acid-reactive chemicals Topotecan HCl (Hycamtin) (TBARS) and 8-epi-isoprostanes are raised in sufferers with hypertension (45 116 Antioxidant capability and degrees of antioxidant vitamins and enzymes have been shown to be reduced in individuals with hypertension (66 107 Such studies between hypertension and oxidative stress are purely correlative and are far from showing cause. (researchassistantresume.com)
  • Hence despite the notion that oxidative stress underlies hypertension there is still little solid evidence for this in the medical level. (researchassistantresume.com)
  • The researchers also found that vitamin D-3 significantly reduces oxidative stress in the vascular system. (vita-sy.com)
  • They note that their study "provides direct molecular insight to previously published observations that have suggested that vitamin D-3 deficiency-induced hypertension is associated with vascular oxidative stress. (vita-sy.com)
  • Oxidative Stress and Hypertension -- 16. (nshealth.ca)
Mortality2
  • We hypothesised that long term intake of low or high calcium increases the risk of cardiovascular mortality. (bmj.com)
  • We investigated associations between long term dietary and supplemental intake of calcium with all cause mortality as well as with cardiovascular mortality in a large population based prospective study of Swedish women. (bmj.com)
Myocardial infarction1
  • Preventive Lessons from Hypertension and Myocardial Infarction: Treating Asymptomatic Individuals to Lower the Risk for Subsequent Cardiovascular Events -- Part III. (nshealth.ca)
Mechanisms5
  • Possible reasons relate to a paucity of info on molecular mechanisms of ROS biology in human being tissue lack of adequate methods to evaluate ROS in the medical establishing and inappropriately designed medical trials to evaluate the effects of antioxidant therapy on hypertension. (researchassistantresume.com)
  • In a paper published in the International Journal of Nanomedicine , they describe how they used nanosensors and a cell model to identify the molecular mechanisms that vitamin D-3 can trigger in the endothelium, which is the thin layer of tissue that lines blood vessels. (vita-sy.com)
  • Large Arteries, Microcirculation, and Mechanisms of Hypertension -- 3. (nshealth.ca)
  • Blood Pressure and Sodium Balance: Pathophysiological Mechanisms and Cardiovascular Risk -- 9. (nshealth.ca)
  • The cannabinoid system consists of a complex array of receptors, substances with agonist/antagonist properties for those receptors, biosynthetic machineries and mechanisms for cellular uptake and degradation for. (medandlife.org)
Lymphatic6
Systemic1
Dysfunction6
  • When dysregulated Noxs play a role in improved ROS production it prospects to endothelial dysfunction and vascular redesigning Topotecan HCl (Hycamtin) in hypertension. (researchassistantresume.com)
  • Critical illness with multiple organ dysfunction is characterised by complex physiological and metabolic responses requiring support and optimisation of organ systems in the intensive treatment unit (ITU) [ 1 ]. (springeropen.com)
  • The net effect was increased constriction of arteries, reducing cerebral blood flow and behavioural alterations in the mice that approximated to deficits observed in human vascular dementia patients, including executive dysfunction, apathy and memory loss. (hospitalhealthcare.com)
  • Salt and Multiorgan Damage in Hypertension: Vascular Stiffening and Cardiorenal Structural Dysfunction Responses -- 19. (nshealth.ca)
  • Cardiovascular autonomic neuropathy is a common dysfunction autonomic found in DM patients DM, causing abnormalities in heart rate control, and dynamic vascular 4 . (bvsalud.org)
  • Autonomic dysfunction may be evaluated by the heart rate variability (HRV), which reflects the periodic fluctuations in heart rate instantaneous and the duration of intervals between R waves (R-Ri) consecutive electrocardiogram, and is therefore depending on the activity of sympathetic and parasympathetic nervous system 5,6 . (bvsalud.org)
Nitric oxide1
Renal vascular5
  • The renal vascular responses to graded Ang II (30, 100, 300, and 1000 ng kg −1 .min −1 ) infusion using A779 or its vehicle were measured at constant renal perfusion pressure. (hindawi.com)
  • No significant differences were detected between the groups in renal blood flow (RBF) or renal vascular resistance (RVR) responses to Ang II infusion when MasR was not blocked. (hindawi.com)
  • IR promotes a cascade of molecular events that lead to renal vascular and tubular damage and, ultimately, acute kidney injury (AKI) [ 2 - 4 ]. (hindawi.com)
  • In contrast to the negative effects of Ang II on the renal circulation, Ang1-7 as a renoprotective agent improves endothelial function, which increases RBF and decreases renal vascular resistance (RVR) [ 16 ]. (hindawi.com)
  • Conclusion: The results show that RDN significantly improved survival rate in ACF TGR, however, this beneficial effect was not associated with improvement of reduced RBF or with attenuation of exaggerated renal vascular responsiveness to ANG II. (cas.cz)
Cardiac hypertrophy1
  • Development of novel therapeutic approaches to bolster kinin activity in the vascular wall and in specific compartments in the kidney might be a highly effective strategy for the treatment of hypertension and its complications, including cardiac hypertrophy and renal failure. (nature.com)
Pathogenesis2
  • Although comprehensive experimental data support a job for elevated ROS amounts and changed redox signaling in the pathogenesis of hypertension the function in scientific hypertension is certainly unclear as a primary causative function of ROS in blood circulation pressure elevation has however to be confirmed in humans. (researchassistantresume.com)
  • vasculogenesis and vascular permeability and has been implicated in the pathogenesis of pre-eclampsia. (who.int)
Reactivity1
  • In addition, L-citrulline low and high-dose monotherapy demonstrated significant improvements in all evaluated parameters except vascular reactivity. (ijpsonline.com)
Development of hypertension1
  • The early work by Goldblatt, in 1934, demonstrated that the placement of a clip around a renal artery was clearly related to the subsequent development of hypertension. (nshealth.ca)
Induces1
Homeostasis2
  • Due to its potent vasodilatory action and its inotropic and chronotropic effects, CGRP is likely to play a role in cardiovascular homeostasis. (bachem.com)
  • Importantly, CYP epoxygenase-derived EETs are involved in the maintenance of cardiovascular homeostasis. (frontiersin.org)
Insulin1
  • Type 2 diabetes is a complex metabolic disorder characterized by hyperglycemia, impaired glucose tolerance and insulin resistance associated with dyslipidemia and hypertension. (biomedcentral.com)
Risk14
  • VEGFR2 rs11133360 'TT' was associated with a lower risk of grade ≥ 3 hypertension (P = 0.028). (bvsalud.org)
  • Cox proportional hazards models in the derivation cohort to derive risk equations accounting for competing risks. (bmj.com)
  • Age-sex centile values for lifetime cardiovascular risk compared with 10 year risk estimated using QRISK2 (2010). (bmj.com)
  • Of the 10% of patients in the validation cohort classified at highest risk with either the lifetime risk model or the 10 year risk model, only 18 385(14.5%) were at high risk on both measures. (bmj.com)
  • This is because age has such a dominant effect in calculating absolute cardiovascular risk. (bmj.com)
  • This exciting research reveals a specific mechanism by which high blood pressure might increase the risk of vascular dementia. (hospitalhealthcare.com)
  • To identify and quantify risk factors for vascular prostheses (±10%) ( 5 , 7 - 9 ). (cdc.gov)
  • Independent risk factors for development of proven drug therapy, preferably a combination of doxycycline chronic Q fever were valvular surgery, vascular prosthesis, and hydroxychloroquine for 18-24 months. (cdc.gov)
  • In cardiovascular prevention, therehastraditionallybeena small number of cardiovascular risk factors to evaluate and manage, such as hypertension, diabetes,hyperlipidemiaand smoking. (nshealth.ca)
  • Blood Pressure and Arterial Wall Mechanics in Cardiovascular Diseaseshas been written to facilitate understanding of these new concepts regarding bleed pressure and cardiac risk, and prepare the reader for the considerable evolution of the topic in the years to come. (nshealth.ca)
  • Hypertension: Evaluation of Cardiovascular Risk and Organ Damage -- 20. (nshealth.ca)
  • In addition, the number and the migratory activity of these cells are inversely correlated with risk factors such as hypertension, hypercholesterolemia, diabetes, and metabolic syndrome. (intechopen.com)
  • The available drugs are not sufficiently efficacious in reducing cardiovascular risk and restoring normal glucose metabolism associated with type 2 diabetes as a mono- or a combination therapy. (biomedcentral.com)
  • The results suggest that a combination of PPAR agonists and S-Amlodipine has partial benefits in improving the cardiovascular risk factors such as reduction in triglyceride levels, associated with chronic type 2 diabetes, and therefore may be utilized as an approach for addressing some of these devastating metabolic syndrome complications. (biomedcentral.com)
Human vascular1
  • 1993) A kallikrein-like enzyme in human vascular tissue. (nature.com)
Promote vascular1
  • With this nanoparticle we can introduce genes to inhibit vascular injury and/or promote vascular repair, correct gene mutations and turn genes on or off to restore normal function. (eurekalert.org)
Tissue2
  • Genomic DNA extracted from archival FFPE tissue for 325 patients (69% of the MAX trial population) was used to genotype 16 candidate SNPs in VEGF-A, VEGFR1, and VEGFR2, which were analysed for associations with efficacy outcomes and hypertension. (bvsalud.org)
  • Most of the fluid and its constituents is taken up by tissue cells or reabsorbed into the vascular tree, depending on the balance of hydrostatic and oncotic pressures. (msdmanuals.com)
Deoxycorticosterone2
  • The present study investigated the differences in the outcomes between L-citrulline monotherapy and combination therapy with spironolactone as initial treatments for test animals with deoxycorticosterone acetate saltinduced hypertension. (ijpsonline.com)
  • However, no previous research evaluated the impact of CIT alone or in conjunction with marketed anti- hypertensive medications in a Deoxycorticosterone Acetate salt (DOCA salt)-induced hypertension model. (ijpsonline.com)
Responses1
  • Responses of the immune system to host invasion, injurious stimuli, and transplantation. (utoronto.ca)
Dementia5
  • A potential therapeutic target underlying the cause of reduced cerebral blood flow to the brain that results in vascular dementia has been recently discovered by researchers at the University of Manchester. (hospitalhealthcare.com)
  • Published in the journal Proceedings of the National Academy of Sciences , the study, which was carried out in mice, reveals that hypertension disrupts signalling within artery cells in the brain and leads to vascular dementia. (hospitalhealthcare.com)
  • Professor Adam Greenstein, a clinician scientist specialising in high blood pressure at the University of Manchester and one of the leaders of the research, said: 'By uncovering how high blood pressure causes arteries in the brain to remain constricted, our research reveals a new avenue for drug discovery that may help to find the first treatment for vascular dementia. (hospitalhealthcare.com)
  • Professor Sir Nilesh Samani, medical director at the British Heart Foundation, which funded the research, added: 'Vascular dementia affects around 150,000 people in the UK, and this number is going up. (hospitalhealthcare.com)
  • Pinpointing how arteries remain permanently narrowed in vascular dementia could lead to the development of new effective treatments, raising hope that there may soon be a way to prevent this illness from destroying more lives. (hospitalhealthcare.com)
Research3
  • This double certification concerns our fee-for-service and research and development activities in the following areas: - Genetic engineering for the generation of mouse models - Custom management and experienced breeding of mouse lines -Comprehensive, high-throughput and integrative phenotypic analysis of mouse models. (igbmc.fr)
  • Our nanoparticle delivery system for genome editing and transgene expression also is a huge advance for cardiovascular research," added Dr. Zhao. (eurekalert.org)
  • Cardiovascular Research. (monash.edu)
Physiology1
  • The oral cavity, being considered as "the intersection of dentistry and medicine" and "the window to general health", contains some of the most varied and vast flora in the human body and is the main entrance for two systems vital to human function and physiology, the gastrointestinal and respiratory systems. (medscape.com)
Damage3
  • Even so what is becoming more and more evident is certainly that unusual ROS legislation and aberrant signaling through Topotecan HCl (Hycamtin) redox-sensitive pathways are essential in the pathophysiological procedures which is connected with vascular damage and target-organ harm in hypertension. (researchassistantresume.com)
  • Could D-3 reverse cardiovascular damage? (vita-sy.com)
  • Hip fractures with damage to the pelvic bones are one of the most severe combined injuries of the musculoskeletal system. (cardiometry.net)
Arterial3
Health6
  • Here we highlight three key housing policies - "redlining," zoning, and the construction of highways - which have wrought a powerful, sustained, and destructive impact on cardiovascular health in Black/African American communities. (frontiersin.org)
  • At the root of these policy decisions are longstanding, toxic societal factors including racism, segregation, and discrimination, which also serve to perpetuate racial inequities in cardiovascular health. (frontiersin.org)
  • With the PHENOMIN project launched in 2011 (part of the call for projects entitled National Infrastructures in Biology and Health), the objective of the iCS was to create a national infrastructure specialized in the development, analysis and conservation of mouse models. (igbmc.fr)
  • In the 'HEARTS technical package treatment protocols', World Health Organization recommends polytherapy when monotherapy cannot control hypertension. (ijpsonline.com)
  • By probing the effect that vitamin D-3 has on the cells that make up the lining of blood vessels, scientists at Ohio State University in Columbus have identified for the first time the role that the "sunshine vitamin" plays in preserving cardiovascular health. (vita-sy.com)
  • Endothelial cell function has long been viewed as a barometer of overall cardiovascular health. (bu.edu)
Endothelium4
  • This process is mediated by increased lipoprotein trafficking across the vascular endothelium ( 5 , 6 ). (diabetesjournals.org)
  • It was previously believed that the endothelium served no other purpose than to act as an inert "wrapper" of the vascular system, allowing both water and electrolytes to pass in and out of the bloodstream. (vita-sy.com)
  • However, advances over the past 30 years have revealed that the endothelium acts more like an organ that lines the whole of the circulatory system from the "heart to the smallest capillaries," and whose cells carry out many unique biological functions. (vita-sy.com)
  • The study authors note that while their findings came from tests performed on a cellular model of high blood pressure, "[T]he implications of the influence of vitamin D-3 on dysfunctional endothelium is much broader. (vita-sy.com)