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  • hypertrophy
  • The aim of the present study was to investigate the possible role of one such molecule, namely, insulin-like growth factor I, in myocardial hypertrophy developed in response to renal artery stenosis. (ahajournals.org)
  • It has been demonstrated that resting coronary vascular resistance is elevated with chronic hypertension and concomitant cardiac hypertrophy. (ahajournals.org)
  • Idiopathic
  • Hypertension may be primary (also defined as essential or idiopathic) due to multifactorial causes, including cardiac, neurological, renal, endocrine and metabolic aspects. (vin.com)
  • arterial pressure
  • Rats with renal deafferentation (n=11) had lower arterial pressure weeks 9-16 (average reduction AP=10.1±1.4 mmHg, ANOVA, p=0.0049) compared to control (saline treated, n=6) although the final direct recording was not significantly different on week 17 (control AP=184.1±3.4 mmHg vs deafferented AP=173.9±4.3 mmHg, p=0.07). (ahajournals.org)
  • Regulation
  • D. G. Fuster, I. A. Bobulescu, J. Zhang, J. Wade, and O. W. Moe, "Characterization of the regulation of renal Na + /H + exchanger NHE3 by insulin," American Journal of Physiology , vol. 292, no. 2, pp. (hindawi.com)
  • Y. Qiu, L. R. Cardoso, and J. A. L. Arruda, "Regulation of the renal Na-HCO 3 cotransporter: IX. (hindawi.com)
  • Renin
  • Tissue renin-angiotensin systems in renal hypertension. (ahajournals.org)
  • The early phase of hypertension (day 6) was associated with significant increases in plasma renin activity and levels of circulating angiotensin II. (ahajournals.org)
  • The circulating renin-angiotensin system was not activated in the later phase of hypertension (day 24). (ahajournals.org)
  • The differential changes in the expression of angiotensinogen mRNA over the course of development and maintenance of renal hypertension suggest that factors in addition to angiotensin II are important in modulating the expression of renin-angiotensin system genes. (ahajournals.org)
  • Myocardial
  • Although it is clear that endothelin-1 is involved in the pathophysiology of conditions such as myocardial ischemia, 10 11 cyclosporine nephrotoxicity, 12 13 and subarachnoid hemorrhage-induced vasospasm, 14 15 it is questionable whether endothelin-1 would play a role in arterial hypertension. (ahajournals.org)
  • blood pressure
  • Hypertension, or high blood pressure, affects an estimated 10-25 percent of the population of the United States. (wakehealth.edu)
  • This hypertension in the renal blood vessels may occur while the systemic blood pressure remains normal, making it difficult to detect. (wakehealth.edu)
  • Conclusions Specific endothelin-1 receptor antagonism markedly lowers blood pressure in experimental hypertension but is less effective on blood pressure of healthy animals. (ahajournals.org)
  • This suggests that endothelin-1 plays a role in the pathophysiology of hypertension but contributes to a lesser extent to the maintenance of normal blood pressure. (ahajournals.org)
  • Alkaloid concentrations up to the toxic range had little effect on the blood pressure or renal blood flow. (ahajournals.org)