AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
Angiotensin IIReceptor, Angiotensin, Type 1Receptors, AngiotensinHypertensionAngiotensin II Type 1 Receptor BlockersReceptor, Angiotensin, Type 2Angiotensin Receptor AntagonistsAngiotensin IHypertension, PulmonaryLosartanTetrazolesBlood PressureAngiotensin II Type 2 Receptor BlockersAngiotensin IIIAntihypertensive AgentsHypertension, RenalReninAngiotensin-Converting Enzyme InhibitorsBiphenyl CompoundsPeptidyl-Dipeptidase ASaralasin1-Sarcosine-8-Isoleucine Angiotensin IIImidazolesVasoconstrictor AgentsBenzimidazolesAngiotensinsHypertension, RenovascularAldosteroneKidneyHypertension, PortalRats, Sprague-DawleyRenin-Angiotensin SystemAngiotensinogenRats, Inbred SHRRats, Inbred WKYHypertension, MalignantMuscle, Smooth, VascularEnalaprilPyridinesVasoconstrictionRenal CirculationCaptoprilDose-Response Relationship, DrugHemodynamicsCells, CulturedDiet, Sodium-RestrictedNorepinephrineVascular ResistanceAortaSodium Chloride, DietaryRats, WistarTeprotideCardiomegalyHeart RateDisease Models, AnimalValineEnalaprilatMyocardiumRNA, MessengerHypertension, Pregnancy-InducedTime FactorsSodiumLisinoprilBenzoatesDesoxycorticosteroneSympathetic Nervous SystemHydralazineNitric OxideBradykininChymasesHypertrophyAngiotensin AmideSodium, DietaryAdrenal GlandsNADPH OxidasePulmonary ArteryRisk FactorsEndothelin-1Sodium ChlorideFibrosisDiureticsRats, Inbred StrainsSubfornical OrganNephrectomyVasopressinsDrinkingEndothelium, VascularVasodilator AgentsSignal TransductionHypertrophy, Left VentricularNatriuresisAorta, ThoracicPhenylephrineProteinuriaOcular HypertensionRenal ArteryVasodilationArginine VasopressinArteriesMesenteric Arteries
BlockersEnzyme inhibitorsInhibitorsReceptorsRenalTreatment of hypertensionJournal of HypertensionARBsACE2AbstractPrevalenceEssential hypertensionConversion of angiotensinDiabetesAntihypertensive2021BlockadeReceptor antagonistPulmonary hypertensionPeptidesObesityChronic hypertensionPathogenesisHypertensive ratsDysfunctionInhibitionMechanismsGestational hypertensionComplicationsKidneyAldosteroneMiceSystolicInhibitorPrimary hypertensionRatsHypotensionDeterminantsAsymptomaticDiabeticBloodProteinuriaHumansDoseVasodilatorVascular smooth musclLipidsPreeclampsiaAGTR1GeneCardiovascular diseaseRenin receptorBinds
Blockers18
  • For management of heart failure with reduced ejection fraction (HFrEF), medication classes consist of diuretics, angiotensin-receptor blockers (ARBs), angiotensin-converting enzyme (ACE) inhibitors, and beta-blockers. (medscape.com)
  • Systematic review: comparative effectiveness of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers for treating essential hypertension. (qxmd.com)
  • The relative effectiveness of angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) for lowering blood pressure is unknown. (qxmd.com)
  • In this respect, while SARS-CoV-2-infected patients of older age with CVD comorbidities show a more severe clinical course and a worse prognosis, it should be adequately underscored that many of these patients in Italy are currently treated with ACE-inhibitors or angiotensin II receptor blockers (ARBs), which are considered the drugs of first choice for hypertension and other CVD conditions (6). (bmj.com)
  • Yang D, Yuan J, Liu G, Ling Z, Zeng H, Chen Y, Zhang Y, She Q, Zhou X. Angiotensin Receptor Blockers and Statins Could Alleviate Atrial Fibrosis via Regulating Platelet-Derived Growth Factor/Rac1 /Nuclear Factor-Kappa B Axis. (medsci.org)
  • first-line antihypertensive medications include angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, dihydropyridine calcium-channel blockers and thiazide diuretics. (nature.com)
  • We conducted a meta-analysis to explore the benefits of angiotensin-converting enzyme inhibitors (ACEIs)/angiotensin II receptor blockers (ARBs) combined with calcium channel blockers (CCBs) on metabolic, renal, and cardiovascular outcomes in hypertensive patients. (unboundmedicine.com)
  • Losartan belongs to the class of medications called angiotensin II receptor blockers . (medbroadcast.com)
  • Angiotensin receptor blockers are as effective as ACE inhibitors in the treatment of heart failure. (medscape.com)
  • Renin-angiotensin-aldosterone system blockers and region-specific variations in COVID-19 outcomes: findings from a systematic review and meta-analysis. (cdc.gov)
  • Natural Language Processing for Rapid Response to Emergent Diseases: Case Study of Calcium Channel Blockers and Hypertension in the COVID-19 Pandemic. (cdc.gov)
  • Control of hypertension and the use of angiotensin converting enzyme inhibitors (ACEI) and/or angiotensin II receptor blockers especially in those with proteinuria have been shown to protect against chronic kidney disease and delay its progression to kidney failure. (bvsalud.org)
  • Blood pressure control using angiotensin converting enzyme inhibitors and angioten- sin receptor blockers as the first line agents because these drugs have beneficial effects on glomerular haemodynamics and proteinuria in addition to their antihypertensive actions b. (bvsalud.org)
  • http://www.uptodate.com/contents/angiotensin-ii-receptor-blocker-and-neprilysin-inhibitor-therapy-in-heart-failure-due-to-systolic-dysfunction?source=search_result&search=ANGIOTENSIN+II+RECEPTOR+BLOCKERS+IN+HEART+FAILURE+DUE+TO+SYSTOLIC+DYSFUNCTION%3A+THERAPEUTIC+USE&selectedTitle=2~150 Acesso em: 8 dez 2014. (bvs.br)
  • Heran Balraj S, Musini Vijaya M, Bassett Ken, Taylor Rod S, Wright James M. Angiotensin receptor blockers for heart failure. (bvs.br)
  • Reeder, Guy S. Angiotensin converting enzyme inhibitors and receptor blockers in acute myocardial infarction: Clinical trials. (bvs.br)
  • http://www.uptodate.com/contents/angiotensin-converting-enzyme-inhibitors-and-receptor-blockers-in-acute-myocardial-infarction-clinical-trials?source=search_result&search=ANGIOTENSIN+CONVERTING+ENZYME+INHIBITORS+AND+RECEPTOR+BLOCKERS+IN+ACUTE+MYOCARDIAL+INFARCTION%3A+CLINICAL+TRIALS&selectedTitle=1~150 Acesso em: 8 dez 2014. (bvs.br)
  • Heran Balraj S, Wong Michelle MY, Heran Inderjit K, Wright James M. Blood pressure lowering efficacy of angiotensin receptor blockers for primary hypertension. (bvs.br)
Enzyme inhibitors2
Inhibitors22
  • Phosphodiesterase-5 (PDE-5) inhibitors cause smooth muscle relaxation and antiproliferative effects in the vasculature, leading to a reduction in pulmonary artery pressure in patients with WHO group 1 pulmonary hypertension. (medscape.com)
  • To compare the benefits and harms of ACE inhibitors versus ARBs for treating essential hypertension in adults. (qxmd.com)
  • 61 clinical studies that directly compared ACE inhibitors versus ARBs in adult patients with essential hypertension, reported an outcome of interest, lasted at least 12 weeks, and included at least 20 patients. (qxmd.com)
  • Structure-Guided Chemical Optimization of Bicyclic Peptide (Bicycle) Inhibitors of Angiotensin-Converting Enzyme 2. (acs.org)
  • Development of Potent and Selective Phosphinic Peptide Inhibitors of Angiotensin-Converting Enzyme 2. (acs.org)
  • The story of angiotensin converting enzyme (ACE) inhibitors started approximately 50 years ago, when it was discovered that human plasma incubated with the venom of the Brazilian viper, Bothrops Jararaca , generated a hypotensive compound. (bmj.com)
  • Role of ACE inhibitors in the renin-angiotensin aldosterone system. (bmj.com)
  • Hypertension was the original indication for ACE inhibitors. (bmj.com)
  • Two key studies have recently been published which examine the role of ACE inhibitors in hypertension: UKPDS and CAPPP. (bmj.com)
  • 3 The recently completed STOP-Hypertension-2 study provides further evidence of the role of ACE inhibitors in the treatment of hypertension. (bmj.com)
  • The effectiveness of angiotensin converting enzyme (ACE) inhibitors in reducing heart failure mortality 1 may be largely attributable to hormone suppression. (bmj.com)
  • Inhibitors of the renin-angiotensin-aldosterone system and CoViD-19-affected patients: A two-faced Janus? (bmj.com)
  • To investigate whether the administration of renin-angiotensin system (RAS) inhibitors and statins could alleviate atrial fibrosis via platelet-derived growth factor (PDGF)/Rac1 /nuclear factor-kappa B (NF-κB) axis. (medsci.org)
  • Doctors often prescribe angiotensin converting enzyme (ACE) inhibitors to treat high blood pressure, or hypertension, and other cardiovascular conditions. (medicalnewstoday.com)
  • ACE inhibitors prevent the body from making the hormone Angiotensin II. (medicalnewstoday.com)
  • By inhibiting the production of Angiotensin II, ACE inhibitors keep the blood vessels open. (medicalnewstoday.com)
  • Nonsteroidal Anti-inflammatory Drugs (NSAIDs) and COX-2 inhibitors: Increased risk of renal impairment. (nih.gov)
  • Antiatherosclerotic Effects of Sodium-Glucose Cotransporter 2 Inhibitors: An Underrecognized Piece of the Big Puzzle? (kcl.ac.uk)
  • tients taking angiotensin-converting enzyme [ACE] inhibitors), the VBDs were healthy. (cdc.gov)
  • It may induce more complete inhibition of the renin-angiotensin system than ACE inhibitors. (medscape.com)
  • It may induce a more complete inhibition of the renin-angiotensin system than ACE inhibitors, it does not affect the response to bradykinin, and it is less likely to be associated with cough and angioedema. (medscape.com)
  • Angiotensin-Converting-Enzyme 2 and Renin-Angiotensin System Inhibitors in COVID-19: An Update. (cdc.gov)
Receptors7
  • Soluble ACE2 lowers blood pressure by catalyzing the hydrolysis of angiotensin II (a vasoconstrictor peptide) into angiotensin (1-7) (a vasodilator) which in turns binds to MasR receptors creating localized vasodilation and hence decreasing blood pressure. (wikipedia.org)
  • It is released into the bloodstream where one of sACE2's functions is to turn excess angiotensin II into angiotensin 1-7 which binds to MasR receptors creating localized vasodilation and hence decreasing blood pressure. (wikipedia.org)
  • sACE2, as part of RAAS's protective phase, cleaves the carboxyl-terminal amino acid phenylalanine from angiotensin II (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe) and hydrolyses it into the vasodilator angiotensin (1-7) (H-Asp-Arg-Val-Tyr-Ile-His-Pro-OH), which binds to Mas Receptors and ultimately leads to a decrease in blood pressure. (wikipedia.org)
  • Investigations of the brain regions involved revealed robust increases in ER stress biomarkers and profound ER morphological abnormalities in the circumventricular subfornical organ (SFO), a region outside the blood-brain barrier and replete with Ang II receptors. (jci.org)
  • All components of the RAS (angiotensinogen, angiotensin converting enzyme, angiotensin receptors) are expressed in many types of tumours, including endometrial cancer ( 2 , 4 ). (spandidos-publications.com)
  • Moreover, both angiotensin receptors (AT1 and AT2) are overexpressed in different types of cancers, which confirms the role of local RAS in cancer development and progression ( 3 , 5 - 8 ). (spandidos-publications.com)
  • angiotensin receptors in SARS-CoV-2 infection. (lsuhsc.edu)
Renal10
  • Membrane bound angiotensin-converting enzyme 2 (mACE2) is a zinc-containing metalloenzyme located on the surface of intestinal enterocytes, renal tubular cells and other cells. (wikipedia.org)
  • Additionally, a significant increase in B 1 receptor protein expression in renal cortex of Ang II-infused rats was observed compared to control suggesting that bradykinin receptor activation could account for the effect of enalapril to enhance the actions of tempol. (elsevierpure.com)
  • Isolated systolic hypertension (ISH) is an important treatment target, recognized as a dominant risk factor for heart disease, stroke and renal failure [1,2]. (cardioprotect.gr)
  • Microalbuminuria and macroalbuminuria are also widely accepted risk factors for cardiovascular and renal disease in patients with diabetes [3,4] and hypertension [5-7]. (cardioprotect.gr)
  • This article is a review of exciting, recently generated genetic, biochemical and clinical data from studies that have examined the importance of the tissue kallikrein-kinin system in protection from hypertension, vascular remodeling and renal fibrosis. (nature.com)
  • Development of novel therapeutic approaches to bolster kinin activity in the vascular wall and in specific compartments in the kidney might be a highly effective strategy for the treatment of hypertension and its complications, including cardiac hypertrophy and renal failure. (nature.com)
  • Dual blockade of the renin-angiotensin system: Increased risk of renal impairment, hypotension, and hyperkalemia. (nih.gov)
  • Increased urinary angiotensin-converting enzyme 2 in renal transplant patients with diabetes. (ohri.ca)
  • Renal tubular dysgenesis can be caused by mutations in both copies of any of the genes involved in the renin-angiotensin system. (medlineplus.gov)
  • Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis. (medlineplus.gov)
Treatment of hypertension5
Journal of Hypertension1
ARBs1
  • Conversely, it has been also hypothesized that ARBs could result potentially useful in the clinical course of SARS-CoV-2-infected patients (13). (bmj.com)
ACE211
  • Angiotensin-converting enzyme 2 (ACE2) is an enzyme that can be found either attached to the membrane of cells (mACE2) in the intestines, kidney, testis, gallbladder, and heart or in a soluble form (sACE2). (wikipedia.org)
  • Both membrane bound and soluble ACE2 are integral parts of the renin-angiotensin-aldosterone system (RAAS) that exists to keep the body's blood pressure in check. (wikipedia.org)
  • The SARS-CoV-2 spike protein itself is known to damage the endothelium via downregulation of ACE2. (wikipedia.org)
  • ACE2 has an opposing effect to ACE, degrading angiotensin II into angiotensin (1-7), thereby lowering blood pressure. (wikipedia.org)
  • Angiotensin-converting enzyme-related carboxypeptidase (ACE2) is a recently identified zinc metalloprotease with carboxypeptidase activity that was identified using our genomics platform. (acs.org)
  • Effect of an Inhibitor on the ACE2-Receptor-Binding Domain of SARS-CoV-2. (acs.org)
  • An Active Site Inhibitor Induces Conformational Penalties for ACE2 Recognition by the Spike Protein of SARS-CoV-2. (acs.org)
  • As already shown for SARS-CoV, the viral pathogen responsible for severe acute respiratory syndrome (SARS), ACE2 is the main cell receptor also for SARS-CoV-2. (bmj.com)
  • Within such framework, valuable insights into the molecular bases driving the complex interactions occurring at the SARS-CoV-2/ACE2 interface have been recently provided (8,9). (bmj.com)
  • As a matter of fact, it has been additionally claimed that the ACE2 upregulation putatively induced by these two drug classes, although elicited through different mechanisms, could favour SARS-CoV-2 human lung tissue colonization (12). (bmj.com)
  • SCFAs reduced viral burdens in the airways and intestines by downregulating the SARS-CoV-2 entry receptor, angiotensin-converting enzyme 2 (ACE2), and enhancing adaptive immunity via GPR41 and 43 in male animals. (rockefeller.edu)
Abstract1
  • abstract = "Cardiac AT(2)R expression is upregulated in the normal process of aging. (monash.edu)
Prevalence4
Essential hypertension2
  • In patients with essential hypertension and healthy controls, plasma levels of atrial natriuretic peptide (ANP), angiotensin II (Ang II), aldosterone (Aldo), arginine vasopressin (AVP) and urinary excretion of prostaglandin E2 (PGE2) were measured under basal conditions, and before and after acute volume expansion with a 2.5% hypertonic sodium chloride solution. (nih.gov)
  • It is concluded that in essential hypertension ANP is increased under basal conditions and the increase in natriuresis and ANP is exaggerated during acute volume expansion. (nih.gov)
Conversion of angiotensin2
Diabetes17
  • 2 3 In UKPDS, patients with type II diabetes and concomitant hypertension were randomised either to very active antihypertensive treatment (with captopril or atenolol) or to a less stringent management strategy. (bmj.com)
  • In Chinese cohorts, the most prevalent comorbidities are hypertension (24%), diabetes (16%) and cardiovascular disease (CVD) conditions (9%) (4). (bmj.com)
  • In another study by Dr Wu and coworkers (5), focused on 201 SARS-CoV-2-infected patients, the median age was 51 years and, among the 42% of them who developed acute respiratory distress syndrome, 27% had hypertension, 19% diabetes and 52% died. (bmj.com)
  • Treatment of diabetic nephropathy in hypertensive patients with type 2 diabetes, an elevated serum creatinine, and proteinuria. (nih.gov)
  • Type 2 diabetes mellitus (T2DM) is a significant global public health problem affecting more than 285 million people worldwide. (springer.com)
  • The International Diabetes Federation recently reported that the number of people with diabetes will escalate from 285 million in 2010 to 438 million by 2,030, with more than 70% of cases already from developing countries [ 2 ]. (springer.com)
  • In patients with Type 2 diabetes mellitus (T2DM) parameters characterizing the degree of obesity significantly positively correlated with levels of CRP and CCL2. (medsci.org)
  • The results suggest the probable active participation of higher concentrations of C-peptide in the intensification of inflammatory and atherogenic processes in obese patients with type 2 diabetes. (medsci.org)
  • In patients with obesity and type 2 diabetes, altered serum concentrations of Il-10 seems to be dependent on the degree of insulin resistance and proinflammatory status. (medsci.org)
  • Both, obesity which is a major risk factor for the insulin resistance development and type 2 diabetes (T2DM), and the chronic hyperglycemia itself play an important role in its pathogenesis. (medsci.org)
  • Does Dapagliflozin influence arterial stiffness and levels of circulating anti-aging hormone soluble Klotho in people with type 2 diabetes and kidney disease? (kcl.ac.uk)
  • His research aims to develop clinical biomarkers and novel therapeutics for (physio)pathological conditions associated with neurodegeneration and/or endothelial dysfunction, notably stroke, hypertension, diabetes and ageing. (nottingham.ac.uk)
  • Long-term hemodynamic and molecular effects persist after discontinued renin-angiotensin system blockade in patients with type 1 diabetes mellitus. (ohri.ca)
  • Renoprotective effects of a novel Nox1/4 inhibitor in a momodel of type 2 diabetes. (ohri.ca)
  • Iranian population of patients with type 2 diabetes mellitus. (who.int)
  • The specific objectives were to review the current evidence supporting management of ten major modifiable risk factors for prevention of stroke: hypertension, current smoking, diabetes, obesity, poor diet, physical inactivity, atrial fibrillation, excessive alcohol consumption, abnormal lipid profile and psychosocial stress/ depression. (cdc.gov)
  • Background: Type 2 diabetes (T2D) is a major cause of chronic kidney disease. (bvsalud.org)
Antihypertensive3
  • In this study we determined the contribution of AT(2)R to chronic antihypertensive and remodelling effects of AT(1)R blockade in aged hypertensive rats. (monash.edu)
  • These results suggest that AT(2)R stimulation does not significantly influence the antihypertensive effect of chronic AT(1)R blockade, but plays a role in the regulation of vascular structure. (monash.edu)
  • Nonadherence to taking prescribed antihypertensive medication (antihypertensive) regimens has been identified as a leading cause of poor blood pressure control among persons with hypertension and an important risk factor for adverse cardiovascular disease outcomes. (cdc.gov)
20213
Blockade1
  • The severe degree of cardiac perivascular fibrosis in senescent animals was regressed by AT(1)R blockade and this effect was reversed by simultaneous AT(2)R inhibition, demonstrating an antifibrotic role of AT(2)R stimulation in the aging hypertensive heart. (monash.edu)
Receptor antagonist2
  • The angiotensin II receptor antagonist telmisartan reduces rinary albumin excretion in patients with isolated systolic hypertension: results of a randomized, double-blind, placebo-controlled trial. (cardioprotect.gr)
  • Olmesartan is an angiotensin II receptor antagonist (sometimes called an ARB). (drugs.com)
Pulmonary hypertension5
  • The goal of medication treatment of group 2 pulmonary hypertension is to lower filling pressures and provide afterload reduction in patients with heart failure. (medscape.com)
  • In settings of combined postcapillary and precapillary pulmonary hypertension, pulmonary vasodilators have not consistently been shown to improve symptoms or hemodynamics and some harm has been demonstrated in trials of these medications. (medscape.com)
  • Diuretics are the mainstay of therapy for pulmonary hypertension due to left-sided heart disease (PH-LHD). (medscape.com)
  • Approved for use in group 1 pulmonary arterial hypertension, there have been few trials evaluating their efficacy in group 2 pulmonary hypertension. (medscape.com)
  • [ 16 ] Additionally, a smaller study looking at 34 patients with symptomatic heart failure and pulmonary hypertension showed improvement in exercise capacity, quality of life, and fewer hospitalizations for heart failure exacerbations in the sildenafil group compared with placebo. (medscape.com)
Peptides2
  • Therefore, various biologically active peptides such as angiotensin, affecting cell proliferation, have become a new area of study in endometrial cancer research. (spandidos-publications.com)
  • Kinins (bradykinin and lys-bradykinin) are endogenous vasodilators and natriuretic peptides known best for their ability to antagonize angiotensin-induced vasoconstriction and sodium retention. (nature.com)
Obesity1
  • DMhavehigherlevelsofatherogenic diseaseorabsenceofperipheralpulse cholesterolwascalculatedaccording lipids [3], hypertension [4], obesity were defined as symptomatic CVD. (who.int)
Chronic hypertension4
Pathogenesis3
Hypertensive rats1
  • Adult (20 weeks) and senescent (20 months) spontaneously hypertensive rats (SHRs) were treated with either the AT(1)R antagonist, candesartan cilexetil (2 mg/kg/day), the AT(2)R antagonist, PD123319 (10 mg/kg/day), or a combination of the 2 compounds. (monash.edu)
Dysfunction1
Inhibition1
  • Experiments were designed to test the hypothesis that antioxidant treatment would increase the anti-hypertensive actions of endogenous kinins during angiotensin converting enzyme (ACE) inhibition. (elsevierpure.com)
Mechanisms4
  • Dysregulation of brain mechanisms controlling arterial pressure is strongly implicated in HTN, particularly in models involving angiotensin II (Ang II). (jci.org)
  • Atrial fibrosis is one of the most fundamental mechanisms involved in the physiopathology of cardiovascular disease, which includes atrial fibrillation (AF) [ 1 , 2 ] and heart failure (HF) [ 3 ] . (medsci.org)
  • Many recent studies in both animal models and humans have revealed that renin-angiotensin system (RAS) activation is one of the most vital mechanisms involved in atrial fibrosis [ 1 , 4 ] . (medsci.org)
  • Although it is still not well-established that Ang II has beneficial effects on malaria and particularly on CM, different lines of evidence suggest a possible 'protective' effect that could be mediated by different, non-exclusive mechanisms that could affect parasite development and/or host susceptibility to Plasmodium-induced pathology. (frontiersin.org)
Gestational hypertension1
  • The Society of Obstetricians and Gynecologists of Canada (SOGC) released revised guidelines that simplified the classification of hypertension in pregnancy into four categories, pre-existing hypertension, gestational hypertension, preeclampsia, or "other hypertensive effects" on the basis of different diagnostic considerations. (medscape.com)
Complications2
Kidney5
  • The antagonists of the renin-angiotensin-aldosterone system (RAAS) have been shown to interfere with angiotensin converting enzyme (ACE)-2 receptor expression in heart and kidney tissues. (bmj.com)
  • The evaluation of patients with hypertension includes accurate standardized blood pressure (BP) measurement, assessment of the patients' predicted risk of atherosclerotic CVD and evidence of target-organ damage, and detection of secondary causes of hypertension and presence of comorbidities (such as CVD and kidney disease). (nature.com)
  • 2. The transition from acute kidney injury (AKI) through to chronic kidney disease. (ed.ac.uk)
  • Nitrate, Nitrite, and Nitric Oxide Find a Home in the Kidney by Offsetting Angiotensin II-Mediated Hypertension. (ohri.ca)
  • In addition, angiotensin II may play a more direct role in kidney development, perhaps by affecting growth factors involved in the development of kidney structures. (medlineplus.gov)
Aldosterone12
Mice4
  • Effects of FG-4592 on the regulation of AGTR1, AGTR2, eNOS, p-eNOS, and HIF1α in aorta tissue of mice challenged with Ang II. (jci.org)
  • Chronic systemic infusion of low-dose Ang II in C57BL/6 mice induced slowly developing HTN, which was abolished by co-infusion of the ER stress inhibitor tauroursodeoxycholic acid (TUDCA) into the lateral cerebroventricle. (jci.org)
  • this could be a potential explanation for Ang II protection from CM. Our unpublished results using mice infected with Plasmodium berghei seem to confirm that the elevation of Ang II levels results in modestly decreased parasitemias in this animal model. (frontiersin.org)
  • Podocyte-specific overexpression of human angiotensin-converting enzyme 2 attenuates diabetic nephropathy in mice. (ohri.ca)
Systolic2
  • Objective: To examine the effect of telmisartan or hydrochlorothiazide on the control of urinary albumin excretion (UAE) in patients with isolated systolic hypertension (ISH) unselected for albuminuria in a pre-planned substudy of a large, multicentre, double-blind, placebo-controlled, randomized study. (cardioprotect.gr)
  • PCBs that exceeded 3.5 for both systolic and diastolic hypertension. (cdc.gov)
Inhibitor1
  • Taken together, these experimental data add further concern to the fear that ACE-inhibitor or ARB-based treatments could worsen the prognosis of SARS-CoV-2 infection in patients suffering from simultaneously occurring CVD conditions. (bmj.com)
Primary hypertension1
Rats3
  • Four groups of rats, all given angiotensin II (Ang II) for 2 weeks, were studied: 1) control, 2) enalapril, 3) tempol or 4) both tempol and enalapril. (elsevierpure.com)
  • In additional experiments, we used the bradykinin B 2 antagonist, icatibant to determine if increased B 2 receptor contributes to the anti-hypertensive effect of combined tempol and enalapril in Ang II-infused rats. (elsevierpure.com)
  • Methods: Fifty-four female rats were first divided equally into two groups: ovariectomized (Ovx) and simulated ovariectomy (Sham). (bvsalud.org)
Hypotension2
  • Figure 4: Pathways affected in single gene, Mendelian hypertension and hypotension syndromes. (nature.com)
  • Nephropathy in type 2 diabetic patients: The most common adverse reactions which were more frequent than placebo were hyperkalemia dizziness, orthostatic dizziness, and orthostatic hypotension. (nih.gov)
Determinants1
  • Angiotensin-Converting Enzyme 2 Ectodomain Shedding Cleavage-Site Identification: Determinants and Constraints. (acs.org)
Asymptomatic2
  • is more frequent in membranous nephropathy and is usually asymptomatic but may manifest with flank pain, hematuria, and hypertension. (msdmanuals.com)
  • Because hypertension is asymptomatic, it is often not ing persistent organic pollutants (POPs) in New York was diagnosed and treated. (cdc.gov)
Diabetic1
  • In this respect, among over 9,000 SARS-CoV-2-infected patients in Italy who succumbed, 73% were hypertensive, 28% suffered from ischemic heart disease and 31% were diabetic, with their median age being 78 years, in comparison to 63 years of those surviving (2). (bmj.com)
Blood15
  • ACE cleaves angiotensin I hormone into the vasoconstricting angiotensin II which causes a cascade of hormonal reactions which is part of the body's harmful phase of RAAS, which ultimately leads to an increase in the body's blood pressure. (wikipedia.org)
  • These data support the hypothesis that combined reduction of superoxide along with enhanced endogenous kinins may facilitate blood pressure lowering in Ang II hypertension. (elsevierpure.com)
  • The renin-angiotensin system (RAS) represents a critical endocrine regulator for maintaining blood pressure and blood fluid volume in the circulatory system. (hindawi.com)
  • Figure 2: The major neuroendocrine systems involved in the regulation of blood pressure. (nature.com)
  • Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension. (nature.com)
  • Hypertension (increased blood pressure) is an insidious pathological condition that leads to numerous diseases. (nova.edu)
  • Azor is used to treat high blood pressure (hypertension) . (drugs.com)
  • Hypertension, or high blood pressure, is a primary risk factor for heart disease and stroke, and approximately 70% of adults aged ≥65 years have the condition. (cdc.gov)
  • This is a combination product that contains 2 medications used to lower high blood pressure (hypertension), losartan and hydrochlorothiazide. (medbroadcast.com)
  • We evaluated SARS-CoV-2 antibody response in volun- ed to VBDs' prevaccination histories of symptomatic tary blood donors in Italy at different timepoints. (cdc.gov)
  • evaluated SARS-CoV-2 antibody levels and types in This 2-year prospective study showed that a voluntary blood donor (VBD) population in Mode- SARS-CoV-2 seroprevalence in VBDs is a reliable in- na, Italy, at different timepoints from the beginning dicator of the epidemiologic situation in the general of the COVID-19 pandemic and examined the effects population. (cdc.gov)
  • This protein is part of the renin-angiotensin system, which regulates blood pressure and the balance of fluids and salts in the body. (medlineplus.gov)
  • Methods A total of 758 Anniston residents had multiple hypertension and blood pressure suggests that PCB measurements of blood pressure, provided information on exposure may be an important contributing factor in demographic factors, medications, smoking, and exercise, regulation of blood pressure. (cdc.gov)
  • Two investigations in which noise was assessed as a stressor indicated noise as a significant predictor of diastolic blood pressure. (cdc.gov)
  • We aimed to identify the relationship between adiposity and blood pressure, independent of a robust set of lifestyle and metabolic factors, and to examine the modulating role of sex and Angiotensin-Converting Enzyme (ACE) insertion/deletion (I/D) polymorphisms. (lu.se)
Proteinuria1
Humans1
  • Angiotensin II type 1 receptor gene polymorphisms in humans: physiology and pathophysiology of the genotypes. (medlineplus.gov)
Dose1
  • may increase dose after 1 to 2 weeks of therapy. (drugs.com)
Vasodilator1
  • Experimental and clinical evidence implicate an imbalance between endogenous vasoconstrictor and vasodilator systems in the development and maintenance of hypertension. (nature.com)
Vascular smooth muscl2
  • In vascular smooth muscle cells, FG-4592 treatment reduced angiotensin receptor type 1 (AGTR1) and increased AGTR2 levels, while preventing Ang II-induced oxidative stress. (jci.org)
  • When Ang II binds to AT1 on vascular smooth muscle cells, it mobilizes intracellular Ca 2+ , leading to cellular contraction. (frontiersin.org)
Lipids1
  • Hyperglycemia contributes to glycosylation of proteins and lipids, increases the production of reactive oxygen species, stimulates the synthesis and secretion of pro-inflammatory cytokines and acute phase proteins in various tissues, promoting thus inflammation processes in the vascular wall [ 2 , 3 ]. (medsci.org)
Preeclampsia3
  • Preeclampsia occurs in 3-6% of all pregnancies and the incidence is 1.5 to 2 times higher in first time pregnancies. (medscape.com)
  • There are 2 categories of preeclampsia, mild and severe. (health.am)
  • The theory emphasizes that there is more to preeclampsia than hypertension. (health.am)
AGTR13
  • In summary, FG-4592 treatment remarkably ameliorated hypertension and organ injury, possibly through stabilizing HIF1α and subsequently targeting eNOS, AGTR1, AGTR2, and oxidative stress. (jci.org)
  • The AGTR1 gene provides instructions for making a protein called the angiotensin II receptor type 1 (AT1 receptor). (medlineplus.gov)
  • The AGTR1 gene mutations that cause this disorder likely change or block the AT1 receptor's ability to stimulate signaling, which results in a nonfunctional renin-angiotensin system. (medlineplus.gov)
Gene5
  • The expression profile of mACE2 in the human body was recently thoroughly evaluated by the Human Protein Atlas team using a large-scale multiomics approach combining several different methods for analysis of gene expression, including a stringent immunohistochemical analysis using two independent antibodies. (wikipedia.org)
  • For example, the SNP G-217A of AGT gene but not the SNPs A-6G and M235T of AGT gene may associate with hypertension in patients from Taiwan [ 1 ]. (hindawi.com)
  • The I allele of ACE gene and +1166 C allele of AT 1 R gene are reportedly associated with hypertension [ 10 ]. (hindawi.com)
  • Here, we describe a case-control study of hypertension susceptibility that specifically evaluates gene-gene interactions using unbalanced function based MDR [ 25 ] that combines traditional statistical methods with novel computational algorithms. (hindawi.com)
  • This is to classify by MDR classifier, to analyze possible gene-gene interactions associated with hypertension. (hindawi.com)
Cardiovascular disease2
  • Systemic arterial hypertension is the most important modifiable risk factor for all-cause morbidity and mortality worldwide and is associated with an increased risk of cardiovascular disease (CVD). (nature.com)
  • Nitroxide small molecule agents are in development as preventative or therapeutic pharmaceutical drugs for age-related macular degeneration (AMD) and cardiovascular disease, which are two major diseases of aging. (frontiersin.org)
Renin receptor1
  • Recent discoveries of a (pro)renin receptor ((P)RR) and the monocarboxypeptidase angiotensin-converting enzyme-2 (ACE-2) have revolutionized thinking about the renin-angiotensin system (RAS) and. (nova.edu)
Binds1