Hypersensitivity (also called hypersensitivity reaction or intolerance) is an abnormal physiological condition in which there is an undesirable and adverse immune response to antigen. (wikipedia.org)
The fourth type is considered a delayed hypersensitivity reaction because it usually occurs more than 12 hours after exposure to the allergen, with a maximal reaction time between 48 and 72 hours. (wikipedia.org)
Medication-induced reactions: antibiotics Type II hypersensitivity reaction refers to an antibody-mediated immune reaction in which antibodies (IgG or IgM) are directed against cellular or extracellular matrix antigens with the resultant cellular destruction, functional loss, or damage to tissues. (wikipedia.org)
The most common diseases involving a type III hypersensitivity reaction are serum sickness, post-streptococcal glomerulonephritis, systemic lupus erythematosus, farmers' lung (hypersensitivity pneumonitis), and rheumatoid arthritis. (wikipedia.org)
The principal feature that separates type III reactions from other hypersensitivity reactions is that in type III reaction, the antigen-antibody complexes are pre-formed in the circulation before their deposition in tissues. (wikipedia.org)
Erythema multiforme, which is due to a hypersensitivity reaction, presents with annular, raised lesions with central clearing. (aafp.org)
Theories of pathogenesis are diverse and include a T-cell mediated hypersensitivity reaction, an immune-mediated vasculopathy, or a primary degenerative disorder of dermal collagen. (dermatologyadvisor.com)
Its etiology remains elucidated, but it seems that can be mediated by a hypersensitivity reaction in which cytokines, followed by infiltration of neutrophils, may be involved. (actasdermo.org)
Rifampicin2
OBJECTIVE: The World Health Organization (WHO) recommends multidrug therapy (MDT) with rifampicin, dapsone, and clofazimine for treating leprosy, which is based on very low-quality evidence. (bvsalud.org)
Dapsone is primarily known for his leprosy effect (being associated in triple therapy to rifampicin and clofazimine) and antidermatique. (dd-database.org)
Reactions3
The first three types are considered immediate hypersensitivity reactions because they occur within 24 hours. (wikipedia.org)
The pathophysiology of type II hypersensitivity reactions can be broadly classified into three types: Cell depletion or destruction without inflammation Inflammation mediated by complement or Fc receptor Cellular dysfunction by antibodies The process involves a series of immune-mediated events that might take different forms. (wikipedia.org)
Type IV hypersensitivity reactions are, to some extent, normal physiological events that help fight infections, and dysfunction in this system can predispose to multiple opportunistic infections. (wikipedia.org)
Leprosy10
Dapsone, clofazimine and rifampicin, the three most important constituents of multidrug therapy against leprosy, were studied with respect to their effects on the rat serum complement system, in vitro as well as in vivo. (nih.gov)
Immunoelectrophoretic study of mixtures of fresh rat sera and anti-leprosy drugs against specific anti-rat-C3 antisera demonstrated that dapsone and clofazimine could not cleave the C3 complement component. (nih.gov)
For the treatment of multibacillary leprosy, the World Health Organization (WHO) and other clinicians recommend that adults receive clofazimine in a dosage of 50 mg once daily (with an additional 300-mg dose given once monthly) in conjunction with rifampin (600 mg once daily) and dapsone (100 mg daily) given for 12 months. (antiinfectivemeds.com)
If an adult with multibacillary leprosy will not accept or cannot tolerate clofazimine, the WHO states that these adults may receive supervised administration of a once-monthly rifampin-based multiple-drug regimen (ROM) that includes rifampin (600 mg once monthly), ofloxacin (400 mg once monthly), and minocycline (100 mg once monthly) given for 24 months. (antiinfectivemeds.com)
If a patient with paucibacillary leprosy receiving the usually recommended regimen of rifampin and dapsone experiences severe adverse effects related to dapsone, dapsone may be discontinued from the regimen and clofazimine substituted (using the dosage recommended for the treatment of multibacillary leprosy) for 6 months. (antiinfectivemeds.com)
Dapsone, also known as 4,4'-sulfonyldianiline (SDA) or diaminodiphenyl sulfone (DDS), is an antibiotic commonly used in combination with rifampicin and clofazimine for the treatment of leprosy. (definitions.net)
Leprosy reactional states, including cutaneous, are not hypersensitivity reactions to Dapsone and do not require discontinuation. (nih.gov)
The occurrence of dapsonehypersensitivity syndrome (DHS), a sudden, potentially fatal and traumatic adverse reaction due to dapsone, may affect treatment adherence and may result in fatality if untreated. (bvsalud.org)
Rifampin3
If a patient has been previously treated with dapsone monotherapy, re-treatment with a modified MDT regimen of rifampin, clofazimine, and dapsone can reduce or delay the risk of relapse. (medscape.com)
for children, dapsone at 1 mg/kg/d plus rifampin 10-20 mg/kg/d plus clofazimine at 1 mg/kg/d for 2 years (In the United States, clofazimine can only be obtained as an Investigational New Drug (IND) through the National Hansen's Disease Program [1-800-642-2477]. (medscape.com)
If an where To Purchase Trecator Sc Pills Online agent is needed for these regimens in patients who will not accept or gullerupstrandkro.dk tolerate clofazimine or in brands who Trecator receive rifampin because of adverse pills, where To Purchase Trecator Sc Pills Online disease e. (gullerupstrandkro.dk)
Lamprene2
Researchers want to see if a combination of medicines that includes the drug clofazimine (Lamprene) can help treat NTM. (nih.gov)
To test the effectiveness of clofazimine (Lamprene) to treat non-tuberculous mycobacteria. (nih.gov)
Corticosteroid therapy1
When prolonged corticosteroid therapy is necessary in patients with ENL, clofazimine in a dosage of 100-300 mg daily given in 2 or 3 divided doses for up to 3 months or longer may eliminate or reduce corticosteroid requirements. (antiinfectivemeds.com)
Dosages1
Clofazimine dosages exceeding 100 mg daily should be given for as short a period as possible and only under close medical supervision. (antiinfectivemeds.com)
Occurrence1
Hypersensitivity is a common occurrence, it is estimated that about 15% of humans are having at least one type during their lives, and has increased since the latter half of the 20th century. (wikipedia.org)
Drugs2
Of the three drugs only dapsone and clofazimine exhibited significant in vitro anti-complement activity and only at a very high, non-therapeutic dose of 0.24 mg/ml. (nih.gov)
6. History of allergy or hypersensitivity to any of the study drugs or medications in the same class as the study drugs. (who.int)
Regimen1
Clofazimine also is given in a dosage regimen that includes 50 mg once daily plus an additional 300-mg dose given once monthly. (antiinfectivemeds.com)
Adverse1
Hypersensitivity (also called hypersensitivity reaction or intolerance) is an abnormal physiological condition in which there is an undesirable and adverse immune response to antigen. (wikipedia.org)
Diseases1
The most common diseases involving a type III hypersensitivity reaction are serum sickness, post-streptococcal glomerulonephritis, systemic lupus erythematosus, farmers' lung (hypersensitivity pneumonitis), and rheumatoid arthritis. (wikipedia.org)
Medications2
Cases of Torsade de Pointes with QT prolongation have been reported in patients receiving clofazimine in combination with QT prolonging medications, such as bedaquiline, delamanid, fluoroquinolones, efavirenz and several other antiretrovirals for the treatment of HIV, or azole anti-fungals. (who.int)
Hepatotoxicity from sulfonamides may represent a part of a spectrum of hypersensitivity due to sulfa-derived medications and have been linked to many cases of DRESS (drug rash with eosinophilia and systemic symptoms) as well as Stevens Johnson syndrome and toxic epidermal necrosis. (nih.gov)
Patients3
In patients with severe, corticosteroid-dependent ENL, adequate control (reduction of severity and frequency of attacks and corticosteroid use) may require prolonged initial clofazimine therapy (for up to about 7 months), and extended therapy with the drug (an additional 9-24 months) may be necessary to prevent recurrence. (antiinfectivemeds.com)
An initial exacerbation may occur in some patients during the first several weeks of clofazimine therapy, but this generally is followed by progressive improvement. (antiinfectivemeds.com)
Between 1% and 2% of patients have hypersensitivity responses to sulfonamides, but most of these are mild and self-limited and not associated with significant liver injury. (nih.gov)
Derivatives1
Hypersensitivity to Dapsone and/or its derivatives. (nih.gov)
Therapy1
Most typically, the injury appears precipitously within one to three weeks of starting therapy, often preceded or accompanied by signs of hypersensitivity such as fever, rash, facial edema, lymphadenopathy, arthralgias, and eosinophilia or atypical lymphocytosis (or both). (nih.gov)
Drug1
Clofazimine should be taken with a meal to maximize absorption of the drug. (antiinfectivemeds.com)
Reduce1
Furthermore, dapsone and clofazimine could reduce rat-serum-mediated rabbit erythrocyte haemolysis in the presence of Mg2+-EGTA, indicating that they could also affect the alternative pathway of complement activation. (nih.gov)
Activity2
In a separate experiment we attempted to reconstitute the haemolytic complement activity consumed by dapsone and clofazimine by adding Crat-EDTA sera (a source of C3, C5, C6, C7, C8 and C9), but at most only 12% reconstitution of haemolytic activity could be achieved. (nih.gov)
Clofazimine is a phenazine dye with antimycobacterial and anti-inflammatory activity. (antiinfectivemeds.com)
Types2
In 1963, Philip George Houthem Gell and Robin Coombs introduced a systematic classification of the different types of hypersensitivity based on the types of antigens and immune responses involved. (wikipedia.org)
The Gell and Coombs classification of hypersensitivity is the most widely used, and distinguishes four types of immune response which result in bystander tissue damage. (wikipedia.org)
Effective1
Dosage of clofazimine should be reduced to the lowest effective level (e.g., to 100 mg daily) as soon as possible after the reactive episode is controlled. (antiinfectivemeds.com)