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  • glucagon
  • Elevated plasma glucagon levels after a glucose challenge or ingestion of a high-fat diet and increased duration of glucagon release during hyperglycemia have been observed in Adora1 knockout (KO) mice ( 12 - 14 ), suggesting that loss of Adora1 expression in α-cells may contribute to the pathology of NOD disease and human T1D. (diabetesjournals.org)
  • renal
  • These hormonal alterations in DKA and HHS lead to increased hepatic and renal glucose production and impaired glucose utilization in peripheral tissues, which result in hyperglycemia and parallel changes in osmolality of the extra-cellular space ( 12 , 13 ). (diabetesjournals.org)
  • possibility
  • Another possible contributory mechanism that has not been well investigated is the possibility that hypoglycaemia may accelerate atherosclerosis, as suggested by some animal studies. (hindawi.com)
  • aortic
  • For example, Yasunari and colleagues reported that repeated hypoglycaemia worsens injury-provoked intimal thickening in a male Goto-Kakizaki rat carotid artery [ 12 ], whilst Jin and colleagues reported that hypoglycaemia induced monocyte adhesion to rat aortic endothelium [ 13 ]. (hindawi.com)