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  • stress
  • While the hyperglycemia response to stress may be adaptive in some respects, there are many deleterious effects, including impaired nitric oxide generation with resulting impaired vasodilation, decreased complement function, increased endothelial cell adhesion molecules, increased cytokine levels and impaired neutrophil chemotaxis and phagocytosis. (oncologynurseadvisor.com)
  • effects
  • Hyperglycemia has several deleterious effects on the cardiovascular system as it promotes microvascular inflammatory reaction, activation of the coagulation system, and free radical oxygen liberation. (clinicaltrials.gov)
  • If these detrimental effects of hyperglycemia during CPB were confirmed, then aggressive therapy would be justified to correct and maintain normoglycemia. (asahq.org)
  • cause
  • PFS was defined as the time from randomization until either the emergence of radiographic evidence of disease progression or death due to any cause, whichever occurs first. (clinicaltrials.gov)
  • below
  • A subject with a consistent range above 126 mg/dl or 7 mmol/l is generally held to have hyperglycemia, whereas a consistent range below 70 mg/dl or 4 mmol/l is considered hypoglycemic. (thisisms.com)
  • Approximately
  • As pre-specified by the protocol, final analysis of PFS was to take place after approximately 49 PFS events or deaths had occurred in the Phase II part of the trial. (clinicaltrials.gov)