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PhysiologyTherapeuticsDiabetic RatsMetabolicWistarInsulinObesityVitroGlucoseVivoCardiovascularComplicationsReductionTreatmentFoodModelsAmerican JournalContentWeightMouseResearchStressInternationalCompared with control ratsBlood glucoseDiabetesStreptozotocinDiabetic ratInflammationSurvivalCardiacMetabolismChronicControlControlsArticleTitleWorld JournalInternational Journal
Physiology1
Therapeutics1
Diabetic Rats1
  • This study aimed to determine the effect of porang flour macerated with SC on the blood glucose levels of diabetic rats. (oamjms.eu)
Metabolic3
  • Diabetes mellitus (DM) is a group of metabolic diseases indicated by hyperglycemia. (oamjms.eu)
  • Filipović D, Inderhees J, Korda A, Tadić P, Schwaninger M, Inta D, Borgwardt S. Metabolic Fingerprints of Effective Fluoxetine Treatment in the Prefrontal Cortex of Chronically Socially Isolated Rats: Marker Candidates and Predictive Metabolites . (uni-luebeck.de)
  • Type 2 diabetes is a complex metabolic disorder characterized by hyperglycemia, impaired glucose tolerance and insulin resistance associated with dyslipidemia and hypertension. (biomedcentral.com)
Wistar1
  • Healthy male Wistar rats were randomly divided into 4 groups: control, diabetes mellitus (DM) model, low dose of exenatide treatment, and high dose of exenatide treatment. (hindawi.com)
Insulin1
  • The present study examined the combined effects of an antihypertensive (S-Amlodipine) and an insulin-sensitizing agent, peroxisome proliferator-activated receptor (PPAR) agonists (Pioglitazone and Ragaglitazar), on cardiovascular risk factors in aged diabetic and insulin-resistant Zucker fa/fa rats. (biomedcentral.com)
Obesity2
Vitro4
  • We will investigate the effects of exenatide on vascular endothelial injury and nitrooxidative stress in hyperglycemia both in vivo and in vitro and explore the role of nitrooxidative stress in endothelium-protective action of exenatide. (hindawi.com)
  • In vitro study showed that, compared with control group, the DM rats exhibited a lowered endothelium-dependent relaxation and damaged structural integrity of thoracic aortas, and there was a significant increase in plasma nitrotyrosine concentration. (hindawi.com)
  • Recent evidence has indicated that the vascular endothelial injury induced by hyperglycemia is associated with the enhanced nitrooxidative stress both in vivo and in vitro [ 3 - 6 ]. (hindawi.com)
  • We examined whether peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) overexpression and a subsequent increase in mitochondrial content and function in rat primary hepatocytes (in vitro) and Sprague-Dawley rats (in vivo) would comprehensively alter mitochondrial lipid metabolism, including complete (CO(2)) and incomplete (acid-soluble metabolites) fatty acid oxidation (FAO), tricarboxylic acid cycle flux, and triacylglycerol (TAG) storage and export. (eurekamag.com)
Glucose6
  • A single oral gavage of tofogliflozin increased renal glucose clearance and lowered the blood glucose level in Zucker diabetic fatty rats. (aspetjournals.org)
  • Tofogliflozin also improved postprandial glucose excursion in a meal tolerance test with GK rats. (aspetjournals.org)
  • No blood glucose reduction was observed in normoglycemic SD rats treated with tofogliflozin. (aspetjournals.org)
  • The rats' food intakes, stools, and BWs were recorded throughout the study, while their blood glucose levels were measured before the induction of DM, 3 days after the induction of DM, and at the end of the study (14-day treatment period). (oamjms.eu)
  • This weight loss may have been better controlled in the treatment groups because the glucomannan content of the porang led to an improvement in the rats' glucose metabolism, especially in the NP and SP groups. (oamjms.eu)
  • In combination, S-Amlodipine and Pioglitazone significantly reduced blood glucose (115.1 ± 6.6 vs. 81.7 ± 4.2), BP (184.4 ± 5.0 vs. 155.1 ± 5.0), serum triglycerides (362.5 ± 47.5 vs. 211.1 ± 23.7) and glucose intolerance when compared with vehicle treated Zucker fa/fa rats. (biomedcentral.com)
Vivo1
  • Adenoviral transduction of rats with PGC-1α resulted in a liver-specific increase in PGC-1α expression and produced an in vivo liver phenotype of increased FAO via increased mitochondrial function that also resulted in reduced hepatic TAG storage and decreased plasma TAG levels. (eurekamag.com)
Cardiovascular1
  • The international journal of cardiovascular imaging. (regionh.dk)
Complications1
  • Journal of Diabetes and its Complications, 28 (2). (edu.au)
Reduction1
  • In conclusion, this study demonstrates that exenatide treatment can alleviate the vascular endothelial injury, as well as attenuating the nitrooxidative stress in hyperglycemia, implying that the endothelium-protective effect of exenatide might be related to the reduction of nitrooxidative stress. (hindawi.com)
Treatment1
  • The rats' feed intakes during the 14-day treatment period were almost the same, which influenced their BWs. (oamjms.eu)
Food2
  • Journal of Medicinal Food, 16, 823-830. (scirp.org)
  • Furthermore, there was less body weight gain and food intake with S-Amlodipine and Pioglitazone combination in Zucker fa/fa rats. (biomedcentral.com)
Models1
  • 2011). Bradley C. and other authors have shown in Zucker rat models that ALA has protective effects against hypercholesterolemia and the accumulation of hepatic fat in conditions of overeating and in case of genetic predisposition. (jmedicalcasereports.org)
American Journal1
Content1
  • 2002) Comparative Content of Some Bioactive Compounds in Apples, Peaches and Pears and Their Influence on Lipids and Antioxidant Capacity in Rats. (scirp.org)
Weight1
  • Cho, K.D., Han, C.K. and Lee, B.H. (2013) Loss of Body Weight and Fat and Improved Lipid Profiles in Obese Rats Fed Apple Pomace or Apple Juice Concentrate. (scirp.org)
Mouse1
  • Tofogliflozin competitively inhibited SGLT2 in cells overexpressing SGLT2, and K i values for human, rat, and mouse SGLT2 inhibition were 2.9, 14.9, and 6.4 nM, respectively. (aspetjournals.org)
Research3
  • Editors select a small number of articles recently published in the journal that they believe will be particularly interesting to readers, or important in the respective research area. (mdpi.com)
  • The aim is to provide a snapshot of some of the most exciting work published in the various research areas of the journal. (mdpi.com)
  • Dementia: The international journal of social research and practice. (edu.au)
Stress1
  • There is evidence that the endothelial dysfunction induced by hyperglycemia is associated with the enhanced nitrooxidative stress. (hindawi.com)
International1
  • International Journal of Experimental Pathology, 96 (3). (edu.au)
Compared with control rats2
  • Sarcoplasmic reticulum Ca(2+) content was decreased in both treated and untreated rats compared with control rats. (nih.gov)
  • This study showed that the gut bacterial microbiome in diabetic rats with retinal changes was different compared with control rats. (arvojournals.org)
Blood glucose1
  • University of California-Davis-type 2 diabetes mellitus (UCD-T2DM) rats with nonfasting blood glucose levels in the range of 150-200 mg/dl were treated with the sEH inhibitor 1-(1-acetypiperidin-4-yl)-3-adamantanylurea (APAU) for 6 wk. (nih.gov)
Diabetes6
  • Because pioglitazone provides the combined benefit of reducing hyperglycemia, hyperalgesia, and central sensitization, we suggest that TZDs represent an attractive pharmacotherapy in patients with type 2 diabetes-associated pain. (uky.edu)
  • Las personas usan con mayor frecuencia ácido alfa lipoico para el dolor de nervios en personas con diabetes. (medlineplus.gov)
  • Tomar de 600-1800 mg de ácido alfa lipoico por vía oral o por vía intravenosa parece mejorar los síntomas como ardor, dolor y entumecimiento en las piernas y los brazos de las personas con diabetes. (medlineplus.gov)
  • Tomar ácido alfa lipoico por vía oral o por vía intravenosa no mejora los niveles de azúcar en sangre en personas con diabetes tipo 2. (medlineplus.gov)
  • Therefore, we aimed at comparing speckle-tracking echocardiography (STE)-derived parameters to the indices of left ventricular (LV) pressure-volume (PV) analysis to detect cardiac dysfunction in rat models of type-1 (T1DM) and type-2 (T2DM) diabetes mellitus. (biomedcentral.com)
  • Journal of Diabetes and its Complications, 28 (2). (edu.au)
Streptozotocin3
  • Rats were made diabetic with streptozotocin (STZ). (nih.gov)
  • Rat models of T1DM (induced by 60 mg/kg streptozotocin, n = 8) and T2DM (32-week-old Zucker Diabetic Fatty rats, n = 7) and corresponding control animals (n = 5 and n = 8, respectively) were compared. (biomedcentral.com)
  • To analyze the gut bacterial microbiome of streptozotocin-induced diabetic rats and rats with retinal changes. (arvojournals.org)
Diabetic rat1
  • B1R was upregulated on these immune cells infiltrating the diabetic rat pancreas while it was not expressed on primary sensory C-fibres even if the expression of TRPV1 and CGRP was enhanced. (nih.gov)
Inflammation2
  • Glucagon-like peptide 1 (GLP-1) is a gut-derived hormone released after a meal, which alleviates hyperglycemia, increases β-cell survival, reduces body weight, and reduces inflammation. (openmedicinalchemistryjournal.com)
  • Functional analysis indicated that the enhanced inflammation in diabetic rats showing retinal changes could be ascribed to a decrease in anti-inflammatory bacteria and an increase in pathogenic and proinflammatory bacteria. (arvojournals.org)
Survival1
  • SSR240612 corrected hyperglycaemia and hypoinsulinaemia by improving the Langerhans islets survival or regeneration. (nih.gov)
Cardiac2
  • Here, we tested whether the administration of sEH inhibitors preserves cardiac myocyte structure and function in hyperglycemic rats. (nih.gov)
  • Fluorescence microscopy with Ca(2+) indicators also showed a 40% improvement of cardiac Ca(2+) transients in treated rats. (nih.gov)
Metabolism1
  • plastic year spine, two or three dieters of a LinkedIn metabolism would get in public distribution around that critical hyperglycemia. (mmeade.com)
Chronic2
  • Therefore, we tested the hypothesis that chronic administration of pioglitazone would reduce PDN in Zucker Diabetic Fatty (ZDF fa/fa [ZDF]) rats. (uky.edu)
  • Crepidiastrum denticulatum extract protects the liver against chronic alcohol-induced damage and fat accumulation in rats. (shengsci.com)
Control4
  • Macrophages and TCD4+ lymphocytes were absent in control, but distributed abundantly in the pancreas of STZ-diabetic rats. (nih.gov)
  • Dysbiosis in the gut microbiome of diabetic rats and diabetic rats with retinal changes was observed at the phylum and genus levels compared with the control rats. (arvojournals.org)
  • The majority of the microbiomes in diabetic rats with retinal changes also formed a distinct cluster from the control rats. (arvojournals.org)
  • β-diversity analysis separated the microbiome of control rats from the microbiome of diabetic rats and diabetic rats with retinal changes, but the microbiomes of diabetic rats and diabetic rats with retinal changes showed an overlap. (arvojournals.org)
Controls1
  • Heat-map analysis based on the differentially abundant genera indicated that the microbiomes of controls and diabetic rats separated into two distinct clusters. (arvojournals.org)
Article1
  • eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. (ahajournals.org)
Title1
World Journal1
International Journal1
  • International Journal of Experimental Pathology, 96 (3). (edu.au)