Hyperglycemia in mice. Medical search. Frequent questions

In the present study, we investigated the role of TLR2 during the development of experimental deep dermatophytosis in normal mice and mice with alloxan-induced diabetes mellitus, an experimental model of diabetes that exhibits a delay in the clearance of the dermatophyte, Trichophyton mentagrophytes (Tm). (frontiersin.org)
To induce hyperglycemia, mice were intraperitoneally injected with STZ, which can damage pancreatic β cells resulting in the development of insulin dependent diabetes, a model of type 1 diabetes mellitus (T1DM). (nature.com)
Methods: We employed the type 1 diabetes mellitus (T1DM) model induced by streptozotocin (STZ) injection in a transgenic mouse line (BAC-α-syn-GFP) overexpressing human α-syn, to investigate the direct effect of elevated blood glucose on nigrostriatal degeneration. (lu.se)
Non-obese diabetic (NOD) mice exhibit a susceptibility to spontaneous development of autoimmune insulin dependent diabetes mellitus (IDDM). (wikipedia.org)
Type 1 diabetes mellitus is a metabolic disease resulting from the destruction of insulinproducing β cells in the pancreas, that leads to hyperglycemia [1,2,20]. (researchgate.net)
Type 1 diabetes mellitus (insulin-dependent diabetes) is characterized by hyperglycemia caused by an insulin deficiency. (researchgate.net)
KKAy mice, a genetically susceptible model of type II diabetes mellitus, were administered intra-cerebroventricularly with IKK2 inhibitor (IMD-0354) and were exposed to either concentrated PM2.5 or filtered air (FA) for 4 weeks simultaneously via a versatile aerosol concentration exposure system. (deepdyve.com)
Diabetes mellitus (DM) is a chronic disease characterized by a disorder in the metabolism of insulin, causing hyperglycemia (decreased glucose entry into cells and increase in the blood), changes in the metabolism of fat, protein, and carbohydrates 25 . (bvsalud.org)

LDL-RD mice were injected either with streptozotocin to induce hyperglycemia or with citrate buffer (control). (diabetesjournals.org)
Plasma glucose, cholesterol, and triglyceride levels were elevated in mice injected with streptozotocin compared with control mice. (diabetesjournals.org)
Both humoral and cellular immune response to HSP65 was more pronounced in streptozotocin-injected mice. (diabetesjournals.org)
When challenged with HSP65 in vitro, splenocytes from streptozotocin-injected mice favored the production of the T-helper (TH)-1 cytokine gamma-interferon. (diabetesjournals.org)
We analyzed the effect of PD-1-Ab on tumor growth in streptozotocin-induced diabetic mice (STZ-mice) subcutaneously inoculated with MC38 (a colon carcinoma cell line). (nature.com)
Persistent correction of hyperglycemia in streptozotocin-nicotinamide-induced diabetic mice by a non-conventional radical scavenger. (unibo.it)
Diabetes was induced in C57Bl/6J mice by streptozotocin (STZ) and nicotinamide (NA) administration. (unibo.it)
Concordant xenotransplantation of microencapsulated rat islets significantly prolonged mean time of restored normoglycemia (46:t 15 days) in streptozotocin-diabetic BALB/c mice recipients comparing to uncoated grafts (7:t 2 days). (annalsoftransplantation.com)
Streptozotocin was used to establish the mouse model of DN. (techscience.com)
In this study, we investigated whether DIM could improve insulin-dependent diabetes and nephropathy in streptozotocin (STZ)-induced diabetic mice. (researchgate.net)

Moreover, I3C exerts anti-obesity effects by reducing body weight and fat accumulation in epididymal adipose tissue in HFD-induced obese mice and thereby improves hyperglycemia and hyperinsulinemia [126]. (researchgate.net)

The HFD caused hyperglycemia, hyperinsulinemia, and impaired glucose absorption in GF mice independent of the increase associated with the microbiota in CV mice. (oregonstate.edu)
Thus liver p38 and MK2, like CaMKII, play an important role in the development of hyperglycemia and hyperinsulinemia in obese mice," they wrote. (medpagetoday.com)

Lipid Metabolism Is Dysregulated before, during and after Pregnancy in a Mouse Model of Gestational Diabetes. (cam.ac.uk)
We tested this hypothesis using an established mouse model of diet-induced obesity with pregnancy-associated loss of glucose tolerance and a novel lipid analysis tool, Lipid Traffic Analysis, that uses the temporal distribution of lipids to identify differences in the control of lipid metabolism through a time course. (cam.ac.uk)

The mice (as well as C57BL/6 and SJL) are known to carry IgG2c allele. (wikipedia.org)
Male C57BL/6J and db/db mice aged 8 weeks were randomly divided into the diabetic (DB) and control groups. (techscience.com)
Man C57BL/6J mice (The Jackson Lab) aged 8C12 weeks aged had been used for tests. (exposed-skin-care.net)
METHODS: Intracerebral arterioles were isolated from wild type C57BL/6J mouse (9-12 months old) brains and from human brain biopsies. (bvsalud.org)

In the STZ-NA diabetic mouse model, the radical scavenger IAC induces a prolonged reduction of hyperglycaemia associated with partial restoration of beta-cell mass and function, likely dependent on blockade of oxidative stress-induced damaging mechanisms. (unibo.it)
Conclusion: Our results solidify the potential link between DM and PD, providing insights into how hyperglycemia induces nigrostriatal degeneration and contributes to pathogenic mechanisms in PD. (lu.se)

Objective Indole‐3‐carbinol (I3C), a naturally occurring compound found in cruciferous vegetables, and its metabolite 3,3′‐diindolylmethane (DIM) reduce body mass and serum glucose levels in high‐fat‐diet‐induced obese mice. (researchgate.net)
Previous studies have found that DIM can improve type 2 diabetes by enhancing glucose uptake through the activation of insulin signaling in 3T3-L1 cells, and by lowering the plasma glucose levels in high-fat-diet-fed obese mice [13, 14]. (researchgate.net)
In one experiment in obese mice, they found that no matter how CaMKII was knocked out, it led to lower blood glucose levels and lower fasting plasma insulin levels in response to a glucose challenge. (medpagetoday.com)
In further analyses, the researchers discovered deleting or inhibiting any of these three elements ultimately improved insulin-induced Akt-phosphorylation in obese mice -- an important part of improving insulin sensitivity. (medpagetoday.com)

Although all diabetic cells are exposed to elevated levels of plasma glucose, hyperglycemic damage is limited to those cell types that are unable to down regulate glucose transport into the cell (e.g., endothelial cells), leading to intra-cellular hyperglycemia ( Brownlee, 2001 ). (scialert.net)

OBJECTIVE: We sought to evaluate the effects of acute hyperglycemia induced by intraperitoneal injection of glucose (2.7 g/kg) on vascular delivery to GL261 mouse gliomas kept at moderate hypothermia (~30 °C). MATERIALS AND METHODS: Seven GL261 glioma-bearing mice were studied by T1-weighted DCE MRI before and after an injection of glucose (n = 4) or saline (n = 3). (ox.ac.uk)
diabetic mice, that process was from the improved manifestation of vascular endothelial development factor (VEGF), which HMGB1-induced angiogenesis was considerably decreased by inhibiting VEGF activity. (exposed-skin-care.net)

Modeling diabetic nephropathy in mice. (scielo.br)
Mouse models of diabetic nephropathy. (scielo.br)
Diabetic nephropathy is a major complication of hyperglycemia. (researchgate.net)
DIM also improved diabetic nephropathy by inhibiting the expression of PKC-α, the marker of albuminuria, and TGF-β1, an indicator of renal hypertrophy, in diabetic mice. (researchgate.net)
Our findings suggest that DIM may ameliorate hyperglycemia and diabetic nephropathy through the inhibition of PKC-α and TGF-β1 signaling. (researchgate.net)
Although diabetic nephropathy, neuropathy and retinopathy are the most common microvascular complications of hyperglycemia, it also affects choroid plexus. (scialert.net)

Germ-Free Swiss Webster Mice on a High-Fat Diet Develop Obesity, Hyperglycemia, and Dyslipidemia. (oregonstate.edu)
Therefore, GF male Tac:SW mice developed several detrimental effects of obesity and MetS from a high-fat, calorie dense diet. (oregonstate.edu)
Our objective is to utilize a mouse model, displaying polygenic obesity, to elucidate regulatory roles of specific loci in the insulin signaling pathway. (usda.gov)
In contrast, in mice with normal immune systems, emulsifiers induced low-grade or mild intestinal inflammation and metabolic syndrome, characterized by increased levels of food consumption, obesity, hyperglycemia and insulin resistance. (eurekalert.org)

In type II diabetes - the most common form of the disease - the cells of the body become inefficient at responding to insulin and as a consequence, glucose in circulation can become dangerously high (hyperglycemia) while the pancreas cannot produce enough insulin to compensate. (newswise.com)
More striking, the pancreas in these mice appeared relatively normal, with well-demarcated islets, suggesting that Pax4 misexpression was inducing an orderly and spatially correct program of cellular conversion that probably recapitulated the normal cellular differentiation process. (medscape.com)

Inhibition of PTEN expression also dramatically reduced insulin concentrations in ob/ob mice, improved the performance of db/db mice during insulin tolerance tests, and increased Akt phosphorylation in liver in response to insulin. (diabetesjournals.org)
Tofogliflozin competitively inhibited SGLT2 in cells overexpressing SGLT2, and K i values for human, rat, and mouse SGLT2 inhibition were 2.9, 14.9, and 6.4 nM, respectively. (aspetjournals.org)
Moreover, I. obliquus extract-treated mice demonstrated the increase in tumor agglomeration and inhibition of vascularization. (researchgate.net)
In a series of experiments in mice, researchers found that inhibition of the kinase CaMKII -- or even some of its downstream components -- lowered blood glucose and insulin levels, Ira Tabas, MD, PhD , of Columbia University Medical Center in New York City, and colleagues reported online in Cell Metabolism . (medpagetoday.com)

Design: Genes associated with the ADGRG1 in human islets was probed by RNA-sequencing of human pancreatic islet isolated from cadaveric donors, followed by functional studies on β-cell proliferation, apoptosis, and insulin secretion in human and mouse islets and in INS-1 cells. (lu.se)

Results: STZ treatment induced more severe pathological alterations in the pancreatic islets and T1DM symptoms in α-syn-overexpressing mice than in wild-type mice, at one month and three months after STZ injections. (lu.se)
Diabetes develops in NOD mice as a result of insulitis, a leukocytic infiltrate of the pancreatic islets. (wikipedia.org)
In addition, we found that isolated islets from Chop -/- mice displayed increased expression of UPR and oxidative stress response genes and reduced levels of oxidative damage. (jci.org)
Results: ADGRG1 is the most abundant GPCR mRNA in both human and mouse islets, and its expression inhumanislets strongly correlates with genes important for β-cell function and T2 Drisk. (lu.se)
Theexpression ofADGRG1wasreduced in islets ofT2Ddonors, in db/dbmouseislets,andin isolated human islets exposed to chronic hyperglycemia. (lu.se)

Our results demonstrated that inoculation of Tm into the footpads of normal mice increases the expression of TLR2 in CD115 + Ly6C high blood monocytes and, in hypoinsulinemic-hyperglycemic (HH) mice infected with Tm, the increased expression of TLR2 was exacerbated. (frontiersin.org)
Photobiomodulation reduces abdominal adipose tissue inflammatory infiltrate of diet-induced obese and hyperglycemic mice. (google.com)
Nonketotic hyperglycemia (NKH) includes hyperosmolar hyperglycemic state, which refers to a condition that includes hyperglycemia, hyperosmotic pressure, and dehydration without severe acidosis. (koreamed.org)

Effect of hyperglycemia and hyperlipidemia on atherosclerosis in LDL receptor-deficient mice: establishment of a combined model and association with heat shock protein 65 immunity. (diabetesjournals.org)
We therefore have developed a transgenic mouse model that closely mimics atherosclerosis in humans with type 1 diabetes by breeding low-density lipoprotein receptor-deficient mice with transgenic mice in which type 1 diabetes can be induced at will. (jci.org)

In the current study, we established a model combining hyperglycemia with hyperlipidemia in LDL receptor-deficient (LDL-RD) mice and assessed its possible influences on lipid profile, HSP60/65, and atherogenesis. (diabetesjournals.org)
In conclusion, we have established a mouse model that combines hyperglycemia with diet-induced hyperlipidemia in LDL-RD mice and studied its effect on atherosclerosis progression. (diabetesjournals.org)
We previously reported that in a diabetes mouse model, characterised by moderate hyperglycaemia and reduced beta-cell mass, the radical scavenger bis(1-hydroxy-2,2,6,6-tetramethyl-4-piperidinyl)decandioate di-hydrochloride (IAC), a non-conventional cyclic hydroxylamine derivative, improves metabolic alterations by counteracting beta-cell dysfunction associated with oxidative stress. (unibo.it)
Small mesenteric arteries were isolated from healthy and diabetic db/db mice, which were used as a model of chronic hyperglycaemia. (ox.ac.uk)
Non-obese diabetic or NOD mice, like biobreeding rats, are used as an animal model for type 1 diabetes. (wikipedia.org)
Progressive erosion of β-cell function precedes the onset of hyperglycemia in the NOD mouse model of type 1 diabetes. (nih.gov)
2020. A mouse model for vitamin D-induced human cathelicidin antimicrobial peptide gene expression. . (oregonstate.edu)
The prototype combination product has been tested in hundreds of animals, is routinely curative in a mouse model of chemically-induced diabetes, and has been shown to be safe in several animal studies. (ca.gov)
The team fed mice two very commonly used emulsifiers, polysorbate 80 and carboxymethylcellulsose, at doses seeking to model the broad consumption of the numerous emulsifiers that are incorporated into almost all processed foods. (eurekalert.org)
The study published in ACS Synthetic Biology shows that glucose levels can be controlled in a mouse model of diabetes without pharmacological intervention. (newswise.com)
The present study utilized db/db mice as a DKD animal model administered with low (30 mg/kg) and high doses (60 mg/kg) of HPS, in addition to glyburide (7.2 mg/kg). (spandidos-publications.com)
A knock-out mouse model similar to the mut0 human form of methylmalonic acidemia has been developed. (medscape.com)

Fig. 3: Hyperphagia in BCAA200 mice is linked to Trp-mediated serotonin (5-HT) depletion. (nature.com)
These mice exhibit hyperphagia, hyperglycemia, NIDDM and are moderately obese compared to the ICR control line. (usda.gov)

Amelioration of hyperglycemia by intestinal overexpression of glucagon-like peptide-1 in mice. (nih.gov)

Chronic hyperglycaemia did not affect either EC Ca2+ or local vasodilation to SLIGRL. (ox.ac.uk)
Such changes in bacteria triggered chronic colitis in mice genetically prone to this disorder, due to abnormal immune systems. (eurekalert.org)
1997. Genotoxicity of malathion- a sub-chronic study in mice. (cdc.gov)

However, due to the complicated effect of insulin resistance on PD onset, the actual mechanism of hyperglycemia-induced dopaminergic degeneration remains unknown. (lu.se)
The onset of diabetes is associated with a moderate glycosuria and a non-fasting hyperglycemia. (wikipedia.org)

Peritoneal glucose absorption in peritoneal dialysis causes hyperglycemia. (koreamed.org)

At ultrastructural level, beta cells of IAC-treated diabetic mice were protected against degranulation and mitochondrial alterations. (unibo.it)

In summary, CEH supplementation has favorable effects on improving glucose metabolism and regulating the gut microbiome in HFD-fed mice. (rsc.org)
CONCLUSION: Perturbing the metabolism of GL261 tumors kept at moderate hypothermia with hyperglycemia did not induce significant changes in the permeability/perfusion of these tumors. (ox.ac.uk)
Effect of arabinoxylan from wastewater generated during vital wheat gluten production on liver metabolism in type 2 diabetic mice. (cabi.org)
DKD arises from various consequences associated with aberrant glucose metabolism, hyperglycemia and altered renal hemodynamics, which can activate numerous growth factors and cytokines, ultimately contributing to the development of DKD ( 3 , 4 ). (spandidos-publications.com)

The relative contributions of hyperglycemia and dyslipidemia to atherosclerosis in patients with diabetes are not clear, largely because there is a lack of suitable animal models. (jci.org)
This progression to advanced lesions is largely dependent on diabetes-induced dyslipidemia, because hyperlipidemic diabetic and nondiabetic mice with similar plasma cholesterol levels show a similar extent of atherosclerosis. (jci.org)

Diabetic microvasular complications, which are considered as an important group of hyperglycemia imperfections, caused by increased endothelial permeability and can progress to severe impairments in several organs. (scialert.net)

Stomach absorption of intubated insecticides in fasted mice. (cdc.gov)

Effect of acute hyperglycemia on moderately hypothermic GL261 mouse glioma monitored by T1-weighted DCE MRI. (ox.ac.uk)

Indeed, when mice were made to overexpress TRB3, the improvement in phosphorylation disappeared, "indicating that the suppression of TRB3 by CaMKII deficiency is causally important in the improvement in insulin signaling," they wrote. (medpagetoday.com)

Transfection of cells in culture with ASO targeting PTEN reduced PTEN mRNA and protein levels and increased insulin-stimulated Akt phosphorylation in α-mouse liver-12 (AML12) cells. (diabetesjournals.org)
Systemic administration of PTEN ASO once a week in mice suppressed PTEN mRNA and protein expression in liver and fat by up to 90 and 75%, respectively, and normalized blood glucose concentrations in db / db and ob / ob mice. (diabetesjournals.org)
mRNA expression levels of CXCL9, a chemokine recruiting CD8 + T cells, were lower in dLNs of STZ-mice than in normoglycemic mice after PD-1-Ab treatment, and its protein was expressed in DCs. (nature.com)
2012). Our previous study demonstrated that PM2.5 exposure led to hyperglycemia and IR, which were accompanied by hypothalamic inflammation evidenced by increased mRNA levels of Interleukin-6 (IL-6), tumor necrosis factor α (TNFα), Inhibitor kappa B kinase 2 (IKK2), and enhanced microglial/astrocyte reactivity (Song et al. (deepdyve.com)

A HFD also elevated plasma LDL-cholesterol and increased hepatic triacylglycerol, free fatty acids, and ceramides in all mice, whereas hypertriglyceridemia and increased hepatic medium and long-chain acylcarnitines were only observed in CV mice. (oregonstate.edu)

Liver metabolic disorders frequently coincide with the development of type 2 diabetes, but research on the hepatoprotective effects of AX in type 2 diabetic mice is lacking. (cabi.org)

STZ-NA mice showed moderate hyperglycaemia, glucose intolerance and reduced beta-cell mass (25% of controls). (unibo.it)

Furthermore, we assessed the expression of chemokines by polymerase chain reaction (PCR) array in tumor-draining lymph nodes (dLNs) of these mice and MC38 cells cultured in different glucose concentrations. (nature.com)
This was accompanied by fewer tumor-infiltrating CD8 + T cells, and STZ-mice had fewer tumor-infiltrating CD11c + dendritic cells (DCs) than normoglycemic mice. (nature.com)
These results suggest that the STZ-induced hyperglycemia impairs the effect of PD-1-Ab treatment on MC38 tumor growth, and is accompanied by reduced infiltration of DCs and CD8 + T cells and decreased expression of CCL7 and CXCL9. (nature.com)
To investigate the effect of hyperglycemia on anti-tumor function induced by anti-PD-1 antibody treatment, we treated STZ-induced diabetic mice with subcutaneous MC38 colon carcinoma tumors with anti-PD-1 antibody, and examined changes in tumor growth, the number of tumor-infiltrating immune cells, and the expression of chemokines and chemokine receptors. (nature.com)
The effect of anti-PD-1 antibody on MC38 tumor is attenuated in STZ-induced diabetic mice. (nature.com)
Thus, in tumor-bearing mice, 60% tumor reduction was observed, while in metastatic mice, the number of nodules decreased by 25% compared to the control group. (researchgate.net)
Furthermore, I. obliquus prevented temperature drop in mice after tumor implantation. (researchgate.net)

Thus, biochemical indexes related to diet-induced hyperglycemia were mainly detected using hematoxylin and eosin (H&E) staining, fluorescence quantitative PCR, and ultrahigh performance liquid chromatography-mass spectrometry (UPLC-MS). Then 16s rRNA gene sequencing was performed to analyze the effects of CEH on the gut microbiome in high-fat diet (HFD)-fed mice. (rsc.org)
Analysis of hematologic and biochemical blood tests revealed mild hyperglycemia (6.88 mmol/L) and elevated γ-glutamyltransferase (104 IU/L) and C-reactive protein levels (57 mg/L). Cerebrospinal fluid (CSF) analysis showed 3,500 leukocytes/μL (70% lymphocytes, 30% neutrophils), and glucose and protein levels of 2.5 mmol/L and 2.749 mg/L, respectively. (cdc.gov)

We assessed the effect of Chop deletion in multiple mouse models of type 2 diabetes and found that Chop -/- mice had improved glycemic control and expanded β cell mass in all conditions analyzed. (jci.org)

Genetic Loci associated with susceptibility to IDDM have been identified in the NOD mouse strain through the development of congenic mouse strains, which have identified several insulin dependent diabetes (Idd) loci. (wikipedia.org)

The effects of emulsifier consumption were eliminated in germ-free mice, which lack a microbiota. (eurekalert.org)
Transplant of microbiota from emulsifiers-treated mice to germ-free mice was sufficient to transfer some parameters of low-grade inflammation and metabolic syndrome, indicating a central role for the microbiota in mediating the adverse effect of emulsifiers. (eurekalert.org)

When these mice are fed a cholesterol-free diet, diabetes, in the absence of associated lipid abnormalities, causes both accelerated lesion initiation and increased arterial macrophage accumulation. (jci.org)
Diabetes is known to affect zinc homeostasis in variety of ways, although it is the hyperglycemia rather than any primary lesion related to diabetes, which is responsible for the increased urinary loss and decrease in total body zinc. (scirp.org)

Actually, diabetic human being and mouse pores and skin show lower regional degrees of HMGB1 than their normoglycemic counterparts (8). (exposed-skin-care.net)
Provided the preexisting data, this research examines whether HMGB1 is important in peripheral ischemiaCinduced angiogenesis in both normoglycemic and diabetic mice. (exposed-skin-care.net)

Hyperglycaemia-associated effects on endothelium-dependent vasodilation have been well characterized, but effects on conducted vasodilation in the resistance vasculature are not known. (ox.ac.uk)
Our findings reiterate the importance of studying the effects of hyperglycaemia in the vasculature, and provide the basis for further studies regarding the modulation of junctional proteins involved in cell to cell communication by diseases such as diabetes. (ox.ac.uk)
Therefore, the effects of heat stress on genes or pathways related to the reproductive system of male mice were experimentally explored in this paper to further determine the effects of heat stimulation on mammals. (techscience.com)
Further mechanistic analysis revealed that the therapeutic effects of HPS on DKD mice may be mediated by inhibiting the high mobility group box 1/receptor for advanced glycation end‑products/toll‑like receptor 4 pathway. (spandidos-publications.com)

These mice express a viral protein under control of the insulin promoter and, when infected by the virus, develop an autoimmune attack on the insulin-producing β cells and subsequently develop type 1 diabetes. (jci.org)
Thus this single pathway targets "two cardinal features of type 2 diabetes -- hyperglycemia and defective insulin signaling," the researchers wrote. (medpagetoday.com)
The findings suggest the possibility of a drug that can target both hyperglycemia and insulin resistance in type 2 diabetes, they said. (medpagetoday.com)

Adenovirus early region 3 antiapoptotic 10.4K, 14.5K, and 14.7K genes decrease the incidence of autoimmune diabetes in NOD mice. (nih.gov)

In db/db mice, 4-week tofogliflozin treatment reduced glycated hemoglobin and improved glucose tolerance in the oral glucose tolerance test 4 days after the final administration. (aspetjournals.org)

Blood and urine samples were collected from mice and blood glucose, serum creatinine, urinary albumin excretion and urinary β2‑microglobulin were measured. (spandidos-publications.com)

Diabetic mice demonstrated hyperglycemia throughout the study, and their metabolic control was improved by intense insulin therapy. (jci.org)

Main methods: Anticancer activity of the I. obliquus extract was examined in mouse models of Lewis lung carcinoma growth and spontaneous metastasis after 3 weeks of continuous extract intake at the dose of 6 mg/kg/day, which corresponded to that ingested daily with Chaga infusion in Japan. (researchgate.net)
MATERIALS AND METHODS Animals and animal care KKAy mice of 7-week-old were purchased from Jackson Laboratories (Bar Harbor, Maine), which were maintained at 21°C on a 12-h light/12-h dark cycle with free access to water and food. (deepdyve.com)

To understand the role of TLR2 during the development of murine experimental deep dermatophytosis, we employed TLR2 knockout mice. (frontiersin.org)

The HFD increased feed conversion and body weight in GF mice independent of the increase associated with the microbiota in CV mice. (oregonstate.edu)
Chassaing and Gewirtz hypothesized that emulsifiers might affect the gut microbiota to promote these inflammatory diseases and designed experiments in mice to test this possibility. (eurekalert.org)

DIM decreased STZ-increased high blood glucose levels and food and water intake in diabetic mice. (researchgate.net)
CONCLUSIONS 476310-60-8 The outcomes of this research display that endogenous HMGB1 is vital for ischemia-induced angiogenesis in diabetic mice which HMGB1 proteins administration enhances security blood circulation in the ischemic hind limbs of diabetic mice through a VEGF-dependent system. (exposed-skin-care.net)
A diabetes-induced decrease in security vessel formation continues to be exhibited in murine versions: hind limb ischemia produced by femoral artery ligation is usually from the decreased development of capillaries and a decrease in blood flow towards the ischemic hind limb in diabetic versus non-diabetic mice (3). (exposed-skin-care.net)
Certainly, vessel-associated stem cells (mesoangioblasts), injected in to the general blood circulation of dystrophic mice, migrate to sites of injury in response towards the HMGB1 transmission, with 476310-60-8 a nuclear factor-BCdependent system (10). (exposed-skin-care.net)

IAC-treated STZ-NA mice (at both doses of 15 and 30 mg/kg b.w.) showed long-term reduction of hyperglycaemia even after discontinuation of treatment, attenuation of glucose intolerance and partial preservation of beta-cell mass. (unibo.it)

2002. Cytogenitic studies on the effect of feeding mice with stored wheat grains treated with malathion. (cdc.gov)

Anatomy7

Organisms5

Diseases30

Chemicals and Drugs31

Analytical, Diagnostic and Therapeutic Techniques and Equipment12

Psychiatry and Psychology1

Phenomena and Processes11

Health Care1

Diabetes mellitus8

Streptozotocin10

Improves hyperglycemia1

Hyperinsulinemia2

Lipid Metabolism2

C57Bl4

Induces2

Obese mice4

Endothelial Cells1

Vascular2

Diabetic nephropathy6

Obesity4

Pancreas2

Inhibition4

Secretion1

Islets5

Hyperglycemic3

Receptor-deficient mice2

Model12

Hyperphagia2

Amelioration1

Chronic3

Onset2

Glucose absorption1

Mitochondrial1

Metabolism4

Dyslipidemia2

Complications1

Absorption1

Moderately1

Deficiency1

MRNA4

Hepatic1

Liver1

Moderate1

Tumor7

Biochemical2

Glycemic Control1

Insulin dependent1

Germ-free2

Lesion2

Normoglycemic2

Effects4

Type3

Autoimmune diabetes1

Improved glucose tolerance1

Serum creatinine1

Metabolic1

Methods2

Experimental1

Microbiota2

Blood4

Reduction1

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