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  • visceral
  • Repeated administration of SSR149415 at 1 or 3 mg/kg completely prevented stress-induced visceral hyperalgesia. (nih.gov)
  • These data support a major role for V(3) receptors in repeated psychological stress-induced visceral hyperalgesia and suggest that pharmacological manipulation of the AVP/V(3) pathway might represent an attractive alternative to the CRF/CRF(1) pathway for the treatment of chronic stress-related gastrointestinal disorders. (nih.gov)
  • Here we compared visceral pain and referred hyperalgesia in Nav1.8-null mice and their wild-type littermates in five tests that differ in the degree to which behavior depends on spontaneous, ongoing firing in sensitized nociceptors. (jneurosci.org)
  • EA at ST36 and ST37 could relieve visceral hypersensitivity and, in particular, attenuate referral hindpaw hyperalgesia by suppressing the enhanced spinal LTP. (hindawi.com)
  • Although the convergence of somatic and visceral sensory circuits in the peripheral and central nervous systems (CNS) is deemed as the neuroanatomical evidence for the referral somatic hyperalgesia [ 6 , 7 ], the functional neural basis of this phenomenon still remains elusive. (hindawi.com)
  • opioid
  • The investigators want to test the influence of remifentanil, an ultra-short acting opioid, on hyperalgesia observed after UV-B irradiation in human volunteers in a double blind cross-over prospective active placebo controlled clinical trial. (clinicaltrials.gov)
  • This project investigates the phenomenon of opioid-induced hyperalgesia (OIH). (clinicaltrials.gov)
  • This study investigated the time-course of opioid-induced hyperalgesia development in healthy normal volunteers (N=12 completers), using a series of acute alfentanil administrations (15 mg/kg mg intramuscular (IM) per day) spaced at 3-4 day intervals, with testing for pain tolerance using the cold pressor test (CPT), and mechanical quantitative sensory testing (MQST) each administered repeatedly over time within each testing day. (clinicaltrials.gov)
  • Analgesia
  • Fentanyl administration exhibited a biphasic time-dependent effect: first, an early response (for 2-5 h) associated with a marked increase in nociceptive threshold (analgesia), and second, a later response associated with sustained lowering of the nociceptive threshold (5 days for the longest effect) below the basal value (30% of decrease for the maximal effect) indicative of hyperalgesia. (nih.gov)
  • Ketamine pretreatment, which had no analgesic effect on its own, enhanced the earlier response (analgesia) and prevented the development of long-lasting hyperalgesia. (nih.gov)
  • Preemptive hyperalgesia, not analgesia? (nih.gov)
  • intrathecal
  • For example, switching from oral to intrathecal administration, but this is not a common treatment for hyperalgesia. (opiates.com)
  • Intrathecal administration of anti-nerve growth factor (anti-NGF), p38 MAPK inhibitor, or TRPA1 antisense oligodeoxynucleotide decreased the induction of TRPA1 and suppressed inflammation- and nerve injury-induced cold hyperalgesia. (nih.gov)
  • blockade
  • Here we report that the pharmacological blockade of TRPA1 in primary sensory neurons reversed cold hyperalgesia caused by inflammation and nerve injury. (nih.gov)
  • placebo
  • In this review, we focus on the contribution of conditioning in the induction of placebo hypoalgesia and nocebo hyperalgesia and present accumulating evidence that conditioning independent from explicit expectation can cause these effects. (hindawi.com)
  • After giving a brief overview over current evidence and models on the development of placebo hypoalgesia and nocebo hyperalgesia including conditioning and expectation approaches, we will turn to studies that stress the significance of conditioning and demonstrate that conditioning effects might have been misunderstood and/or underestimated. (hindawi.com)
  • In this multicenter, randomised, placebo-controlled, double-blind trial, hyperalgesia area around the scarce following colorectal laparoscopic surgery (piece removal) will be assessed in 3 groups of patients : group 1: continuous ropivacaine preperitoneal infusion, group 2 : intravenous lidocaine infusion, or group 3 : control group without local anesthetics. (clinicaltrials.gov)
  • Moreover, a significant negative correlation was found between the magnitude of mPFC (but not posterior cingulate) BOLD response and the size of secondary hyperalgesia response under placebo. (jneurosci.org)
  • Conclusions: Compared with placebo, DM enabled reduction of postoperative analgesics consumption, improved well-being, and reduced sedation, pain intensity and primary and secondary thermal hyperalgesia. (springer.com)
  • remifentanil
  • In our clinical trial we will try to determine if the preoperative administration of acetazolamide could prevent the hyperalgesia induced by remifentanil in patients scheduled for thyroidectomy with general anesthesia. (clinicaltrials.gov)
  • sensory
  • Together, these results demonstrate that an NGF-induced TRPA1 increase in sensory neurons via p38 activation is necessary for cold hyperalgesia. (nih.gov)
  • Thus, blocking TRPA1 in sensory neurons might provide a fruitful strategy for treating cold hyperalgesia caused by inflammation and nerve damage. (nih.gov)
  • Sensation
  • When local anesthetics administered through an epidural catheter were able to block sensation over only half of the operative site for a patient under general anesthesia, pain assessment for several weeks after surgery demonstrated increased pain and hyperalgesia on the side that was not effectively blocked during surgery. (lww.com)
  • development
  • Global Markets Directs Pharmaceutical and Healthcare latest pipeline guide Hyperalgesia - Pipeline Review, H2 2018, provides comprehensive information on the therapeutics under development for Hyperalgesia (Central Nervous System), complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. (aarkstore.com)
  • Find and recognize significant and varied types of therapeutics under development for Hyperalgesia (Central Nervous System). (aarkstore.com)
  • In addition to spontaneous pain symptoms, study results indicated the development of long-lasting punctate hyperalgesia. (hindawi.com)
  • fMRI
  • The authors of this study used a balanced design that used electrical stimulation to induce trauma, normally benign pin pricks to assess hyperalgesia, and subsequent intravenous application of lidocaine, a potent analgesic, to block perception of secondary hyperalgesia in normal participants undergoing fMRI scanning. (jneurosci.org)
  • Functional magnetic resonance imaging (fMRI) was used to tease out the cortical regions associated with the processing of ET-1-induced punctate hyperalgesia, as compared to a nonnoxious mechanical stimulation of the contralateral arm. (hindawi.com)
  • measures
  • Formulate corrective measures for pipeline projects by understanding Hyperalgesia (Central Nervous System) pipeline depth and focus of Indication therapeutics. (aarkstore.com)
  • Dose
  • The higher the fentanyl dose used, the more pronounced was the fentanyl-induced hyperalgesia. (nih.gov)
  • Here, we show that both magnitude and duration of heroin-induced delayed hyperalgesia increase with intermittent heroin administrations, leading to an apparent decrease in the analgesic effectiveness of a given heroin dose. (jneurosci.org)