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  • erythrocytosis
  • For the individual in which phlebotomy works well, we typically see that the need for a number of phlebotomies goes down relatively rapidly and that we are inducing an iatrogenic state of iron deficiency to try to control the erythrocytosis that individuals have with polycythemia vera. (targetedonc.com)
  • Erythrocytosis - Causes include secondary polycythemia (an increase in red blood cell [RBC] counts, typically due to chronic hypoxemia), familial erythrocythemia, and relative polycythemia (a benign condition in which RBC numbers are normal but plasma volume is contracted, due to dehydration or to reduced venous compliance). (medscape.com)
  • phlebotomies
  • We want to decrease that number of phlebotomies to a minimal level and try to monitor for any progression, as well as any toxicity related to hydroxyurea, whether it be neutropenia, thrombocytopenia, or other difficulties. (targetedonc.com)
  • leukemia
  • Concern exists about prolonged use of this drug leading to leukemia and the inability of hydroxyurea to eliminate the malignant clone. (clinicaltrials.gov)
  • Hematologic response evaluation employed Polycythemia Vera Study Group criteria, and molecular response evaluation, European Leukemia Net criteria. (haematologica.org)
  • 17 However, the particular study 17 did not include a control arm that would have allowed accurate assessment of leukemia risk associated with hydroxyurea therapy. (bloodjournal.org)
  • retrospective
  • 6 The safety and nonleukemogenicity of hydroxyurea, in this context, have repeatedly been highlighted by large retrospective studies, 7 ⇓ - 9 and there is no controlled evidence to the contrary. (bloodjournal.org)
  • response
  • The individual who needs significantly more than that is really an outlier and, in many ways, is not really having an adequate response to hydroxyurea. (targetedonc.com)
  • disease
  • There are other mutations found in people with polycythemia vera, but it's not yet known what role these mutations play in the development of the disease or what the implications of these mutations might mean for treating the disease. (checkorphan.org)
  • blood cells
  • Polycythemia is a neoplasm in which the bone marrow makes too many red blood cells. (checkorphan.org)
  • Most of the health concerns associated with polycythemia vera are caused by the blood being thicker as a result of the increased red blood cells. (checkorphan.org)
  • But in polycythemia vera, the mechanism your body uses to control the production of blood cells becomes damaged, and your bone marrow makes too many of some blood cells. (checkorphan.org)
  • If an examination of your bone marrow shows that it's producing higher than normal numbers of blood cells, it may be a sign of polycythemia vera. (checkorphan.org)
  • Polycythemia is characterized by increased cell counts in all cell lines in the myeloid series (ie, red blood cells, white blood cells [preferentially granulocytes], and platelets). (medscape.com)