• In this study, the contribution of UGT1A6 to the glucuronidation of endogenous structural analogs of serotonin, including 5-hydroxytryptophol, N -acetylserotonin, and 6-hydroxymelatonin, was evaluated using available recombinant human UGT isoforms, human liver microsomes, and liver microsomes from animals that do not express functional UGT1A6 (Gunn rats and cats). (aspetjournals.org)
  • 5-Hydroxytryptophol glucuronidation by human liver microsomes ( n = 54) correlated well with serotonin glucuronidation ( R s = 0.83) and UGT1A6 protein content ( R s = 0.85). (aspetjournals.org)
  • 5-Hydroxytryptophol also competitively inhibited serotonin glucuronidation by human liver microsomes ( K i = 291 μM) and UGT1A6 ( K i = 200 μM). (aspetjournals.org)
  • By contrast, 5-hydroxyindole metabolites of L-tryptophan such as 5-hydroxytryptamine (serotonin), 5-hydroxytryptophol and other serotonin catabolites do not control COX-2 expression. (biomedcentral.com)
  • Other pineal-derived antigonadotrophic indoles include serotonin, 5-hydroxytryptophol, 5-methoxytroptophol, and N-acetylserotonin. (justia.com)
  • Summary The serotonin metabolite 5-hydroxytryptophol was determined in cerebrospinal fluid and urine of alcoholics and healthy subjects, by a glass capillary gas chromatographic-mass spectrometric method. (nationallizenzen.de)
  • The urinary ratio of 5-hydroxytryptophol (5-HTOL) and 5-hydroxyindole-3-acetic acid (5-HLAA) inverts due to alcohol consumption [ 4 ]. (beds.ac.uk)
  • 5-hydroxytryptophol and 5-hydroxyindole-3-acetic acid when tested at 4 mM. 5-methoxytryptamine was as effective as 5-hydroxytryptophol and 5-hydroxyindole-3-acetic acid when tested at 4 mM but was inactive at 1 mM. 5-methoxytryptophol was marginally active at 4 mM. (biomedsearch.com)
  • 5-hydroxytryptophan, 5-hydroxytryptamine, N-acetyl-5-hydroxytryptamine, 5-hydroxyindole-3-acetic acid, and 5-hydroxytryptophol) is described. (infona.pl)
  • Psilocin is broken down by the enzyme monoamine oxidase to produce several metabolites that can circulate in the blood plasma, buy generic clonazepam including 4-hydroxyindole-3-acetaldehyde, 4-hydroxytryptophol, and 4-hydroxyindole-3-acetic acid. (isisnotinmyname.com)
  • Kroke A, Klipstein-Grobusch K, Hoffman K, Terbeck I, Boeing H, Helander A ( 2001) Comparison of self reported alcohol intake with the urinary excretion of 5-hydroxytryptophol:5-hydroxyindole-3-acetic acid, a biomarker of recent alcohol intake. (nutrition-nutritionists.com)
  • control = 17.1 × 10 -8 M). Contractile responses to 5-hydroxyindole acetic acid and 5-hydroxytryptophol were greater in mesenteric arteries from hypertensive rats, whereas reactivity to 5-methoxytryptamine and melatonin in arteries from hypertensive rats did not differ from that in arteries from normotensive rats. (elsevier.com)
  • These include carbohydrate deficient transferrin, serum sialic acid, beta hexosamine, ethyl glucuronide and 5-hydroxytryptophol … as well as the direct measurement of ethyl alcohol itself in serum, urine and other body fluids (Robert Swift, p73). (blogspot.com)
  • 254 citations: Laboratory testing for recent alcohol consumption: comparison of ethanol, methanol, and 5-hydroxytryptophol. (wikipedia.org)
  • 5-Hydroxytryptophol in the cerebrospinal fluid and urine of alcoholics and healthy subjects in: Naunyn-Schmiedeberg's archives of pharmacology , ISSN 1432-1912, Vol. 321 (4. (nationallizenzen.de)