• This condition is due to defects in type II 3-beta-hydroxysteroid dehydrogenase, an enzyme that occurs almost exclusively in the gonads and adrenal glands. (medscape.com)
  • A variety of mutations in the HSD3B2 gene affect the activity of this enzyme, resulting in the extremely variable, phenotypic presentations of 3-beta-hydroxysteroid dehydrogenase deficiency. (medscape.com)
  • 17ß- Hydroxysteroid dehydrogenase 1 (17ß-HSD1) is a steroidogenic enzyme that catalyzes the activation of estradiol from estrone in human placenta and rat ovary . (bvsalud.org)
  • We observed some bisphenols with substituents were found to significantly inhibit both human and rat 17ß-HSD1 with the most potent inhibition on human enzyme by bisphenol H ( IC50 = 0.90 µM) when compared to bisphenol A ( IC50 = 113.38 µM). (bvsalud.org)
  • Rat enzyme was less sensitive to the inhibition of bisphenols than human enzyme with bisphenol H ( IC50 = 32.94 µM) for rat enzyme . (bvsalud.org)
  • To address the second, we investigated RNAs bound by the metabolic enzyme hydroxysteroid dehydrogenase 17-β 10 (HSD17B10). (nature.com)
  • I am looking for monoclonal antibodies against the human enzyme 11beta-Hydroxy-steroid-dehydrogenase. (bio.net)
  • Our previous findings indicate increased expression of the GC-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) in primary human dermal fibroblasts (HDF), full-thickness skin from older donors and during the inflammatory phase of mouse skin WH. (endocrine-abstracts.org)
  • Michael E. Baker, PhD, a researcher at the University of California, San Diego School of Medicine has discovered that zebrafish - an important animal model in disease and environmental studies - could provide the means to help scientists eventually reveal the function of a mysterious enzyme linked to the steroid cortisol, and found in the human brain. (scienceblog.com)
  • The human body regulates cortisol by employing an enzyme called 11 beta-hydroxysteroid dehydrogenase-type 1 or 11beta-HSD1, which catalyzes the synthesis of cortisol in liver and fat cells. (scienceblog.com)
  • Recently, it was shown that also in dogs, trilostane has an inhibitory effect on the 3β-hydroxysteroid dehydrogenase enzyme system. (vin.com)
  • We examined in humans the association between venous umbilical cord blood glucocorticoids, a potential marker for placental 11β-HSD2 enzyme activity, and blood pressure at age 3 years. (umass.edu)
  • 17b-hydroxysteroid dehydrogenase (HSD) is a steroidogenic enzyme essential for invertebrate spermatogenesis. (molcells.org)
  • Animal data show that decreased activity of placental 11-beta-hydroxysteroid dehydrogenase type 2 (11β-HSD2), which potently inactivates glucocorticoids (e.g. cortisol) to inert forms (cortisone), allows increased access of maternal glucocorticoids to the fetus and 'programs' hypertension. (umass.edu)
  • Association between a variant in the 11 beta-hydroxysteroid dehydrogenase type 2 gene and primary hypertension. (cdc.gov)
  • Expression profiling of 11beta-hydroxysteroid dehydrogenase type-1 and glucocorticoid-target genes in subcutaneous and omental human preadipocytes. (ox.ac.uk)
  • Anti-inflammatory effect of a selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitor via the stimulation of heme oxygenase-1 in LPS-activated mice and J774.1 murine macrophages. (ac.ir)
  • 5. Itoi S, Terao M, Murota H, Katayama I. 11beta-Hydroxysteroid dehydrogenase 1 contributes to the pro-inflammatory response of keratinocytes. (ac.ir)
  • Anti-inflammatory effects of levalbuterol-induced 11beta-hydroxysteroid dehydrogenase type 1 activity in airway epithelial cells. (ac.ir)
  • Carbenoxolone prevents chemical eye ischemia-reperfusion-induced cell death via 11beta-hydroxysteroid dehydrogenase type 1 inhibition. (ac.ir)
  • 11. Chapman KE, Coutinho AE, Zhang Z, Kipari T, Savill JS, Seckl JR. Changing glucocorticoid action: 11beta-hydroxysteroid dehydrogenase type 1 in acute and chronic inflammation. (ac.ir)
  • Association studies between the HSD11B2 gene (encoding human 11beta-hydroxysteroid dehydrogenase type 2), type 1 diabetes mellitus and diabetic nephropathy. (cdc.gov)
  • The MDR superfamily with ~350-residue subunits contains the classical liver alcohol dehydrogenase (ADH), quinone reductase, leukotriene B4 dehydrogenase and many more forms. (researchgate.net)
  • 11β-hydroxysteroid dehydrogenase/reductase (11β-HSD) enzymes 1 and 2 regulate the amount of cortisone and cortisol in human tissues. (helsinki.fi)
  • This is usually due to a 5-alpha-reductase deficiency (5alpha-RD-2) or 17-beta-hydroxysteroid dehydrogenase deficiency (17beta-HSD-3). (todayifoundout.com)
  • Platelets express steroidogenic 17beta-hydroxysteroid dehydrogenases. (ny.gov)
  • Analyses of the mitochondrial hydroxysteroid dehydrogenase (HSD17B10) uncover the RNA-binding specificity of an enigmRBP. (nature.com)
  • Submicroscopic duplications of the hydroxysteroid dehydrogenase HSD17B10 and the E3 ubiquitin ligase HUWE1 are associated with mental retardation. (ru.nl)
  • Mutations and associated deficiency have not been reported in humans. (wikipedia.org)
  • 3-Beta-hydroxysteroid dehydrogenase (3BHSD) deficiency is a rare form of congenital adrenal hyperplasia that results in decreased production of all three groups of adrenal steroids: mineralocorticoids, glucocorticoids, and sex steroids. (medscape.com)
  • Although first described in male infants with ambiguous genitalia and severe salt wasting, 3-beta-hydroxysteroid dehydrogenase deficiency also occurs in 46,XX female infants (who may have mild clitoromegaly), as well as in older patients who present with a milder or so-called late-onset variant. (medscape.com)
  • hydroxysteroid dehydrogenase type 2 deficiency. (cdc.gov)
  • Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor and steroid dehydrogenase activity. (nih.gov)
  • 17β-Hydroxysteroid dehydrogenases (17β-HSD, HSD17B) (EC 1.1.1.51), also 17-ketosteroid reductases (17-KSR), are a group of alcohol oxidoreductases which catalyze the reduction of 17-ketosteroids and the dehydrogenation of 17β-hydroxysteroids in steroidogenesis and steroid metabolism. (wikipedia.org)
  • Synthesis:Estriol is only produced in significant amounts during pregnancy as it is made by the placenta from 16-Hydroxydehydroepiandrosterone sulfate , an androgen steroid made in the fetal liver and adrenal glands.The human. (absoluteastronomy.com)
  • It is a conjugated steroid converted by the sulfation of dehydroepiandrosterone (DHEA) at the 3β position via hydroxysteroid sulfotransferase. (cdc.gov)
  • d ) Validation of the yeast mRNA interactome using western blotting of input samples and eluate after interactome capture with specific antibodies (ADH1, alcohol dehydrogenase 1, PUB1) or against TAP-tagged proteins (PGK1, phosphoglycerate kinase 1, TDH1, triose phosphate dehydrogenase, TRX2, thioredoxine 2, SHE2, Swi5p-dependent HO Expression 2). (nature.com)
  • Zinc binding to the peptide replica and analogs to residues 93-115 of horse liver alcohol dehydrogenase (ADH) was examined by competition of the peptides and the chromophoric chelator 4-(2- pyridylazo)resorcinol for zinc and X-ray absorption fine structure analysis of the zinc ligands. (researchgate.net)
  • 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) that gen. (endocrine-abstracts.org)
  • We and others have demonstrated decreased hepatic cortisol regeneration through reduced 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) activity that converts inactive cortisone to cortisol. (endocrine-abstracts.org)
  • Type I 3-beta-hydroxysteroid dehydrogenase isoenzyme occurs in the peripheral tissues, primarily the liver. (medscape.com)
  • However, the role of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which catalyzes the conversion of inactive cortisone into active cortisol, in inflammation remains unclear. (ac.ir)
  • Expression of 11β-hydroxysteroid dehydrogenase type 1 in the human hypothalamus. (hersenbank.nl)
  • 11ß-Hydroxysteroid dehydrogenase type 2 in hypertension: comparison of phenotype and genotype analysis. (cdc.gov)
  • BACKGROUND: Despite evidence supporting a role for the gut bacteria in multitude of human diseases including type 2 diabetes (T2D) and cardiovascular disease (CVD), causal- and mechanistic evidence in humans is limited, and prospective studies are lacking. (lu.se)
  • Only 60% of yeast and 73% of the human RBPs have functions assigned to RNA biology or structural motifs known to convey RNA binding, and many intensively studied proteins surprisingly emerge as RBPs (termed 'enigmRBPs'), including almost all glycolytic enzymes, pointing to emerging connections between gene regulation and metabolism. (nature.com)
  • ADH is a dimeric zinc metalloprotein and occurs as five different classes in humans, resulting from gene duplications during vertebrate evolution, the first one traced to ~500. (researchgate.net)
  • Transcript profiling of human platelets using microarray and serial analysis of gene expression (SAGE). (ny.gov)
  • An 8-kilobase (kb) gene, HSD3B2 , located on the p11-13 region of chromosome 1 encodes 3-beta-hydroxysteroid dehydrogenase. (medscape.com)
  • Analysis of age-related changes in gene expression in human microglia. (hersenbank.nl)
  • HSD17B6: Has 3α-HSDTooltip 3α-hydroxysteroid dehydrogenase activity and catalyzes conversion of the weak androgen androstanediol into the powerful androgen dihydrotestosterone in the prostate gland. (wikipedia.org)
  • Expression of protease activated receptor 3 (PAR3) is upregulated by induction of megakaryocyte phenotype in human erythroleukemia (HEL) cells. (ny.gov)
  • A 293-EBNA-based cell line with stable expression of transfected human 17β-HSD3 was created and used to develop a whole cell radiometric TLC-based assay to assess the 17β-HSD3 inhibitory potency of a series of compounds. (bath.ac.uk)
  • Evidence supports that 17-beta hydroxysteroid dehydrogenase 13 (HSD17B13) rs72613567 plays a role in NAFLD development by affecting lipid homeostasis. (lu.se)
  • Full length human recombinant protein of human HSD17B4(NP_000405) produced in HEK293T cell. (origene.com)
  • This protease activity has recently been ascribed to serine metalloprotease(s), including pregnancy-associated plasma protein-A (PAPP-A), which was first detected in human follicular fluid nearly 20 yr ago. (bioone.org)
  • pp. 558-572) demonstrate that recombinant human hyaluronan and proteoglycan link protein 1 (rhHAPLN1) significantly reduces the extended airspaces of the emphysematous alveoli by increasing the levels of TGF-β receptor I and SIRT1/6, as a previously unrecognized mechanism in human alveolar epithelial cells, and consequently mitigates COPD. (molcells.org)
  • 7. Chapman K, Holmes M, Seckl J. 11beta-hydroxysteroid dehydrogenases: Intracellular gate-keepers of tissue glucocorticoid action. (ac.ir)
  • This study we screened 17 bisphenols for inhibiting human 17ß-HSD1 in placental microsomes and rat 17ß-HSD1 in ovarian microsomes and determined 3D- quantitative structure-activity relationship ( 3D-QSAR ) and mode of action. (bvsalud.org)
  • From studies in humans and various other species it is known that trilostane is a competitive inhibitor of 3β-hydroxysteroid-dehydrogenase. (vin.com)
  • Se cree que la depresión post-parto (DPP) causa una variedad de problemas del desarrollo, incluyendo alteraciones funcionales en el eje hypotálamo-hipofisario-adrenal (HHA). (bvsalud.org)
  • Estrone sulfate acts as a long-lived reservoir that can be converted as needed to the more active estradiol (from estrone via 17 beta-hydroxysteroid dehydrogenase). (hmdb.ca)
  • C/EBPbeta was highly expressed both in SC and in OM preadipocytes, but was not regulated by F. Our results provide insight into the genes involved in the regulation of adipocyte differentiation by cortisol, highlighting the depot specifically in human adipose tissue. (ox.ac.uk)
  • That makes the fish a potentially useful analog for cortisol studies, including discovering the purpose and function of 11 beta-HSD3 in human brains, which may be an evolutionary precursor to 11 beta-HSD1. (scienceblog.com)
  • Nuestro objetivo era el investigar la posible asociación entre niveles de cortisol salivar en hijos y depresión materna en tres momentos distintos: 2 días después del parto (N=58), cuatro meses después (N=64) y 36 meses después (N=81). (bvsalud.org)
  • Un test de ANOVA mostró diferencias marginales de efecto moderado en los niveles de cortisol en hijos de madres con DPP comparados con grupo de control. (bvsalud.org)
  • Suponiendo que los hijos de madres con DPP tienen niveles de cortisol ligeramente elevados al nacer, no se observaron estas diferencias en otros momentos. (bvsalud.org)
  • For this purpose, we will integrate clinical phenotype data with multi-omics data of human (genomic, metabolomic, proteomic) and gut origin to clarify connections between dietary patterns/intakes, host genetic factors, circulating metabolites and inflammatory proteins and gut microbiota composition, diversity and functional capacity, and how such connections relate to risk of cardiometabolic disease (CMD). (lu.se)
  • 17β-Hydroxysteroid dehydrogenases (17β-HSDs) are responsible for the pre-receptor reduction/oxidation of steroids at the 17-position into active/inactive hormones, and the 15 known enzymes vary in their substrate specificity, localisation, and directional activity. (bath.ac.uk)
  • In the vast majority of these cases where the change occurs naturally, a human born with female genitalia, will turn male after puberty. (todayifoundout.com)
  • Has 3α-HSDTooltip 3α-hydroxysteroid dehydrogenase and 20α-HSDTooltip 20α-hydroxysteroid dehydrogenase activity in addition to 17β-HSD activity. (wikipedia.org)
  • Older patients with mild defects in 3-beta-hydroxysteroid dehydrogenase activity (late-onset or nonclassic variant) may present with premature pubic hair development, hirsutism, irregular menstrual cycles or primary amenorrhea. (medscape.com)
  • Bisphenol analogues inhibit human and rat 17ß-hydroxysteroid dehydrogenase 1: 3D-quantitative structure-activity relationship (3D-QSAR) and in silico docking analysis. (bvsalud.org)
  • The GR was similarly expressed and not regulated by glucocorticoids in SC and OM human preadipocytes. (ox.ac.uk)
  • This study reports useful information on the limits of the organotypic culture of neonatal mouse testes, which has been regarded as an experimental strategy that can be extended to humans in the clinical setting for the conservation and subsequent re-use of testicular tissue. (elifesciences.org)
  • We developed and validated an LC-MS/MS method to separate Abi and its 7 steroidal metabolites in human serum3 (Fig 2). (aacc.org)
  • Development and validation of a novel LC-MS/MS method for simultaneous determination of abiraterone and its seven steroidal metabolites in human serum: Innovation in separation of diastereoisomers without use of a chiral column. (aacc.org)
  • Diagnosis is by measurement of serum testosterone , luteinizing hormone, and follicle-stimulating hormone and by stimulation tests with human chorionic gonadotropin or gonadotropin-releasing hormone. (msdmanuals.com)
  • To explore the scope of RBPs across eukaryotic evolution, we determined the in vivo RBP repertoire of the yeast Saccharomyces cerevisiae and identified 678 RBPs from yeast and additionally 729 RBPs from human hepatocytic HuH-7 cells. (nature.com)
  • S. cerevisiae ) (BY4741) and of human hepatocytic cells (HuH-7). (nature.com)
  • Here we identify a large set of RBPs that are conserved between yeast and human cells. (nature.com)
  • Methods: The human multiple myeloma SKO-007 cells in logarithm growth phase were selected and randomly divided into control group, LDM group, BZM group, and BZM combined with LDM group. (researchgate.net)
  • Objective: To investigate the induction of tanshinone [1 A (Tan fl A) on the differentiation of human placenta-derived mesenchymal stem cells (hPDMSCs) into cardiomyocytes, and to provide an experimental basis for Tan IT A as a cardiomyocytc differentiation inducer. (researchgate.net)
  • Other recent studies verified the presence of PAPP-A mRNA in granulosa cells of humans, monkeys, cattle, mice, and pigs. (bioone.org)
  • Estrone is one of the three estrogens found in humans. (hmdb.ca)
  • its serum levels are somewhat higher than that of estrone during the reproductive years of the human female. (absoluteastronomy.com)
  • Estrogens , oestrogens , or œstrogens, are a group of compounds named for their importance in the estrous cycle of humans and other animals. (absoluteastronomy.com)
  • Estriol is one of the three main estrogens produced by the human body. (absoluteastronomy.com)
  • En 1999 me incorporé a la Universidad de Navarra, en la cual he desarrollado mi labor investigadora hasta la actualidad. (unav.edu)
  • Dr. Richard Carson's research uses Positron Emission Tomography (PET) as a tool to noninvasively measure a wide range of in vivo physiology in human beings and laboratory animals. (yale.edu)
  • Journal of human hypertension 2000 Dec 14 (12): 819-23. (cdc.gov)
  • Journal of human hypertension 2013 Aug 27 (8): 510-5. (cdc.gov)
  • 6. Wang W, Chen ZJ, Myatt L, Sun K. 11beta-HSD1 in human fetal membranes as a potential therapeutic target for preterm birth. (ac.ir)
  • Description: A competitive ELISA for quantitative measurement of Human 17 β hydroxysteroid dehydrogenase 14(HSD17B14) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (glideruniversity.org)
  • Submicroscopic copy-number imbalances contribute significantly to the genetic etiology of human disease. (ru.nl)
  • Animal studies are typically performed to characterize the tracers, followed by initially complex human studies, typically leading to the development of simplified methods, e.g., using continuous tracer infusion. (yale.edu)
  • While initially the human preparation was used (Modrenal®), trilostane is now officially registered for use in dogs under the name of Vetoryl® in many countries. (vin.com)
  • A critical component in the application to real data is the correction for subject motion, particularly as the resolution of modern machines has improved (better than 3-mm in human brain machines). (yale.edu)
  • The development of the human blood-CSF-brain barrier. (cdc.gov)
  • Short-chain dehydrogenases/reductases (SDRs) constitute a large family of NAD(P)(H)-dependent oxidoreductases, sharing sequence motifs and displaying similar mechanisms. (researchgate.net)