• Many synthetic ionophores are based on crown ethers, cryptands, and calixarenes. (wikipedia.org)
  • Alfonso, Quesada, Biological activity of synthetic ionophores: Ion transporters as prospective drugs? (c19hcq.org)
  • Ionophores selective for cations and anions have found many applications in analysis. (wikipedia.org)
  • Ionophores are chemical compounds that reversibly bind and transport ions through biological membranes in the absence of a protein pore. (wikipedia.org)
  • Ionophores modify the permeability of biological membranes toward certain ions to which they show affinity and selectivity. (wikipedia.org)
  • The term ionophore (from Greek ion carrier or ion bearer) was proposed by Berton Pressman in 1967 when he and his colleagues were investigating the antibiotic mechanisms of valinomycin and nigericin. (wikipedia.org)
  • PBT2 - or 2-(dimethylamino) methyl-5,7-dichloro-8-hydroxyquinoline - is an orally bioavailable hydroxyquinoline analogue ionophore capable of mediating the transfer of metal ions such as zinc across biological membranes. (medscape.com)
  • The current data demonstrate that ionophore activity, inhibition of in vitro metal-mediated Aß reactions, and bloodbrain barrier permeability are indices that predict a potential disease-modifying drug for AD. (nih.gov)
  • The term ionophore (from Greek ion carrier or ion bearer) was proposed by Berton Pressman in 1967 when he and his colleagues were investigating the antibiotic mechanisms of valinomycin and nigericin. (wikipedia.org)
  • Ionophores modify the permeability of biological membranes toward certain ions to which they show affinity and selectivity. (wikipedia.org)
  • This study characterizes the second-generation 8-hydroxy quinoline analog PBT2, which also targets metal-induced aggregation of Aß, but is more effective as a Zn/Cu ionophore and has greater blood-brain barrier permeability. (nih.gov)
  • Structurally, an ionophore contains a hydrophilic center and a hydrophobic portion that interacts with the membrane. (wikipedia.org)
  • Ions are bound to the hydrophilic center and form an ionophore-ion complex. (wikipedia.org)
  • Ionophores are chemical compounds that reversibly bind and transport ions through biological membranes in the absence of a protein pore. (wikipedia.org)
  • A series of alkynyl-containing compounds containing a formazan, 8-hydroxyquinoline, or 1,3-dicarbonyl moeity, as well as propargyl-containing tetrazolium salts were obtained. (aip.org)
  • Several chemical factors affect the ionophore activity. (wikipedia.org)
  • The activity of an ionophore-metal complex depends on its geometric configuration and the coordinating sites and atoms which create coordination environment surrounding the metal center. (wikipedia.org)
  • Many ionophores are lipid-soluble entities that transport ions across the cell membrane. (wikipedia.org)
  • Ionophores catalyze ion transport across hydrophobic membranes, such as liquid polymeric membranes (carrier-based ion selective electrodes) or lipid bilayers found in the living cells or synthetic vesicles (liposomes). (wikipedia.org)
  • However, these ionophores become unable to transport ions under very low temperatures. (wikipedia.org)
  • Ionophores that transport hydrogen ions (H+, i.e. protons) across the cell membrane are called protonophores. (wikipedia.org)
  • Small molecules as well as complexes ionophore-Zn +2 or Cu +2 were found to inhibit the acetylation reaction and induced phenotypic conversion to susceptibility in bacteria harboring the aac(6')-Ib gene. (nih.gov)