How Do HMG-CoA Reductase Inhibitors Work? (rxlist.com)
Statins like Mevacor and Zocor bind with a cholesterol precursor chemical called hydroxymethylglutaryl- coenzyme A reductase or HMG-CoA (statins are also called HMG-CoA inhibitors). (rxlist.com)
In the last few years, statins, HMG-coenzyme A reductase inhibitors, became an important class of drugs, widely used in clinics to treat dyslipidemia. (aspetjournals.org)
RESULTS: Based on the estimated prevalence of lipid-lowering drug use in the Netherlands in 1998 (n = 520 800), we expected 60 cases of idiopathic myopathy due to hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) or fibric acid derivatives (fibrates). (uu.nl)
Beta-hydroxy-beta-methylglutaryl CoA-reductase1
Other names in common use include beta-hydroxy-beta-methylglutaryl coenzyme A reductase, beta-hydroxy-beta-methylglutaryl CoA-reductase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and hydroxymethylglutaryl coenzyme A reductase. (wikipedia.org)
Coenzyme6
Statins act by inhibiting 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and thereby reducing cholesterol synthesis. (nih.gov)
Bucher, N.L.R., Overath, P. and Lynen, F. β-Hydroxy-β-methylglutaryl coenzyme A reductase, cleavage and condensing enzymes in relation to cholesterol formation in rat liver. (enzyme-database.org)
Kawachi, T. and Rudney, H. Solubilization and purification of β-hydroxy-β-methylglutaryl coenzyme A reductase from rat liver. (enzyme-database.org)
Glycerol-3-phosphate is first acylated with acyl-coenzyme A (acyl-CoA) to form lysophosphatidic acid, which is then acylated with another molecule of acyl-CoA to yield phosphatidic acid. (hmdb.ca)
LIPITOR (atorvastatin) is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. (hipaaspace.com)
It has been shown that 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibition blocks hypertrophy, and we report here that "statin" therapy effectively suppresses small G protein activation and blunts hypertrophic growth in vitro and in vivo. (tamu.edu)
1.341
In Archaeal lipids its role is Hydroxymethylglutaryl-CoA reductase (EC 1.1.1.34) . (theseed.org)
Inhibition4
Differences in statin structure and binding characteristics may partially contribute to differences in potency of HMG-CoA reductase inhibition and other pharmacologic properties. (nih.gov)
Replacement of 14 C-acetate by 14 C-mevalonate largely omitted the inhibiting effect of artichoke extracts indicating an inhibition at the level of hydroxymethylglutaryl-CoA-reductase. (aspetjournals.org)
The reduction of HMG-CoA to mevalonate is regulated by feedback inhibition by sterols and non-sterol metabolites derived from mevalonate, including cholesterol. (embl.de)
The treatment with artichoke led to the inhibition of the liver hydroxymethylglutaryl-CoA (HMG-CoA) reductase. (bvsalud.org)
NADP1
Class I HMG-CoA reductases catalyse the NADP-dependent synthesis of mevalonate from 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA). (embl.de)
Cholesterol synthesis1
Unexpectedly, HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase) and G6PD (glucose-6-phosphate dehydrogenase), the rate-limiting enzymes of cholesterol synthesis and the PPP, were identified as direct targets of microRNA-206. (nature.com)
Biosynthesis1
In vertebrates, membrane-bound HMG-CoA reductase is the rate-limiting enzyme in the biosynthesis of cholesterol and other isoprenoids. (embl.de)
1.881
In enzymology, a Hydroxymethylglutaryl-CoA reductase (EC 1.1.1.88) is an enzyme that catalyzes the chemical reaction (R)-mevalonate + CoA + 2 NAD+ ⇌ {\displaystyle \rightleftharpoons } 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+ The 3 substrates of this enzyme are (R)-mevalonate, CoA, and NAD+, whereas its 3 products are 3-hydroxy-3-methylglutaryl-CoA, NADH, and H+. (wikipedia.org)
Mevalonate1
The systematic name of this enzyme class is (R)-mevalonate:NAD+ oxidoreductase (CoA-acylating). (wikipedia.org)
Liver1
HMG-CoA is one step in the process the liver cells use to manufacture cholesterol from simpler molecules. (rxlist.com)
Archaeal1
Class I HMG-CoA reductases consist of an N-terminal membrane domain (lacking in archaeal enzymes), and a C-terminal catalytic region. (embl.de)
MeSH1
Une recherche documentaire a été effectuée dans PubMed de 1980 à 2021 en utilisant diverses combinaisons de termes MeSH comme tabac, diabète, hypertension, dyslipidémie, trouble dépressif majeur, trouble bipolaire, schizophrénie. (bvsalud.org)
Consists1
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. (cancerindex.org)
Artichoke1
These results suggest an indirect modulation of hydroxymethylglutaryl-CoA-reductase activity as the most likely inhibitory mechanism of the artichoke extracts. (aspetjournals.org)
Activity1
In addition, the stimulation of HMGCoA-reductase activity by insulin was efficiently blocked by the extracts, although other insulin-dependent phenomena, such as increased lactate production, were not influenced. (aspetjournals.org)
Shown1
the E-value for the HMG-CoA_red domain shown below is 8.8e-76. (embl.de)
The statin drugs ('statins') potently inhibit hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase by competitively blocking the active site of the enzyme. (nih.gov)
Statins are synthetic drugs developed by pharmaceutical companies that block HMG-CoA reductase thereby lowering the level of cholesterol in the blood. (scientificpsychic.com)
Inhibitor3
The effect of erythromycin on the pharmacokinetics of atorvastatin, an inhibitor of HMG-CoA reductase, was investigated in 12 healthy volunteers. (nih.gov)
1. In the present study, we tested the hypothesis that long-term administration of the hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor simvastatin may regress hypertrophy and the possible effect of simvastatin on angiotensin-converting enzyme (ACE) activity in rats with pressure-overload cardiac hypertrophy. (nih.gov)
Hyperlipidemia: Familial hypercholesterolemia is managed with a hydroxymethylglutaryl coenzyme A (HMG CoA) reductase inhibitor, which is the mainstay of therapy and may be used in combination with other agents. (medscape.com)
Inhibit3
Both medications selectively inhibit hydroxymethylglutaryl-coenzyme A reductase (HMG-CoA reductase), thereby decreasing bile cholesterol supersaturation and lithogenicity. (medscape.com)
Compounds that inhibit HYDROXYMETHYLGLUTARYL COA REDUCTASES . (bvsalud.org)
Cholesterol2
The enzyme hydroxy-methylglutaryl-coenzyme A reductase (HMG-CoA reductase or HMGR) is responsible for making cholesterol in the liver. (scientificpsychic.com)
This causes an increased demand for cholesterol in the liver cells, resulting in the dual effect of increasing transcription and activity of the cholesterol biosynthetic enzyme, HMG-CoA reductase, and increasing the number of hepatic LDL receptors. (clustermed.info)
Enzyme2
In enzymology, a Hydroxymethylglutaryl-CoA reductase (EC 1.1.1.88) is an enzyme that catalyzes the chemical reaction (R)-mevalonate + CoA + 2 NAD+ ⇌ {\displaystyle \rightleftharpoons } 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+ The 3 substrates of this enzyme are (R)-mevalonate, CoA, and NAD+, whereas its 3 products are 3-hydroxy-3-methylglutaryl-CoA, NADH, and H+. (wikipedia.org)
The systematic name of this enzyme class is (R)-mevalonate:NAD+ oxidoreductase (CoA-acylating). (wikipedia.org)