AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation ScienceHealth Care
Hydroxyl RadicalFree Radical ScavengersHydroxidesFree RadicalsThioureaBenzoic AcidDeoxyriboseMannitolMethylurea CompoundsDimethyl SulfoxideHydrogen PeroxideCitrullusCatalaseDeferoxamineSuperoxide DismutaseHypochlorous AcidXanthine OxidaseReactive Oxygen SpeciesFerrous CompoundsBenzoatesReceptors, ScavengerSuperoxidesElectron Spin Resonance SpectroscopyOxidation-ReductionAntioxidantsAntipyrineScavenger Receptors, Class AOxygenCyclic N-OxidesIronCopperScavenger Receptors, Class BDNA DamagePicratesHydroxybenzoatesLipid PeroxidationKineticsProtein FootprintingOxidative StressSpin LabelsNeutrophilsAscorbic AcidTioproninNitrogen OxidesOxidantsCells, CulturedSpin TrappingIron Chelating AgentsFerric CompoundsLipid PeroxidesAnserineAcetylcysteinePeroxidesGentisatesChelating AgentsMalondialdehydeSalicylatesHydroxylationXanthineEdetic AcidReceptors, LipoproteinBiphenyl CompoundsMolecular StructureCarnosineGlutathionePlant ExtractsDeoxyguanosinePulse RadiolysisRats, WistarScavenger Receptors, Class FNitric OxideSulfonic AcidsPhenolsAntigens, CD36Thiobarbituric Acid Reactive Substances2,2'-DipyridylVitamin EPeroxidaseDose-Response Relationship, DrugCell SurvivalSinglet OxygenNitratesRats, Sprague-DawleyDNAPeroxynitrous AcidAllopurinolChromatography, High Pressure LiquidMelatoninReperfusion InjuryButylated HydroxytolueneLuminescent MeasurementsTime FactorsImidazolinesL-Lactate DehydrogenaseReceptors, ImmunologicMolecular Sequence DataPyrogallolMetalloporphyrinsParaquatSulfhydryl Compounds
Singlet oxygenReactiveAnionOxygenSuperoxide radicalsMannitolPotentOxidativeAntioxidantAntioxidantsLipid peroxidationMediatorsCatalaseH2O2BehavesHydrogenSelectivelyPathwaysAcuteCationAerobicImmune systemAnionsProteinsFree radical inducedSubstancesDMSODamageDiseasesMoleculesCellElectronTransitionBiologicalRoleYieldsPowerfulEffectsResults
Singlet oxygen2
  • and the singlet oxygen scavenger, histidine, supporting the idea that the hydroxyl radical (.OH) and singlet oxygen are involved in X/XO-induced relaxation of ileum. (usask.ca)
  • Mannitol, DMTU, and histidine partially inhibited the DHF/FeCl3-ADP-induced contraction, supporting the idea that hydroxyl radicals and singlet oxygen are involved in DHF/FeCl3-ADP-induced contraction of ileum. (usask.ca)
Reactive13
  • Free radicals are molecules with irregular number of electrons, which makes them very reactive and unstable. (scca-enterprises.com)
  • Additionally, we perform trapping experiments to elucidate the mechanism behind the magnetic field induced catalytic degradation of organic pollutants by using scavengers for each of the reactive species. (arxiv.org)
  • Our results indicate that hydroxyl and superoxide radicals are the main reactive species in the magnetoelectrically induced catalytic degradation of organic compounds. (arxiv.org)
  • respiratory burst (the rapid release of Reactions of oxygen radicals with Mitochondrial oxidative phosphor- reactive oxygen species from cells) cel ular components can deplete an- ylation is a major source of oxy- that involves nicotinamide adenine tioxidants, can cause direct oxidative gen radicals of endogenous origin. (who.int)
  • Metabolism of glutathione peroxidase, can further inflammation, and - along with oth- many exogenous agents through cy- convert these reactive species to er radical species - play key roles tochrome P450-mediated reactions wate r (Benzie, 2000) . (who.int)
  • Aftereffect of Reactive Air Scavengers for the Flavonoids-Induced DNA Damage in Permeabilized Lymphocytes To be able to concur that the flavonoid-induced lymphocyte DNA damage outcomes from ROS era, the effect continues to be studied by us of some scavengers of ROS on comet tail length formation by plant polyphenols [5]. (pkc-inhibitor.com)
  • Desk 2 Aftereffect of scavengers of reactive air varieties on flavonoid-induced mobile DNA damage in permeabilized cells. (pkc-inhibitor.com)
  • Iodine will protect the testes and testosterone from free radicals and oxidative stress, however, when there too way too much iodine in the testes, without enough cofactors, it can actually increase reactive oxygen species (free radicals) and lower testosterone via down-regulation of varies enzymes. (men-elite.com)
  • ROS include superoxide, peroxide, hydroxyl radicals and reactive nitrogen species. (biomedcentral.com)
  • Metronidazole, being electron-affinic, can accept an electron from neutral free radical centres to generate a reactive cation that binds to an anion such as hydroxyl (OH-), causing a permanent lesion. (who.int)
  • Sigma Chemical Company, Germany, un- radical centres to generate a reactive cation less otherwise mentioned. (who.int)
  • 2011). Larger quantities of free radicals (reactive disease, diabetes, chronic respiratory diseases, and oxygen species [ROS]) present in the cigarette cancer (WHO, 2012). (bvsalud.org)
  • In addition, reactive oxygen species generated by damage to both muscle and kidney epithelial cells promote the oxidation of ferrous oxide to ferric oxide (Fe+3), thus generating a hydroxyl radical. (medscape.com)
Anion2
  • EPR spectroscopy measurements demonstrate that salinity (NaCl) triggers the accumulation of root apoplastic ascorbyl radicals in an A9C-dependent manner, confirming that l-ascorbate leaks through anion channels under depolarization. (deepdyve.com)
  • The FHA cycle is active inside the cell, detoxifying superoxide anion radicals (O2·-), which are mainly generated as a result of so-called 'electron leakage' to triplet oxygen (O2) in photosynthetic, mitochondrial, peroxisomal, and probably other electron transport chains (Ozyigit et al. (deepdyve.com)
Oxygen12
  • Oxygen radical scavengers selectively inhibit interleukin 8 production in human whole blood. (jci.org)
  • Other oxygen radical scavengers that have been shown to inhibit OH. (jci.org)
  • The unsuccessful phagocytosis of long fibers of asbestos coupled with generation of oxygen free radicals might explain the increased pathogenic potential of long fibers in asbestos-associated diseases of the respiratory tract. (cdc.gov)
  • One of the most relevant central dogmas of the aging theories was the free radical theory of aging (FRTA), claiming that oxygen free radicals are harmful by-products of the aerobic life and as such, are responsible for aging and numerous diseases. (antiaging-systems.com)
  • I have analyzed the contradictory items of the FRTA, outlining a new, comprehensive interpretation of the possible biological role of oxygen free radicals in the living state, cell differentiation and aging, called the membrane hypothesis of aging (MHA). (antiaging-systems.com)
  • The MHA attributes a role to the constant flux of oxygen free radicals in the living state, i.e., offers a much wider basis for the interpretation of the free radical function. (antiaging-systems.com)
  • Also, aging has been proposed to be a result of continuous reactions of the cell components with oxygen free radicals throughout the life span (Reznick et al . (scialert.net)
  • 1992). These oxygen free radicals can modify DNA, proteins and membrane lipids, leading to cellular degeneration (Olanow, 1992). (scialert.net)
  • These results suggest that oxygen radicals play a role in the motility of ileum. (usask.ca)
  • to superoxide or that "autoxidize", and when coupled with catalase Oxygen radicals clearly contribute to probably through reactions catalysed within peroxisomes or with cytosolic genomic instability, are produced by by transition metals. (who.int)
  • Radiosensitizers are chemical agents that have the potential to increase the lethal effect of radicals induced during irradiation [1-6].The extent of radiation damage to cells is dependent on the amount of oxygen available to the cell [1,2,7,8]. (who.int)
  • Under aerobic conditions, there is enough oxygen to react with all the free radicals and addition of metronidazole, or any other sensitizers, yields no further benefit. (who.int)
Superoxide radicals1
  • There are several Types of free radical molecules, the superoxide radicals, hydroxyl radicals, proxy radicals and alkoxyl radicals. (scca-enterprises.com)
Mannitol2
Potent2
Oxidative4
  • Consumption of fruits and vegetables containing high amounts of antioxidative nutraceuticals have been associated with the balance of the free radicals/antioxidants status, which helps to minimize the oxidative stress in the body and to reduce the risk of diseases (Kaur and Kapoor, 2001). (scialert.net)
  • 10. Saha D, Tamrakar A. Xenobiotics, Oxidative Stress, Free Radicals Vs. Antioxidants: Dance Of Death to Heaven's Life. (rjptonline.org)
  • This review will address these aspects of the chemical biology of this multifaceted free radical and explore the beneficial effect of NO against oxidative stress. (researchgate.net)
  • The results suggest that the hydroxyl radical scavenger H 2 effectively reduces oxidative stress in patients with this condition. (biomedcentral.com)
Antioxidant7
  • Citrulline is a nonessential amino acid that is reported to be an efficient hydroxyl radical scavenger and is a strong antioxidant [ 11 ]. (hindawi.com)
  • By comparison, antioxidant enzymes may convert free radicals into other less dangerous forms and inert and valuable compounds without getting free radicals themselves. (scca-enterprises.com)
  • Minerals like selenium and zinc are not antioxidants themselves, but significant integral components of antioxidant enzymes, so they also play an essential role in free radical defence. (scca-enterprises.com)
  • These results indicate that the administration of T. chebula acts as a free radical scavenger with potential antioxidant effects in erythrocytes of aged rats. (scialert.net)
  • Debated as equal to vitamin E as a chain-breaking antioxidant against peroxyl radical. (healyourselfathome.com)
  • This theory postulates that aging and its related diseases are the consequence of free-radical induced damage to cellular macromolecules and the inability to counterbalance these changes by endogenous antioxidant defenses [1]. (symbiosisonlinepublishing.com)
  • Green tea acts as a powerful antioxidant to protect hair and skin from environmental free radical damage, while also protecting hair and skin from UV radiation. (alimarlabs.com)
Antioxidants6
Lipid peroxidation2
Mediators1
  • Both the heme moieties and the free iron-driven hydroxyl radicals may be critical mediators of the direct tubule toxicity, which mainly occurs in the proximal tubule. (medscape.com)
Catalase2
H2O22
  • H2O2, subsequently, leads towards the era of hydroxyl radicals through an activity that is reliant on the oxidation of decreased changeover metals [40]. (pkc-inhibitor.com)
  • Intracellular Era of H2O2/ROS by Flavonoids It's been reported that polyphenols can auto-oxidize under circumstances resulting in era of H2O2 radicals and quinone, that may enter mobile nuclei possibly, leading to harm to many substances [42] thus. (pkc-inhibitor.com)
Behaves1
  • The molecule is a steroid derivative that behaves as a hydroxyl radical scavenger and is used for the treatment of skin blemishes such as blocked pores and acne. (wikipedia.org)
Hydrogen6
  • Improved brain MRI indices in the acute brain stem infarct sites treated with hydroxyl radical scavengers, Edaravone and hydrogen, as compared to Edaravone alone. (nih.gov)
  • We treated brainstem infarction patients in acute stage with hydroxyl radical scavengers (Edaravone and hydrogen) by intravenous administration and evaluated the effects of the treatment by a serial observation and analysis of these MRI indices. (nih.gov)
  • These findings may imply the need for more frequent daily administration of hydroxyl scavenger, or possible additional hydrogen effects on scavenger mechanisms. (nih.gov)
  • So, CO2 also from any CO presence which leads to Zinc Hydrogen Carbonate (see discussion in this thesis https://digitalcommons.usu.edu/cgi/viewcontent.cgi?referer=h... ) and yes, eventually a carbonate (actually, per Wikipedia on Zinc carbonate, a "basic zinc carbonate (Zn5(CO3)2(OH)6)", see https://en.wikipedia.org/wiki/Zinc_carbonate ). (sciencemadness.org)
  • It neutralizes and breaks down hydrogen peroxide to form water, preventing the formation of a hydroxyl radical. (men-elite.com)
  • Recently, molecular hydrogen (H 2 ) was demonstrated to be a selective scavenger for the hydroxyl radical. (biomedcentral.com)
Selectively1
  • Metronidazole selectively radiosensitizes of metronidazole (in a range of therapeutic hypoxic cells without influencing the ra- concentrations) on PMN-generated free diation response of normal well-oxygenated radicals during phagocytosis activity in cells [ 5,7-9 ]. (who.int)
Pathways1
  • Microsomes have the potential to oxidize alcohols by two pathways, one dependent on hydroxyl radicals (·OH) and the other dependent on cytochrome P-450 in which ·OH does not seem to be involved. (mssm.edu)
Acute2
  • Administration of hydroxyl radical scavengers in acute stage of brainstem infarction improved MRI indices against the natural course. (nih.gov)
  • Involvement of oxygenderived free radicals in l-arginine-induced acute pancreatitis. (endocrinologiaveterinaria.com)
Cation1
  • elevation, while cation channel blockers, free radical scavengers, low extracellular [Ca2+], transition metal chelators, and removal of the cell wall inhibit this reaction. (deepdyve.com)
Aerobic1
  • This theory suggested that free radicals produced during aerobic respiration have deleterious effects on cell components and connective tissues, causing cumulative damage over time that ultimately results in aging and death. (symbiosisonlinepublishing.com)
Immune system1
Anions1
  • Through the experiment presented right here, we are able to safely infer that ROS can be primarily mixed up in cellular harm due to flavonoids which the primary ROS mixed up in process will be the superoxide anions as well as the hydroxyl radicals. (pkc-inhibitor.com)
Proteins2
  • The compatible solutes can also act as free-radical scavengers and directly stabilize membranes and/or proteins [ 10 ]. (hindawi.com)
  • Free radicals can cause damage in structural and metabolic components like lipids, proteins, enzymes, carbohydrates and DNA in cells and tissues. (hindawi.com)
Free radical induced1
  • The alterations are due in part to free radical induced molecular damage, and also to the 'residual heat' formed during each depolarization of the resting potential. (antiaging-systems.com)
Substances1
DMSO2
  • scavenger dimethyl sulfoxide (DMSO) was found to dose-dependently inhibit interleukin 8 (IL-8) production in LPS-stimulated human whole blood. (jci.org)
  • DMSO is probably the most powerful free radical scavenger-at least for hydroxyl groups-and a well-tested carrier for others. (1200artists.com)
Damage1
Diseases1
Molecules2
  • They work by devoting their electrons to free radical molecules, restoring equilibrium to them. (scca-enterprises.com)
  • Free radicals can be defined as molecules or molecular fragments containing one or more unpaired electrons in atomic or molecular orbitals formed during a variety of biochemical reactions and cellular functions. (hindawi.com)
Cell1
Electron1
  • In the process, the electron equilibrium of the stable molecule is disturbed and the stable molecule becomes a free radical itself. (scca-enterprises.com)
Transition1
  • Sequestration in many of the processes identified can also result in the release of ox- of transition metals, principally iron above as necessary for conversion ygen radicals ( Hrycay and Bandiera, and copper, in their oxidized forms of normal cel s into cancer cel s. (who.int)
Biological2
  • Digalloyl-resveratrol (di-GA) is a synthetic compound aimed to combine the biological effects of the plant polyhydroxy phenols gallic acid and resveratrol, which are both radical scavengers and cyclooxygenase inhibitors exhibiting anticancer activity. (nature.com)
  • has provided strong biological evidence that free radicals are involved in the aging process. (symbiosisonlinepublishing.com)
Role2
  • Scymnol's role in quenching free radicals may play a role in inhibiting acne. (wikipedia.org)
  • Our collaborative article titled " The dominant role of the peroxymonosulfate radical for removing contaminants in a Fenton process with metabisulfite " has been accepted for publication in Environmental Chemistry Letter . (polito.it)
Yields6
  • Meesungnoen, J., Benrahmoune, M., Filali-Mouhim, A., Mankhetkorn, S. and Jay-Gerin, J-P. Monte Carlo Calculation of the Primary Radical and Molecular Yields of Liquid Water Radiolysis in the Linear Energy Transfer Range 0.3-6.5 keV/μm: Application to 137 Cs Gamma Rays. (bioone.org)
  • Monte Carlo simulations of the radiolysis of neutral liquid water and 0.4 M H 2 SO 4 aqueous solutions at ambient temperature are used to calculate the variations of the primary radical and molecular yields (at 10 -6 s) as a function of linear energy transfer (LET) in the range ∼0.3 to 6.5 keV/μm. (bioone.org)
  • After normalization of our computed yields relative to the standard radical and molecular yields for 60 Co γ radiation (average LET ∼0.3 keV/μm), we obtain empirical relationships of the primary radiolytic yields as a function of LET over the LET range studied. (bioone.org)
  • Such relationships are of practical interest since they allow us to predict a priori values of the radical and molecular yields for any radiation from the knowledge of the average LET of this radiation only. (bioone.org)
  • The uncertainty range on those primary radical and molecular yields are also determined knowing the experimental error (∼2%) for the measured G (Fe 3 ) value. (bioone.org)
  • Venous blood samples were obtained from gen to react with all the free radicals and apparently healthy volunteers aged 30-55 addition of metronidazole, or any other years using vials with heparin as the antico- sensitizers, yields no further benefit. (who.int)
Powerful1
Effects1
  • Although the MHA implicitly contradicts the central dogma of the FRTA, it does not deny the possibility of damaging side effects of these radicals. (antiaging-systems.com)
Results1
  • PMN results in the production of super- cer cells are known to be relatively resistant oxide radicals [ 7,8 ]. (who.int)