• Hydroxocobalamin converts cyanide to the much less toxic cyanocobalamin. (wikipedia.org)
  • Hydroxocobalamin shares the cobalamin molecular structure with cyanocobalamin. (drugs.com)
  • Consider alternative therapies, if available, in patients with known anaphylactic reactions to hydroxocobalamin or cyanocobalamin. (nih.gov)
  • Two common forms include cyanocobalamin and hydroxocobalamin. (medicalnewstoday.com)
  • Hydroxocobalamin is equally as effective as cyanocobalamin, and they share the cobalamin molecular structure. (nih.gov)
  • The specific upper ligand present defines the form of B12: methylcobalamin, adenosylcobalamin, hydroxocobalamin, or cyanocobalamin. (colorwithleo.com)
  • Hydroxocobalamin contains cobalt ion, which is able to bind to cyanide with greater affinity than cytochrome oxidase to form nontoxic cyanocobalamin (vitamin B-12), which is excreted in urine. (medscape.com)
  • Hydroxocobalamin is a natural transport form of B-12 in the blood that is converted into the coenzyme forms of methylcobalamin or adenosylcobalamin inside the cell. (sourcenaturals.com)
  • Methylcobalamin or hydroxocobalamin the best form to get. (pernicious-anaemia-society.org)
  • In this video, Dr. Russell Jaffe discusses the differences between adenosylcobalamin B12 and hydroxocobalamin B12, which is preferred, and why. (perque.com)
  • Hydroxocobalamin is the natural form of vitamin B12 and a member of the cobalamin family of compounds. (wikipedia.org)
  • In a newly diagnosed vitamin B12-deficient patient, normally defined as when serum levels are less than 200 pg/ml, daily IM injections of hydroxocobalamin up to 1,000 μg (1 mg) per day are given to replenish the body's depleted cobalamin stores. (wikipedia.org)
  • Although the recommended treatment for acute cyanide toxicity is hydroxocobalamin (injectable vitamin B12) ( 4 ), persons who went to health care facilities were managed on intravenous antibiotics and oral rehydration salts. (cdc.gov)
  • Hydroxocobalamin (HCO, vitamin B-12) is the first-line therapy for cyanide toxicity. (medscape.com)
  • Hydroxocobalamin may be used in combination with sodium thiosulfate for treatment of acute cyanide toxicity. (medscape.com)
  • Low-dose hydroxocobalamin in combination with sodium thiosulfate has been used successfully to prevent cyanide toxicity in patients receiving prolonged sodium nitroprusside infusions. (medscape.com)
  • Hydroxocobalamin acetate occurs as odorless, dark-red orthorhombic crystals. (wikipedia.org)
  • Each mL contains: Hydroxocobalamin Acetate equivalent to 1000 mcg Hydroxocobalamin, Sodium Acetate Anhydrous 0.2 mg, Glacial Acetic Acid 0.442 mg, Sodium Chloride 8.2 mg, with Methylparaben 1.5 mg and Propylparaben 0.2 mg as preservatives, in Water for Injection q.s. (drugs.com)
  • CYANOKIT (hydroxocobalamin for injection) for intravenous infusion consists of 1 vial, containing 5 g lyophilized hydroxocobalamin dark red crystalline powder for injection. (nih.gov)
  • To compare the efficacy of methylene blue with combination therapy with hydroxocobalamin in patients experiencing vasoplegic syndrome after cardiac surgery. (nih.gov)
  • Patients who received methylene blue with or without hydroxocobalamin for refractory vasoplegic syndrome rescue therapy. (nih.gov)
  • Overall, 28 doses were administered in 14 patients in the monotherapy group and 17 doses (10 methylene blue, 7 hydroxocobalamin) were administered in 6 patients in the combination therapy group. (nih.gov)
  • Source Naturals Hydroxocobalamin B-12 supports brain health and energy levels with a meaningful dose of B-12 in a convenient lozenge form. (sourcenaturals.com)
  • The literature data on the acute toxicity profile of hydroxocobalamin show it is generally regarded as safe with local and systemic exposure. (wikipedia.org)
  • The ability of hydroxocobalamin to rapidly scavenge and detoxify cyanide by chelation has resulted in several acute animal and human studies using systemic hydroxocobalamin doses at suprapharmacological doses as high as 140 mg/kg to support its use as an intravenous (IV) treatment for cyanide exposure. (wikipedia.org)
  • The US FDA at the end of 2006 approved the use hydroxocobalamin as an injection for the treatment of cyanide poisoning. (wikipedia.org)
  • Hydroxocobalamin injection is a sterile solution of hydroxocobalamin for intramuscular administration. (drugs.com)
  • Fifty percent of the administered dose of hydroxocobalamin disappears from the injection site in 2.5 hours. (drugs.com)
  • Within 72 hours after injection of 500 to 1000 mcg of hydroxocobalamin, 16 to 66 percent of the injected dose may appear in the urine. (drugs.com)
  • The disadvantages of hydroxocobalamin are that a large dose is required for antidotal efficacy and that it is available in the United States only in very dilute solutions. (medscape.com)
  • A. Identify the 250 ml glass vial containing 5 g of lyophilized hydroxocobalamin. (paramedickardex.com)
  • Hydroxocobalamin, also known as vitamin B12a and hydroxycobalamin, is a vitamin found in food and used as a dietary supplement. (wikipedia.org)
  • Hydroxocobalamin is a man-made injectable form of vitamin B12 used to treat low levels (deficiency) of this vitamin. (iwantgreatcare.org)
  • Standard therapy for treatment of vitamin B12 deficiency has been intramuscular (IM) or intravenous (IV) injections of hydroxocobalamin (OHCbl), since the majority of cases are due to malabsorption by the enteral route (gut). (wikipedia.org)
  • Hydroxocobalamin is bound to plasma proteins and stored in the liver. (drugs.com)
  • Hydroxocobalamin is extensively bound to specific plasma proteins (transcobalamin). (foxpharma.co.uk)
  • Methyl-Life's® B12 Hydroxocobalamin Tablets (bottle of 90 servings) are some of the most cost-effective versions of Hydroxocobalamin available over-the-counter today. (methyl-life.com)
  • Hydroxocobalamin is used in the treatment and prevention of Vitamin B12 deficiency . (foxpharma.co.uk)
  • Hydroxocobalamin, or another form of vitamin B12, are required for the body to make DNA. (wikipedia.org)
  • Methyl-Life's® Hydroxocobalamin contains a rarer (but biologically active) form of B12. (methyl-life.com)
  • The small, chewable form of Methyl-Life's® Hydroxocobalamin tablet provides for maximum B12 absorption sublingually through the mucous membranes in the mouth. (methyl-life.com)
  • Previous work published in the 1970's and research conducted in the VCURES lab group has indicated that a reduced form of vitamin B12, hydroxocobalamin (B12r), can potentially serve as an antidote for CO poisoning by converting CO bound to hemoglobin to carbon dioxide (CO2) and mitigating the deleterious neurological effects of CO poisoning. (vcu.edu)
  • Dr. Russell Jaffe (DrJ) discusses the hydroxocobalamin form of vitamin B12 and whether it might be problematic in patients with nitric oxide deficiency. (perque.com)
  • sodium thiosulfate can also be administered with hydroxocobalamin in severe cases. (medscape.com)
  • treatment should begin immediately with hydroxocobalamin (preferred) or sodium nitrite plus sodium thiosulfate . (medscape.com)
  • The use of hydroxocobalamin became first line due to its low adverse risk profile, rapid onset of action, and ease of use in the prehospital setting. (wikipedia.org)
  • Hydroxocobalamin has few adverse effects and is tolerated by critically ill patients. (medscape.com)
  • Hydroxocobalamin appears as dark red orthorhombic needles or as an amorphous or crystalline red powder. (drugs.com)
  • Think of hydroxocobalamin as a scavenger that can "mop up" the peroxynitrites in the body and convert them back into methionine. (methyl-life.com)
  • Previous administration of hydroxocobalamin (300 mg/kg, i.p.) or glibenclamide (40 mg/kg, p.o.) attenuated PTD-HS antiallodynic activity. (iasp-pain.org)
  • 1. Make Base Hospital contact for hydroxocobalamin order and possible burn center destination. (paramedickardex.com)
  • The results are presented of a double-blind therapeutic trial of hydroxocobalamin and riboflavine in Nigerian patients suffering from a degenerative neuropathy. (bmj.com)
  • 2. Increases in blood pressure may be observed and expected following hydroxocobalamin infusion. (paramedickardex.com)