• This enzyme catalyzes the hydrolysis of a terminal beta-linked galactose residue from ganglioside substrates and other glycoconjugates. (thermofisher.com)
  • β-galactosidase , also called lactase , beta-gal or β-gal , is a glycoside hydrolase enzyme that catalyzes the hydrolysis of β-galactosides into monosaccharides through the breaking of a glycosidic bond . (wikidoc.org)
  • [10] The active site of β-galactosidase catalyzes the hydrolysis of its disaccharide substrate via "shallow" (nonproductive site) and "deep" (productive site) binding. (wikidoc.org)
  • Cycloastragenol can also be derived from Astragaloside IV via hydrolysis action. (phcoker.com)
  • While both cycloastragenol and astragaloside IV are derived from astragalus herb, cycloastragenol can also be obtained from astragaloside IV through hydrolysis process. (phcoker.com)
  • Ang cycloastragenol ay maaari ding makuha mula sa Astragaloside IV sa pamamagitan ng aksyon na hydrolysis. (phcoker.com)
  • Gangliosides are active antioxidants, lipid peroxidation inhibitors. (doclecture.net)
  • Lipidomics can reveal the mechanism of lipid oxidative hydrolysis at the level of lipid molecules, which will help to develop novel techniques to control the oxidative hydrolysis of lipids. (creative-proteomics.com)
  • The mutation disrupts the activity of the enzyme, which results in the build-up of the molecule GM2 gangliosideM2within cells, leading to toxicity. (wikipedia.org)
  • Ceramides (N-acylsphingosine) are one of the hydrolysis byproducts of sphingomyelin by the enzyme sphingomyelinase (sphingomyelin phosphorylcholine phosphohydrolase E.C.3.1.4.12) which has been identified in the subcellular fractions of human epidermis (PMID 25935) and many other tissues. (foodb.ca)
  • Normal products of all 3 genes are required for normal catabolism of the G M2 ganglioside substrate. (medscape.com)
  • Crystallographic Structure of Human beta-Hexosaminidase A: Interpretation of Tay-Sachs Mutations and Loss of GM2 GangliosideM2Hydrolysis. (tu-muenchen.de)
  • 2015). Determining the composition of protein, carbohydrate, moisture, fat, and ash in raw EBN is essential for various purposes, including the hydrolysis process for the extraction of its valuable components. (researchgate.net)
  • Serum paraoxonase, arylesterase and lactonase activities were determined by the measuring initial rate of substrate (paraoxon, phenylacetate and dihydrocoumarin) hydrolysis.Streptozotocin-induced diabetes mellitus caused a significant decrease whereas lipoic acid treatment caused a significant increase in serum PON1 and PON3 protein levels and paraoxonase, arylesterase and lactonase activities. (scite.ai)
  • Various reactions occur in lipids during food processing, such as thermal oxidation, hydrolysis, thermal polymerization and Merad reaction. (creative-proteomics.com)
  • Exposure of cells to either octanoic acid (C8:0), a C8-ceramide hydrolysis product, or oleic acid (C18:1) did not affect MDR1 expression. (sphingolipidclub.com)
  • Hydrolyzed Fumonisin B2 (HFB2) is a hydrolysis product of fumonisins (HF), which retains biological activity. (medchemexpress.com)
  • Hydrolyzed Fumonisin B1 (Aminopentol) is the backbone and main hydrolysis product of the mycotoxin Fumonisin B1 (HY-N6719). (medchemexpress.com)
  • Hydrolysis of G M2 ganglioside requires a normal G M2 ganglioside-G M2 activator-Hex A complex. (medscape.com)
  • In the case of GM2 gangliosidosis, an activator protein is deficient, which leads to the accumulation of ganglioside GM2 and related glycolipids in neuronal cells. (medscape.com)
  • Clinical symptoms of progressive neurodegeneration and developmental delay are caused by accumulation of GM2 gangliosideM2in lysosomes, forming membranous cytoplasmic bodies (MCBs) in neuronal cells. (medscape.com)
  • Impaired hydrolysis catalysed by ß-hexosaminidase A (HexA) leads to the accumulation of GM2 gangliosideM2in neuronal lysosomes. (bvsalud.org)
  • Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta-galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A (EC 3.2.1.22). (nih.gov)
  • Hydrolysis of GM2 gangliosideM2requires a normal GM2 ganglioside-GM2 activator-Hex A complex. (medscape.com)
  • 4. Activator protein required for the enzymatic hydrolysis of cerebroside sulfate. (nih.gov)
  • Deficiency in urine of patients affected with cerebroside sulfatase activator deficiency and identity with activators for the enzymatic hydrolysis of GM1 gangliosideM1and globotriaosylceramide. (nih.gov)
  • 5. A triple-binding-domain model explains the specificity of the interaction of a sphingolipid activator protein (SAP-1) with sulphatide, GM1-ganglioside and globotriaosylceramide. (nih.gov)
  • 14. Identity of the activator proteins for the enzymatic hydrolysis of sulfatide, ganglioside GM1, and globotriaosylceramide. (nih.gov)
  • Lysosomal beta-hexosaminidase A (Hex A) is essential for the degradation of GM2 gangliosides in the central and peripheral nervous system. (nih.gov)
  • The influence of fly ash on hydrolysis, degradation and adsorption of methyl parathion in aqueous soil suspensions. (cdc.gov)
  • Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). (nih.gov)
  • 10. Kinetics of ganglioside transfer between liposomal and synaptosomal membranes. (nih.gov)
  • 12. Interaction between glycophorin and ganglioside GM1 on liposomal membranes. (nih.gov)
  • Kinetics of PTEN-mediated PI (3, 4, 5) P3 hydrolysis on solid supported membranes. (upenn.edu)
  • 20. Influence of gangliosides GM1 and GD1a on structural and thermotropic properties of sonicated small 1,2-dipalmitoyl-L-alpha-phosphatidylcholine vesicles. (nih.gov)
  • Progressive damage caused by the buildup of GM2 gangliosideM2leads to the destruction of these cells, which causes the signs and symptoms of Tay-Sachs disease. (medlineplus.gov)
  • AF102B and AF150(S) are partial agonists, but AF150, AF151, and AF151 (S) are full agonists in stimulating phosphoinositides hydrolysis or arachidonic acid release in these cells. (inrae.fr)
  • Significantly, the relatively scarce ganglioside 9-O-acetyl GD3 was found to comprise approximately 23% of the total ganglioside content of normal rainbow trout liver. (nih.gov)
  • 3. Evidence for the presence of a ganglioside transfer protein in brain. (nih.gov)
  • Morphological changes observed in a somatic neurohybrid clonal cell line SB21B1 are accompanied by a 9 fold increase in the expression of mRNA sequences for tubulin 14 days following the addition of various brain gangliosides to the culture medium. (inrae.fr)
  • Only the alpha-subunit active site can hydrolyze GM2 gangliosides due to a flexible loop structure that is removed post-translationally from beta, and to the presence of alphaAsn423 and alphaArg424. (nih.gov)
  • Upon removal of gangliosides, the expression of the tubulin message is restored to near basal levels. (inrae.fr)