• AKAP13 is a member of a group of four RhoGEF proteins known to be activated by G protein coupled receptors coupled to the G12 and G13 heterotrimeric G proteins. (wikipedia.org)
  • In this active, GTP-bound conformation, Rho can bind to and activate specific effector proteins and enzymes to regulate cellular functions. (wikipedia.org)
  • A-kinase anchor protein 13 is a protein that in humans, is encoded by the AKAP13 gene. (wikipedia.org)
  • A-kinase anchor protein 13/Rho guanine nucleotide exchange factor 13 is guanine nucleotide exchange factor (GEF) for the RhoA small GTPase protein. (wikipedia.org)
  • The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins that have the common function of binding to the regulatory subunit of protein kinase A (PKA), thus confining the holoenzyme to discrete locations within the cell. (wikipedia.org)
  • Therefore, these isoforms may function as scaffolding proteins to coordinate Rho signaling and protein kinase A signaling. (wikipedia.org)
  • When dissociated from the heterotrimeric complex these subunits interact with a variety of second messenger systems. (jefferson.edu)
  • Rho is a small GTPase protein that is inactive when bound to the guanine nucleotide GDP. (wikipedia.org)
  • Hydrolysis of GTP by the inherent GTPase activity of the subunit causes it to revert to its inactive (heterotrimeric) form. (jefferson.edu)