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  • PMID
  • This family describes trehalose-6-phosphate hydrolase, product of the treC (or treA) gene, which is often found together with a trehalose uptake transporter and a trehalose operon repressor [ PMID: 8083158 ]. (ebi.ac.uk)
  • and are inactivated by bleomycin hydrolase, which hydrolyses the carboxyamide bond of the beta-aminoalanine moiety [ PMID: 4122312 ]. (ebi.ac.uk)
  • Bleomycin hydrolase acts mainly as an aminopeptidase on short peptides, but the rat orthologue has been shown to cleave amyloid beta-peptides, acting as an endopeptidase or a carboxypeptidase, as well as an aminopeptidase [ PMID: 16472072 ]. (ebi.ac.uk)
  • Bleomycin hydrolase is intracellular and exists naturally as a homohexamer, with all the active site in the central cavity of the barrel [ PMID: 7638617 ]. (ebi.ac.uk)
  • This domain is also found in lysophospholipases such as cytosolic phospholipase A2 (which has additional structural features) [ PMID: 10319815 ], and in patatin proteins, which are plant glycoproteins that act as non-specific lipid acyl hydrolases [ PMID: 12779324 ]. (ebi.ac.uk)
  • Fatty-acid amide hydrolase 1 (FAAH) is a mammalian integral membrane enzyme that degrades the fatty acid amide family of endogenous signalling lipids, which includes the endogenous cannabinoid anandamide and the sleep-inducing substance oleamide [ PMID: 15952893 ]. (ebi.ac.uk)
  • glycoside hydrolases
  • Glycoside hydrolases and glycosyltransferases: families and functional modules. (nih.gov)
  • The past year has witnessed the expected increase in the number of solved structures of glycoside hydrolases and glycosyltransferases, and their constitutive modules. (nih.gov)
  • These structures show that, while glycoside hydrolases display an extraordinary variety of folds, glycosyltransferases and carbohydrate-binding modules appear to belong to a much smaller number of folding families. (nih.gov)
  • catalyzes
  • An iron(II) dependent formamide hydrolase catalyzes the second step in the archaeal biosynthetic pathway to riboflavin and 7,8-didemethyl-8-hydroxy-5-deazariboflavin. (ebi.ac.uk)
  • activity
  • Polysaccharide hydrolase activity was assayed in a group of 28 selected Rhizopus strains. (springer.com)
  • The activity of some pneumococcal murein hydrolases (MHs) appears to be constrained by the membrane lipoteichoic acid (LTA) at the posttranslational level. (asmscience.org)
  • domain
  • This entry represents the SGNH hydrolase-type esterase domain, which has a similar fold to flavoproteins, namely a three-layer alpha/beta/alpha structure, where the beta-sheets are composed of five parallel strands. (ebi.ac.uk)
  • type
  • 1) A hydrolase which binds other hydrolase molecules of its type may have gotten eliminated thru natural selection if it did not impart any evolutionary advantage to the organism. (biology-online.org)