• Among different types of scaffolds, polymeric hydrogel scaffolds have received considerable attention because of their biocompatibility and structural similarity to native tissues. (mdpi.com)
  • However, hydrogel scaffolds have several limitations, such as weak mechanical property and a lack of bioactive property. (mdpi.com)
  • Microvascular endothelial cells cultured in three-dimensional hydrogel scaffolds form a network of microvessel structures when implanted subcutaneously in mice, inosculate with host vessels, and over time remodel into large ectatic vascular structures resembling hemangiomas. (cdc.gov)
  • Hydrogels are 1-3 solid/fluid composites. (imechanica.org)
  • Qiao K, Zheng YD, Guo SL, Tan J, Chen XH, Li J, Xu D, Wang J. Hydrophilic nanofiber of bacterial cellulose guided the changes in the micro-structure and mechanical properties of nf-BC/PVA composites hydrogels. (exponent.com)
  • Phys.org)-Nanoengineers at the University of California, San Diego have developed a novel technology that can fabricate, in mere seconds, microscale three dimensional (3D) structures out of soft, biocompatible hydrogels. (phys.org)
  • 3D Structuring of biocompatible hydrogels by means of 2-photon polymerization [Diploma Thesis, Technische Universität Wien]. (tuwien.at)
  • Particularly, microstructures inside microfluidic gadgets facilitate 3D cell tradition by guiding hydrogel precursors containing cells. (ncbcs.org)
  • This control in the spatial composition and microstructure is achieved with a microfluidic Hele-Shaw cell that possesses traps with varying trapping strengths to selectively immobilize different types of drops. (rsc.org)
  • Microstructures composed of optimised hydrogels were photopolymerised within microfluidic channels, and their application as photo-controlled valves demonstrated. (dcu.ie)
  • 1. Photo-actuator hydrogels were developed using copolymers of N-isopropylacrylamide, acrylated spiropyran and acrylic acid. (dcu.ie)
  • Aim: Due to the various drawbacks associated with current treatment therapy of onychomycosis, the main aim was to develop thermosensitive hydrogels and thermosensitive polypseudorotaxanes hydrogels-based nail lacquer for transungual delivery of Efinaconazole for the management of onychomycosis. (eurekaselect.com)
  • Objective The present study focused on the development of a poloxamer 407 thermosensitive hydrogel loaded with keratinocyte growth factor-2 (KGF-2) and fibroblast growth factor-21 (FGF-21) as a therapeutic biomaterial in a scald-wound model of type-2 diabetes in Goto-Kakizaki (GK) rats. (bmj.com)
  • Research design and methods In this study, a poloxamer 407 thermosensitive hydrogel loaded with KGF-2 and/or FGF-21 was prepared and its physical and biological properties were characterized. (bmj.com)
  • For the application of advanced hydrogel-based artificial muscle systems, conventional polymeric hydrogels usually suffer from various limitations such as structural inhomogeneity and poor mechanical strengths. (lboro.ac.uk)
  • The caption is: Mimicking small intestinal tissue by culturing intestinal-organoid derived cells on poly(ethylene glycol) diacrylate (PEGDA) microstructures. (ibecbarcelona.eu)
  • MIT engineers have now found that polyethylene glycol (PEG) - a hydrogel commonly used in cosmetic creams, industrial coatings, and pharmaceutical capsules - can absorb moisture from the atmosphere even as temperatures climb. (sflorg.com)
  • This in turn influences the diffusion pathlength of water into/out of the gel, which has a dramatic impact on the swelling and shrinking kinetics of the hydrogel. (dcu.ie)
  • Thus, the objective of this project will be to evaluate the co-encapsulation and release kinetics of dyes used as model compounds in systems formed by biopolymeric microparticles incorporated in hydrogels. (fapesp.br)
  • The systems will be evaluated according to their microstructure, encapsulation efficiency and release kinetics. (fapesp.br)
  • In this project, three different approaches were employed to improve the mechanical properties of hydrogels though microstructural control, including physical cross-links, copolymerisation, and interpenetrating systems. (lboro.ac.uk)
  • Using immunofluorescence staining of type I collagen (Col I) and machine learning of its fibrous patterns in the polymerized human breast ECM hydrogel, we have defined the microstructural characteristics of the hydrogel and compared the microstructures with those of other native ECM hydrogels. (providence.org)
  • Equilibrium water swelling tests as well as uniaxial compression measurements were conducted to evaluate the influences of various experimental parameters on the hydrogels water-holding and mechanical properties. (lboro.ac.uk)
  • This cartoon explains how a focal laser light pointed at an area of the photo-responsive hydrogel causes it to locally contract, passively pulling at the embedded microplate tips and the cell structures attached to them. (harvard.edu)
  • The main analysis tools for 3D hydrogel structures are optical and laser scanning microscopy. (tuwien.at)
  • In this work, to engineer the BMME of articular chondrocytes, heterogeneous hydrogel structures of gelatin methacrylated (GelMA) containing differential-stiffness domains were first fabricated, and then periodic dynamic mechanical stimulations were applied to the hydrogel structures. (bvsalud.org)
  • This form is hydrophilic, allowing the hydrogel to swell. (dcu.ie)
  • Hydrogels consist of a hydrophilic polymer network and a large amount of water as the dispersion medium. (imechanica.org)
  • The research team's idea is that of an architecture consisting of a "skeleton" component made of arrays of tiny microplates embedded in a hydrogel, the "muscle" component. (harvard.edu)
  • The hydrogel can be locally heated up and induced to contract like a muscle, by shining a focal laser light on it, pulling closeby microplates apart and stretching cells on the surface. (harvard.edu)
  • Intriguingly, the shear-thinning behavior of the hydrogel may also make it suitable to be applied and spread over non-homogeneous surfaces, therefore, we hypothesize that the hybrid biomaterial proposed may be a real asset in the treatment of cartilage defects and injuries. (bvsalud.org)
  • A study by Harvard University ('Structural absorption by barbule microstructures of super black bird of paradise feathers') looked at what is probably the deepest black in the animal kingdom, the plumage of the bird-of-paradise. (swarovskioptik.com)
  • Subbu S. Venkatraman has included themes like Regenerative medicine, Cell morphology, Extracellular matrix, Gelatin and Mesenchymal stem cell in his Self-healing hydrogels study. (research.com)
  • His studies deal with areas such as Biocompatibility, Stent and Self-healing hydrogels as well as Biomedical engineering. (research.com)
  • Transmission electron microscopy (TEM), scanning electron microscopy (SEM), environmental SEM (ESEM) and cryo-SEM studies were also performed to study the microstructure. (bham.ac.uk)
  • Scanning and transmission electron microscopy and X-ray photoelectron spectroscopy were used to evaluate the microstructure and chemistry of the carbon nanomaterial coatings. (edu.pl)
  • The effects of addition of ground granulated blast furnace slag on mechanical properties and microstructure of fly ash-based geopolymers were investigated via compressive strength testing, X-ray diffractometry (XRD), Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). (edu.au)
  • The SELP hydrogel displayed a very interesting physical behavior due to its high degree of resistance to mechanical stress, which is generally associated with physiological mechanical load during locomotion. (bvsalud.org)
  • Biomedical applications of 2PP are of particular interest, since this technology is capable of reproducing the microstructure of different tissue types. (tuwien.at)
  • For this, we produced an engineered construct composed of decellularized ECM (dECM) obtained from horse joint cartilage, to support tissue regeneration, coupled with a Silk-Elastin-Like Proteins (SELP) hydrogel, which acts as a biological glue, to guarantee an adequate adherence to the host tissue. (bvsalud.org)
  • Tough hydrogels derive their high toughness through dissipation [4-6]. (imechanica.org)
  • Interests in the fracture of soft materials were also driven by the invention of pressure sensitive adhesives, and were recently renewed due to the developments of tough hydrogels [2-4] and elastomers [5]. (imechanica.org)
  • In this manner, reversible photo-control over the volume of the hydrogel was achieved. (dcu.ie)
  • This process is safe for cells as they are not heated together with the hydrogel and it is quickly reversible. (harvard.edu)
  • As shown in the top view of the hydrogel pictured in the clip, the displacement of the microplate tips in local areas happens fast and is entirely reversible. (harvard.edu)
  • Thus, improving the mechanical strength of a specific hydrogel system while maintaining its other useful properties become increasingly important. (lboro.ac.uk)
  • Although the contents of the filling water molecules may reach as high as 90%, one can realize extraordinary fracture energy as high as 9000Jm-2 for polyacrylamide-alginate hydrogel [5]. (imechanica.org)
  • It was found that different polymerization solvents directly influenced the morphology of the resulting hydrogels, and in particular, the porosity. (dcu.ie)
  • Inspired by nature, we introduce a drop-based technique that enables the design of microstructured hydrogel sheets possessing tuneable locally varying compositions. (rsc.org)
  • Coordinadora del grup d'investigació "Biomimetic Supramolecular Chemistry and Materials", desenvolupa la seua activitat investigadora en el àmbit dels materials orgànics supramoleculars amb especial interés en els materials biomimetics i en la seua aplicació en biomedicina i en catàlisi. (uji.es)
  • In this regard, hydrogels represent an especially attractive class of materials, since they potentially allow to produce 3D constructs in the presence of living cells. (tuwien.at)
  • Functional Materials for Responsive Systems - Stimuli-responsive Hydrogel & Liquid Crystalline based microstructures. (5dnanoprinting.eu)
  • The team discovered PEG's unusual properties as they were assessing a slew of similar hydrogels for their water-harvesting abilities. (sflorg.com)
  • As its surroundings heat up, the hydrogel's microstructure morphs from a crystal to a less organized "amorphous" phase, which enhances the material's ability to capture water. (sflorg.com)
  • Hydrogels are a perfect candidate, because they are mostly made of water and a polymer network. (sflorg.com)
  • This work proposes a microfibers-hydrogel assembled composite as delivery vehicle able to combine into a single system both burst and prolonged release of lactate. (ibecbarcelona.eu)
  • Importantly, the ECM hydrogel supported 3D growth and cell-ECM interaction of both normal and cancerous mammary epithelial cells. (providence.org)
  • Title : A Hydrogel-Endothelial Cell implant Mimics Infantile Hemangioma: Modulation by Survivin and the Hippo pathway* Personal Author(s) : Tsuneki, Masayuki;Hardee, Steven;Michaud, Michael;Morotti, Raffaella;Lavik, Erin;Madri, Joseph A. (cdc.gov)
  • It likely opens up new possibilities for the design of structured, load-bearing hydrogels, as well as for the next generation of soft actuators and sensors. (rsc.org)
  • Attention is focused on three representative cases of the generalized soft matters: hydrogels, brains, and social media. (imechanica.org)
  • PDF) MICROSTRUCTURES IN COVID VACCINES: ¿inorganic crystals or Wireless Nanosensors Network? (researchgate.net)
  • According to the experts he contacted, these microstructures could be part of a Wireless Nanosensors Network, whether as nanosensors, as nanorouters, or as nanoantennae. (researchgate.net)
  • In this review, we provide a summary of various studies that used these 3D hydrogel models to assess the regulation of the ECM on lung fibroblast phenotype and function in altered lung ECM homeostasis in health and in chronic respiratory disease. (bvsalud.org)
  • Subbu S. Venkatraman mostly deals with Self-healing hydrogels, Biomedical engineering, Nanotechnology, Drug delivery and Scaffold. (research.com)
  • Microparticles can be incorporated into hydrogels, producing a system with great potential in drug delivery applications. (fapesp.br)
  • Its distinctive color-changing ability inspired Chinese scientists to develop a hydrogel with a butterfly-shaped microstructure, which changes color as it expands. (swarovskioptik.com)
  • Human Breast Extracellular Matrix Microstructures and Protein Hydrogel" by Chandler R Keller, Yang Hu et al. (providence.org)
  • Human Breast Extracellular Matrix Microstructures and Protein Hydrogel 3D Cultures of Mammary Epithelial Cells. (providence.org)
  • For the first time, a hydrogel was successfully fabricated using whole protein extracts of human normal breast ECM. (providence.org)
  • This modular platform is not limited to the fabrication of hydrogels but can be employed for any material that can be processed into drops and solidified within them. (rsc.org)
  • The team analyzed a variety of hydrogels, including PEG, by placing each material on a scale that was set within a climate-controlled chamber. (sflorg.com)
  • They found that the material has a natural melting point at around 50 degrees Celsius, meaning that the hydrogel's normally crystal-like microstructure completely breaks down and transforms into an amorphous phase. (sflorg.com)
  • MIT engineers have found that a common hydrogel has unique, super-soaking abilities. (sflorg.com)
  • The alkaline activation of slag and fly ash forms a kind of homogeneous product with microstructure between typical alkali aluminosilicate gels (N-A-S-H) and calcium silicate hydrates (C-S-H). Distinct phase separation has not been found as the slag ratio varies or the modulus of the alkali activator decreases from 1.2 to 2.0. (edu.au)
  • The repairing effects of this hydrogel were investigated in a scald-wound model of type-2 diabetes in GK rats. (bmj.com)