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HydrocarbonsPolycyclic Hydrocarbons, AromaticReceptors, Aryl HydrocarbonHydrocarbons, AromaticPolycyclic CompoundsTetrachlorodibenzodioxinCell NucleusHydrocarbons, HalogenatedDNA, MitochondrialAryl Hydrocarbon Receptor Nuclear TranslocatorHydrocarbons, ChlorinatedCytochrome P-450 CYP1A1Benzo(a)pyreneAryl Hydrocarbon HydroxylasesDNAAlkanesPetroleumBenz(a)AnthracenesPyrenesBenzopyrenesDNA, PlantDioxinsBiodegradation, EnvironmentalSoil PollutantsMethylcholanthrenePloidiesHydrocarbons, AlicyclicDNA AdductsPhenanthrenesEnvironmental PollutantsPhylogenyHydrocarbons, AcyclicDNA FragmentationFuel OilsPhysarumBase SequenceDNA DamageMolecular Sequence DataGasolineNucleic Acid RenaturationWater Pollutants, ChemicalCarcinogensMitochondriaSpecies SpecificitySequence Analysis, DNAPetroleum PollutionChrysenesDNA, NeoplasmEnvironmental MonitoringDNA, ChloroplastAngiospermsBenzoflavonesAlkenesCoal TarEnzyme InductionPolychlorinated BiphenylsCokebeta-NaphthoflavoneGas Chromatography-Mass SpectrometryGenome, PlantBay-Region, Polycyclic Aromatic HydrocarbonCreosoteDNA ReplicationCaricaceaeCarcinogens, EnvironmentalGenetic VariationLiverAcenaphthenesDeoxyguanosineCytochrome P-450 Enzyme SystemAir PollutantsToluenePolyploidyPhylogeographyChromatography, GasNucleic Acid HybridizationBiotransformationIntegumentary System7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxideNucleic Acid DenaturationDNA, FungalHybridization, GeneticXylenesBenzopyrene HydroxylaseBenzene DerivativesImage CytometryMutationMitochondrial DiseasesFlow CytometryMutagensKeroseneXenobioticsGulf of MexicoPlantsApoptosisAir Pollutants, OccupationalRNA, Messenger9,10-Dimethyl-1,2-benzanthraceneOccupational ExposureAtlantic Islands
Polycyclic Aromatic HydARNTAromatic hydrocarbonsTranslocatorLigand-activated transcription factorReceptorsReceptorAhRRMetabolitesProteinGeneMoleculesSubunitsGeneticHumansDegradationPolymeraseMechanismsEnvironmentalNucleiDustDamageSpectroscopyMolecularDuplexesCellsExposureSequenceAnimalsImplicationsStudyHumanDistributionStudiesRadiationRangeCapacity
Polycyclic Aromatic Hyd4
  • Most of these genes are involved in the activation and detoxification of polycyclic aromatic hydrocarbons, suggesting a potential role of these compounds in gastric carcinogenesis. (ox.ac.uk)
  • A new innovative methodology system framework for source apportionment and source-specific risk assessment has been proposed and actively applied to identify the contamination characteristics, oriented sources and health risks associated with contamination levels of Heavy metals (HMs) and Polycyclic Aromatic Hydrocarbons (PAHs) in soils, a typical cold agricultural region in Northeastern China. (bvsalud.org)
  • Polycyclic aromatic hydrocarbons (PAH) are ubiquitous environmental chemicals that suppress the immune system at multiple levels, including at the level of B cell development in the bone marrow microenvironment. (aspetjournals.org)
  • Organic pollutants**: These are organic compounds that are present in the air, such as polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), dioxins and furans. (sbrockpond.com)
ARNT6
  • Dioxins and dioxin-like compounds are teratogens that exert their effects through the aryl hydrocarbon receptor (AhR) in conjunction with the receptor's binding partner, aryl hydrocarbon receptor nuclear translocator (ARNT). (wikipedia.org)
  • Analyses of nuclear AhR demonstrated that cycloheximide increases nuclear AhR protein and functional AhR/Arnt DNA-binding complex, resulting in superinduction of CYP1A1. (cdc.gov)
  • The HIF-1 protein is composed of two HIF-1α and HIF-1β/aryl hydrocarbon receptor nuclear translocator (ARNT) subunits. (biomedcentral.com)
  • These planar compounds are able to bind to the AhR causing heterodimerization with the aryl hydrocarbon nuclear translocator (ARNT) and interaction with dioxin-responsive elements on the DNA causing an up-regulation in dioxin responsive genes. (aopwiki.org)
  • Upon ligand binding in the cytoplasm, the activated AhR-ligand complex heterodimerizes with the AhR nuclear translocator (ARNT), resulting in transformation of the complex into a high-affinity DNA-binding transcription factor. (immune-system-research.com)
  • Aryl hydrocarbon receptor nuclear translocator (ARNT) gene as a positional and functional candidate for type 2 diabetes and prediabetic intermediate traits: Mutation detection, case-control studies, and gene expression analysis. (wakehealth.edu)
Aromatic hydrocarbons3
  • 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), a prototype of environmental halogenated aromatic hydrocarbons, induces a rapid reduction in steady state aryl hydrocarbon receptor (AhR). (cdc.gov)
  • This AOP can be initiated by a range of planar aromatic hydrocarbons, but is best known as the target of dioxin-like compounds (DLCs). (aopwiki.org)
  • 1994). Because of the long-half life of most of the halogenated aromatic hydrocarbons, animals or humans will be exposed for relatively long periods of time following single exposures. (cdc.gov)
Translocator4
Ligand-activated transcription factor2
  • We capitalize on a recent genome duplication in Xenopus laevis (African clawed frog) to interrogate possible functional differentiation between alloalleles of the aryl hydrocarbon receptor ( AHR ), a ligand-activated transcription factor that mediates toxicity of dioxin-like compounds and plays a role in the physiology and development of the cardiovascular, hepatic, and immune systems in vertebrates. (xenbase.org)
  • The ligand-activated transcription factor, known as the aryl hydrocarbon receptor (AhR), plays an essential role in the interactions between genes and the environment. (biomed.news)
Receptors2
  • Subfunctionalization of Paralogous Aryl Hydrocarbon Receptors from the Frog Xenopus Laevis: Distinct Target Genes and Differential Responses to Specific Agonists in a Single Cell Type. (xenbase.org)
  • Recent studies have shown that several mechanisms of action involve the ability of agrochemicals to mimic the interaction of endogenous hormones with nuclear receptors such as estrogen receptors, androgen receptors, peroxisome proliferator activated receptors, the aryl hydrocarbon receptor, and thyroid hormone receptors. (njit.edu)
Receptor13
  • The aryl-hydrocarbon receptor repressor also known as AHRR is a human gene. (wikipedia.org)
  • A cycloheximide-sensitive factor regulates TCDD-induced degradation of the aryl hydrocarbon receptor. (cdc.gov)
  • More modestly induced target genes, encoding aryl hydrocarbon receptor repressor ( AHRR ), spectrin repeat-containing nuclear envelope protein 1 (SYNE-1), and gap junction protein gamma 1 ( GJC1 ), were regulated solely by AHR1α. (xenbase.org)
  • Two forms of aryl hydrocarbon receptor type 2 in rainbow trout (Oncorhynchus mykiss). (xenbase.org)
  • Exactly the same but different: promiscuity and diversity in the molecular mechanisms of action of the aryl hydrocarbon (dioxin) receptor. (xenbase.org)
  • Amino acid sequence of the ligand-binding domain of the aryl hydrocarbon receptor 1 predicts sensitivity of wild birds to effects of dioxin-like compounds. (xenbase.org)
  • Aryl-hydrocarbon receptor-deficient mice are resistant to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced toxicity. (xenbase.org)
  • Click links below to explore AOP 21, Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 in tools offered by third parties. (aopwiki.org)
  • This adverse outcome pathway details the linkage between activation of the aryl hydrocarbon receptor (AhR) and early life stage mortality in oviparous vertebrates. (aopwiki.org)
  • In his works, Oliver Hankinson performs multidisciplinary study on Aryl hydrocarbon receptor and Cytochrome P450. (research.com)
  • His work often combines Transcription factor and Aryl hydrocarbon receptor studies. (research.com)
  • Aryl Hydrocarbon Receptor (AhR or AHR) is a cytoplasmic receptor and transcription factor that belongs to the family of basic helix-loop-helix transcription factors. (immune-system-research.com)
  • Further, studies indicate that agrochemicals can exert toxicity through non-nuclear receptor-mediated mechanisms of action. (njit.edu)
AhRR1
  • In addition, the encoded protein can bind to nuclear factor-kappa B. The AhRR gene may act as a tumor suppressor. (wikipedia.org)
Metabolites3
  • Formation in isolated rat liver microsomes and nuclei of benzo(a)pyrene metabolites that bind to DNA. (lookformedical.com)
  • and (c) direct transfer of reactive microsomal metabolites to nuclear DNA. (lookformedical.com)
  • Through nontarget screening, 515 differential features were identified, and finally, 32 differential compounds were confirmed as candidates for the current study, including 13 polycyclic aromatic hydrocarbon (PAH) metabolites. (bvsalud.org)
Protein4
  • Hypoxia stabilises HIF-1α protein by relaxing its ubiquitin-proteasome degradation [ 12 ] and affects subcellular localisation, DNA binding capacity and transcriptional activation function of the HIF-1 complex. (biomedcentral.com)
  • His Basic helix-loop-helix study frequently involves adjacent topics like DNA-binding protein. (research.com)
  • In his works, he conducts interdisciplinary research on DNA-binding protein and Transcription factor. (research.com)
  • Figure 3: The "Klenow enzyme," a protein fragment of DNA polymerase I of the Escherichia coli bacteria, in the RasMol ribbon view with fragment coloration. (linux-magazine.com)
Gene3
  • In his articles, Oliver Hankinson combines various disciplines, including Gene and DNA. (research.com)
  • Oliver Hankinson undertakes interdisciplinary study in the fields of DNA and Gene through his works. (research.com)
  • 111 In introduced into triplex- and duplex-forming ODNs through hydrocarbon linkers produces sequence-specific DNA strand breaks with an efficiency nearly comparable with that of 125 I. These findings are supportive of our proposed use of 111 In-ODNs for gene-specific radiotherapy. (korea.ac.kr)
Molecules2
  • Usually, the NOE and NMRD in B-DNA is expected to be less ``integral'' than methods can only provide bounds on the residence water molecules buried inside proteins. (lu.se)
  • What looks a little like technical overkill in the simple ethylene molecule in Figure 1 turns out to be extremely helpful with complex molecules such as DNA. (linux-magazine.com)
Subunits1
  • Analysis of DNA-binding proteins extracted from the nuclei of untreated BU-11 cells indicated DNA-binding complexes comprising NF-κB subunits p50, c-Rel, and/or Rel A. NF-κB down-regulation with previously described inhibitors induced BU-11 cell apoptosis, demonstrating that the default apoptosis pathway blocked by NF-κB is functional at this early stage in B cell development. (aspetjournals.org)
Genetic1
  • They can emit ionizing radiation that can damage living cells and DNA and cause cancer and genetic defects. (sbrockpond.com)
Humans1
Degradation1
  • Such non-genomic mechanisms of action include interference with peptide, steroid, or amino acid hormone response, synthesis and degradation as well as epigenetic changes (DNA methylation and histone modifications). (njit.edu)
Polymerase2
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Polymerase DNA Directed Delta 1 (POLd) in Tissue homogenates, cell lysates and other biological fluids. (myelisakit.com)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human Polymerase DNA Directed Gamma 1 (POLg1) in samples from tissue homogenates, cell lysates or other biological fluids. (myelisakit.com)
Mechanisms1
Environmental1
  • The last set of chapters focuses on applications in health physics and cancer therapy, applications to polymers, the applications and interface formation in space science and technology, and applications for the research and development of radiation detectors, environmental conservation, plant breeding, and nuclear engineering. (routledge.com)
Nuclei1
  • In contrast to nuclei from control rats, the nuclear fraction from MC-treated rats showed an increase in bound radioactivity when incubated with a microsome-free supernatant, obtained by incubating microsomes from MC-treated rats with [3H]BP. (lookformedical.com)
Dust1
  • Radioactive pollutants**: These are radioactive substances that are present in the air, such as radon gas, uranium dust and fallout from nuclear tests or accidents. (sbrockpond.com)
Damage3
  • We found that the damage inflicted on DNA for planets at Earth-equivalent positions is between a factor of 2.5 and 7.1 higher than for solar-like stars, and there are intricate relations for the time-dependence of damage during stellar main-sequence evolution. (cambridge.org)
  • We studied the fine structure of DNA damage produced by the decay of rain incorporated into duplex and triplex DNA strands to evaluate the usefulness of this radionuclide for sequence-specific DNA cleavage. (korea.ac.kr)
  • DNA damage. (edu.au)
Spectroscopy1
  • Molecular dynamics simulations and solid-state nuclear magnetic resonance spectroscopy measurements of C-H bond order parameters and effective correlation times in a POPC-GM3 bilayer. (lu.se)
Molecular3
  • Figure 1: The various representations of the simple hydrocarbon molecule, ethylene, from the simple molecular formula through a structural formula, to visualization. (linux-magazine.com)
  • Representing the electron distribution around the nuclear framework of the molecule is another excellent capability of molecular visualization: If you want to understand how electrostatic attraction and repulsion processes act within the molecule, an electron density map is a big help. (linux-magazine.com)
  • Molecular mobility in keratin-rich materials monitored by nuclear magnetic resonance: A tool for the evaluation of structure-giving properties. (lu.se)
Duplexes2
  • Subsequent formation of DNA duplexes and triplexes was confirmed by gel electrophoresis. (korea.ac.kr)
  • Localized DNA breaks were observed in all duplexes and triplexes formed. (korea.ac.kr)
Cells1
  • carefully like any Strong The Goddess distribution, DNA writes to delete cells. (lgne.org)
Exposure2
  • Similarly, exposure of BU-11/BMS2 cocultures to 7,12-dimethylbenz[ a ]anthracene (DMBA), a prototypic PAH, down-regulated nuclear Rel A and c-Rel before overt apoptosis. (aspetjournals.org)
  • Serological and DNA indicators show widespread exposure of Nigerian children to Pm with lower rates to Po and Pv. (cdc.gov)
Sequence1
  • We explore the general astrobiological significance of F-type main-sequence stars with masses between 1.2 and 1.5 M ⊙ . Special consideration is given to stellar evolutionary aspects due to nuclear main-sequence evolution. (cambridge.org)
Animals1
  • After incubation of the nuclear fraction with [3H]BP and reduced nicotinamide adenine dinculeotide phosphate, radioactivity was found to be associated with nuclear DNA and the extent of binding was markedly enhanced by pretreatment of the animals with MC. (lookformedical.com)
Implications1
Study1
  • Spectroscopic Study of Radiation-Induced DNA Lesions and Their Susceptibility to Enzymatic Repair. (routledge.com)
Human1
  • They are mainly emitted from natural sources such as rocks and soil or from human activities involving nuclear energy or weapons. (sbrockpond.com)
Distribution1
  • The distribution of DNA breaks was wider in comparison with the duplex experiment. (korea.ac.kr)
Studies1
  • It then introduces new theoretical studies on the physicochemical and chemical stages that describe the behavior of electrons in liquid hydrocarbons and the high-LET radiolysis of liquid water. (routledge.com)
Radiation1
  • Consequently, the DNA action spectrum is utilized to represent the impact of the stellar ultraviolet (UV) radiation. (cambridge.org)
Range1
  • DNA solution, however, are in a range where the ecules in the minor groove of DNA are exposed to residence time can actually be pinpointed by either the external solvent medium and should therefore method. (lu.se)
Capacity2
  • data have examined moving and offering arms for the several pdf Reviews of Physiology, Biochemistry and Pharmacology, Volume 87 1980 in a Capacity that explains them to like also, running the DNA for new levels. (lgne.org)
  • The MNC quantification in buccal mucosa has the benefits that this tissue present a limited capacity of DNA reparation and therefore may reflect with a better precision the genomic instability, maybe that's why most tumors are epithelial origin [1]. (austinpublishinggroup.com)