• The labeled probe is first denatured (by heating or under alkaline conditions such as exposure to sodium hydroxide) into single stranded DNA (ssDNA) and then hybridized to the target ssDNA (Southern blotting) or RNA (northern blotting) immobilized on a membrane or in situ. (wikipedia.org)
  • Scorpion® probes Molecular Beacon probes TaqMan® probes LNA® (Locked Nucleic Acid) probes Cycling Probe Technology (CPT) Within the field of microbial ecology, oligonucleotide probes are used in order to determine the presence of microbial species, genera, or microorganisms classified on a more broad level, such as bacteria, archaea, and eukaryotes via fluorescence in situ hybridization (FISH). (wikipedia.org)
  • Delve into the vibrant sector of the global fluorescent in situ hybridization (FISH) probe market, a domain exhibiting unprecedented growth powered by escalating demand and scientific progression. (researchandmarkets.com)
  • The global fluorescent in situ hybridization (FISH) probe market size reached US$ 816 Million in 2022. (researchandmarkets.com)
  • Fluorescent in Situ Hybridization (FISH) Probe refers to a sub-atomic cytogenetic technique that uses fluorescent probes to visualize genetic materials. (researchandmarkets.com)
  • The report provides an analysis of the key trends in each sub-segment of the global fluorescent in situ hybridization (FISH) probe market report, along with forecasts at the global, regional and country level from 2023-2028. (researchandmarkets.com)
  • In situ hybridization of a radioactive RNA probe on resin-embedded legume root-nodule sections: a tool for observing gene expression in the rhizosphere? (agronomy-journal.org)
  • In this work we performed in situ hybridization of a carbonic anhydrase RNA 35 S-labeled probe on nodule sections previously embedded in a methacrylate resin. (agronomy-journal.org)
  • De plus, la qualité de ces résultats avec une sonde radioactive suggère qu'il serait possible d'utiliser l'hybridation in situ pour des applications telles que la localisation et la quantification d'une invasion microbienne de l'endorhizosphère ou du rhizoplan en utilisant des sondes ARN spécifiques de champignons ou de bactéries, et en comptant le nombre de signaux radioactifs par cellule. (agronomy-journal.org)
  • Use of histopathology, PCR and in situ hybridization methods to detect the parasite Mikrocytos sp. (agronomy-journal.org)
  • With flexible custom design, synthesis, and delivery formats to suit any species or application, myTags® Custom (F)ISH probes support every in situ hybridization (ISH) research goal. (arborbiosci.com)
  • With immortal and labeled options and a wide range of available synthesis scales, myTags probes are the perfect choice for any in situ hybridization experiment. (arborbiosci.com)
  • In situ hybridization with a blotin-labeled DNA probe was used to detect wheatrye translocations. (illinois.edu)
  • This study examines the expression of mu, delta, and kappa receptor mRNAs in the rat brain and spinal cord using in situ hybridization techniques. (nih.gov)
  • A method is described for visualizing three nucleic acid sequences simultaneously by in situ hybridization using a new blue immunofluorescent label, amino methyl coumarin acetic acid (AMCA), in combination with green and red fluorescing FITC and TRITC. (nih.gov)
  • Three-color in situ hybridization was applied to the study of numerical chromosome abnormalities as occur in human solid tumors. (nih.gov)
  • A small number of whole-cell fluorescence in situ hybridization (FISH) probes have been reported to detect S. aureus. (edu.au)
  • Moreover, zebrafish is very well-suited for systematic analysis of gene expression patterns at transcript level by whole-mount in situ hybridization (WISH), and at protein level by immunohistochemistry/immunofluorescence (IHC/IF). (frontiersin.org)
  • Oligonucleotide probes are increasingly being used to characterize natural microbial assemblages by Tyramide Signal Amplification-Fluorescent in situ Hybridization (TSA-FISH, or CAtalysed Reporter Deposition CARD-FISH). (hal.science)
  • ABSTRACT Fluorescent in situ hybridization with a 16S rRNA probe specific for Verrucomicrobia was used to (i) confirm the division-level identity of and (ii) study the behavior of the obligate intracellular verrucomicrobium " Candidatus Xiphinematobacter" in its nematode hosts. (uibk.ac.at)
  • Visualization of the mycelia of wood-rotting fungi by fluorescence in situ hybridization using a peptide nucleic acid probe. (bvsalud.org)
  • White rot fungus , Phanerochaete chrysosporium , and brown rot fungus , Postia placenta , grown on agar plates, were visualized by fluorescence in situ hybridization (FISH) using a peptide nucleic acid (PNA) probe. (bvsalud.org)
  • We here present a micrometer-scale implementation of fluorescence in situ hybridization that we term μFISH. (springer.com)
  • A key milestone in ISH-based techniques was fluorescence in situ hybridization (FISH) (Bauman et al. (springer.com)
  • RNAscope in situ hybridization (ISH) is a highly sensitive and specific spatial biology technology. (biospace.com)
  • Detection of transcriptionally active high-risk HPV in patients with head and neck squamous cell carcinoma as visualized by a novel E6/E7 mRNA in situ hybridization method. (biospace.com)
  • With our probe' says Baik, 'the target gene within the chromosome can be localized with the ssDNA-SWNT conjugates, and this method can be used for the in situ detection of the specific genome in cells, tissue sections or infectious agents with the possibility of long term storage and re-evaluation of the results in the future. (nanowerk.com)
  • What is in situ hybridization and what are the recent advancements with this indispensable technique? (enzolifesciences.com)
  • Their expression pattern was examined by immunofluorescence and in situ hybridization. (molvis.org)
  • Diagnosis is made by confirming a deletion in the WHS critical region (WHSCR) using conventional chromosome analysis, fluorescence in situ hybridization (FISH), or chromosomal microarray. (medscape.com)
  • In situ hybridization (ISH) was used to investigate the presence of HPV-16, while immunohistochemistry (IHC) was used to estimate the expression level of TIMP-2. (bvsalud.org)
  • Fluorescence and chromogenic in situ hybridization, using an ABCC3-specific probe, was used to analyze 11 breast cancer cell lines and 112 clinical tumor samples. (lu.se)
  • Advances in fluorescence microscopy, fluorescent dyes, biotechnology, bioinformatics, and research on the human genome project in the late 90's accelerated the development of methods to synthesize and design NA probes for FISH. (springer.com)
  • 1,2 A novel probe hybridization quantitative polymerase chain reaction (qPCR) assay targeting the cytochrome oxidase I (COI) gene of P. andersoni was developed. (vin.com)
  • Beyond the bulk fluid assay and droplet devices, use of dsPNA probes may be advantageous in a wide variety of assays that employ homogenous nucleic acid hybridization. (psu.edu)
  • When tested in a FISH assay, Staaur and a new probe, KT18, were found to have the same performance. (edu.au)
  • The continuous flow of probes and shaping liquid on these selected cells resulted in a 120-fold reduction of the hybridization time compared with the standard protocol (3 min vs. 6 h) and efficient rinsing, thereby shortening the total FISH assay time for centromeric probes. (springer.com)
  • A tissue blot DNA hybridization assay was developed to detect Clavibacter xyli subsp. (usda.gov)
  • The assay used a 560 bp PCR product as the probe which was amplified from the intergenic transcribed spacer region of the 16S/23S ribosomal DNA of Cxx with two universal primers. (usda.gov)
  • Assays on 346 duplicate sets of sugarcane tissue blots indicated that the tissue blot DNA hybridization assay detected Cxx as effectively as a tissue blot immunobinding assay. (usda.gov)
  • The tissue blot DNA hybridization assay can be immediately applicable in many sugarcane diagnostic laboratories to compliment current diagnostic methods, thereby enhancing the sensitivity and accuracy of Cxx detection. (usda.gov)
  • The Molecular Inversion Probe assay (Parallele Biosciences, South San Francisco, Calif, USA) [ 6 ] uses probes that can be circularized and contain two sequences complementary to regions adjacent to SNPs in the DNA target in the first step of the genotyping reaction. (hindawi.com)
  • RNAscope ISH Probe High Risk HPV is used in an RNAscope ISH assay for the qualitative detection of HPV E6/E7 mRNA in FFPE tissue specimens. (biospace.com)
  • In a recent paper, titled 'The DNA hybridization assay using single-walled carbon nanotubes as ultrasensitive, long-term optical labels' the Korean scientists present single- stranded DNA (ssDNA)-coated SWNT probes to locate a particular sequence of DNA. (nanowerk.com)
  • Loss of detectable HBV DNA by a solution phase hybridization assay is an earlier indicator of response to antiviral therapy than loss of HBeAg. (medscape.com)
  • rRNA probes have enabled scientists to visualize microorganisms, yet to be cultured in laboratory settings, by retrieval of rRNA sequences directly from the environment. (wikipedia.org)
  • The global standard library of rRNA sequences is constantly becoming larger and continuously being updated, and thus the possibility of a random hybridization event between a specifically-designed probe (based on complete and current data from a range of test organisms) and an undesired/unknown target organism cannot be easily dismissed. (wikipedia.org)
  • In view of the fast-growing rRNA databases, we re-evaluated the in silico specificity of eleven bacterial and eukaryotic probes and competitor frequently used for the quantification of marine picoplankton. (hal.science)
  • ISH was first demonstrated by Gall and Pardue ( 1969 ) using radioactive rRNA probes to visualize extrachromosomal rDNA. (springer.com)
  • Locus specific, Alphoid/centromeric repeat and whole chromosome probes are some of the types of FISH probes that are being commonly used. (researchandmarkets.com)
  • myTags Custom probes from Daicel Arbor Biosciences have been used successfully in (F)ISH experiments with a wide range of organisms such as animals, plants, and microbes - and for a variety of research applications such as 3D DNA-FISH, RNA-FISH, chromosome painting and barcoding, and much more. (arborbiosci.com)
  • Flexible design -We can design your probes from any genome reference sequence(s), and can accommodate any cytogenetics use case, such as chromosome painting or barcoding, RNA-FISH, and much more. (arborbiosci.com)
  • Both panels include myTags human chromosome 17 centromere probes [ATTO 647N] and chromosomes [stained with Hoescht 33342] pseudo-colored gray. (arborbiosci.com)
  • myTags (F)ISH probes have been used successfully across a diverse range of cytogenetic applications including 3D DNA-FISH, Cryo-FISH, RNA-FISH, Oligopaints, and chromosome painting for a variety of cell types. (arborbiosci.com)
  • Three chromosome-specific repetitive probes labeled with either amino acetyl fluorene (AAF), mercury, or biotin were hybridized simultaneously to metaphase chromosomes prepared from human blood lymphocytes or to interphase tumor nuclei. (nih.gov)
  • Here, we compared the sensitivity and specificity of double stranded PNA probes (dsPNA) and PNA molecular beacons targeting E. coli and P. aeruginosa for direct detection of bacterial pathogens. (psu.edu)
  • In addition, we found that recent changes in the Gammaproteobacteria classification decreased the specificity of Gam42a probe, and that the Roseo536R and Ros537 probes were not specific to, and missed part of the Roseobacter clade. (hal.science)
  • Experiences acquired through these investigations leads us to propose the use of seven steps protocol for complete FISH probe specificity checkup to improve data quality in environmental studies. (hal.science)
  • Specificity of the product was confirmed with hybridization to a labeled probe. (cdc.gov)
  • The specificity of the product was confirmed by hybridization to a digoxigenin-labeled probe according to the method described in Boehringer Mannhein's Genius System User's Guide for Filter Hybridization. (cdc.gov)
  • Southern blotting, which uses photostable Raman signals of nanotubes instead of fluorescent dyes, demonstrates excellent sensitivity and specificity of the probes. (nanowerk.com)
  • Previously, a probe-selection method based on hybridisation of genomic DNA (gDNA) was developed, which enables GeneChips to be used for species that they were not designed for. (cambridge.org)
  • Array comparative genomic hybridization (aCGH) is a type of microarray now routinely used to identify deleted or duplicated regions of DNA sequence in specific chromosomes on a genome-wide basis. (msdmanuals.com)
  • HP can be used to detect the presence of nucleotide sequences in analyzed RNA or DNA that are complementary to the sequence in the probe. (wikipedia.org)
  • DNA sequences or RNA transcripts that have moderate to high sequence similarity to the probe are then detected by visualizing the hybridized probe via autoradiography or other imaging techniques. (wikipedia.org)
  • Detection of sequences with moderate or high similarity depends on how stringent the hybridization conditions were applied-high stringency, such as high hybridization temperature and low salt in hybridization buffers, permits only hybridization between nucleic acid sequences that are highly similar, whereas low stringency, such as lower temperature and high salt, allows hybridization when the sequences are less similar. (wikipedia.org)
  • Molecular DNA- or RNA-based probes are routinely used in screening gene libraries, detecting nucleotide sequences with blotting methods, and in other gene technologies, such as nucleic acid and tissue microarrays. (wikipedia.org)
  • The probes themselves are domain specific for Universal, Eucarya, Bacteria, and Archaeal sequences in the 16S rDNA. (bio.net)
  • Seunghyun Baik and co-workers from the SKKU Advanced Institute of Nanotechnology at Sungkyunkwan University and the Seoul National University College of Medicine, explain their group's recent research to Nanowerk: ' The sensing mechanism relies on the hybridization of the ssDNA-SWNT conjugate to the target DNA by the binding of complementary sequences. (nanowerk.com)
  • To detect hybridization of the probe to its target sequence, the probe is tagged (or "labeled") with a molecular marker of either radioactive or (more recently) fluorescent molecules. (wikipedia.org)
  • DIG-labeled DNA probe complementary to the coat protein (CP) region of TSV sunflower isolate was designed and used to detect the TSV presence at field levels. (elis.sk)
  • Gene probes can detect a number of disorders before and after birth. (msdmanuals.com)
  • We previously developed a highly specific method for detecting SNPs with a microarray-based system using stem-loop probes. (hindawi.com)
  • A microarray containing the probes, and a kit containing the array and the HLA gene-specific primers, is also claimed. (genomeweb.com)
  • Another technique, the tissue blot hybridization offered a simple, reliable procedure and did not require a sample processing. (elis.sk)
  • FISH Probe, a sophisticated cytogenetic technique, plays a crucial role in identifying severe genetic diseases, monitoring therapeutic drugs, and tracking the abnormalities in chromosomes. (researchandmarkets.com)
  • The probe containing a 120-bp repetitive DNA sequence from rye, hybridized to the entire length of all rye chromosomes, but only to a few sites in 14 wheat chromosomes. (illinois.edu)
  • The overall distribution of this DNA probe in the rye chromosomes has not been detected previously with the use of radioactively labeled probes. (illinois.edu)
  • As a result of the formation of a brown precipitate over sites of hybridization in this technique, the rye chromosomes were entirely brown in color, whereas the wheat chromosomes appeared blue. (illinois.edu)
  • Currently, a range of probes can be synthesized to locate and quantify specific short RNAs, genes, entire chromosomes, and even cells (Evanko 2007 ). (springer.com)
  • DesPlaines, Ill), which includes probes for the centromeres for chromosomes 3, 7, and 17 and has a locus-specific probe for 9p21, was developed to screen for recurrent urothelial carcinoma and was approved by the US Food and Drug Administration (FDA) in 2005. (medscape.com)
  • It relies on the sequence-specific hybridization of probes to their complementary targets in individual cells, followed by direct or indirect detection of the labelled probe. (springer.com)
  • After hybridization with perfectly complementary labeled targets, the stems of probes are opened for the subsequent detection of these targets. (hindawi.com)
  • Our myTags probes can be easily integrated into your existing workflows to enable (F)ISH research on chromosomal material or whole cells. (arborbiosci.com)
  • c) selective hybridization with the target chromosomal DNA. (nanowerk.com)
  • We are excited to launch the new CE-IVD RNAscope ISH Probe High Risk HPV, which provides pathologists a highly accurate tool for the direct detection of HPV mRNA to inform treatment selection in oropharyngeal squamous cell carcinoma patients. (biospace.com)
  • In molecular biology, a hybridization probe (HP) is a fragment of DNA or RNA of usually 15-10000 nucleotide long which can be radioactively or fluorescently labeled. (wikipedia.org)
  • Nucleic acid hybridization is at the core of many amplification-free molecular diagnostics and detection probe configuration is key to diagnostic performance. (psu.edu)
  • Modified nucleic acids such as peptide nucleic acid (PNA) offer advantages compared to conventional DNA probes allowing for faster hybridization, better stability and minimal sample preparation for direct detection of pathogens. (psu.edu)
  • Commonly used markers are 32P (a radioactive isotope of phosphorus incorporated into the phosphodiester bond in the probe DNA), digoxigenin, a non-radioactive, antibody-based marker, biotin or fluorescein. (wikipedia.org)
  • Digoxigenin (DIG)-labeled DNA probe was developed for a sensitive and rapid detection of the Tobacco streak virus (TSV) isolates in India by dot-blot and tissue print hybridization techniques. (elis.sk)
  • Sensitivity and accuracy are inherent features of these probes , making them a preferred choice for scrutinizing microscopic genetic changes traditionally overlooked by standard cytogenetic tests. (researchandmarkets.com)
  • Additionally, various technological advancements, such as the development of FISH probes with higher sensitivity and accuracy, are creating a positive outlook for the market. (researchandmarkets.com)
  • Hybridization probes targeted these descriptive SNPs and Luminex MagPlex hybridization protocols were developed and optimized. (usda.gov)
  • Moreover, the quality of these results with a radioactive probe makes it possible to consider using ISH for such rhizospheric applications as localizing and quantifying a microbial invasion of the endorhizosphere or the rhizoplan by using bacterial- or fungal-specific RNA probes, and counting the number of radioactive dots per cell. (agronomy-journal.org)
  • The probe did not hybridize to the PCR products from Xanthomonas albilineans, the leaf scald bacterial pathogen, other Xanthomonads, and saprophytic bacteria commonly found in sugarcane. (usda.gov)
  • The same membrane was then hybridized with the Bacterial-specific probe. (bio.net)
  • The probes were confronted to recent databases and hybridization conditions were tested against target strains matching perfectly with the probes, and against the closest non-target strains presenting one to four mismatches. (hal.science)
  • We show here that the multiplex genotyping of multiple mutation sites is possible, based on multiplex PCR DNA amplification and a stem-loop probe method. (hindawi.com)
  • The membrane was stripped of probe using a NaOH treatment and neutralized with TE buffer (pH 7.5). (bio.net)
  • Exposure of the membrane between hybridizations showed most of the universal probe stripped, so that probably wasn't the problem. (bio.net)
  • Extensive utilization of FISH probes in diagnosing and managing cancerous conditions and genetic disorders, coupled with growth in targeted therapies and In Vitro Diagnostics (IVD) testing, underline the market's expansion potential. (researchandmarkets.com)
  • New online computational tools for in silico design and testing make it possible to assess candidate FISH probes for S. aureus. (edu.au)
  • Materials and Methods: Six online tools, NCBI-Nucleotide, Ribosomal Database Project, NCBI-Blast, Reverse-Complement, Probecheck, and mathFISH, were employed in a workflow to evaluate FISH probes for S. aureus. (edu.au)
  • Conclusion: Existing and new FISH probes for S. aureus were found to be accurately identified and characterized with online computational tools. (edu.au)
  • By confining FISH probes at the tip of this microfabricated scanning probe, we locally exposed approximately 1000 selected MCF-7 cells of a monolayer to perform incubation of probes - the rate-limiting step in conventional FISH. (springer.com)
  • This method is compatible with the standard workflow of conventional FISH, allows re-budgeting of the sample for various tests, and results in a ~ 15-fold reduction in probe consumption. (springer.com)
  • We further demonstrated spatially multiplexed μFISH, enabling the use of spectrally equivalent probes for detailed and real-time analysis of a cell monolayer, which paves the way towards rapid and automated multiplexed FISH on standard cytological supports. (springer.com)
  • a Using a pipette in conventional FISH, CEP7 probes are deposited on the entire cell monolayer. (springer.com)
  • b In μFISH implemented with an MFP, CEP7 probes are localized on selected cells, and the FISH signal is inspected in real time. (springer.com)
  • Multiplexed FISH is often used to locate multiple targets in a cell nucleus simultaneously using probes of different colors, in order to study sparse cytological substrates (Lichter 1997 ). (springer.com)
  • This system now combines the principle of highly specific genotyping based on stem-loop structure probes with the advantages of multiplex analysis. (hindawi.com)
  • In silico evaluation of probes has the potential to reduce the time spent evaluating probes in the laboratory. (edu.au)
  • Results: A number of new probes for S. aureus were predicted to perform as well or better in silico as those previously reported. (edu.au)
  • MINNEAPOLIS , July 6, 2022 /PRNewswire/ -- Bio-Techne (NASDAQ: TECH), a global life sciences company providing innovative tools and bioactive reagents for the research and clinical diagnostic communities today announced the European launch of the CE-IVD marked RNAscope ISH Probe High Risk HPV, intended for use in patients diagnosed with oropharyngeal squamous cell carcinoma (OPSCC) to aid in the identification of high-risk human papillomavirus (HPV). (biospace.com)
  • Hybridization probes used in DNA microarrays refer to DNA covalently attached to an inert surface, such as coated glass slides or gene chips, to which a mobile cDNA target is hybridized. (wikipedia.org)
  • In this study, we demonstrate that gDNA-based probe selection on the Affymetrix Human U133+2 GeneChip array can be used to study gene expression profiles in sheep tissues. (cambridge.org)
  • Also discussed are HLA gene-specific primers and HLA allele-specific or SNP-specific hybridization probes. (genomeweb.com)
  • Gene probes can be used to locate specific segments of normal or mutated DNA. (msdmanuals.com)
  • In order to increase the in vivo stability of the probe RNA is not used. (wikipedia.org)
  • The binding sites for these primers are introduced via the "circularizable" detector probes. (hindawi.com)
  • Probes with tethered fluorophore and quencher allow for solution-based assays and eliminate the need for washing steps thereby facilitating integration into microfluidic devices. (psu.edu)
  • Dot-blot hybridization was used to check a large number of TSV isolates with a single probe. (elis.sk)
  • We performed tests on cell cultures to decrease the risk for non-specific hybridization, before they are used on environmental samples. (hal.science)
  • Depending on the method, the probe may be synthesized using the phosphoramidite method, or it can be generated and labeled by PCR amplification or cloning (both are older methods). (wikipedia.org)
  • In forensic science, hybridization probes are used, for example, for detection of short tandem repeats (microsatellite) regions and in restriction fragment length polymorphism (RFLP) methods, all of which are widely used as part of DNA profiling analysis. (wikipedia.org)
  • We further designed and tested an expanded panel of dsPNA probes for detection of a wide variety of pathogenic bacteria including probes for universal detection of eubacteria, Enterobacteriaceae family, and P. mirablis. (psu.edu)
  • We increased the hybridization stringency from 55 to 65% formamide for the Eub338+EubII+EubIII probe mix to be specific to the Eubacteria domain. (hal.science)
  • Easy to use -With ready-to-use labeled options and multiple optimized protocols available, myTags probes are ideal for new or expert cytogenetics ISH users. (arborbiosci.com)
  • Affordable and scalable -Our proprietary oligo synthesis platform and flexible labeling options allow production of high-quality probe pools at extremely competitive pricing for any project size. (arborbiosci.com)
  • Research in the Miller group focuses on two fundamental areas: the control of biomolecular interactions through the synthesis of new small-molecule probes, and the observation of biomolecular interactions through the development of novel optical sensing technologies. (rochester.edu)
  • Access to expertise -Our team of expert scientists provide complimentary probe and project design assistance. (arborbiosci.com)
  • Comparing myTags synthetic probes (a) versus BAC-derived probes (b) for the human TP53 locus [ATTO 550] demonstrates that the myTags probes only hybridize to the intended locus, while the BAC-derived probes also display multiple off-target hybridizations, denoted by asterisks in (b). (arborbiosci.com)
  • However, major artifacts observed with a digoxegin RNA cold probe makes it necessary to recommend the use of a radioactive RNA probe for these prospects. (agronomy-journal.org)
  • On the contrary, it is plausible that there exist microorganisms, yet to be identified, which are phylogenetically members of a probe target group, but have partial or near-perfect target sites, usually applies when designing group-specific probes. (wikipedia.org)
  • Besides demonstrating that the probe selection method can be used to study the ovine transcriptome, the benefits of this approach are that it can greatly increase the number of annotated and novel genes that can be studied beyond those currently possible using ovine- or bovine-specific microarrays. (cambridge.org)
  • These probes are molecules that absorb light of a specific wavelength and emit light upon binding with a particular DNA/RNA sequence. (researchandmarkets.com)
  • myTags Custom probes have been demonstrated to achieve highly specific targeted F(ISH) across a wide range of applications and species. (arborbiosci.com)
  • We previously developed a highly specific genotyping method based on hairpin probes. (hindawi.com)
  • Our probes, also called hairloops, consist of a GC-rich stem and a target-specific loop [ 15 ]. (hindawi.com)
  • Dyes are also provided that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. (genomeweb.com)
  • Different types of probes may investigate a broad range of sizes of DNA sequence. (msdmanuals.com)
  • These probes are therefore widely used for the diagnosis, prediction of outcomes and clinical management of cancer and genetic disorders. (researchandmarkets.com)
  • The results of MSRF were confirmed by southern hybridization analysis using the aberrantly methylated DNA fragments as the probes. (cdc.gov)