Hybrid quadrupole linear ion trap. Medical search. Frequent questions

The Q Exactive HF system combines a state-of-the-art segmented quadrupole for high-performance precursor ion selection with a high-resolution, accurate-mass (HR/AM) ultra-high-field Orbitrap mass analyzer to deliver a superior combination of scan speed, resolving power, mass accuracy, spectral quality and sensitivity. (northwestern.edu)

A triple quadrupole mass spectrometer with the final quadrupole replaced by a time-of-flight device is known as a quadrupole time-of-flight instrument. (wikipedia.org)
The SCIEX QTRAP 6500+ ( YouTube Video ) is a state-of-the-art hybrid triple quadrupole mass spectrometer with a linear ion trap as Q3. (ccrc-hauner.de)
Overall, the SCIEX QTRAP 6500+ mass spectrometer provides enhanced sensitivity and selectivity for targeted small and large molecule quantitation from 5 to 2000 Da in triple quadrupol mode and 50 to 2000 Da in Linear Ion Trap mode. (ccrc-hauner.de)
After that, final confirmation of the positive findings using two MRM transitions and accurate quantitation is performed by LC-MS/MS using a hybrid triple quadrupole linear ion trap (QqLIT) mass spectrometer. (eurl-pesticides.eu)
Aliquots (10 ?L) were separated by online LC and analyzed with an Applied Biosystems hybrid triple quadrupole / linear ion trap mass spectrometer in Information Dependent Acquisition (IDA) mode, consisting of an enhanced MS survey scan followed by enhanced product ion scans for the two most intense parent ions as dependent MS/MS experiments. (massspec.com)
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An optimized method using liquid chromatography coupled with electrospray ionization ion trap mass spectrometry (LC/ESI-ITMS) in negative ion mode has been developed for screening different structural classes of intact glucosinolates in six Chinese medicinal herbs. (unboundmedicine.com)

The symbol Q represents a quadrupole mass analyzer, q is a radio frequency collision quadrupole, TOF is a time-of-flight mass spectrometer, B is a magnetic sector and E is an electric sector. (wikipedia.org)
Our paper presents an approach to trapping electrons without the use of magnetic fields, using radio frequency (RF) fields established between two perforated electrodes. (osti.gov)
Linear strings of trapped atomic ions held in radio-frequency (rf) traps constitute one of the leading platforms for quantum simulation experiments, allowing the investigation of interacting quantum matter. (iqoqi.at)

The extensive generation of fragment ions in AI-ETD+ substantially increases peptide sequence coverage while also improving peptide identifications over all other ETD methods, making it a valuable new tool for hybrid fragmentation approaches. (analyteguru.com)
In addition, the use of this QqLIT instrument also offers additional advantageous scanning modes (enhanced product ion and MS3 modes) for confirmatory purposes in compounds with poor fragmentation. (eurl-pesticides.eu)
The metabolite structures predicted by METEOR were used to generate a set of predicted parent ion isotope patterns and product ion fragmentation spectra. (massspec.com)
Rejected structures were either inconsistent with observed parent ions or had poor correlation between predicted and observed fragmentation spectra. (massspec.com)
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The improved Active Ion Management (AIM™) technology, segmented quadrupoles, advanced electron multipliers, and enhanced ion transmission tubes, help you to achieve unprecedented experimental sensitivity for all molecular species in complex matrices without sacrificing robustness. (northwestern.edu)
Here, we introduce and benchmark Zeno SWATH MS, a data-independent acquisition technique that employs a linear ion trap pulsing (Zeno trap pulsing) to increase the sensitivity in high-throughput proteomic experiments. (elifesciences.org)

This reaction scheme introduces no addition time to the scan duty cycle but generates MS/MS spectra rich in b/y-type and c/z●-type product ions. (analyteguru.com)
address this problem by generating fragment ion spectra from all precursor ions that fall within a predefined precursor m/z range window. (elifesciences.org)
The structures of the identified glucosinolates were confirmed with the use of group-specific product ions at m/z 195, 241, 259, 275 in their corresponding MS/MS product ion spectra. (unboundmedicine.com)

Modern hybrid tandem MS instruments can automatically and routinely acquire enhanced and highly sensitive parent and product ion scans for all significant components in an LC eluent stream. (massspec.com)
Using the linear ion trap mass spectrometer to perform enhanced MS survey and product ion MS/MS scans, six rat S9 metabolites of indinavir were identified with rich fragment information. (massspec.com)
Three of the six metabolites, formed by N-dealkylation and N-oxidation of the aromatic heterocycle and by hydroxylation did not produce the same major fragments observed in the product ion spectrum of indinavir. (massspec.com)
Three others, an amide reduction and two aromatic and hetero-aromatic ring hydroxylation metabolites, consisted not only of higher mass fragments, but a significant fraction of the lower mass fragments also observed in the product ion spectrum of indinavir. (massspec.com)

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Here we describe the first implementation of AI-ETD on a quadrupole-Orbitrap-quadrupole linear ion trap (QLT) hybrid MS system (Orbitrap Fusion Lumos) and demonstrate the substantial benefits it offers for peptide characterization. (analyteguru.com)
However, because the masses of complementary ions are peptide-dependent and include the heavy isotope labels of the balancer-region (blue rectangles), they can be used for interference-free, accurate MS2 quantification. (biorxiv.org)
This occurs through the γ -carboxyglutamic acid (Gla) domain and results in simultaneous activation of protease-activated receptor-1 (PAR-1) signaling via the thrombin receptor agonist peptide (TRAP) domain [ 12 , 13 ]. (biomedcentral.com)

During MS/MS analysis, each isobaric tag is fragmented to produce a unique reporter ion mass that is used for quantitation 1 . (openaccesspub.org)

But, atomic microsystems require active maintenance of ultrahigh vacuum in order to have reasonable operating lifetimes and are particularly sensitive to magnetic fields that are used to trap electrons in traditional sputter ion pumps. (osti.gov)
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A linear ion trap combined with a Fourier transform ion cyclotron resonance or Orbitrap mass spectrometer is marketed by Thermo Scientific as the LTQ FT and LTQ Orbitrap, respectively. (wikipedia.org)
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We have a variety of hybrid mass spectrometer instrument configurations including quadrupole, quadrupole linear ion trap, and Orbitrap mass analyzers. (coonlabs.com)

A sector instrument can be combined with a collision quadrupole and quadrupole mass analyzer to form a hybrid instrument. (wikipedia.org)
A BEqQ configuration with a magnetic sector (B), electric sector (E), collision quadrupole (q) and m/z selection quadrupole (Q) have been constructed and an instrument with two electric sectors (BEEQ) has been described. (wikipedia.org)
In an ion trap instrument, ions are trapped in a quadrupole ion trap and then injected into the TOF. (wikipedia.org)
First, we show that AI-ETD can be implemented in a straight-forward manner by fastening the laser and guiding optics to the instrument chassis itself, making alignment with the trapping volume of the QLT simple and robust. (analyteguru.com)

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These include both the inherent quantum bit systems and materials playing supportive or enabling roles, and cover trapped ions, neutral atom arrays, rare earth ion systems, donors in silicon, color centers and defects in wide-band gap materials, two-dimensional materials and superconducting materials for single-photon detectors. (edu.au)

This information is used for determining which condition the ions stem from and permits relative quantification of peptides. (biorxiv.org)
If MS2 reporter ions are used for quantification, the interfering peptides lead to a distortion of the measured ratios, as the source of reporter ions (red squares) cannot be distinguished. (biorxiv.org)

Using concurrent IR photo-activation during electron transfer dissociation (ETD) reactions, i.e., activated ion ETD (AI-ETD), significantly increases dissociation efficiency resulting in improved overall performance. (analyteguru.com)

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Magnetism: magneto-optical Kerr effect (MOKE), vibrating sample magnetometry (VSM), superconducting quantum interference device (SQUID), X-ray magnetic (circular, linear) dichroism (XMCD, XMLD). (infim.ro)

The Thermo Scientific™ Q Exactive™ Plus benchtop LC-MS/MS combines high performance quadrupole precursor selection with high-resolution, accurate mass (HR/AM) Orbitrap™ detection to deliver high performance and tremendous versatility. (northwestern.edu)

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The adoption of on-line fractionation and optimised acquisition protocols utilising ion mobility separation (IMS) technology has significantly increased the scope for protein identifications ten-fold. (biomedcentral.com)

High resolution quadrupole-orbitrap capable of esolving power up to 140,000 FWHM. (ucsd.edu)

Resolving the locations and discriminating the spin states of individual trapped ions with high fidelity is critical for a large class of applications in quantum computing, simulation, and sensing. (edu.au)
However, linear ion strings have drawbacks, such as the difficulty of scaling beyond approximately 50 particles as well as the inability to naturally implement spin models with more than one spatial dimension. (iqoqi.at)

Here, we evaluate and optimize complementary ion quantification for the recently released TMTPro tag, which increases plexing capacity to eight channels (TMTProC). (biorxiv.org)

We initiate the experimental testing of its predictions, with a trapped-ion simulator. (iqoqi.at)

Differentiation of intact glucosinolates was achieved through their respective retention times and molecular masses as well as the characteristic product ions. (unboundmedicine.com)

the Linear Accelerator™ Trap as Q3 allows ion fragmentations up to MS3 and the IonDrive™ High Energy detector provides an increased linearity range at higher count rates compared to previous models. (ccrc-hauner.de)
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Finally, we prepare the out-of-plane motional modes of planar crystals consisting of up to 105 ions close to their ground state by electromagnetically induced transparency cooling, an important prerequisite for implementing long-range entangling interactions. (iqoqi.at)

The Thermo Scientific™ Orbitrap Fusion™ Tribrid™ mass spectrometer combines the best of quadrupole, Orbitrap, and ion trap mass analysis in a revolutionary Tribrid architecture that delivers unprecedented depth of analysis. (northwestern.edu)
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We characterize the trapping potential by analysis of crystal images and compare the observed crystal configurations with numerical simulations. (iqoqi.at)

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Our laboratory is equipped with a dozen state-of-the-art hybrid mass spectrometers. (coonlabs.com)

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Divalent atoms and ions with a singlet $S$ ground state and triplet $P$ excited state form the basis of many high-precision optical atomic clocks. (researchgate.net)
Surface science techniques: low energy electron diffraction (LEED), reflection high energy electron diffraction (RHEED), Auger electron spectroscopy, secondary ion mass spectroscopy (SIMS), sample preparations in UHV, molecular beam epitaxy (MBE), positron annihilation-induced Auger electron spectroscopy (PAES). (infim.ro)

A hybrid mass spectrometer is a device for tandem mass spectrometry that consists of a combination of two or more m/z separation devices of different types. (wikipedia.org)

Time-of-flight secondary ion mass spectrometry (ToF-SIMS) is a powerful analytical technique whose application has great potential for battery research and that today is not used at its full potential. (aip.org)

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The different m/z separation elements of a hybrid mass spectrometer can be represented by a shorthand notation. (wikipedia.org)

Using this approach, known as Floquet engineering, we experimentally realize a long-ranged, anisotropic Heisenberg model with tunable interactions in a trapped ion quantum simulator. (iqoqi.at)

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Anatomy2

Organisms6

Chemicals and Drugs55

Analytical, Diagnostic and Therapeutic Techniques and Equipment46

Phenomena and Processes42

Disciplines and Occupations9

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture4

Information Science9

Health Care12

Precursor ion1

Triple6

Electrospray ionization1

Radio frequency3

Fragmentation6

Multipole3

Sensitivity2

Spectra3

Product Ion4

Confinement7

Peptide3

Quantitation1

Vacuum2

Facebook3

Fourier2

Mass analyzers1

Instrument4

Amplitude1

Neutral1

Peptides2

Electron transfer dis1

Magnetic2

Detection1

Calorimeter1

Acquisition1

FWHM1

Spin2

Increases1

Experimental1

Masses1

Detector2

Illustrates3

Crystals1

Analysis5

Sliding mode co2

State-of-1

Guide2

High2

Tandem1

Secondary1

Scan1

INTRODUCTION2

Small2

Election1

Separation1

Approach1

Transmission1

Computational1