Humans studies protected from chemotherapy induced. Medical search. Frequent questions

To date, there are no effective and well-tolerated cytostatics for the palliative treatment of patients who are not suitable for aggressive anthracycline-based chemotherapy. (spandidos-publications.com)
One example is a human study in which researchers discovered that higher levels of the antioxidant selenium in the blood of patients with aggressive B-cell non-Hodgkin's lymphoma correlated with increased achievable doses of anthracycline based chemotherapy, better treatment response, achievement of long term remission, and longer overall survival. (pinestreetfoundation.org)

Antioxidant and apoptosis-inducing activities of ellagic acid. (nutrimedical.com)
BACKGROUND: Antioxidant, antiproliferative and apoptosis inducing activities of a natural polyphenolic compound, ellagic acid, were studied. (nutrimedical.com)
For apoptotic inducing activity, human osteogenic sarcoma (HOS) cell proliferation, chromosomal DNA degradation and changes in apoptosis-related protein levels were measured. (nutrimedical.com)
Ellagic acid significantly reduced HOS cell proliferation, and induced apoptosis evidenced by chromosomal DNA degradation and apoptotic body appearance. (nutrimedical.com)
CONCLUSION: Ellagic acid exhibited both antioxidant activity in V79-4 cells and apoptosis-inducing activity in HOS cells through the up-regulation of Bax and activation of caspase-3. (nutrimedical.com)
Currently, little is known about HO-1 and its role in human acute myeloid leukaemia (AML) to regulate apoptosis in response to chemotherapy. (oncotarget.com)
Recently, we showed that HO-1 protects AML samples from tumour necrosis factor-α (TNF)-induced apoptosis - it being regulated by transcription factors Nrf2, NF-ĸB and AP-1. (oncotarget.com)
This study aims to analyse the role of HO-1 in regulating apoptosis in AML cells in response to two front-line chemotherapeutic agents used for AML, cytarabine and daunorubicin. (oncotarget.com)
Moreover, we showed that both daunorubicin and cytarabine induced reactive oxygen species (ROS) accumulation to induce apoptosis in AML. (oncotarget.com)
The authors of the above-mentioned study on Burkitt lymphoma cells and chemotherapy suggest that including antioxidants in the treatment protocol may enhance chemotherapy-induced apoptosis and phagocytosis. (pinestreetfoundation.org)
2000) A second study, involving the chemotherapy drugs etoposide and calcimycin, confirms this finding: Human Burkitt's lymphoma cells were unable to die quickly by apoptosis in the presence of oxidative stress and instead died using the slower and messier method of necrosis. (pinestreetfoundation.org)
In this study, it was found that oxidative stress inhibited apoptosis by depleting cells of their energy source, which is called adenosine triphosphate (ATP). (pinestreetfoundation.org)
Western blot analysis was performed to study Boswellia sacra essential oil-regulated proteins involved in apoptosis, signaling pathways, and cell cycle regulation. (biomedcentral.com)
Boswellia sacra essential oil hydrodistilled at 100 o C was more potent than the essential oil prepared at 78 o C in inducing cancer cell death, preventing the cellular network formation (MDA-MB-231) cells on Matrigel, causing the breakdown of multicellular tumor spheroids (T47D cells), and regulating molecules involved in apoptosis, signal transduction, and cell cycle progression. (biomedcentral.com)
Cucurbitacin E which has been shown in studies to induce cell cycle arrest and apoptosis in breast cancer cells. (divinejuicery.com)
Compared with the corresponding parental cells, the SP cells of SWCNT-transformed and H460 cells acquired apoptosis resistance to various chemotherapy including antimycin A, cisplatin, doxorubicin and etoposide. (cdc.gov)

Can ferroptosis be specifically induced in tumors but not in normal tissues? (nature.com)
Most studies in the p53 field have focused on its roles in tumors. (nature.com)
The study suggests that tumors may be preferentially generating non-cytotoxic GSDMB variants in order to protect against pyroptosis. (mdanderson.org)
Design and Methods OPM2 and high-risk primary myeloma tumors were grown in human fetal bone implanted into non-obese diabetic severe combined immunodeficiency mice with a deficient interleukin-2 receptor gamma chain. (haematologica.org)
Most solid tumors including lung cancer cells are believed to contain poorly differentiated cancer stem-like cells (CSCs) that initiate tumorigenesis and confer resistance to chemotherapy. (cdc.gov)
We conducted a retrospective study of 326 patients with solid tumors treated with anti-cancer medications to determine the proportion of cancer patients with immunogenicity against SARS-CoV2, following two doses of the BNT162b2 vaccine. (cdc.gov)
In a phase II study of pembrolizumab in patients with microsatellite-high (MSI-H) solid tumors, the objective response rate was 39.6% (95% CI = 31.7% to 47.9%), including 7.4% complete responses (CRs) and 32.2% partial responses (PRs). (medscape.com)
[ 10 ] Based partly on this study, pembrolizumab was recently approved by the FDA for treatment of advanced MSI-H tumors. (medscape.com)

Radiosensitizers are chemical agents that have the potential to increase the lethal effect of radicals induced during irradiation [1-6].The extent of radiation damage to cells is dependent on the amount of oxygen available to the cell [1,2,7,8]. (who.int)

Ginger (Zingiber officinale) can be helpful in alleviating nausea and vomiting caused by chemotherapy. (peacehealth.org)
Drinking grape juice 30 minutes before meals for a week following each cycle of chemotherapy doesn't seem to reduce nausea or vomiting caused by chemotherapy. (medlineplus.gov)

In this article, we turn our focus to lymphoma, conducting a systematic search for published research that would support or discourage the use of antioxidants in combination with chemotherapy. (pinestreetfoundation.org)

The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine. (peacehealth.org)
People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status. (peacehealth.org)
Patients with inoperable head and neck cancer were treated with a spleen peptide preparation (Polyerga) in a double-blind trial during chemotherapy with cisplatin and 5-FU. (peacehealth.org)
Acetyl-L-carnitine in the amount of 1,000 mg three times per day for eight weeks has been shown to improve nerve damage (neuropathy) caused by the chemotherapy drug cisplatin. (peacehealth.org)
For example, a study using human Burkitt lymphoma cells found that oxidative stress actually interferes with the ability of the chemotherapy drugs doxorubicin, cisplatin, etoposide, and cytarabine to cause cancer cell death. (pinestreetfoundation.org)

Prolonged fasting can protect hematopoietic stem cells from aging and cancer chemotherapy. (drcarney.com)
Our study demonstrates that the polyphenol-rich purified OMWW extract A009 combined with cancer chemotherapy could represent a potential candidate for cardiovascular protection in breast cancer patients, while increasing the effects of breast cancer chemotherapy. (uninsubria.it)

The goal of chemotherapy is to kill tumour cells by inducing DNA lesions, which cause cancer cell collapse and death. (eurekalert.org)
These studies demonstrate that inflammation promotes tumour development. (sherrytorkos.com)
In other words, inflammation protects the tumour from attack by the immune system. (sherrytorkos.com)

Fifteen patients with advanced gastric cancer undergoing palliative chemotherapy with etoposide, leucovorin and 5-fluorouracil (ELF) received for 10 days (beginning 3 days before chemotherapy) daily i.v. injections of 2 mg of a polysaccharide fraction isolated from Echinacea purpurea herb cell cultures (EPS-EPO VIIa). (greenmedinfo.com)

The study has major implications for healthier aging, in which immune system decline contributes to increased susceptibility to disease as we age. (usc.edu)
By outlining how prolonged fasting cycles - periods of no food for two to four days at a time over the course of six months - kill older and damaged immune cells and generate new ones, the research also has implications for chemotherapy tolerance and for those with a wide range of immune system deficiencies, including autoimmunity disorders. (usc.edu)
During each cycle of fasting, this depletion of white blood cells induces changes that trigger stem cell-based regeneration of new immune system cells. (usc.edu)
Now, if you start with a system heavily damaged by chemotherapy or aging, fasting cycles can generate, literally, a new immune system. (usc.edu)
While chemotherapy saves lives, it causes significant collateral damage to the immune system. (usc.edu)
The research shows that cycles of prolonged fasting protect against immune system damage and induce immune system regeneration. (halalfinder.com)
Prolonged fasting also protected against toxicity in a pilot clinical trial in which a small group of patients fasted for a 72-hour period prior to chemotherapy, extending Longo's influential past research: "While chemotherapy saves lives, it causes significant collateral damage to the immune system. (lactobacto.com)
We are investigating the possibility that these effects are applicable to many different systems and organs, not just the immune system ," said Longo, whose lab is in the process of conducting further research on controlled dietary interventions and stem cell regeneration in both animal and clinical studies. (lactobacto.com)
Indeed, studies have shown that fasting for just three days can not only boost your immune system, but regenerate it entirely , helping to ensure a long and healthy life. (pttpnederland.nl)
Chemo can be quite taxing on the immune system, but the results of this study suggest that fasting can help to alleviate some of the harmful effects that come along with chemotherapy treatment. (pttpnederland.nl)
Professor Valter Longo, lead researcher of the study and a professor of both gerontology and biological sciences at the University of California, said the study proved that fasting can, in fact, assist the body with producing a new immune system. (pttpnederland.nl)

It's mechanism of action is to boost the cancer cell's reactive oxygen species -- which is like pushing the stress level of the cell over the edge -- to the point where the cell can no long protect itself and dies, said Monica L. Guzman, Ph.D., the lead researcher on the DMAPT project and a senior instructor at the University of Rochester Medical Center. (sciencedaily.com)
The in vitro effects of metronidazole on the production of reactive oxygen species by polymorphonuclear (PMN) cells were studied by means of nitroblue tetrazolium and luminol-dependent chemiluminescence. (who.int)

In both mice and a Phase 1 human clinical trial, long periods of not eating significantly lowered white blood cell counts. (usc.edu)
Mice and humans were studied for this research work. (drcarney.com)
NaturalNews) Researchers have just discovered that flavonoids extracted from common onions slow the rate of colon cancer growth in mice just as effectively as a chemotherapy drug. (naturalnews.com)
In this study, researchers fed three different doses of flavonoids extracted from onion, an oral chemo drug, or saline (as control) to mice, along with a high-fat diet. (naturalnews.com)
It is also known that the chemo drug may induce hyperlipidemia (high cholesterol and/or triglycerides) in humans and that is exactly what happened with the mice -- their average LDL cholesterol levels went up significantly. (naturalnews.com)
Unfortunately, the authors of the mice study did not disclose what quantity of extract was used. (naturalnews.com)
Rochester investigators looked at whether DMAPT could eliminate leukemia in donated human cells, and in mice and dogs. (sciencedaily.com)
In a 2009 animal study, scientists found that treating mice with AHCC helped protect them from chemotherapy-induced bone marrow suppression and liver damage, though we cannot say if it will have the same effects on humans. (supplementsyoucantrust.com)
A 2014 study found that AHCC had therapeutic effects on lymphocyte-driven colitis in mice, suggesting that AHCC may have beneficial inflammatory effects on IBS, though human studies are needed to be sure. (supplementsyoucantrust.com)
In a 2009 animal study, AHCC appeared to reduce the severity of infection and boost natural killer cell activity - a major factor in immune response - in mice infected with influenza, though the scientists couldn't definitively prove it. (supplementsyoucantrust.com)
A new mouse cardiac electrophysiology method was used to study mice harboring an alpha-myosin heavy chain Arg403Gln missense mutation (alpha-MHC403/+), which results in histological and hemodynamic abnormalities characteristic of familial hypertrophic cardiomyopathy (FHC) and sudden death of uncertain etiology during exercise. (jci.org)

(4) It's also noteworthy to mention that fasting protected against toxicity in a pilot clinical trial where patients fasted for 72 hours prior to chemotherapy. (halalfinder.com)
Cardiovascular toxicity in cancer patients receiving chemotherapy remains one of the most undesirable side effects, limiting the choice of the most efficient therapeutic regimen, including combinations of different anticancer agents. (uninsubria.it)
Fasting for 72 hours will also help protect cancer patients from the toxicity of chemotherapy. (pttpnederland.nl)

Applications Tested: This 12G5 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. (thermofisher.com)
Development of mechanical and thermal allodynia with decreased sensory nerve conduction velocity due to mitochondrial dysfunction and intra-epidermal nerve fiber (IENF) loss has been reported as a distinct pathobiological feature of Paclitaxel induced peripheral neuropathy in animal models. (edu.hk)
Our studies showed that hHsp27 overexpression accelerated the axonal regeneration with better functional recovery after peripheral nerve injury. (edu.hk)
Paclitaxel was injected intraperitoneally to transgenic (TG) hHsp27 and their littermate (LM) controls to induce peripheral neuropathy. (edu.hk)
In summary, our data suggest that Hsp27 could be a potential therapeutic target for chemotherapy induced peripheral neuropathy. (edu.hk)
Brain infection is thought to occur by means of direct neuronal transmission of the virus from a peripheral site to the brain via the trigeminal or olfactory nerve and indirect immune-mediated processes inducing neuroinflammation. (medscape.com)

Studies have also shown that ellagic acid may protect against chromosome damage and reduce the effects of chemically induced hepatic structural degeneration. (nutrimedical.com)
this resulted in a pronounced suppression of cell proliferation and higher apoptotic rates, as well as sensitization of cells to chemically induced oxidative stress. (londonmet.ac.uk)

We also discuss the possibility of targeting p53-mediated ferroptotic responses for the treatment of human cancers and potentially, other diseases. (nature.com)
Though cancer cells use glutamine as a fuel source, studies in humans have not found that glutamine stimulates growth of cancers in people taking chemotherapy. (peacehealth.org)
Haem oxygenase-1 (HO-1) is increasingly regarded as a pro-tumoral target in the treatment of human cancers. (oncotarget.com)
In the mortality meta-analysis for all cancers, the pooled OR was higher for studies conducted in Asia than studies conducted in Europe or North America. (elifesciences.org)

Previous studies have shown that Dermal Papilla Cells (DPC) from balding hair follicles were more susceptible to go into senescence after exposure to oxidative stress and growth inhibition by androgens than DPC from non-balding hair follicles. (imedpub.com)

Importantly, alkylating agents induce DNA damage at different genomic sites, which subsequently leads to lethal and/or mutagenic DNA base lesions. (frontiersin.org)
In comparison, the SN2 agent methyl methane sulfonate (MMS) induces N 1 -methyladenine (m 1 A) and N 3 -methylcytosine (m 3 C) lesions, preferably in single-stranded DNA (ssDNA). (frontiersin.org)
Each one of the trillions of cells that make up the human body suffers more than 10,000 DNA lesions every day. (eurekalert.org)

Due to its high antioxidant content, GSE can help prevent disease and protect against oxidative stress, tissue damage, and inflammation. (healthline.com)
Therefore, GSE likely protected against further heart damage. (healthline.com)
In a double-blind study, Japanese researchers found that the combination of vitamin E , vitamin C, and N-acetyl cysteine (NAC) -all antioxidants-protected against chemotherapy-induced heart damage without interfering with the action of the chemotherapy. (peacehealth.org)
In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage. (peacehealth.org)
However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage. (peacehealth.org)
This study investigated the role of TIGAR in DNA damage response (DDR) induced by genotoxic drugs and hypoxia in tumor cells. (nature.com)
Whether the elevated TIGAR expression protects DNA damage induced by chemotherapeutic agents or hypoxia has not been explored. (nature.com)
Epirubicin, a DNA damaging anticancer agent and CoCl 2 , which was used to imitate hypoxia condition, was applied to induce DNA damage in TIGAR knockdown HepG2 cells. (nature.com)
It is well established that can induce sufficient DNA damage to lead to cellular senescence, in vitro . (imedpub.com)
This research work was carried out to determine the effect of prolonged fasting on age-induced and chemotherapy-induced damage to hematopoietic stem cells (HSCs). (drcarney.com)
In particular, the loss of ALKBH6 in human pancreatic cancer cells increases alkylating agent-induced DNA damage and significantly decreases cell survival. (frontiersin.org)
The extremely low 5-year overall survival of patients is, in part, due to pancreatic cancer cells having several mechanisms of resistance to different chemotherapeutic treatments, one of which is their capacity to efficiently repair alkylating agent-induced DNA damage. (frontiersin.org)
Several alkylating agents are commonly used in chemotherapy but may induce DNA damage to cancer cells as well as normal cells. (frontiersin.org)
Lipoic acid increases the abundance of other protective antioxidants while improving mitochondrial function and preventing glycation-induced damage in the kidney and blood vessels of those with diabetes-thus defending against diabetic kidney disease, vision loss, and vascular dysfunction. (lifeextension.com)
As terrible as cancer is, chemotherapy can have a wide range of side effects - from hair loss to liver damage - though AHCC may reduce some of these. (supplementsyoucantrust.com)
Published in the journal, EMBO Molecular Medicine , the study from the laboratory of Professor Ralf Paus of the Centre for Dermatology Research describes how damage in the hair follicle caused by taxanes, cancer drugs which can cause permanent hair loss, can be prevented. (manchester.ac.uk)
The team hope that their work will support the development of externally applicable medicines that will slow or briefly suspend cell division in the scalp hair follicles of patients undergoing chemotherapy to mitigate against chemotherapy-induced hair damage. (manchester.ac.uk)
Dr Purba said: "Despite the fact that taxanes have been used in the clinic for decades, and have long been known to cause hair loss, we're only now scratching the surface of how they damage the human hair follicle. (manchester.ac.uk)
Chemotherapy damages the genes inside of dividing cells (i.e. hair, skin, stomach lining, bone marrow) because these tissues have dividing cells, chemotherapy can damage them causing side effects. (divinejuicery.com)
A small 2017 study found that alpha-lipoic acid was useful in protecting against oxidative damage in people with diabetic neuropathy. (healthline.com)

Now, some of those same researchers are back, reporting on the first-ever study of the appendix through the ages. (sciencedaily.com)
Ethan Evers is author of the award-winning medical thriller "The Eden Prescription," in which cutting-edge researchers perfect an effective, all-natural treatment for cancer, only to be hunted down by pharmaceutical interests which will stop at nothing to protect their $80 billion cancer drug cash machine. (naturalnews.com)
The study was published in the June 5 issue of Cell Stem Cell by researchers from the University of Southern California. (halalfinder.com)
In a first-in-human Phase I/II clinical trial, researchers led by Michael Wang, M.D. , examined the safety and efficacy of pirtobrutinib monotherapy in 90 patients with R/R MCL who previously received cBTKi treatment. (mdanderson.org)
In this study, researchers led by Qing Kong, Ph.D. and Zhibin Zhang, Ph.D. , examined six GSDMB splicing variants to provide insights into which are involved in pyroptosis. (mdanderson.org)
Researchers based at The University of Manchester have discovered a new strategy for how to protect hair follicles from chemotherapy, which could lead to new treatments that prevent chemotherapy-induced hair loss - arguably one of the most psychologically distressing side effects of modern cancer therapy. (manchester.ac.uk)
The researchers who conducted the study described it as remarkable and a major breakthrough - no kidding! (pttpnederland.nl)
According to Longo, the researchers were actually surprised when they realized the outcome of the experiment: "What we started noticing in both our human work and animal work is that white blood cell count goes down with prolonged fasting. (pttpnederland.nl)

Humans have been struggling with the big "C" without a decisive victory for centuries, so could AHCC be the trick to beating those malignant cells? (supplementsyoucantrust.com)
Our previous studies have shown that chronic exposure to single-walled carbon nanotube s (SWCNTs) induces malignant transformation of human lung epithelial cells. (cdc.gov)

We need time to further develop approaches like this to not only prevent hair loss, but promote hair follicle regeneration in patients who have already lost their hair due to chemotherapy. (manchester.ac.uk)

For example, research has found strong associations for the Human papiloma virus (HPV) and cervical cancer, Helicobacter pylori bacterial infection and gastric adenocarcinoma , the hepatitis B virus and cirrhosis and hepato-cellular carcinoma, asbestos-induced inflammation and lung cancer, and cigarette smoke-induced inflammation and lung, bowel and pancreatic cancer. (sherrytorkos.com)

Vitamin C appears to increase the effectiveness of chemotherapy in animals and with human breast cancer cells in test tube research. (peacehealth.org)
In fact, animal studies show that glutamine may actually decrease tumor growth while increasing susceptibility of cancer cells to radiation and chemotherapy, though such effects have not yet been studied in humans. (peacehealth.org)
Within the scope of this trial, we investigated the effects of the natural pine bark extract pycnogenol on human fibrosarcoma cells. (spandidos-publications.com)
In this assay, over 40 actives were screened for their ability to stimulate the proliferation of hair follicle dermal papilla cells and protect against induced cellular senescence. (imedpub.com)
However, because few perifollicular NK cells are found around healthy human anagen HFs, we asked how HFs escape from NK cell attack. (imedpub.com)
Here we show that HO-1 expression in AML samples was increased in response to both cytarabine and daunorubicin treatment, and micro RNA (miRNA) silenced HO-1 expression in combination with either daunorubicin or cytarabine induced a greater apoptotic responses in AML cells. (oncotarget.com)
In all cases, DMAPT induced rapid death of AML stem and progenitor cells, without harming healthy blood cells. (sciencedaily.com)
image: Images of human cells with their DNA damaged by a laser beam in the laboratory. (eurekalert.org)
Any new discovery in DNA repair will help develop better cancer therapies , whilst protecting our healthy cells," says Martinez. (eurekalert.org)
While a 2018 study found that AHCC limits the proliferation of ovarian cancer cells, it's far from a miracle cure, and you should only use it in addition to conventional treatments, even if you think you have the best AHCC supplements. (supplementsyoucantrust.com)
We developed a method that, for the first time, is able to study the complete genome of glial cells and see how they accumulate somatic mutations, starting from fetal life and through older stages. (abta.org)
NNT has a central role within mitochondrial antioxidant pathways, protecting cells from oxidative stress. (londonmet.ac.uk)
We hypothesized that NNT silencing in ACC cells will induce toxic levels of oxidative stress. (londonmet.ac.uk)
This study provides preclinical evidence of the therapeutic merit of antioxidant targeting in ACC as well as illuminating the long-term adaptive response of cells to oxidative stress. (londonmet.ac.uk)
We tested whether natural killer cells expanded by co-culture with K562 cells transfected with 41BBL and membrane-bound interleukin-15 could kill myeloma cells with a high-risk gene expression profile in vitro and in a unique model which recapitulates human myeloma. (haematologica.org)
The transferred, expanded natural killer cells proliferated in vivo in an interleukin-2 dose-dependent fashion, persisted up to 4 weeks, were readily detectable in the human bone, inhibited myeloma growth and protected bone from myeloma-induced osteolysis. (haematologica.org)
Conclusions These studies provide the rationale for testing expanded natural killer cells in humans. (haematologica.org)
The objective of this study was to optimize conditions for preparing Boswellea sacra essential oil with the highest biological activity in inducing tumor cell-specific cytotoxicity and suppressing aggressive tumor phenotypes in human breast cancer cells. (biomedcentral.com)
Similar to our previous observations in human bladder cancer cells, Boswellia sacra essential oil induces breast cancer cell-specific cytotoxicity. (biomedcentral.com)
A pivotal part of our study was to first get to grips with how exactly hair follicles responded to taxane chemotherapy, and we found that the specialised dividing cells at the base of the hair follicle that are critical for producing hair itself, and the stem cells from which they arise, are most vulnerable to taxanes. (manchester.ac.uk)
Therefore, we must protect these cells most from undesired chemotherapy effects - but so that the cancer does not profit from it. (manchester.ac.uk)
Your hair is constantly dividing new cells so that it can continuously grow, however, because of this the treatment of chemotherapy and hair loss becomes the side effect. (divinejuicery.com)
Is constantly producing new blood cells (red blood cells, white cells and platelets) because of the continuous dividing of cells to generate new ones it becomes compromised by chemotherapy. (divinejuicery.com)
Are constantly renewing themselves every 3-5 days and because of their continuous dividing of cells they too become compromised by chemotherapy. (divinejuicery.com)
Bromelain a natural occurring enzyme in our juice that has powerful anti-cancer properties and has been shown in studies to induce cell cycle arrest in cancer cells. (divinejuicery.com)
Vitamins A, E and folic acid help protect and assist with the production of red blood cells. (divinejuicery.com)
This study showcases how starving the body actually kickstarts stem cells into producing new white blood cells, which will then fight off infection. (pttpnederland.nl)
Metronidazole (Flagyl) is a drug used to treat infections and has been studied in the treatment of cancer [10,11] as a radiosensitizer drug, especially for hypoxic cells [9]. (who.int)
Parietal cells are mainly present in the gastric corpus and fundus, although complete mapping in the human stomach is not fully known. (medscape.com)
In this study we investigated whether SWCNT-transformed lung epithelial cells present CSC traits. (cdc.gov)
Similar to human non-small cell lung cancer H460 cells, SWCNT-transformed lung epithelial BEAS-2B cells but not its passage-matched control cells formed tumor spheres in stem cell-selective conditions, indicating the existence of lung CSCs. (cdc.gov)
Together, our results indicate the ability of SWCNT to transform human lung epithelial cells and induce CSCs which could represent a novel mechanism of carcinogenesis induced by CNTs. (cdc.gov)

Although angiogenesis has been considered as a potential therapeutic target of obesity, the inhibitory effect of endostatin on adipogenesis and dietary-induced obesity has never been demonstrated. (diabetesjournals.org)

The efficacy and safety should be investigated in further studies. (greenmedinfo.com)
The study demonstrated that pirtobrutinib was safe and showed durable efficacy in R/R MCL. (mdanderson.org)
Future pre-clinical and clinical studies are urgently needed to evaluate the safety and efficacy of Boswellia sacra essential oil as a therapeutic agent for treating breast cancer. (biomedcentral.com)

A comprehensive review of antioxidants and chemotherapy leaves open the question of whether supplemental antioxidants definitely help people with chemotherapy side effects, but it clearly shows that antioxidants need not be avoided for fear that the actions of chemotherapy are interfered with. (peacehealth.org)
Although research remains incomplete, the idea that people taking chemotherapy should avoid antioxidants is not supported by scientific research. (peacehealth.org)
However, when one looks more closely at the existing published science on how antioxidants and chemotherapy combine, the true answer is not so definitive. (pinestreetfoundation.org)
Many research studies, encompassing cell culture tests in the laboratory and also animal and some human studies, are coming to a conclusion often very different from the conventional perspective that chemotherapy and antioxidants should never be combined. (pinestreetfoundation.org)
2003) As seen in this study, higher levels of natural antioxidants can help treatment outcomes. (pinestreetfoundation.org)
On the other hand, the decreased levels of antioxidants (or oxidative stress) that are caused by many chemotherapy treatments correlates with increased side effects. (pinestreetfoundation.org)
Using antioxidants during chemotherapy is an important and controversial question among health care providers, patients, and their support teams. (pinestreetfoundation.org)
The overwhelming majority of studies find a favorable interaction between antioxidants and chemotherapy, providing evidence that antioxidants can decrease chemotherapy side effects, increase treatment effectiveness, and decrease resistance to chemotherapy. (pinestreetfoundation.org)

Animal studies have shown that GSE may suppress bone destruction in inflammatory autoimmune arthritis . (healthline.com)

What we started noticing in both our human work and animal work is that the white blood cell count goes down with prolonged fasting. (usc.edu)
The results of this study suggest that fasting may mitigate some of the harmful effects of chemotherapy," said co-author Tanya Dorff , assistant professor of clinical medicine at the USC Norris Comprehensive Cancer Center and Hospital. (usc.edu)
The findings of this study show that prolonged fasting can reverse immunosuppression and immunosenescence (loss of HSCs) by reducing the concentrations and activity of IGF-1 and PKA. (drcarney.com)
Several other promising scientific studies now show that lipoic acid has a beneficial effect on a number of the factors involved in metabolic syndrome: it reduces triglyceride levels, lowers cholesterol, improves fasting plasma glucose, and causes weight loss in rodent models of obesity. (lifeextension.com)
Studies show that fasting releases a significant surge in human growth hormone, which is associated with speeding up metabolism and burning off fat. (halalfinder.com)
The results of this study suggest that fasting may mitigate some of the harmful effects of chemotherapy. (halalfinder.com)
A study from the scientific journal of aging found that cancer patients who included fasting into their therapy perceived fewer side effects from chemotherapy. (halalfinder.com)
The National Institute on Aging has also studied one type of breast cancer in detail to further understand the effects of fasting on cancer. (halalfinder.com)

Recent promising studies demonstrate that immune checkpoint inhibitors (ICI) can induce objective intracranial response. (abta.org)
Dr Talveen Purba, lead author on the study explains: "Although at first this seems counter-intuitive, we found that CDK4/6 inhibitors can be used temporarily to halt cell division without promoting additional toxic effects in the hair follicle. (manchester.ac.uk)
Among the origins of achlorhydria that are related to medical care, medications like proton pump inhibitors that block H + /K + -ATPase activity can induce achlorhydria. (medscape.com)

Chronic inflammatory changes related to gastric Helicobacter pylori infection can also induce parietal cell changes. (medscape.com)
First, the Roux-en-Y gastric bypass surgery involves formation of a 15- to 30-mL fundal pouch. (medscape.com)
Anti-PD-1 or PD-L1 antibodies alone or in combination with CTLA-4 were shown to induce objective responses in approximately 10% to 20% of patients with gastric and gastroesophageal adenocarcinoma in small nonrandomized trials. (medscape.com)
In the recently presented study, KEYNOTE-059, [ 9 ] 259 patients with advanced refractory gastric cancer received pembrolizumab 200 mg every three weeks until progression. (medscape.com)
The first randomized phase III trial to investigate a checkpoint inhibitor in gastric cancer was the ONO-4358 study. (medscape.com)

Scientists have determined a new way to protect the hair follicle from chemotherapy in an effort to prevent hair loss as a result of cancer treatments. (manchester.ac.uk)
2,3] The majority employ them as adjuncts to chemotherapy or other cancer treatments to alleviate symptoms and to prevent recurrence. (cancernetwork.com)

The tumor suppressor TP53 (also called p53) has been among the most extensively studied genes since its discovery in 1979 [ 1 , 2 ]. (nature.com)
However, vast data from 30 years of further study indicate a tumor-suppressive role of p53 [ 1 , 3 ]. (nature.com)
TACE induced a reduction in tumor size mainly due to ischemia resulting from embolization 11 which expose tumor to acute hypoxia. (nature.com)
The study conducted here is an attempt to explore the potential of Withania somnifera's major constituent WA (Withaferin A) in attenuating the Hsp90/Cdc37 chaperone/co-chaperone interactions for enhanced tumor arresting activity and to elucidate the underlying mode of action using computational approaches. (biomedcentral.com)
Our preliminary and published studies uncovered a remarkably better response to standard care in female glioblastoma patients than in male patients as well as sex-specific differences in signaling networks and interactions in the tumor microenvironment. (abta.org)
Recent developments include a new treatment option for relapsed/refractory mantle cell lymphoma, a better understanding of protein variants that trigger tumor cell death and activate antitumor immunity, insights into the relationship between sickle cell trait and renal medullary carcinoma, the clinical relevance of CD8 T cell state in acute myeloid leukemia, and an understanding of the distinct neuronal pathways triggered by chemotherapy and nerve injury. (mdanderson.org)
Other factors have been suggested to correlate with response to immunotherapy based on clinical and preclinical studies, including elevated type 1 helper T cell (Th1) tumoral gene signature, [ 11 ] and IFN-γ expression, possibly attributable to its ties to other proteins and cytokines within the tumor microenvironment. (medscape.com)

Lipoic acid displays striking benefits in components of metabolic syndrome, including inducing weight loss, improving insulin resistance, and lowering blood pressure. (lifeextension.com)
Through the combined functions on adipogenesis and angiogenesis, endostatin prevents dietary-induced obesity and its related metabolic disorders, including insulin resistance, glucose intolerance, and hepatic steatosis. (diabetesjournals.org)

In clinical conditions, parietal cell dysfunction can be induced by antiparietal cell antibodies. (medscape.com)

In another study, patients receiving high-dose paclitaxel and melphalan had significantly fewer episodes of oral ulcers and bleeding when they took 6 grams of glutamine four times daily along with the chemotherapy. (peacehealth.org)
Our recent studies revealed that Paclitaxel disrupt microtubule organization in mouse primary dorsal root ganglion neuron measured by atomic force microscopy and confocal imaging. (edu.hk)

Thus the molecular docking analysis of WA into Hsp90 and active Hsp90/Cdc37 complex conducted in this study provides significant evidence in support of the proposed mechanism of chaperone assembly suppression by inhibition or disruption of active Hsp90/Cdc37 complex formation being accounted by non-assembly of the catalytically active Hsp90/Cdc37 complex. (biomedcentral.com)
It has long been known that oxidative stress is an essential mechanism by which chemotherapy works to treat cancer. (pinestreetfoundation.org)

Herein we report the development of a high-throughput screening assay, using low, repeat dosing of to induce senescence. (imedpub.com)
Of the promising actives, three types of activities were observed actives that stimulated cellular proliferation without an observable protection against induced senescence. (imedpub.com)
Actives that stimulated cellular proliferation and protected against induced senescence. (imedpub.com)
Actives that protected against induced senescence with no cellular proliferative activity. (imedpub.com)
Finally, in human cardio myocytes, we observed 5-FU-induced upregulation of the inflammatory, senescence-associated cytokine IL6 and p16 genes, which expression was reduced by OMWW treatment. (uninsubria.it)

Side effects from melatonin supplements are minimal at low doses for short durations (in the studies reported about equally for both melatonin and placebo). (wikipedia.org)
Several studies have researched the effects of GSE on high blood pressure . (healthline.com)
In an 8-week study in 17 healthy postmenopausal women, taking 400 mg of GSE had blood-thinning effects, potentially reducing the risk of blood clots. (healthline.com)
An additional study in 8 healthy young women assessed the effects of a single 400-mg dose of proanthocyanidin from GSE immediately followed by 6 hours of sitting. (healthline.com)
Chemo drugs are known to carry some serious side effects, and the drug used in this study was no exception -- over 100 possible side effects are known, including coma, temporary blindness, loss of ability to speak, convulsions, paralysis and collapse. (naturalnews.com)
So far, there have been few reliable clinical trials testing the effects of AHCC, though there is a lot of preliminary research - such as test-tube and animal studies - with promising findings. (supplementsyoucantrust.com)
Polysaccharides isolated from Echinacea purpurea herba cell cultures to counteract undesired effects of chemotherapy. (greenmedinfo.com)
In an open prospective study with matched historical controls we aimed to evaluate whether a polysaccharide fraction isolated from the herb Echinacea purpurea could counteract the undesired effects of chemotherapy. (greenmedinfo.com)

Additionally, a study in 87 people undergoing heart surgery found that taking 400 mg of GSE the day before surgery significantly reduced oxidative stress. (healthline.com)

Linkage and comparative mapping studies indicate that the transferred chromosome segment contains a number of candidate genes for hypertension, including genes encoding a brain dopamine receptor and a renal epithelial potassium channel. (jci.org)

More clinical studies are needed, and any such dietary intervention should be undertaken only under the guidance of a physician. (usc.edu)
Over 15 randomized clinical studies have shown that intravenous administration of 300-600 mg of lipoic acid a day greatly improves nerve function and relieves pain symptoms in diabetic neuropathy patients. (lifeextension.com)

Adrenocortical carcinoma (ACC) is an aggressive malignancy with poor response to chemotherapy. (londonmet.ac.uk)

Since pycnogenol is a naturally occurring compound that is very well-tolerated with a high oral bioavailability, it has been highly studied for the treatment of many diseases including cancer ( 17 , 18 ). (spandidos-publications.com)
Bax expression was induced and caspase-3 was activated by ellagic acid treatment. (nutrimedical.com)
DMAPT also has shown potential as a treatment for breast and prostate cancer, melanoma, and multiple myeloma, Guzman said, although those studies have only been conducted in cell cultures to date. (sciencedaily.com)
In this study, we evaluated a potential new treatment target for ACC, focusing on the mitochondrial reduced form of NAD phosphate (NADPH) generator nicotinamide nucleotide transhydrogenase (NNT). (londonmet.ac.uk)
All three human breast cancer cell lines were sensitive to essential oil treatment with reduced cell viability and elevated cell death, whereas the immortalized normal human breast cell line was more resistant to essential oil treatment. (biomedcentral.com)
Combination chemotherapy results in improvement in overall survival in comparison with single-agent treatment or supportive care. (medscape.com)

The 12G5 antibody shows partial inhibition of chemotaxis and calcium influx induced by SDF-1 (the natural ligand of CD184), blocks CD4-independent HIV-2 infection, and blocks CD4-dependent infection by some T-tropic HIV-1 isolates. (thermofisher.com)
Bacteriophages , like our EcoPhage , selectively target harmful bacteria (like E. coli ), and completely wipe them out (this was pioneered in Europe before the advent of antibiotics) 2,3,4 , leaving beneficial microbes to flourish, supporting the growth of beneficial bacteria and protecting against future infection. (bodyecology.com)
The authors conducted a systematic review and baseline meta-analysis of studies on the impact of SARS-Cov-2 infection on morbidity and mortality among cancer patients not previously vaccinated against the virus. (elifesciences.org)
Since the emergence of SARS-CoV-2, many studies have been conducted on the outcomes of COVID-19, in order to identify factors associated with a higher death rate and a more severe infection course. (elifesciences.org)
Elderly individuals (60+) who received their second dose in March 2021 were 1.6 (CI: [1.3, 2]) times more protected against infection and 1.7 (CI: [1.0, 2.7]) times more protected against severe COVID-19 compared to those who received their second dose in January 2021. (cdc.gov)

GSE supplements have been found to reduce LDL oxidation triggered by high fat diets in several animal studies . (healthline.com)
Light sensitivity: This tandem dye is sensitive photo-induced oxidation. (thermofisher.com)

This nutrient protects vital cellular energy and shields against diabetes, obesity, cardiovascular disease, and neurodegeneration. (lifeextension.com)
Neuropathy is a particularly common complication of diabetes and a side effect of chemotherapy. (healthline.com)
But a small 2012 study found that people with type 1 diabetes who took 300 milligrams per day of benfotiamine showed no significant improvements in nerve function or inflammation. (healthline.com)

Amino Up Co. promotes AHCC as an immune booster , claiming that the best AHCC supplements "[ turn] the dial up on your natural immune response ," but there is little human research to support these claims. (supplementsyoucantrust.com)
Furthermore, this inflammatory response can compromise the response to chemotherapy. (sherrytorkos.com)

It remains unclear how important this effect is or if people taking chemotherapy should take taurine supplements. (peacehealth.org)
Since it was first developed, AHCC has gained popularity as a Complementary and Alternative Medicine (CAM) for immune support, with some proponents recommending the best AHCC supplements for chemotherapy patients. (supplementsyoucantrust.com)

Previous study revealed that the protective effect of TIGAR in cell survival is mediated through the increase in PPP (pentose phosphate pathway) flux. (nature.com)
This study suggests that this happens via an active NK cell suppression. (imedpub.com)
Moreover, ellagic acid induced nodule mineralization in an osteoblastic cell line (KS483), an effect that was abolished by the estrogen antagonist. (nutrimedical.com)
By studying this at the single cell level, will give us a unique opportunity to obtain information with unprecedented resolution, no attainable by any other means. (abta.org)
In this study, we investigated the activities of polyphenol-rich extract from OMWW, A009, in cooperation with chemotherapy on two breast cancer cell lines, namely, BT459 and MDA-MB-231, in a cardio-oncology perspective. (uninsubria.it)
We found that the A009 extract exhibited antiangiogenic activities induced by breast cancer cell supernatants and increased T-cell recruitment in vivo. (uninsubria.it)
Boswellia sacra essential oil-mediated cell viability and death were studied in established human breast cancer cell lines (T47D, MCF7, MDA-MB-231) and an immortalized normal human breast cell line (MCF10-2A). (biomedcentral.com)
In the Kcne2 potassium channel ancillary subunit knockout model, disruption of this gene induces achlorhydria and is related to reduced parietal cell protein secretion and abnormal parietal cell morphology. (medscape.com)

Using a modern approach to evolutionary biology called cladistics, which utilizes genetic information in combination with a variety of other data to evaluate biological relationships that emerge over the ages, Parker and colleagues found that the appendix has evolved at least twice, once among Australian marsupials and another time among rats, lemmings and other rodents, selected primates and humans. (sciencedaily.com)
Progress in our studies will establish a model approach for future studies that take into account sex as a biological variable in cancer care. (abta.org)

Anatomy4

Organisms1

Diseases85

Chemicals and Drugs71

Analytical, Diagnostic and Therapeutic Techniques and Equipment76

Phenomena and Processes11

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena2

Humanities1

Information Science3

Health Care31

Anthracycline-based chemotherapy2

Apoptosis16

Tumors8

Radicals induced during irra1

Vomiting caused by chemotherapy2

Combination with chemotherapy1

Cisplatin5

Cancer chemotherapy2

Tumour3

Etoposide1

Immune system11

Reactive oxygen2

Mice11

Toxicity3

Peripheral6

Chemically induced2

Cancers4

Balding hair follicles1

Lesions3

Damage20

Researchers8

Malignant2

Regeneration1

Pancreatic cancer1

Cells32

Therapeutic target1

Efficacy3

Antioxidants8

Bone1

Fasting8

Inhibitors3

Gastric5

Treatments2

Tumor7

Metabolic2

Antibodies1

Paclitaxel2

Mechanism2

Senescence5

Effects8

Oxidative stress1

Genes1

Clinical studies2

Malignancy1

Treatment6

Infection5

Oxidation2

Diabetes3

Response2

Supplements2

Cell8

Biological2