Humans mathematical modeling models cardiovascular. Medical search. Frequent questions

Computational models and simulations are used to predict the relationship between parameters that are otherwise challenging to test experimentally, or used to design more relevant experiments reducing the time and costs of experiments. (wikipedia.org)
Simulations of experimental conditions not used for model development corroborate the model's predictive capabilities. (tamu.edu)
Development of appropriate mathematical and numerical models for large-scale computational simulations of the human cardiovascular system. (utl.pt)
In recent years, a novel research direction was initiated with a focus on the mathematical modelling, advanced computational simulations, and state-of-art experiments based on the combined particle imaging velocimetry (PIV) and magnetic resonance imaging (MRI) to mimic complex blood and air flows in the patient-specific cardiovascular and respiratory systems. (tudelft.nl)
Computational Life is a young company which has the specialty on computational flow simulations and mathematical models for the medical technology field. (cardiovascularmechanics.org)
In this work, we test the hypothesis that in a statistical shape model (SSM), the modes that are most relevant for describing anatomy are also most important for determining the output of cardiac electromechanics simulations. (plos.org)
This highlights the need to have high fidelity anatomical models in cardiac simulations and demonstrates that subtle changes in cardiac anatomy can have a large impact on cardiac function. (plos.org)
He and his team use mathematical computation to research and develop beating heart simulations, modeling the interactions of the heart's fluid movement, physical structure, and electrical system. (unc.edu)

The model consisted of 21 compartments, including the upper body, renal, splanchnic, and leg circulation, as well as a four-chamber heart and pulmonary circulation. (tamu.edu)
Therapeutic targeting of P2X4 receptor and mitochondrial metabolism in clear cell renal carcinoma models. (ucsd.edu)
Micro to macro scale analysis of the intact human renal arterial tree with Synchrotron Tomography. (umassmed.edu)
More than 400,000 children worldwide suffer from type 1 diabetes, a chronic disease that can lead to severe complications, such as blindness, cardiovascular disease, renal disease, coma or even death. (scienceblog.com)

Emphasis is given to the setup of physiologically accurate models associated with some vascular diseases built on virtual realistic geometries reconstructed from in vivo medical images, and to the use of highly integrated and efficient numerical algorithms for their simulation at acceptable computational costs. (utl.pt)
An associate professor in the Department of Mathematics at UNC, Griffith runs the Cardiovascular Modeling and Simulation Lab . (unc.edu)

With a deeper understanding of human cardiovascular physiology, Dr. Randles seeks to empower medical professionals who can tap the models for insights that enable more effective treatments for patients. (technologynetworks.com)
The Guyton model of fluid, electrolyte, and circulatory regulation is an extensive mathematical model of human circulatory physiology, capable of simulating a variety of experimental conditions, and contains a number of linked subsystems relating to circulation and its neuroendocrine control. (cellml.org)

Lishak S, Grigorian G, George SV, Ovenden NC, Shipley RJ, Arridge S. A variable heart rate multi-compartmental coupled model of the cardiovascular and respiratory systems. (umassmed.edu)

Mathematical modeling is a powerful tool for prediction and investigation of cardiovascular diseases. (kobv.de)
Prediction of human cardiotoxic QT prolongation using in vitro multiple ion channel data and mathematical models of cardiac myocytes. (ox.ac.uk)
Beatquency domain and machine learning improve prediction of cardiovascular death after acute coronary syndrome. (mit.edu)
Now a UNC mathematician, he creates computational models of the human heart to improve the prediction and treatment of cardiac diseases. (unc.edu)
The model accurately predicted that implementing a low frequency nasal insulin dosing regimen in animal models was more beneficial in controlling type 1 diabetes than a high frequency regimen," said Dr. von Herrath, noting that the software's prediction of the biomarkers was key in this process. (scienceblog.com)

As a result, in cardiac models, representing patient anatomy using a limited number of modes of anatomical variation can cause a loss in accuracy of simulated electromechanical function. (plos.org)
As an undergraduate student at Rice University, he became interested in heart models while working on a cardiac electrophysiology project with his undergraduate advisor, Steve Cox. (unc.edu)
Cardiac output represents the work capacity of the cardiovascular system (HR x SV), whereas SV represents the volume of blood pumped out of the left ventricle with each beat. (fit-pro.com)

Huang A., Stultz CM. Modeling Intrinsically Disordered Proteins with Bayesian Statistics. (mit.edu)
Mathematical modelling with Bayesian inference to quantitatively characterize therapeutic cell behaviour in nerve tissue engineering. (umassmed.edu)

But instead of simulating asteroid deflection or programming games, he's trying to understand the fluid mechanics of the human heart. (unc.edu)
While imaging techniques such as MRI have laid the groundwork for understanding cardiovascular mechanics, they can be expensive and time-consuming. (unc.edu)
He was hooked and went to graduate school at New York University, specifically, to work with Charlie Peskin -- a pioneer in heart modeling -- with the intent of modeling the coupling between the heart's electrical system and its mechanics. (unc.edu)
Abdul Barakat, co-author of the paper, is a professor of biodynamics at the Ecole Polytechnique where he specializes in modeling cardiovascular mechanics to better understand heart disease. (seeker.com)

We review major parameters of COVID-19 transmission dynamics from statistical and mathematical modeling studies using epidemiologic data reported in the first 60 days of the epidemic. (cdc.gov)

Cardiovascular diseases are one of the major problems in medicine today and the number of patients increases worldwide. (kobv.de)
I strongly believe in the tremendous potential of combining engineering (chemical, biomedical, mechanical), science (applied physics, applied mathematics, computer science, high-performance computing), medicine and biology in solving some of the most challenging research questions dealing with the early identification, diagnostics, and efficient treatment of various diseases in humans. (tudelft.nl)

ENGLISH ABSTRACT: The insulin signalling cascade is one of the most important regulatory and signalling pathways in humans. (sun.ac.za)
Mathematical modelling of insulin signalling is indispensable in the effort to un- derstand the dynamics of the insulin signalling cascade and how malfunctions therein lead to disease. (sun.ac.za)
A novel mathematical model detecting early individual changes of insulin resistance. (ucsd.edu)
SAN DIEGO - (December 9, 2010) - A La Jolla Institute team, led by leading type 1 diabetes researcher Matthias von Herrath, M.D., has demonstrated the effectiveness of a recently developed computer model in predicting key information about nasal insulin treatment regimens in type 1 (juvenile) diabetes. (scienceblog.com)
Dr. von Herrath's team used a different approach to test the model, asking it to predict the outcome of a hypothetical experiment on nasal insulin dosing frequency in animal models that had not yet been performed. (scienceblog.com)
But even more importantly, the advantage of applying computer modeling in optimizing the therapeutic efficacy of nasal insulin immunotherapy was confirmed. (scienceblog.com)
Specifically, Dr. von Herrath's team employed the model to investigate the possible mechanisms underlying the effectiveness of nasal insulin therapy, using the B: 9-23 peptide. (scienceblog.com)

This study describes a multidimensional 3D/lumped parameter (LP) model which contains appropriate inflow/outflow boundary conditions in order to model the entire human arterial trees. (sharif.edu)
A new extensive LP model of the entire arterial network (48 arteries) was developed including the effect of vessel diameter tapering and the parameterization of resistance, conductor and inductor variables. (sharif.edu)

Comparative biomechanics is the application of biomechanics to non-human organisms, whether used to gain greater insights into humans (as in physical anthropology ) or into the functions, ecology and adaptations of the organisms themselves. (wikipedia.org)
Comparative biomechanics is often applied in medicine (with regards to common model organisms such as mice and rats) as well as in biomimetics , which looks to nature for solutions to engineering problems. (wikipedia.org)
This has led FE modeling (or other discretization techniques) to the point of becoming ubiquitous in several fields of Biomechanics while several projects have even adopted an open source philosophy (e.g. (wikipedia.org)
The geometric models in this repository are collected from past research projects in the Cardiovascular Biomechanics Research Laboratory at Stanford University. (simtk.org)

Stuart's teaching expertise covers climate and ocean modelling, weather and climate, numerical oceanography and impacts of environmental change on ecosystems and society. (edu.au)
Through the IMAS 2+2 partnership with Ocean University of China he teaches Subject 4B Numerical Ocean Modelling each year in Qingdao, China. (edu.au)

WASHINGTON, DC (July 27th, 2020) The Mathematical Association of America (MAA) is pleased to recognize Dr. William. (maa.org)
WASHINGTON, DC (July 27th, 2020) Mathematical Association of America members receive service awards for their. (maa.org)

An often studied liquid biofluid problem is that of blood flow in the human cardiovascular system. (wikipedia.org)
It has been shown that the Windkessel model, being based on an analogy between electrical circuits and fluid flow, is a simple but effective method to model the human cardiovascular system. (kobv.de)
The consistent thread through Stuart's career has been using computational models to describe a physical system and then use that knowledge to understand the impacts of that change on social, biological and ecological systems. (edu.au)
Circulation system, cerebrospinal fluids, transport of pharmaceutical products throughout the body can be simulated for the human and animal body with DAP. (cardiovascularmechanics.org)
Conventional models of cardiovascular system frequently lack required detail and focus primarily on the overall relationship between pressure, flow and volume. (sharif.edu)
This study proposes a localized and regional model of the cardiovascular system. (sharif.edu)
It is well known that the modern understanding of the cardiovascular system undoubtedly starts with the work of William Harvey (1578-1657) who published his discovery of the circulation of blood in 1628. (scirp.org)
Today, HARVEY can accurately predict and emulate the path of hundreds of millions of blood cells as they move through the complex maze of the human vascular system. (technologynetworks.com)
A model of blood buffer system. (physiome.cz)
A quasidynamic model of the blood buffer system. (physiome.cz)
This is a CellML translation of the Guyton model of the regulation of the circulatory system. (cellml.org)
The other modules characterise the dynamics of the kidney, electrolytes and cell water, thirst and drinking, hormone regulation, autonomic regulation, cardiovascular system etc, and these feedback on the central circulation model. (cellml.org)

As these kinds of health effects data become available and methods to assess levels of significant human exposure improve, these MRLs will be revised. (cdc.gov)

Realistic boundary conditions and Navier-Stokes equations in healthy and stenosed models of carotid artery bifurcation. (sharif.edu)

Biophysical computational models of the heart provide a quantitative framework for mapping changes in anatomy to whole heart function. (plos.org)

We examined the diagnostic performance of CT-FFRML compared to stress perfusion cardiovascular magnetic resonance (CMR) and tested if there is an additional value of CT-FFRML over coronary computed tomography angiography (cCTA). (bvsalud.org)

death is associated with increasing age and underlying conditions (e.g., hypertension, cardiovascular disease, and diabetes) ( 3 ). (cdc.gov)

In this paper, we have applied parametric local sensitivity analysis (LSA) to a linear elastic model of the arm arteries, to find and rank sensitive param- eters that may be helpful in clinical diagnosis. (kobv.de)

We developed and validated a computational model to study the acute cardiovascular response to centrifugation combined with lower body ergometer exercise. (tamu.edu)
The model captures the cardiovascular response for a range of centrifugation and exercise profiles, and it shows promise in simulating additional conditions where data collection is difficult, expensive, or infeasible.NEW & NOTEWORTHY Artificial gravity combined with exercise is a potential countermeasure for spaceflight deconditioning, but the long-term and acute cardiovascular response to such gravitational stress is still largely unknown. (tamu.edu)

In Silico human-based methodologies for evaluation of drug safety and efficacy".2016-2021. (ox.ac.uk)

Effect of maternal cardiovascular conditions and risk factors on offspring cardiovascular disease. (ucsd.edu)
It takes three to tango: genes complicate the association between birth weight and cardiovascular disease. (ucsd.edu)
Heart Failure (HF) is the only cardiovascular disease for which incidence, prevalence, morbidity, mortality, and costs are not decreasing. (frontiersin.org)
More than 91 million people in the United States live with some form of cardiovascular disease, which claims more lives than all forms of cancer and chronic lower respiratory disease combined. (unc.edu)
The Type 1 Diabetes PhysioLab® Platform is a large-scale mathematical model of disease pathogenesis based on non-obese diabetic (NOD) mice. (scienceblog.com)
The MMWR series of publications is published by the Epidemiology Program Office, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia 30333. (cdc.gov)

Biotribology is the study of friction , wear and lubrication of biological systems, especially human joints such as hips and knees. (wikipedia.org)

Mechanical modeling using finite element analysis has been used to interpret the experimental observation of plant cell growth to understand how they differentiate, for instance. (wikipedia.org)

The model was then used to simulate the hemodynamic response of hypovolemic subjects (blood volume reduced by 5-15%) subjected to similar gravitational stress and exercise profiles, providing insights into the physiological responses of experimental conditions not tested before. (tamu.edu)

The software is designed to enable researchers to rapidly streamline laboratory research through the evaluation of alternative scenarios for therapeutic strategies that show the most promise for working in humans. (scienceblog.com)
By allowing us to pre-test our theories in computer models, we can ensure that the more time-intensive and costly process of laboratory testing is focused on the most promising therapeutic strategies, with the greatest chance of success. (scienceblog.com)

A computational model for end-to-side anastomosis (superior ulnar collateral anastomosis with posterior ulnar recurrent, SUC-PUR) is carried out to study the effects of some clinically relevant haemodynamic parameters like blood flow resistance and terminal re- sistance on pressure and flow at different locations of the arm artery. (kobv.de)
The sensitivities with respect to cardiovascular parameters reveal the flow resistance and diameter of the vessels as most sensitive parameters. (kobv.de)

Pediatric re-stenosed pulmonary artery model is depicted with marked points of unstable wall shear stress (WSS) which brings about the thinner layers by platelets. (cardiovascularmechanics.org)

The geometric models in this repository are mostly built from imaging data of healthy and diseased individuals. (simtk.org)
A more up-to-date repository of cardiovascular models can be found at http://www.vascularmodel.com/sandbox/doku.php . (simtk.org)

Computational model of cardiovascular response to centrifugation and lower body cycling exercise. (tamu.edu)
Centrifugation and exercise profiles were simulated and compared with experimental data gathered on 12 subjects exposed to a range of gravitational levels (1 and 1.4G measured at the feet) and workload intensities (25-100 W). The model was capable of reproducing cardiovascular changes (within1 SD from the group-averaged behavior) due to both centrifugation and exercise, including dynamic responses during transitions between the different phases of the protocol. (tamu.edu)

In the mixed effects model, random intercepts of the country and parallel of latitude were applied as 3 levels of the model (prevalence rate of each study, nested within countries and latitude parallel). (who.int)

In fact, although in the introduction to the problem (paragraphs 1-8), Euler focuses on the discussion on blood flow through arteries, to such a degree to even proposing adhoc models for the behavior of their elastic cross-sections, surprisingly, and also somehow disappointing, is that the main body of the manuscript (paragraphs 9-34) is devoted to the modeling of flows through rigid tubes, driven by a piston pump. (scirp.org)
The focus of modern neuroscience on cognitive processes has relegated to behavior the epiphenomenal status of neural processing and the difficulties generated by this interpretation have encouraged the use of computational models. (bvsalud.org)
The objective of this work was to review the concept of behavior by a selectionist approach and propose a connectionist computational model that operates integrally with its neurophysiological bases. (bvsalud.org)

Since laboratory studies can cost hundreds of thousands of dollars, and early stage human clinical trials can cost $10 million dollars or more, predicting the right conditions to try is important," said Dr. von Herrath, director of the Type 1 Diabetes Research Center at the La Jolla Institute for Allergy & Immunology, where the studies were conducted. (scienceblog.com)

The most convincing result was that Barakat and Suja's bubble-collapsing model produced pressure and sound waves with nearly identical amplitudes across time as real-world knuckle-cracking experiments. (seeker.com)

We therefore explored a physics-based mathematical [finite element (FE)] model of the normal human LV to test the hypothesis that reduced subendocardial contractility combined with compensatory high subepicardial contractility may help in preserving LVEF independent of changes in myocardial geometry and material properties. (frontiersin.org)

This is a CellML 1.1 version of the Stress Relaxation Module of the Guyton Circulation model. (cellml.org)
A systems analysis diagram for the full Guyton model describing circulation regulation. (cellml.org)

DTEM) has developed and coordinated a mixtures program that includes trend analysis to identify the mixtures most often found in environmental media, in vivo and in vitro toxicological testing of mixtures, quantitative modeling of joint action, and methodological development for assessment of joint toxicity. (cdc.gov)
Lust ST, Shanahan CM, Shipley RJ, Lamata P, Gentleman E. Design considerations for engineering 3D models to study vascular pathologies in vitro. (umassmed.edu)

Estimates of exposure levels posing minimal risk to humans (Minimal Risk Levels or MRLs) have been made for chlorine dioxide and chlorite. (cdc.gov)

At that time, the existing modelling software included fluid and structural dynamics - but not electrophysiology. (unc.edu)

Stuart's research expertise is focused computational modelling. (edu.au)
His research interests include climate change, climate modelling and understanding how our changing climate impacts on ecological and social systems. (edu.au)
Narayan directs the Computational Arrhythmia Research Lab (CARL), that operates at the intersection of cardiovascular medicine, bioengineering, and data science. (stanford.edu)
Permission is granted to use these models for research purposes, but not for commercial use. (simtk.org)
Because his passion for computer modeling seems innate, it's no surprise that Griffith pursued research. (unc.edu)
The findings, which also showed the platform's ability to predict critical type 1 diabetes molecular "biomarkers," were published in the December issue of the scientific journal Diabetes , and further validate the importance of the new model as a valuable research tool in type 1 diabetes. (scienceblog.com)
Math-CVML is a research group within the Centre for Mathematical Sciences. (lu.se)
2 Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Islamic Republic of Iran. (who.int)

He has extensive experience in developing and interpreting output of ocean and climate models, but also specialises in developing and using ecosystem models, particularly those that describe aspects of the Southern Ocean marine ecosystem. (edu.au)

European Science Foundation Award for the organization of the European Heart Modelling workshop. (ox.ac.uk)
CARL pioneered computational mapping of 'chaotic' heart rhythm disturbances (arrhythmias), targeting mechanistic drivers for atrial and ventricular fibrillation (AF, VF) using machine learning and computational models. (stanford.edu)
In the healthy adult human heart, shape modes that explain large portions of anatomical variance do not explain equivalent levels of electromechanical functional variation. (plos.org)
Many models utilize a mathematical formula to determine maximal heart rate (MHR) based upon one's age, assuming all people of the same age have the same MHR - this cannot be further from the truth. (fit-pro.com)

My personal goal is to see the transfer of knowledge, models, computer codes, and experimental approaches from my engineering Lab to practical clinical applications. (tudelft.nl)

Under certain mathematical circumstances, blood flow can be modeled by the Navier-Stokes equations . (wikipedia.org)
Dr. Randles is renowned in the scientific community for her innovative work developing HARVEY, a computational fluid dynamics model with the extraordinary capability to simulate the blood flow throughout the human body. (technologynetworks.com)

In addition, he said, the model was able to accurately identify the particular time frame at which key type 1 diabetes "biomarkers" kicked in. (scienceblog.com)

We conducted multilevel modeling using Stata 14 for data analysis. (who.int)

This may affect the transient behaviour of the model, however the steady-state behaviour would remain the same. (cellml.org)

The proposed method of parameter estimation for hydraulic electric analogy model is recursive least squares algorithm. (sharif.edu)

Anatomy21

Organisms43

Diseases20

Chemicals and Drugs35

Analytical, Diagnostic and Therapeutic Techniques and Equipment43

Psychiatry and Psychology16

Phenomena and Processes77

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20211

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