Humans approaches models cardiovascular. Medical search. Frequent questions

Human chymase is a very important target for the treatment of cardiovascular diseases. (scienceopen.com)
3) The role of translation machinery and translational control in cardiovascular system and identification of therapeutic targets for treatment of cardiovascular diseases (e.g., cardiac hypertrophy and heart failure). (rochester.edu)
The long-term objective of our laboratory is to identify novel RNA-based molecular mechanisms that control gene expression and conduct pathophysiological function in cardiac system, as well as to develop novel therapeutic approaches for the prevention or treatment of human cardiovascular diseases. (rochester.edu)
These funds will make it possible to launch CYNBIOME, the first excellence network on microbiota and infectious diseases based on the Non-Human Primate (NHP) model. (pharmiweb.com)
To date, there is no NHP efficacy model for studying the microbiome, in particular in the context of infectious human diseases. (pharmiweb.com)
This will allow CYNBIOME to offer unique preclinical services in the field of microbiome and infectious diseases, centered on the use of the NHP model. (pharmiweb.com)
Dr Bick's current scientific focus is on clonal hematopoiesis, a unifying feature of aging diseases as diverse as blood cancer and cardiovascular disease. (vicc.org)
By computationally sifting through public databases of genomic information, Stanford University researchers have matched 53 human diseases, including cancers, Crohn's disease and cardiovascular conditions, to existing drugs that might work as treatments for them. (livescience.com)
As a result of improved medical and surgical management of congenital cardiovascular malformations, about 90% of children born with congenital heart diseases now live into neonatal, postnatal and adult stages of life. (sc.edu)
The long term goal also includes an investigation into the role of the three TGFβ ligands in the susceptibility, onset, and progression of adult cardiovascular diseases. (sc.edu)
My current research program focuses on understanding the cellular and molecular mechanisms of HO-1 cytoprotective actions and developing therapeutic strategies for treatment of cardiovascular and metabolic diseases. (nymc.edu)
Environmental factors, including air and noise pollution, and the built environment, are typically associated with cardiovascular and metabolic non-communicable diseases (NCDs), e.g. obesity, type 2 diabetes, heart diseases and atherosclerosis. (europa.eu)
Experimental gastrointestinal models of human diseases. (norecopa.no)
The cardiovascular system and models for human diseases. (norecopa.no)
The primary goal of the A2I lab is to understand human health as a complex adaptive system so that we can improve the prediction, diagnosis, prevention, and treatment of common diseases such as Alzheimer's, cancer, and cardiovascular disease. (epistasis.org)
NIEHS research uses state-of-the-art science and technology to investigate the interplay between environmental exposures, human biology, genetics, and common diseases to help prevent disease and improve human health. (nih.gov)
Here we are interested in the non-enzymatic detection of cortisol in human sweat, as a mean to monitor the risk of cardiovascular diseases. (cnrs.fr)
Our primary focus is to develop synthetic antisense oligonucleotide based therapeutics targeting specific non-coding RNAs as a revolutionary pharmacological tool fighting cardiovascular diseases. (mhh.de)
Cardiovascular diseases are identified as one strategic use case of interest for clinical trials supported by digital twinning technologies. (eithealth.eu)
Cardiovascular diseases are the leading cause of death worldwide, with 15 million people living with heart failure in Europe alone. (eithealth.eu)
She uses genetic approaches to identify novel disease genes for dominantly inherited polycystic kidney and liver diseases: a phenotypic spectrum from autosomal dominant polycystic kidney disease (ADPKD) to isolated polycystic liver disease (PCLD), and both in vitro and animal models to further disease gene mechanism investigation. (yale.edu)
My laboratory is engaged in system biology approaches to investigate cardiovascular diseases. (yale.edu)
Due to the conserved nature of vertebrate cell behaviour, our results will be relevant to Wnt signalling during human embryonic development and could suggest novel vulnerabilities to Wnt-dependent diseases - a prerequisite for the development of novel therapeutics. (exeter.ac.uk)
Title : A Statistical Model for Assessing Genetic Susceptibility as a Risk Factor in Multifactorial Diseases: Lessons from Occupational Asthma Personal Author(s) : Demchuk, Eugene;Yucesoy, Berran;Johnson, Victor J.;Andrew, Michael;Weston, Ainsley;Germolec, Dori R.;De Rosa, Christopher T.;Luster, Michael I. (cdc.gov)
Researchers seek to use this information to understand the causes of diseases and the effects of environment, diet, lifestyle, and genetic factors on human health. (medlineplus.gov)
The goal is to find new in vitro approaches to understand and treat human diseases caused by the environment. (medlineplus.gov)
Toxic substances such as heavy metals-for example, arsenic and nickel-are associated with epigenetic changes that may lead to cancer, cardiovascular diseases, autoimmune diseases, and neurological disorders. (medlineplus.gov)
Aberrations in lipid and lipoprotein metabolic pathways can lead to numerous diseases, including cardiovascular disease, diabetes, neurological disorders, and cancer. (cdc.gov)

In this review, we present different strategies yielding encouraging results at the population level, from childhood until old age, that aim to protect against the challenges facing the scientific community when combating cardiovascular disease. (revespcardiol.org)

Internationally known as a leader in the area of nitric oxide (NO) biology, Dr. Huang's research investigates the molecular mechanisms linking diabetes, obesity and hyperlipidemia to cardiovascular and cerebrovascular disease. (massgeneral.org)
Lipid-associated macrophages transition to an inflammatory state in human atherosclerosis, increasing the risk of cerebrovascular complications. (ox.ac.uk)
In acromegaly, a severe disease that is often diagnosed late, morbidity and mortality rates are high, particularly as a result of associated cardiovascular, cerebrovascular, and respiratory disorders and malignancies. (medscape.com)

PET-scanning and development of models for studies of neurological disorders. (norecopa.no)
The most sensitive effects of lead appear to be neurological (particularly in children), hematological, and cardiovascular. (cdc.gov)

Our laboratory uses molecular, biochemical, physiological, pharmacologic (small molecule inhibitors), cell and tissue culture, and combined optical and biomechanical engineering approaches to analyze cell/tissue/organ-specific conditional/inducible gene knockout and transgenic mouse models. (sc.edu)
Interplay between cardiac function and structure in modulating deadly arrhythmias in the human heart, computer modelling and simulation towards a reduction and replacement of animals in research and safer drugs in human, and advanced mathematical modelling for cardiac tissue and magnetic resonance imaging. (ox.ac.uk)
We combine this Dutch tissue bank with state of the art proteomics approaches present in Singapore. (europa.eu)
We will produce several new models of actin and troponin-T-based cardiomyopathies to determine the molecular defects that drive diverse and complex tissue remodeling. (hopkinsmedicine.org)
These findings clarify the molecular and cellular expression pattern of this painless neuropathy gene in human tissue. (bvsalud.org)
To better understand the immunological mechanism operating at the chronic active lesion edge and to identify new therapeutical targets, she recently built a detailed cellular blueprint of multiple sclerosis lesions using single-nucleus RNA sequencing of human MS tissue and identified C1q as critical mediator of microglia activation. (the-asci.org)
Instead of re-growing functional heart tissue, the human heart, in response to a heart attack, produces a non-function scar. (fondationleducq.org)
3) Develop pre-clinical mammalian models of regenerative therapy through the delivery of cardiomyocyte mitogens and the engineering of cardiac tissue patches from stem cell-derived cardiomyocytes. (fondationleducq.org)
New tools have improved our ability to not only define distinct subsets of tissue-associated T cells, but also to address their functions in situ in human tissues. (ox.ac.uk)
The results will contribute to our understanding of the role of vascular immune cells in cardiovascular health and disease and it will explore the fundamental molecular mechanisms regulating vascular tissue immune cell responses. (ox.ac.uk)
The student will benefit from the availability of in-house state-of-the-art single cell technologies including transcriptomics and proteomics approaches using dissociative methods but also spatial methodologies including spatial transcriptomics and CyTOF Hyperion for tissue imaging in human and mouse models of atherogenesis. (ox.ac.uk)
At these levels and everything in between, work is carried out using an enormous range of approaches such as gene arrays, molecular techniques, cell cultures, tissue samples, computer models, animal studies, and human studies. (ox.ac.uk)

During his post-doctoral training under Dr. Paul Fox at Lerner Research Institute of Cleveland Clinic, he made contributions in understanding the translational control mechanisms regulating VEGFA (vascular endothelial growth factor-A) expression in human monocytes. (rochester.edu)
Dr. Paul Huang's research focuses on the roles of nitric oxide (NO) in cardiovascular disease and metabolism, using techniques ranging from molecular biology, physiology, and genetically altered mouse models, to human translational studies and induced pluripotent stem (iPS) cell approaches. (massgeneral.org)
We would like to make the CYNBIOME structure a unique network that connects a translational model with technological tools, scientific and industrial expertise, and specialized partners for the preclinical study of microbiota in NHP models. (pharmiweb.com)

His approach has been highly collaborative and multidisciplinary - combining human genomics and statistical genetics with in-vitro and in-vivo characterization of model systems and human samples. (vicc.org)
Genetics and transgenic models. (norecopa.no)
As a faculty member at the University of Virginia (2007-2014), Washington University (2014-2020) and Yale (2020-present), his work has sought to understand the causes and consequences of genome variation in mammals, with an increasing focus on computational methods development and human genetics. (yale.edu)
He has also served as an Associate Editor at Genome Research (2009-2014) and Genes, Genomes and Genetics (2011-2018).Most recently, Dr. Hall has played a leadership role in several large collaborative projects funded by NIH/NHGRI including the Centers for Common Disease Genomics, the AnVIL cloud-based data repository and analysis platform, and the Human Pangenome Project. (yale.edu)
By recruiting more than thousand kindreds with early onset CAD and multiple metabolic risk factors for genetics and metabolic studies we have been able to map, identify and characterize a dozen of human disease genes for CAD and MetS, which have been reported in leading journals such as Nat Genet, Science, NEJM, Cell Metab, JCI, PNAS, AJHG, etc. (yale.edu)

To reduce cardiovascular disease burden, the World Health Organization (WHO) and partners developed the HEARTS technical package to guide the management of hypertension and other cardiovascular disease risk factors in resource-limited settings [ 5 ]. (nature.com)
RTSL-supported programs, modeled after the India Hypertension Control Initiative, are also being implemented in 12 countries in the Latin America and the Caribbean region (in partnership with the Pan-American Health Organization (PAHO)) and nine other countries in South Asia, East Asia, Southeast Asia, sub-Saharan Africa, and Europe. (nature.com)
ABSTRACT This study aimed to evaluate the compliance of daily meals served to hypertensive and cardiac inpatients in Jordan according to WHO guidelines and the Therapeutic Lifestyle Changes (TLC) and Dietary Approach to Stop Hypertension (DASH) diets plans. (who.int)
RÉSUMÉ La présente étude visait à évaluer dans quelle mesure les repas quotidiens servis aux patients hospitalisés atteints d'hypertension ou de cardiopathie en Jordanie respectaient les recommendations de l'Organisation mondiale de la Santé (OMS) et les régimes alimentaires Therapeutic Lifestyle Changes (TLC) et Dietary Approach to Stop Hypertension (DASH). (who.int)

He received his Ph.D. degree in the laboratory of Dr. En-Duo Wang in Biochemistry and Molecular Biology from Shanghai Institute of Biochemistry and Cell Biology of Chinese Academy of Science in 2008, where he studied the structural and functional interplay of transfer RNA (tRNA) and tRNA synthetase in bacteria, yeast and human. (rochester.edu)
Plos Biology 2013 11: e1001635) and may play a role in cardiovascular disorders and cancers. (rochester.edu)
We employ various approaches and methods of biochemistry and biophysics, molecular and cellular biology, and genetic and surgical mouse models, to dissect the convergent and divergent regulatory pathways. (rochester.edu)
The Computational Cardiovascular Science group is an interdisciplinary team of scientists aiming at translating their background in Engineering, Mathematics, Physics, and Biology to Cardiovascular Research. (ox.ac.uk)
Our systems biology approach employs genomic, epigenomic and proteomic discovery tools to examine animal models and human populations. (vondriskalab.org)
Bioinformatics and computational biology play important roles in our investigations of chromatin biology and cardiovascular health. (vondriskalab.org)
Our mission is to discover the basic principles of chromatin biology as well as to understand the causes of cardiovascular disease-towards the goal of new therapies and cures. (vondriskalab.org)
We have developed expertise in in vivo investigation of lipid and glucose metabolism, insulin secretion and sensitivity, and vascular biology and in human physiological studies, leading to discovery of attractive drug targets that have been either patented or being investigated for their utility in treatment of fatty liver disease and diabetes in 2 clinical trials in the outlier populations of Fars/Iran. (yale.edu)
Researchers and scientists aim to use the information collected by ENCODE to interpret the human genome sequence and apply it to better understand human biology and improve health, and thanks to a new understanding of how people's genomes and epigenomes work, ENCODE's data will help them do so. (medlineplus.gov)

2. Determine the relationship between food preferences, consumption patterns and dietary acculturation, and cardiovascular health using population-based datasets. (usda.gov)
3. Identify novel biomarkers for food and nutrient intake related to dietary patterns and cardiovascular health. (usda.gov)
The CNL will determine the relationship between food preferences, consumption patterns and dietary acculturation, and cardiovascular health using population-based datasets by assessing the impact of acculturation status on dietary patterns and health outcomes. (usda.gov)
Evidence-based life-course causal models will estimate how clinical and policy interventions may sustainably affect the health and economic burden of NCDs. (europa.eu)
Cardiovascular health promotion in childhood: the si! (revespcardiol.org)
Given the enormous extent of the problem and the complexity of its causes, which include cultural, social, political, and health care factors, an equally sophisticated and comprehensive strategy is required to combat cardiovascular disease on a global scale. (revespcardiol.org)
Thus, our efforts should be concentrated not only on cardiovascular disease treatment and prevention, but also on health promotion and primordial prevention. (revespcardiol.org)
Each of our teammates has a different range of skill sets and we enjoy combining them to contribute to improving the understanding of the human hearts in health and disease, and to develop new mathematical and computational methodologies for Cardioascular Research. (ox.ac.uk)
We take a computational approach focused on the development, evaluation, and application of innovative artificial intelligence (AI), machine learning, and systems approaches to modeling biomedical big data for precision health. (epistasis.org)
There is an opportunity for the current definition of sustainability to be expanded beyond technical materials and methods that protect natural resources to include a holistic approach supporting and improving human health. (chausa.org)
The concept of human sustainability can be a center point for all health care building design. (chausa.org)
Understanding the correlation between the built environment and human behavior is essential to understanding and improving population health outcomes. (chausa.org)
Though the newest version of the LEED program has a focus on improved indoor air quality and reduced use of harmful building materials, LEED ratings do not address many important factors relating to human health such as social connectedness and physical activity. (chausa.org)
As a result, the Centers for Disease Control and Prevention, the American Institute of Architects and the Urban Land Institute have developed conceptual frameworks for design that encompass broader aspects of human health. (chausa.org)
One is the Delos WELL Building Standard, which is the world's first building standard focused exclusively on human health and wellness. (chausa.org)
The National Institute of Environmental Health Sciences (NIEHS) is expanding and accelerating its contributions to scientific knowledge of human health and the environment, and to the health and well-being of people everywhere. (nih.gov)
By taking a holistic approach to improving warfighter performance, Total Force Fitness also serves as the Military Health System's connection to first line of effort in the current National Defense Strategy - building a more lethal force. (health.mil)
The DOD is increasingly recognizing that people represent our greatest asset, and the human weapon system is the priority investment to ensure readiness, said retired Army Col. (Dr.) Francis O'Connor, professor in the Department of Military and Emergency Medicine at the Uniformed Services University and the medical director of the Consortium for Health and Military Performance. (health.mil)
Total Force Fitness gets away from a one-size-fits-all model for health and performance. (health.mil)
Everyone's mission demands, occupational risks, culture, and mission-essential skills are different, so their approaches to sustaining health and performance need to be different. (health.mil)
Health Workforce -related implementation issues: Assessing the need for, and competencies of, human resources for community-based care systems, care management systems, cultural notions of and community models for health/social care. (who.int)
Development of novel approaches for risk assessment/public health preparedness for ageing populations and health emergencies (natural disasters, communicable disease outbreaks). (who.int)
Cardiovascular disease is the number-one health problem worldwide. (mhh.de)
In 1986, it emphasized the need for further examination of the relationship between "involuntary smoking" and cardiovascular disease in The Health Consequences of Involuntary Smoking (HHS, 1986). (nationalacademies.org)
Most recently, in The Health Consequences of Involuntary Exposure to Tobacco Smoke (HHS, 2006), it concluded that exposure to secondhand smoke could have immediate adverse effects on the cardiovascular system in adults and that it causes coronary heart disease. (nationalacademies.org)
1974). In addition, the 1990 report The Health Benefits of Smoking Cessation: A Report of the Surgeon General (HHS, 1990) and the National Cancer Institute's Monograph 8: Changes in Cigarette-Related Disease Risks and Their Implications for Prevention and Control (NCI, 1997) discussed the cardiovascular benefits of smoking cessation. (nationalacademies.org)
The immune system is integral to the cardiovascular health and disease. (ox.ac.uk)
Human subject review and approval was obtained through CDC and the Minnesota Department of Health before study initiation. (cdc.gov)
Many environmental factors can influence human health. (medlineplus.gov)
To reduce the impact of these determinants on health, it is necessary to apply integrative comprehensive approaches. (who.int)
3. Health promotion is a cost-effective approach which has great potential for accelerating the realization of health for all in the Region. (who.int)
These methods are combined through comprehensive approaches which ensure action at all levels of society, leading to enhanced health impact. (who.int)
4. By the mid 20th century, the Public Health model was well established and technologies for manipulating the physical environment were regarded as the ultimate answer to critical health issues. (who.int)
The situation is compounded by the complicated political contexts, a draft roadmap for strengthening palliative care in the weak health care systems, and conflicts in some of the Region, covering the four domains of WHO model of countries. (who.int)
Summary of discussions health approach to cancer and other life-threatening illnesses (3) . (who.int)
Palliative care is explicitly recognized under the guidance on integrating palliative care into health care - human rights to health and is fundamental to improving appropriate policies that integrate palliative care services the quality of life, wellbeing, comfort, and dignity of individuals. (who.int)
The Chronic Care Model (CCM) uses a systematic approach to restructuring medical care to create partnerships between health systems and communities. (cdc.gov)
Comprehensive models of care, such as the original Chronic Care Model (CCM) (4,5), advocate for evidence-based health care system changes that meet the needs of growing numbers of people who have chronic disease. (cdc.gov)
The model represents a well-rounded approach to restructuring medical care through partnerships between health systems and communities. (cdc.gov)

Dr. Huang's clinical interests are in cardiovascular disease prevention with a particular interest in links between diabetes and heart disease. (massgeneral.org)
Both human and animal models of diabetes and obesity were utilized to examine the use of stem cell intervention and gene therapy to amplify HO-1 levels. (nymc.edu)
Obesity leads to metabolic syndrome and type 2 diabetes mellitus (DM2), which are associated with increased morbidity and mortality, predominantly as a result of cardiomyopathy and other cardiovascular complications. (nymc.edu)
We found evidence that CCM approaches have been effective in managing diabetes in US primary care settings. (cdc.gov)

Genetic mutations/dysregulation affecting Transforming Growth Factor beta (TGFβ) ligands signaling is found in several neonatal, pediatric, and adult patients with cardiovascular complications, including valvular heart disease, cardiomyopathy, cardiac fibrosis, and arterial aneurysms. (sc.edu)

Mechanisms determining variability in the response of the human heart to anti-arrhythmic therapy in acute myocardial ischaemia, hypertrophic cardiomyopathy and atrial fibrillation. (ox.ac.uk)
Using a transgenic model system, the fruit fly Drosophila melanogaster, we will produce models of human myosin-based muscle disease (distal arthrogryposis) and heart disease (hypertrophic cardiomyopathy) to determine the molecular defects that cause abnormal skeletal and cardiac muscle function. (hopkinsmedicine.org)
AIMS: To examine the relevance of genetic and cardiovascular magnetic resonance (CMR) features of dilated cardiomyopathy (DCM) in individuals with coronary artery disease (CAD). (imperial.ac.uk)

The murine model has allowed for major advances in the field of the microbiome, but the results obtained using it cannot necessarily be transferred to humans, in particular because of the physiological and genetic differences between mice and humans. (pharmiweb.com)
Especially, the modelling of the ionic mechanisms underlying excitation-contraction coupling, genetic disorders in ion channels, and drug response in human. (ox.ac.uk)
We will use genetic suppression and drug treatment to better understand the bases of myosin malfunction and to develop our model system as a means of testing potential therapeutic approaches. (hopkinsmedicine.org)
He has led genome-wide studies of human genome variation, heritable gene expression variation, human genetic disorders, tumor evolution, mouse strain variation, genome stability in reprogrammed stem cells, and single-neuron somatic mosaicism in the human brain. (yale.edu)
Geroscientists have been studying these genetic differences for years (check out our interview with Nir Barzilai , one of the most prominent researchers in this field) and have found many gene variants associated with extreme longevity in humans. (lifespan.io)

Thus, delineating TGF ligands signaling networks involved in specific aspects of cardiovascular development and cardiovascular structure and function during the aging process should inform novel therapeutic approaches with higher specificity and more limited side effects. (sc.edu)

Investigate variability in atrial fibrillation mechanisms through computer simulation studies using populations of models, informed by clinical datasets. (ox.ac.uk)
The European Commission ambitions to develop an integrated human digital twin in Europe, as well as to create a diverse ecosystem in modelling and simulation approaches with a coherent roadmap. (eithealth.eu)
In the recent years, new approaches to modelling and simulation have begun to provide important insights into biomedical perspectives: in-silico models are used in various clinical decision support systems and in the development and testing of medical products and devices. (eithealth.eu)
That area is well-understood, using physiologically based pharmacokinetic (PBPK) modeling and simulation. (centerwatch.com)

This paper describes a protocol for assessing changes in contractility in adult human primary ventricular cardiomyocytes utilizing the MyoBLAZER, a non-invasive optical method that preserves the normal physiology and pharmacology of the cells. (bvsalud.org)
The Virtual Human Twin (VHT) is a technological and methodological framework dedicated to the sharing of experimental observations, derivation of predictive hypotheses and their integration for a continuous improvement of our understanding of human physiology and pathology, by regarding it as a single system. (eithealth.eu)

Recent single cell atlases from human atherosclerotic lesions has identified that - contrary to traditional beliefs - T cells outnumber macrophages by 2:1. (ox.ac.uk)
Lipoproteins are complex molecular assemblies that are key participants in the intricate cascade of extracellular lipid metabolism with important consequences in the formation of atherosclerotic lesions and the development of cardiovascular disease. (cdc.gov)

These findings present a potential molecular approach to enhance heart cell maturation, which could address a major challenge in the domains of cardiac regenerative therapy and disease modeling. (uclahealth.org)
These approaches will define regulatory mechanisms for heart regeneration and derive new regenerative approaches to cardiovascular disease. (fondationleducq.org)

At higher levels of exposure in humans, lead produces cardiac lesions and electrocardiographic abnormalities. (cdc.gov)

After the proteomics approach and return to the Netherlands, we will investigate t he role of the differentially expressed proteins as a blood marker and its function. (europa.eu)
We leverage modern techniques of functional genomics, epigenetics, transcriptomics, proteomics, gene editing and model-driven experimentation to understand the underlying causes of atherosclerosis and metabolic syndrome and discover therapeutic targets. (yale.edu)
To evaluate the differentiating power of integrated lipidomics and proteomics data, we have built an artificial neural network model that simultaneously and accurately categorized the samples from each metabolic risk category based on the determined lipidomics and proteomics profiles. (cdc.gov)

My research focus is on gaining an understanding of the unique and redundant biological function and properties of the three transforming growth factor beta (TGFβ) ligands and their signaling mechanisms in cardiovascular development and homeostasis and in disease pathogenesis. (sc.edu)
Our overall objective is to determine the mechanisms by which TGFβ ligands regulate cardiovascular development and maintain the cardiovascular structure and function at neonatal, postnatal and adult stages. (sc.edu)
The Vondriska Lab at UCLA investigates epigenomic mechanisms of cardiovascular disease. (vondriskalab.org)
Here, we propose to use a transgenic animal model system, Drosophila melanogaster (the fruit fly), to define the mechanisms by which mutations in various thin filament components lead to human cardiac disease. (hopkinsmedicine.org)

Research Objective The objective of this proposal is to develop a human retinal organoid model of adRP to gain insights in pathogenesis and assess clinically relevant approaches to restore RHO protein function. (ca.gov)
Development of therapeutic approaches depends on suitable small and large animal models that replicate pathogenesis in humans. (mhh.de)

LAB NAME: Cardiovascular Nutrition In the next 5 years the Cardiovascular Nutrition Laboratory (CNL) will investigate the effects of diets differing in fat type and carbohydrate type on cardiometabolic risk factors, fatty acid metabolism, response to lipid modifying therapy, and gene-nutrient interactions using human, animal and in vitro models. (usda.gov)
To investigate the effect of variability in the generation of potential pro-arrhythmic conditions in human ventricles. (ox.ac.uk)
Developing 3D computational models of the heart to investigate the effect of hypertrophic-related heterogeneities in the electrical properties of the myocardium on its susceptibility to arrhythmia. (ox.ac.uk)

For the first time, we've shown that by merely altering RNA splicing, we can encourage the significant maturation of heart cells derived from human stem cells," said senior author Yibin Wang, director of the Cardiovascular & Metabolic Disorders Program at Duke-NUS. (uclahealth.org)
Rodents as a model for urological disorders. (norecopa.no)
Aaron Heller, Ph.D. , Associate Professor, MANATEE Lab , uses ethological, personally meaningful events, coupled with experimental designs to model how emotion unfolds over time and which characteristics of emotion are linked to transdiagnostic risk for internalizing disorders. (miami.edu)

He leads CAMP MGH (Cardiovascular and Metabolic Patient Cohort), a large clinical cohort that draws subjects from MGH Heart Center patients. (massgeneral.org)
In this study, we aimed at examining how added sugar and sugar-sweetened beverage intake associate with 136 measured plasma proteins and C-reactive protein in the Malmö Diet and Cancer-Cardiovascular Cohort ( n = 4382), and examine if the identified added sugar- and SSB-associated proteins associate with T2D incidence. (lu.se)

The zebrafish is an important and widely used vertebrate model organism in scientific research, for example in drug development, in particular pre-clinical development. (wikipedia.org)
Chronic progressive cardiovascular (CV) disease, in all its clinical manifestations, is the most significant cause of morbidity and mortality in many developed countries and, increasingly, in countries experiencing economic growth and prosperity. (nih.gov)
Impact The use of patient-derived stem cells to discover novel drug targets for cardiovascular disease, identify drug candidates, and establish clinical trial in a dish to evaluate drug safety and efficacy. (ca.gov)
In-silico computational approaches can be used to predict complex clinical scenarios. (eithealth.eu)
Those models allow to meet the rigour of regulatory demands, so that the associated risks and flaws can be addressed before substantial investments in t in clinical trials. (eithealth.eu)
VHT has been designed to enable collaborative investigations of the human body, particularly for the clinical translation of patient-specific model predictions to support clinical decision-making. (eithealth.eu)
As defined by Pappalardo et al (2019), in the context of in silico medicine, the term "in-silico clinical trials" refer to the development of patient-specific models to form virtual cohorts that enable the testing of the safety and/or efficacy of new drugs and medical devices. (eithealth.eu)

For his thesis, Apollo applied genomic approaches to dissect disease-promoting interactions between members of the oral microbiota. (ccf.org)

Meanwhile, the idea of how to develop inhibitors of the SARS enzyme based on the knowledge of its own peptide substrates (the so-called "distorted key" approach) was also briefly elucidated. (scienceopen.com)
The aim of the network is to develop this model and the relevant analytical tools through collaborative R&D projects. (pharmiweb.com)
A UCLA-led team has identified an essential internal control mechanism that can promote the maturation of human stem cell-derived heart muscle cells, offering a deeper understanding of how heart muscle cells develop from their immature fetal stage to their mature adult form. (uclahealth.org)
We aim to develop and test noncoding RNA-based therapies in small and large animal models of myocardial infarction and heart failure. (mhh.de)
Together, we develop a robust mathematical model for the distribution of signal molecules on the basis of signalling filopodia. (exeter.ac.uk)
Or will survival of the fittest dictate that those among us who can eat UPFs all day and never develop disease get to survive and sire a new kind of human that can eat UPFs and other poisonous substances and stay healthy? (medscape.com)

A striking number of cardiovascular defects of humans are modeled in mice with mutation(s) in one or more genes encoding TGFβ ligands. (sc.edu)

Determine the effect of diets differing in fat and carbohydrate type on cardiometabolic risk indicators, lipoprotein and fatty acid metabolism, response to lipid modifying therapy, and gene-nutrient interactions, using human, animal and in vitro models. (usda.gov)
3.1 - Effect of a comprehensive 12 month approach to family weight management on biomarkers of dietary intake and cardiometabolic risk factors in child-mothers/female guardian pairs. (usda.gov)
Social disparities in heart disease risk and survivor bias among autoworkers: an examination based on survival models and g-estimation. (cdc.gov)
Because exposure to cardiovascular risk factors occurs from early ages, this strategy must be expanded and adjusted throughout the life of an individual. (revespcardiol.org)
However, current approaches to environmental hazard assessment do not specifically address CV bioactivity and hazards, despite growing evidence that environmental exposures contribute to the onset, risk, or progression of chronic CV disease. (nih.gov)
His current work is focused on two broad goals: (1) mapping variants and genes that confer risk to human disease, with ongoing projects focused on coronary artery disease and cardiometabolic traits in unique and underrepresented populations, and (2) developing methods for the detection and interpretation of human genome variation, with an emphasis on structural variation and other difficult-to-detect forms, and on comprehensive trait association in human disease studies. (yale.edu)
We did manage to ban trans fats because they are more harmful than butter in terms of risk for cardiovascular disease (CVD), but I'm not sure that this ban amounted to less risk for CVD. (medscape.com)

Oral studies in animals support the human evidence regarding neurobehavioral toxicity of lead to infants and children from prenatal and postnatal exposure. (cdc.gov)
Another NIH-funded study, Utilizing In Vitro Functional Genomics Advances for Gene-Environment (GxE) Discovery and Validation , aims to better understand the connection between environmental exposure and human disease. (medlineplus.gov)

Our laboratory is interested in the understanding of pathophysiological function and molecular mechanism of new non-coding RNAs (and RBPs) and new modes of gene regulation in cardiac system and cardiovascular disease. (rochester.edu)
We also identified a novel mRNA processing mechanism that expands human proteome at the posttranscriptional level and regulates gene expression (Yao, P, et al. (rochester.edu)
1- Immediately after receiving my Ph.D. degree, my postdoctoral fellowship at the Rockefeller University focused on the purification of a human liver protein (heme oxygenase, HO-1) and its gene sequence, including the promoter region. (nymc.edu)
She has contributed approaches for gene validation to the field. (yale.edu)
The exact mechanism of action, and even the function of the protein produced by this gene, are poorly understood, but it is known to participate in the maintenance of the immune and cardiovascular systems. (lifespan.io)

We are expanding the PBPK models that Certara's Simcyp division has developed and creating models that predict pharmacological effects-the efficacy that will modulate a particular disease or, equally importantly, the safety and the toxicology effects that we don't want. (centerwatch.com)

Development of novel algorithms for biomedical image analysis in combination with computational models, and their application in cardiovascular and pulmonary medicine. (ox.ac.uk)

To test whether computer models could identify which drugs were likely to produce adverse side effects, pharmaceutical chemists at the University of California, San Francisco, teamed up with toxicologists at Novartis Institutes for BioMedical Research. (livescience.com)
Advanced insight into the use and limitation of animal models in biomedical research. (norecopa.no)

Additionally, our research approach proved to be a powerful tool in the identification of novel biomarkers for cardiovascular and metabolic disease (e.g. circulating endothelial cells and progenitor stem cells [EPCs] for better prognosis). (nymc.edu)

Data from this rapidly aging, genetically tractable model system will be correlated with aged mammalian systems (with and without dysfunction) to assess the predictive power of the fly model in determining age-associated negative changes in heart performance. (hopkinsmedicine.org)
Lead has been shown to affect virtually every organ and system in the body in both humans and animals. (cdc.gov)
As it is very difficult to determine the specific impact of individual parameters in a complex biological system by a purely experimental approach, we interact with mathematicians using computational modelling. (exeter.ac.uk)
PhD , Geomatics Engineering with a thesis entitled: 'Development of an SDI Conceptual Model and Web-based System to Facilitate Disaster Management', Faculty of Geodesy & Geomatics Eng. (lu.se)

PTx2-3127 inhibits NaV1.7 currents in mouse and human sensory neurons and shows efficacy in rat models of chronic and thermal pain when administered intrathecally. (bvsalud.org)

In 2005, he founded the MGH Cardiac Metabolic Syndrome Program in the Cardiovascular Disease Prevention Center. (massgeneral.org)
This suggests that individuals with a low birth weight may benefit from early targeted cardiovascular disease prevention strategies, independent of whether this was linked to an adverse intrauterine environment during gestation. (imperial.ac.uk)
The integration of quantitative lipid and lipoprotein profiling of human plasma may provide a powerful approach to inform early disease diagnosis and prevention. (cdc.gov)

Marcy l ' Etoile, France, January 28, 2020 - Cynbiose, a service company specializing in the development and commercialization of innovative preclinical models, today announces that it has procured financing of €1.9 million ($2.1M) under the third phase of the French Program 'Investment for the Future' (PiA3). (pharmiweb.com)
Development of multiscale computer models of human atrial electrophysiology, built through the integration of multimodality datasets. (ox.ac.uk)

Conclusions: We leveraged the strengths of two different analytic approaches to examine the IHD risks of metalworking fluid s. (cdc.gov)

Research Objective Using authentic in vitro models of the human lung, complete with inflammatory cells & vessels, we will validate drugs that might be rapidly repurposed for use in patients with COVID-19. (ca.gov)

1.3 - Synergistic effects of a 'heart healthy' diet and statin therapy on atherosclerosis using a porcine model. (usda.gov)
The collaborative effort with Duke-NUS Medical School in Singapore and other institutions identified an RNA splicing regulator named RBFox1, which was considerably more prevalent in adult heart cells than in newborns, based on a preclinical model. (uclahealth.org)
While RBFox1 alone may not be sufficient to push mature fetal heart muscle cells all the way to fully matured adult cells, our findings uncover a new RNA-based internal network that can substantially drive this maturation process beyond other available approaches. (uclahealth.org)
The design of airplanes, bridges and even heart stents starts with computer-generated models that not only detail what the products could look like, but how they'd work under different conditions. (livescience.com)
The human heart shows limited natural muscle regeneration in response to myocardial infarction. (fondationleducq.org)

Microbiota composition also has an influence on the efficacy of targeted therapies in humans. (pharmiweb.com)

Subsequent molecular and physiological studies in human mutation carriers and animal models have allowed us to unravel novel functions of the identified genes, to delineate their cognate pathways and to discover new targets for pharmaceutical intervention. (yale.edu)

Identifying and manipulating age- and mutation-dependent modifiers of cardiac function using the Drosophila model. (hopkinsmedicine.org)

Cardiovascular disease has been elevated to this position by a combination of factors that include urbanization and its attendant effects, such as obesity, a sedentary lifestyle, changes in dietary habits, and smoking. (revespcardiol.org)
This seems to be the case in animal models of obesity but has not been demonstrated to be operational in humans. (medscape.com)

By incorporating the features into the general form of pseudo amino acid composition that were extracted from protein sequences via the "grey model" and by adopting the random forest operation engine, we proposed a new predictor, called iDNA-Prot, for identifying uncharacterized proteins as DNA-binding proteins or non-DNA binding proteins based on their amino acid sequences information alone. (scienceopen.com)
We recently discovered a new type of stress-responsive, protein-directed human RNA switch that regulates expression of vascular endothelial growth factor-A in human monocytic cells (Ray, PS, et al. (rochester.edu)
To create a drug that will interact with a protein target in the desired way, chemists typically start with a computerized structural model of the protein bound to a natural molecule that "unlocks" a biological action. (livescience.com)
But this approach is only as good (and as accurate) as the starting protein model. (livescience.com)
Biochemists at Southern Methodist University are using this approach - along with supercomputers - to evaluate about 40,000 compounds per day to find the ones that could block a protein that makes chemotherapy drugs less effective. (livescience.com)
The encoded protein is upregulated in human steatosis (NASH). (yale.edu)
The characterization of this protein in vivo has shown that it widely expressed in different tissues and circulates in the blood, its levels rise after food intake in humans and stimulates insulin secretion and sensitivity and inhibits platelet aggregation. (yale.edu)

Experimental procedures in the skin and models for wound healing and psoriasis. (norecopa.no)
Here we used available structural and experimental data to guide Rosetta design of potent and selective ProTx-II-based peptide inhibitors of human NaV1.7 channels. (bvsalud.org)
Applying single cell technologies and functional studies we will study the relevance and prevalence of lymphoid cells in human and experimental atherosclerosis. (ox.ac.uk)

Yet, behavioral and social sciences research is not restricted to a set of disciplines or methodological approaches. (nih.gov)

Targeting inflammation ameliorates cardiovascular outcomes. (ox.ac.uk)

Human in silico drug testing for the prediction of safety and efficacy of drug action in human. (ox.ac.uk)

Gastrointestinal absorption of soluble lead salts in adult humans can be high during fasting (40-50%), but is about 3-15% when ingested with food. (cdc.gov)

Another treatment approach that Hippocrates discussed involved attempting to diminish spinal deformity with a method called succussion. (medscape.com)
FDA used a bone model to evaluate the dosing regimen proposed in the biologics license application for NATPARA, a recombinant human parathyroid hormone, being reviewed for the treatment of hypoparathyroidism. (centerwatch.com)

This landmark publication was the first to place HO-1 in the realm of cardiovascular disease/research. (nymc.edu)
Revista Española de Cardiología is an international scientific journal devoted to the publication of research articles on cardiovascular medicine. (revespcardiol.org)
Research Objective Greenstone Biosciences will use patient-derived stem cells to discover safe and effective drugs for cardiovascular disease. (ca.gov)
This Summer School provides a thorough overview and hands-on experience in state-of-the-art Virtual Physiological Human (VPH) research. (upf.edu)
Although much research has focused on the carcinogenic properties of smoke, this report focuses on its cardiovascular effects. (nationalacademies.org)
A Feature Paper should be a substantial original Article that involves several techniques or approaches, provides an outlook for future research directions and describes possible research applications. (mdpi.com)
The majority of Oxford's medical research is carried out using either in vitro techniques or the study of human beings. (ox.ac.uk)
The NIH National Human Genome Research Institute's Encyclopedia of DNA Elements (ENCODE) was a project created to understand and analyze the human genome. (medlineplus.gov)

Anatomy21

Organisms43

Diseases20

Chemicals and Drugs35

Analytical, Diagnostic and Therapeutic Techniques and Equipment43

Psychiatry and Psychology16

Phenomena and Processes77

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena5

Technology, Industry, Agriculture2

Humanities1

Information Science5

Health Care10

Geographicals1

Diseases28

Combating cardiovascular disease1

Cerebrovascular3

Neurological2

Tissue12

Translational3

Genetics5

Hypertension4

Biology9

Health39

Diabetes4

Complications1

Cardiomyopathy3

Genetic5

Novel therapeutic approaches1

Simulation4

Physiology2

Atherosclerotic lesions2

Regenerative2

Lesions1

Proteomics3

Mechanisms4

Pathogenesis2

Investigate3

Disorders3

Cohort2

Clinical7

Genomic1

Develop6

Mice1

Risk7

Exposure2

Gene5

Pharmacological1

Computational Models1

Biomedical2

Biomarkers1

System4

Chronic1

Prevention3

Development2

Examine1

Vitro models1

Heart5

Therapies1

Targets1

Cardiac function1

Obesity2

Protein7

Experimental3

Methodological1

Outcomes1

Efficacy1

Adult1

Treatment2

Research8