Human vertebrates protein residues. Medical search. Frequent questions

The tub gene is a member of a family of tubby-like genes (TULPs) that encode proteins of unknown function. (nih.gov)
Wnt genes are highly conserved between vertebrate species sharing overall sequence identity and gene structure, and are slightly less conserved between vertebrates and invertebrates. (embl-heidelberg.de)
The gene encoding the Ov-phy-1 open reading frame contained 11 introns, similar in structure to the gene encoding human prolyl 4-hydroxylase isoform I. Genomic Southern blot, EST and genomic PCR studies demonstrated that the O. volvulus genome contained between three and eight genes closely related to Ov-phy-1. (embl.de)
Our studies suggest that the ascidians contain the basic ancestral complement of vertebrate GPCR genes. (biomedcentral.com)
This is evident at the subfamily level comparisons since Ciona GPCR sequences are significantly analogous to vertebrate GPCR subfamilies even while exhibiting Ciona specific genes. (biomedcentral.com)
Potential sites for regulating human ITB gene expression were identified which included CpG islands, transcription factor binding sites and microRNA binding sites within the 3'-UTR of human ITB genes. (edu.au)
The phylogenetic analyses revealed that ITB4 is the most likely primordial form of the vertebrate ߠintegrin subunit encoding genes, that is the only ߠsubunit expressed as a constituent of the sole integrin receptor 'a6ߴ' in the hemidesmosomes of unicellular organisms. (edu.au)
This domain occurred 350 times on human genes ( 803 proteins). (umbc.edu)
The two genes of each Ca2+ of insulin-like residues believe together excessive responses. (familie-vos.de)
The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
The major characteristics of Nrf2 are to some extent mimicked by Nrf2-dependent genes and their proteins including heme oxygenase-1 (HO-1), which besides removing toxic heme, produces biliverdin, iron ions and carbon monoxide. (springer.com)
Variations of hemoglobin protein genes generate different types of hemoglobin. (hemolevel.com)
Sequence and organization of coelacanth neurohypophysial hormone genes: evolutionary history of the vertebrate neurohypophysial hormone gene locus. (xenbase.org)
The genes encoding vasopressin and oxytocin genes are closely linked in the human and rodent genomes in a tail -to- tail orientation. (xenbase.org)
We have sequenced a coelacanth (Latimeria menadoensis) BAC clone encompassing the neurohypophysial hormone genes and investigated the evolutionary history of the vertebrate neurohypophysial hormone gene locus within a comparative genomics framework. (xenbase.org)
The vasotocin and mesotocin genes in chicken and Xenopus, and the vasopressin and mesotocin genes in opossum are linked tail -to- head similar to their orthologs in coelacanth and unlike their homologs in human and rodents. (xenbase.org)
The neurohypophysial hormones and genes in human, fugu and coelacanth. (xenbase.org)
B) Organization of neurohypophysial hormone genes in human, fugu and coelacanth. (xenbase.org)
Studies of the gau ORF will shed light on the origin of novel genes and their functions in organelles and could also have medical implications for human diseases that are caused by mitochondrial dysfunction. (biomedcentral.com)
The number of mitochondrial protein genes is believed to vary from 3 to 67, while the tRNA gene content varies from 0 to 27 [ 2 ]. (biomedcentral.com)
Typical triploblastic animal mtDNAs contain genes that encode the large and small subunit ribosomal RNAs, 22 transfer RNAs (tRNAs), and 13 proteins that are all components of the oxidative phosphorylation process: ATPase subunits 6 and 8 (ATP6 and 8), cytochrome b (Cyt b), cytochrome c oxidase subunits 1-3 (Cox1-3) and NADH dehydrogenase subunits 1-6 and 4L (ND1-6 and 4L). (biomedcentral.com)

While DNMT3, the maintenance DNA methyltransferase DNMT1, HELLS, and CDCA7 are all highly conserved in vertebrates and green plants, they are frequently co-lost in other evolutionary clades. (elifesciences.org)
A common structural feature of GPCRs is the presence of a highly conserved architecture of seven stretches of transmembrane spanning residues linked by alternate extracellular and intracellular loops. (biomedcentral.com)
Sequence alignments of the integrin ߭cytoplasmic domains revealed highly conserved regions possibly for performing essential functions and its maintenance during vertebrate evolution. (edu.au)
Wnt-3a is one of 19 vertebrate members of the Wingless-type MMTV integration site (Wnt) family of highly conserved cysteine-rich secreted glycoproteins important for normal developmental processes (1). (novusbio.com)
The Y-box protein MSY3/Csda represses myogenin transcription in skeletal muscle by binding a highly conserved cis-acting DNA element located just upstream of the myogenin minimal promoter (myogHCE). (biomedcentral.com)

Partial alignment of Vps50 amino acid sequences between human and other vertebrates was aligned using the Clustalx program. (biomedcentral.com)
The 72-amino acid TEA DNA binding domains in mTEAD-2, 3, and 4 are approximately 99% homologous to the same domain in mTEAD-1, and all four proteins bind specifically to the same DNA sequences in vitro with a Kd value of 16-38 nM DNA. (embl-heidelberg.de)
Comparative ITB amino acid sequences and protein structures and ITB gene locations were examined using data from several vertebrate genome projects. (edu.au)
With the exception of the human ITB8 sequence, the other ITB sequences shared a predicted 19 residue a-helix for this region. (edu.au)
However, the nucleoporin protein encoded by this gene does not contain the typical FG repeat sequences found in most vertebrate nucleoporins. (utsouthwestern.edu)
We calculated secondary structures for those human being 60-amino acid sequences from Table S2 and characterized them using Q3 accuracy symbols: -helix (H), -sheet (E), and coil (C) [28]. (biopaqc.com)
Curiously, the prevalence value for the two thirds of the human being caspase targets is around 1, suggesting that there is mostly no difference between the percentage of coils in areas immediately surrounding the cleavage site AUY922 inhibition and in more distant sequences (Number 2b). (biopaqc.com)
Exploring this probability, we determined the sum of hydrophobicity indices (kilo-calories per mole for each of the 20 amino acids at a pH of 7) [30] for the central 20-amino acid sequences with P1 aspartate in the middle, for every human being and orthologous 60-amino acid sequences (Table S2). (biopaqc.com)
However, these signature sequences have not so far been extensively investigated amongst orthologous Bcl-2 family proteins. (sfr-biosciences.fr)
Comparison of amino acid sequences of (A) vasopressin and (B) oxytocin family hormone precursors in vertebrates. (xenbase.org)
random to their competing genomic online artificial risk and the attP of the such trial in suppressor target pIRES2-EGFP-TSLC1 trait4 residues are again associated for the conditionsPrivacy of sequences for collection with a mRNA of elsewhere 50 polynucleotide among the polynomial differences( Figure 1). (scoutconnection.com)
We performed alignment analysis of the complete nucleotide hexon sequences of the 10 novel strains and of reference human and simian adenoviruses by using the MUSCLE program within the MEGA5 software package ( 6 ). (cdc.gov)
Comparison of the hexon gene sequences of simian adenovirus types identified in this study with human and simian adenovirus sequences from GenBank revealed 9 previously reported hypervariable regions (HVRs): HVR1-HVR9 ( 5 , 7 ). (cdc.gov)
Phylogenetic analysis of complete hexon gene nucleotide sequences from human and simian adenoviruses. (cdc.gov)

The third domain is rich in serine and threonine residues and contains clustered O-linked carbohydrate chains. (embl.de)
A group of enzymes that catalyzes the phosphorylation of serine or threonine residues in proteins, with ATP or other nucleotides as phosphate donors. (lookformedical.com)

Very little is known about the structure of Wnts as they are notoriously insoluble, but they share the following features characteristics of secretory proteins: a signal peptide, several potential N-glycosylation sites and 22 conserved cysteines [ ( PUBMED:9891778 ) ] that are probably involved in disulphide bonds. (embl-heidelberg.de)

The deduced 4660-aa sequence, expected to constitute a mature protein of M(r) 516,715, consists of a probable N-terminal signal peptide sequence (25 aa), an extracellular region (4400 aa), a single transmembrane domain (22 aa), and a C-terminal cytoplasmic tail (213 aa). (embl.de)
4) Mutation of the three extracellular cysteine residues of GFKAR beta indicated that the two conserved cysteine residues (C305 and C385), located between two transmembrane segments, form a solvent-accessible disulfide bond. (aspetjournals.org)
Integrins are proteins that function mechanically, by attaching the cell cytoskeleton to the extracellular matrix (ECM), and biochemically, by sensing whether adhesion has occurred. (mechanobio.info)
Integrins function as adhesion receptors for extracellular ligands and transduce biochemical signals into the cell, through downstream effector proteins. (mechanobio.info)

Based on primary sequence comparisons, β subunits are predicted to be modular structures composed of five domains (A-E) that are related to the large family of membrane-associated guanylate kinase proteins. (jneurosci.org)
The derived amino acid sequence of Ov-phy-1 encoded a peptide that was most similar to the two Caenorhabditis elegans prolyl 4-hydroxylase homologues and to the isoform II enzymes of vertebrates. (embl.de)
The T-box is defined as the minimal region within the T-box protein that is both necessary and sufficient for sequence-specific DNA binding, all members of the family so far examined bind to the DNA consensus sequence TCACACCT. (embl-heidelberg.de)
The sequence repeats are offset with respect to the blades of the propeller, such that any given 40-residue YWTD repeat spans strands 24 of one propeller blade and strand 1 of the subsequent blade. (embl.de)
3) Mutations of Q12, A53, and Y54 of GFKAR beta indicate that these three residues are important for ligand binding (particularly L-glutamate), which is consistent with the sequence homology to bacterial periplasmic binding proteins. (aspetjournals.org)
In this report, we describe a testis zinc finger protein (Tzfp) that binds to the upstream flanking sequence of the Aie1 gene. (lookformedical.com)
The reverse activity transcribes the ZAR2 mRNA with 966 nt coding sequence which codes for a 321 amino acid protein. (biomedcentral.com)
Nucleoporins are pore-complex-specific glycoproteins which often have cytoplasmically oriented O-linked N-acetylglucosamine residues and numerous repeats of the pentapeptide sequence XFXFG. (utsouthwestern.edu)
To best fit the sequence data for the hexon gene, we used the DNA/Protein model test to identify the optimal evolutionary model, GTR+Γ+I (general time reversible + gamma + invariable). (cdc.gov)

G protein-coupled receptors (GPCRs) constitute a large family of integral transmembrane receptor proteins that play a central role in signal transduction in eukaryotes. (biomedcentral.com)
GPCRs share a common heptahelical transmembrane structure as well as many conserved key residues and regions. (nih.gov)
The integrin family of proteins consists of alpha and beta subtypes, which form transmembrane heterodimers. (mechanobio.info)

The repeat is found in a variety of proteins that include, vitellogenin receptor from Drosophila melanogaster, low-density lipoprotein (LDL) receptor [ ( PUBMED:6091915 ) ], preproepidermal growth factor, and nidogen (entactin). (embl.de)
Analysis of the angiotensin-converting enzyme 2 (ACE2) receptor across diverse vertebrates suggests a potentially wide breadth of SARS-CoV-2-susceptible mammal host species ( 5 ). (cdc.gov)
Several VOCs, particularly the Alpha (B.1.1.7), Beta (B.1.351), and Gamma (P.1) variants, have convergently evolved an amino acid residue change in the receptor binding domain of the spike protein (N501Y) that was also observed following serial passage of SARS-CoV-2 in BALB/c mice ( 6 ). (cdc.gov)
Intregins are heterodimeric a- and ߭subunit containing membrane receptor proteins which serve various cell adhesion roles in tissue repair, hemostasis, immune response, embryogenesis and metastasis. (edu.au)
Wnts bind to the cell surface Frizzled family receptors in conjunction with low-density lipoprotein receptor-related protein family receptors (LRP5 or 6) resulting in the stabilization of intracellular beta -catenin levels (2). (novusbio.com)
Low-molecular-weight kainate receptors from nonmammalian vertebrate brain belong structurally to the ionotropic glutamate receptor superfamily. (aspetjournals.org)
In this study, two previously cloned goldfish kainate receptor subunits (GFKAR alpha and GFKAR beta) were transiently expressed in human embryonic kidney 293 cells, and their ligand-binding properties and some associated structural features were characterized, resulting in the following findings. (aspetjournals.org)
The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters. (lookformedical.com)
The FH1 domain is also a binding site for diverse SH3-domain containing proteins like Src-like non-receptor tyrosine kinases, WISH (WASP-interacting SH3 protein) and IRSp53 (insulin receptor substrate) in mammals, and Hof1p in yeast [ 6 ]. (biomedcentral.com)

They encode proteins of ~350-400 residues in length, with orthologues identified in several, mostly vertebrate, species. (embl-heidelberg.de)

Members of this family have been identified in plants, vertebrates and invertebrates. (nih.gov)

Although its zoonotic origin remains unclear, animal species potentially susceptible to reverse-zoonotic transmission from humans have been identified (e.g., cats, dogs, minks, deer), some of which (e.g., mink) might maintain the virus and pose a risk of future spillback to humans ( 2 , 3 ). (cdc.gov)
The amino acid chains of globin proteins in hemoglobin differ among different species, although the differences increase with the distance of growth between species. (hemolevel.com)
Like proteins other than hemoglobin, differences in DNA chains between species are greater than differences in amino acid chains coded by them, as different DNA chains may point to the same amino acid. (hemolevel.com)

On a taxonomic and phylogenetic scale, Ciona intestinalis is a protochordate belonging to the ascidian class of urochordates that diverged from a lineage leading to the vertebrates approximately 520 million years ago [ 1 ]. (biomedcentral.com)
This extant ascidian occupies a crucial place in the "Tree of life" as an out-group to the vertebrates and hence studies addressing evolutionary aspects of Ciona have the potential to offer insight into some of the most intriguing questions about the origin of the vertebrates from a chordate lineage. (biomedcentral.com)
Bcl2l10 is an antiapoptotic member of the Bcl-2 family that has evolved rapidly throughout the vertebrate lineage and which shows conserved abundant expression in eggs and oocytes. (sfr-biosciences.fr)
Considering the reliance of female eggs on calcium-dependent proteins and calcium-regulated processes and the exceptional longevity of oocytes in the primate lineage, we propose that this microstructural variation may be an adaptive feature associated with high maternal expression of this Bcl-2 family member. (sfr-biosciences.fr)

An analysis of the Ciona repertoire of GPCRs from a comparative genomic perspective provides insight into the evolutionary origins of the GPCR signalling system in vertebrates. (biomedcentral.com)
and 4: ITB8 and a common evolutionary origin from an ancestral gene, prior to the appearance of fish during vertebrate evolution. (edu.au)
Despite an evolutionary distance of at least 1.5 to 2.0 billion years, the deduced Gau proteins share some conserved amino acid signatures and structure, which suggests a possible conserved function. (biomedcentral.com)

These results raise the possibility that rare mutations in VPS50 may be associated with human NTDs. (biomedcentral.com)
Alterations in mitochondrial dynamics due to mutations in proteins involved in the fusion-fission machinery represent an important pathogenic mechanism of human diseases. (centrodinoferrari.com)

The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K). (umbc.edu)
An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. (lookformedical.com)
Mammalian aurora-A belongs to a multigenic family of mitotic serine/threonine kinases comprising two other members: aurora-B and aurora-C. In this review we will focus on aurora-A that starts to localize to centrosomes only in S phase as soon as centrioles have been duplicated, the protein is then degraded in early G1. (lookformedical.com)

There cause two catalytic proteins of each of the three Drosophila cascades, whose acids contain partially developed: cycle of scalable times vertebrates occur homodimers. (familie-vos.de)

Phylogenetic analyses reveal that Ciona GPCRs have homologous representatives from the five major GRAFS ( Glutamate, Rhodopsin, Adhesion, Frizzled and Secretin ) families concomitant with other vertebrate GPCR repertoires. (biomedcentral.com)

This control is propagated through the alpha-subunit of prolyl 4-hydroxylase where protein levels were previously shown to rise fivefold with increasing cell density. (embl.de)
The name hemoglobin is derived from the combination of the terms heme and globin, suggesting that each subunit of hemoglobin is a globular protein in the heme group. (hemolevel.com)

c-Src is the vertebrate homolog of the oncogenic protein (v-Src) from Rous sarcoma virus. (umbc.edu)
All jawed vertebrates contain at least one homolog each of vasopressin and oxytocin whereas jawless vertebrates contain a single neurohypophysial hormone called vasotocin . (xenbase.org)

Fifteen major Wnt gene families have been identified in vertebrates, with multiple subtypes within some classes. (embl-heidelberg.de)

PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. (umbc.edu)
This happens because substrates can be cleaved only when in an extended conformation [42], and the loop areas are better to unfold locally, compared to -helices and -linens which often require global unfolding of the protein [43]. (biopaqc.com)
Thereafter, hydrophilicity of cleavage sites facilitating caspase digestion of the protein would make the respective substrates more important for apoptosis. (biopaqc.com)

Light regulates physiological, behavioral and biochemical activities in vertebrates through photoreceptors. (bioone.org)
Nrf2 consists of six functional Neh domains (Neh1-Neh6), from which, the amino-terminal Neh2 domain controls binding Keap1-the inhibitor protein Kelch-like ECH-associated protein 1, that is responsible for the cytosolic sequestration of Nrf2 under physiological conditions (Fig. 2 a). (springer.com)
Cell biological experiments are needed to determine the physiological role of this protein. (biomedcentral.com)

MSY3 (MSY4, YB-2, CSDA, dbpA, ZONAB) is a member of the cold shock domain (CSD) family of proteins also known as Y-box proteins, which are evolutionarily conserved proteins that function as transcription factors and regulators of RNA metabolism and protein synthesis. (biomedcentral.com)

Most Vertebrate Caspase Cleavage Sites are Located within Hydrophilic Surroundings Proteins in aqueous conditions, such as the cytosol, tend to have hydrophobic residues hidden within their structure and hydrophilic amino acids exposed to the surface [45]. (biopaqc.com)

Two compounds, Compound 1 (1,4-dihydrophenanthrolin-4-one-3-carboxylic acid) and Compound 5 [8-(N-butyl-N-ethylcarbamoyl)-1,4-dihydrophenathrolin-4-one-3-carboxylic acid], with comparable potencies in vivo, were chosen to investigate the effect of the inhibition of the hydroxylation of newly synthesized uterine collagen on the turnover of this protein in vivo. (embl.de)
Taken with the present results, this suggests that the potential use of inhibitors of prolyl 4-hydroxylase to control excessive collagen deposition in pathological fibrosis may be limited by the need to maintain continuous inhibition of collagen hydroxylation so as to facilitate intracellular degradation of the accumulated protein. (embl.de)
The Weblogo alignment [29] of supplementary framework components around cleavage sites (20 proteins) demonstrated that 60% of components are symbolized by coils, 30% by -helices, and around 10% by -bed sheets (Amount 2), relative AUY922 inhibition to previously observations [39,41,44] (Desk S6). (biopaqc.com)
This feature suggests that proteolysis will most likely happen within the hydrophilic portions of AUY922 inhibition proteins, because these revealed parts would be more accessible for cleavage. (biopaqc.com)
1977. Inhibition of human plasma cholinesterase by ingested dichlorvos: effect of formulation vehicle. (cdc.gov)

Formins are multidomain proteins conserved from plants to fungi and vertebrates. (biomedcentral.com)

Keap1 is a cysteine-rich protein, known to be anchored to actin cytoskeleton [ 5 ], serving as an adaptor protein for the Cul3-dependent E3 ubiquitin ligase complex. (springer.com)
Elafin (Human) , cysteine rich peptide composed of 57 amino acid residues. (peptanova.de)

A family of protein-deglutamylating enzymes associated with neurodegeneration. (sysy.com)

The Wnt proteins seem to adhere to the plasma membrane of the secreting cells and are therefore likely to signal over only few cell diameters. (embl-heidelberg.de)
Some proteins are transported to lysosomes, other internalized proteins are delivered to the trans-Golgi network or back to the plasma membrane by recycling endosomes. (biomedcentral.com)
The most relevant proteins involved in the mitochondrial fusion process are three GTPase dynamin-like proteins: mitofusin 1 (MFN1) and 2 (MFN2), located in the outer mitochondrial membrane, and optic atrophy protein 1 (OPA1), in the inner membrane. (centrodinoferrari.com)
separation of proteins by PAGE and subsequent transfer to a membrane. (sysy.com)

Proteins of the ADP-ribosylhydrolase family are typically associated with the reversal of ADP-ribosylation a posttranslational modification used to regulate protein function. (wikipedia.org)
Wnt proteins constitute a large family of secreted molecules that are involved in intercellular signalling during development. (embl-heidelberg.de)
virtually every tissue expresses at least one family member, consistent with a critical role for TEAD proteins in either cell proliferation or differentiation. (embl-heidelberg.de)
Human Hippo converting is a protein of responses that comprises world family and heterodimer, bound on a cell mRNA surfactant. (familie-vos.de)
Interestingly, immunity-associated GTPase family M (IRGM), the most targeted protein, was found to interact with the autophagy-associated proteins ATG5, ATG10, MAP1CL3C and SH3GLB1. (sfr-biosciences.fr)
Insertions or deletions (indels) of amino acids residues have been recognized as an important source of genetic and structural divergence between paralogous Bcl-2 family members. (sfr-biosciences.fr)
family Nairoviridae) is a tick-borne pathogen that frequently causes lethal disease in humans. (cdc.gov)

Nearly 39% of Ciona GPCRs have unambiguous orthologs of vertebrate GPCR families, as defined for the human, mouse, puffer fish and chicken genomes. (biomedcentral.com)

Biallelic hypomorphic variants in PPA2 , encoding the mitochondrial inorganic pyrophosphatase 2 protein, have been recently identified in individuals presenting with sudden cardiac death, occasionally triggered by alcohol intake or a viral infection. (nature.com)
Dynamin-related protein 1 (DRP1), a cytosolic dynamin-related GTPase, plays a central role in fission by promoting mitochondrial division through its oligomerization into multimeric spiral structures [5]. (centrodinoferrari.com)
Immunohistochemical analyses using an anti-Gau monoclonal antibody revealed strict co-localization of Gau proteins and a mitochondrial marker. (biomedcentral.com)

Together with other Src subfamily proteins, it is involved in signaling pathways that regulate cytokine and growth factor responses, cytoskeleton dynamics, cell proliferation, survival, and differentiation. (umbc.edu)

The nuclear pore complex (NPC) is found on the nuclear envelope and forms a gateway that regulates the flow of proteins and RNAs between the cytoplasm and nucleoplasm. (utsouthwestern.edu)

Using a fluorescent sulfhydryl probe as well as a sulfhydryl inhibitor, one observes a strong cell density response, supporting the hypothesis that cellular redox potential could alter protein stability. (embl.de)

Hemoglobin consists mostly of proteins (globin chains) and these proteins are made up of chains of amino acids. (hemolevel.com)
For example, the most common hemoglobin chains in humans and chimpanzees are similar, while this same chain differs from the most common amino acid chain of guerrillas by only one amino acid in the alpha and beta-globin protein chains. (hemolevel.com)
Like other proteins, chains of hemoglobin's amino acids can be adaptive. (hemolevel.com)

Co-expression of Ov-phy-1 with the O. volvulus homologue of protein disulfide isomerase in a baculovirus system resulted in the production of enzymatically active O. volvulus prolyl 4-hydroxylase. (embl.de)
Ligand-binding characteristics and related structural features of the expressed goldfish kainate receptors: identification of a conserved disulfide bond and three residues important for ligand binding. (aspetjournals.org)

Biophysical and biochemical studies of rhodopsin activation, and the recent crystal structure determination of bovine rhodopsin, have provided new information that enables a more complete mechanism of vertebrate rhodopsin activation to be proposed. (nih.gov)

The clinical C31 online artificial coverage treatments enriched for time Integrate have aimed from the Eukaryotic transgenic vertebrate scan Purification accuracy HEK293 and CHO microRNAs, which are from artifacts of the observed Hamster. (scoutconnection.com)

Comparison of GPCRs in Ciona to that in human reveals a high level of orthology of a protochordate repertoire with that of vertebrate GPCRs. (biomedcentral.com)
Our analysis provides a framework to perform future experimental and comparative studies to understand the roles of the ancestral chordate versions of GPCRs that predated the divergence of the urochordates and the vertebrates. (biomedcentral.com)
G-protein-coupled receptors (GPCRs) are involved in a vast variety of cellular signal transduction processes from visual, taste and odor perceptions to sensing the levels of many hormones and neurotransmitters. (nih.gov)
As a result of agonist-induced conformation changes, GPCRs become activated and catalyze nucleotide exchange within the G proteins, thus detecting and amplifying the signal. (nih.gov)

The synthesis of the heme portion occurs in various steps in the mitochondria and cytosol of immature red blood cells, while the globin protein portion is synthesized by ribosomes in the cytosol. (hemolevel.com)

Bod1 depletion does not affect the activity or localization of Aurora B but does cause mislocalization of the microtubule depolymerase mitotic centromere- associated kinesin and prevents its efficient phosphorylation by Aurora B. Therefore, Bod1 is a novel kinetochore protein that is required for the detection or resolution of syntelic attachments in mitotic spindles. (rupress.org)

The genome of the protochordate Ciona intestinalis has a compact size with an ancestral complement of many diversified gene families of vertebrates and is a good model system for studying protochordate to vertebrate diversification. (biomedcentral.com)

Taxonomic distribution of proteins containing WNT1 domain. (embl-heidelberg.de)
The complete taxonomic breakdown of all proteins with WNT1 domain is also avaliable . (embl-heidelberg.de)
Click on the protein counts, or double click on taxonomic names to display all proteins containing WNT1 domain in the selected taxonomic class. (embl-heidelberg.de)
Taxonomic distribution of proteins containing LY domain. (embl.de)

Adenoviruses commonly infect vertebrates, including humans and nonhuman primates ( 1 ). (cdc.gov)
In the present study, we sought to address are of the same size as engineered nanoparti- human primates, which demonstrated the the hypothesis that a major translocation route cles. (cdc.gov)

The cytoskeleton is a highly dynamic network of filamentous proteins that enables the active transport of cellular cargo, transduces force, and when assembled into higher-order structures, forms the basis for motile cellular structures that promote cell movement. (mechanobio.info)

These results are consistent with the notion that the ligand-binding domain has close structural similarities to bacterial periplasmic binding proteins. (aspetjournals.org)

Catalytic domain of the Protein Tyrosine Kinase, Src. (umbc.edu)

The first one provides length variation at the N-terminus (before the BH4 domain) and the second one is located between the predicted alpha 5-alpha 6 pore-forming helices, providing an unprecedented case in the superfamily of helix-bundled pore-forming proteins. (sfr-biosciences.fr)
Formins are multidomain proteins defined by a conserved FH2 (formin homology 2) domain with actin nucleation activity preceded by a proline-rich FH1 (formin homology 1) domain. (biomedcentral.com)
In vitro, the FH2 domain competes with barbed-end capping proteins and is necessary and sufficient to nucleate actin polymerization, but the FH1 domain, which interacts with profilin-actin, funnels actin to the nucleation vicinity and confers full activity to the molecule [ 1 ]. (biomedcentral.com)

The variation in the types of amino acids in the protein chain of amines acids in all proteins determines the chemical properties and function of that protein. (hemolevel.com)
The same applies to hemoglobin, in which a series of amino acids can affect important functions such as the attraction of proteins to oxygen. (hemolevel.com)
The length of the deduced protein is approximately 100 amino acids. (biomedcentral.com)

The Many Hosts of Mycobacteria (MHM) meeting series brings together basic scientists, clinicians and veterinarians to promote robust discussion and dissemination of recent advances in our knowledge of numerous mycobacterial diseases, including human and bovine tuberculosis (TB), nontuberculous mycobacteria (NTM) infection, Hansen's disease (leprosy), Buruli ulcer and Johne's disease. (bvsalud.org)

Oxidative stress generated during such stressful conditions may damage DNA and proteins, and as a consequence the cellular processes are disturbed. (springer.com)
Although central to autophagy, targeted proteins have also a high number of connections with proteins of other cellular functions. (sfr-biosciences.fr)

This basic two-step process has been confirmed in most mammalian cells, although its regulation and the repertoire of specific accessory proteins are likely to be highly context dependent. (centrodinoferrari.com)

Adult and embryonic Brugia malayi are shown to be susceptible to inhibitors of vertebrate prolyl 4-hydroxylase, with exposed parasites exhibiting pathologies consistent with a disruption in cuticle biosynthesis. (embl.de)
Examples of a novel series of phenanthrolinones are shown to be potent competitive inhibitors of avian prolyl 4-hydroxylase, and of collagen hydroxylation, in embryonic chick tendon cells and human foreskin fibroblasts in vitro and in the oestradiol-stimulated rat uterus in vivo. (embl.de)
Measured by its ability to induce Topflash reporter activity in HEK293T human embryonic kidney cells. (novusbio.com)

rarely, the download Secrets of itself, a cytosolic human FAD( HC) - Many proton( LC) ER( ' complex '), is pulmonary of exercising to carboxylases by proteins with different distribution and damaged cycle urea 2( SV2)( Fu et al. (familie-vos.de)

In this paper, we have unraveled two major sites of divergence between human Bcl2l10 and its vertebrate homologs. (sfr-biosciences.fr)

Conserved nucleotides are indicated by an asterisk and identical amino acid residues are shown in bold font. (xenbase.org)

Anatomy9

Organisms29

Chemicals and Drugs37

Analytical, Diagnostic and Therapeutic Techniques and Equipment17

Phenomena and Processes47

Disciplines and Occupations1

Information Science6

Health Care2

Genes21

Highly conserved5

Sequences14

Threonine residues2

Involved in disulphide1

Extracellular4

Sequence9

Transmembrane3

Receptor9

Encode proteins1

Invertebrates1

Species3

Lineage4

Evolutionary3

Mutations2

Serine3

Drosophila1

Phylogenetic1

Subunit2

Homolog2

Subtypes1

Substrates3

Physiological3

Metabolism1

Hydrophobic1

Inhibition5

Fungi1

Cysteine-rich2

Enzymes1

Membrane4

Family7

Orthologs1

Mitochondrial3

Subfamily1

RNAs1

Inhibitor1

Chains3

Disulfide2

Biochemical1

Purification1

GPCRs4

Cytosol1

Phosphorylation1

Gene families1

Taxonomic4

Primates2

Cytoskeleton1

Ligand1

Catalytic1

Domain3

Acids3

Diseases1

Cellular2

Repertoire1

Embryonic3

Cytosolic1

Divergence1

Identical1