Human tumors tumors injections subcutaneous. Medical search. Frequent questions

These changes in the tumor microenvironment may lead to tumor cell death and eventually to a long-term memory immune response against tumor antigens. (drugdiscoverynews.com)
There is an extensive body of evidence that demonstrates that modulating the tumor microenvironment is critical to a successful outcome in cancer immunotherapy," added Dr. Sudhir Agrawal, president of Research at Idera. (drugdiscoverynews.com)
Thus, addressing the presence of immunosuppressive myeloid cell populations in the periphery and tumor microenvironment of patients with cancer is likely to be required for effective NK cell-based immunotherapy. (elifesciences.org)
While GB tumors are frequently infiltrated by natural killer (NK) cells, these are actively suppressed by the GB cells and the GB tumor microenvironment. (frontiersin.org)
Here, we discuss effects of the GB tumor microenvironment on NK-cell functionality, summarize early treatment attempts with ex vivo activated NK cells, and describe relevant CAR target antigens validated with CAR-T cells. (frontiersin.org)
Nevertheless, the composition of the immunologic tumor microenvironment undergoes changes upon radiotherapy, chemotherapy, or even after anti-angiogenic therapy ( 6 ). (frontiersin.org)
I studied the tumor microenvironment of liver cancer during my graduate training in Hong Kong. (stanford.edu)
Conclusions: Anti-C1-INH treatment could improve the efficacy of irradiation delivered at sub-therapeutic doses and delay tumor growth in the subcutaneous tumor microenvironment. (lu.se)

Injection of in vitro generated melanoma-derived tumor-APCs into subcutaneous melanoma tumors delayed tumor growth and increased survival in mice. (lu.se)

EL4-hCD19-LZ cells form tumors in vivo when injected subcutaneously. (genoway.com)
Furthermore, inhibition of ChoK shows a strong in vivo antitumor activity against human breast cancer xenografts. (aacrjournals.org)
In addition to acquiring improved antigen presentation, tumor-APCs had impaired tumorigenicity in vitro and in vivo. (lu.se)
Notably, intratumoral injection of this cBiTE-expressing adenovirus increased the persistence and accumulation of tumor-infiltrating T cells in vivo , compared with the parental virus lacking such effects. (aacrjournals.org)
In this study, the ability of CRPC cells to grow and develop in vivo tumors in an animal model was evaluated, in order to investigate the anti-tumor effect of desmopressin in combination with docetaxel. (iiarjournals.org)
Thus, as 'proof of principle', the aim of this study was to evaluate the effect of desmopressin and docetaxel on in vivo tumor growth and development in an orthotopic animal model using CRPC PC3 cells. (iiarjournals.org)
Retroviral vectors expressing short hairpin RNAs (shRNAs) targeted against CDC2 were designed and transducted into human glioma cell line ex vivo in order to downregulate the expression of CDC2. (biomedcentral.com)
Following ex vivo study, viral particles containing small interfering RNA for CDC2 were subsequently injected into xenogeneic graft tumor of nude mice and the weight of human glioma xenografts, survival and resulting phenotypic changes of target gene were investigated. (biomedcentral.com)
Retroviral vectors expressing short hairpin RNAs (shRNAs) against CDC2 caused efficient deletion of CDC2, cellular G2/M arrest concluding in apoptosis and inhibition of proliferation in human glioma cells U251 and SHG-44 cell lines ex vivo. (biomedcentral.com)
Downregulation of CDC2 could potentialy inhibit human gliomas cells growth ex vivo and in vivo. (biomedcentral.com)
To reveal the roles of CDC2/Cyclin B1 in human malignant gliomas, CDC2 in glioma cell line, it was down-regulated by retrovirus vectors expressing short hairpin RNAs (shRNAs) ex vivo and in vivo. (biomedcentral.com)
In addition, the feasibility of imaging of DAbR1-positive T cells in vivo after intravenous injection of 86 Y/ 177 Lu-AABD was studied and radiation doses determined. (snmjournals.org)
Background: Tumor-specific cytotoxic T lymphocytes (CTL) can be activated in vivo by vaccination with dendritic cells (DC). (uni-muenchen.de)
SMOC provides technical services such as tumor growth measurement, body weight monitoring, biochemical analysis, pathological examination, expression profiling and in vivo imaging. (modelorg.com)
The expression level of the luciferase gene was measured at 7, 14 and 18 days post injection by in vivo bioluminescence imaging. (modelorg.com)
F) Live animal imaging to track tumor growth in vivo . (modelorg.com)
As a consequence, preclinical evaluation of Interferon alfa-2a, recombinant has involved in vitro experiments with human cells and some in vivo experiments. (drugs.com)
In vivo, Interferon alfa-2a, recombinant has been shown to inhibit the growth of several human tumors growing in immunocompromised (nude) mice. (drugs.com)
We tested whether coxsackievirus A11 (CVA11) has oncolytic activity in human CRC cells in vitro and in vivo. (elsevierpure.com)
Several differences exist in placental organization among different mammalian species, making it difficult to automatically transpose toxicological results from common in vivo models, such as rodents, to humans. (biomedicineandprevention.com)

Indole-3-carbinol causes proliferation arrest and apoptosis in human melanoma cells. (wikipedia.org)
In two different studies using xenografted mouse model of melanoma, they observed that subcutaneous injection of indole-3-carbinol could bring down tumor burden significantly. (wikipedia.org)
Overall scientific evidence shows that in melanoma, indole-3-carbinol specifically inhibits the two most commonly associated driver mutation signaling pathways to cause proliferation, a fact that can be used to design clinical trial to treat human patients with indole-3-carbinol in future. (wikipedia.org)
In contrast to other cancers such as adenocarcinomas of the lung or melanoma, primary brain tumors like GB and low grade gliomas (LGG) are known as rather immunologically "cold" tumors, typically with low numbers of tumor-infiltrating lymphocytes (TILs) ( 4 ), and the mere amount of TILs is not associated with patient survival ( 5 ). (frontiersin.org)
A dectin-2 lentivector encoding the human melanoma antigen NY-ESO-1 primed an NY-ESO-1-specific CD8(+) T-cell response in HLA-A2 transgenic mice and stimulated a CD4(+) T-cell response to a newly identified NY-ESO-1 epitope presented by H2 I-A(b). (ox.ac.uk)
Now one of the top-selling drugs in the world, Opdivo and Opdivo-based combinations have demonstrated mixed effectiveness in treatments for several tumor types, including bladder cancer and melanoma. (pharmamanufacturing.com)

Long-term treatment of the severe diarrhea and flushing episodes associated with metastatic carcinoid tumors. (guidelinecentral.com)
In particular, orthotopic models have a higher metastatic potential, and likely to result in detectable circulating tumor cells ( 11 , 12 ). (iiarjournals.org)
In addition, metastatic sites may re-seed primary tumors in a multi-directional fashion [ 8 ]. (oncotarget.com)
The CheckMate -67T noninferiority trial evaluated the subcutaneous formulation of Opdivo (nivolumab) co-formulated with Halozyme's proprietary recombinant human hyaluronidase (rHuPH20) compared to intravenous Opdivo in patients with advanced or metastatic clear cell renal cell carcinoma who have received prior systemic therapy. (pharmamanufacturing.com)
Fig1: Optical imaging of bioluminescent subcutaneous and metastatic CDX models. (modelorg.com)
D) B16 Luc -mediated in situ /metastatic tumor development. (modelorg.com)
Many of these cell lines have been obtained from a highly metastatic malignant tumor of the trophoblast, the choriocarcinoma, and have been extensively characterized. (biomedicineandprevention.com)
Inclusion criteria: Histologically or cytologically confirmed and documented human epidermal growth factor receptor 2 positive/estrogen receptor positive adenocarcinoma of the breast with metastatic or locally-advanced disease not amenable to curative resection. (who.int)

Bone metastasis occurs through a complex cascade of events that ultimately results in circulating tumor cells (CTCs) from the blood extravasating and invading the bone marrow - these cells within the bone marrow are referred to as disseminated tumor cells (DTCs) [ 4 ]. (oncotarget.com)

Glioblastoma (GB) is the most frequent malignant primary brain tumor in adults, without any curative treatment options available at present. (frontiersin.org)
Particular importance here is the biological applications of Pt NCs such as the bioimaging of various cells as a preferred fluorophore in contrast to traditional fluorescent markers (e.g., organic dye, semiconductor quantum dots, and fluorescent proteins), the usage of Pt NCs-based antitumour drugs as a new class chemotherapeutics for malignant tumour therapy, and the utilization of antibacteria as an alternative of Ag-based antibacterial agent. (hindawi.com)
In the present study, we investigated the relationship of gene expression profiles with malignant progression of human glioma. (biomedcentral.com)
As such we plan to eventually employ the therapeutic mAbs in combination with chemotherapy as a means of enhancing the immunogenicity of the tumor system being treated and to possibly weaken the malignant growth for easier destruction by the mAb. (jcancer.org)
Our aims were to elucidate whether T cells can induce galectin-9 secretion in human cancer cells derived from solid malignant tumors and whether this soluble form displays higher systemic immunosuppressive activity compared with the cell surface-based protein. (bmj.com)
Results We discovered that T lymphocytes induce galectin-9 secretion in various types of human cancer cells derived from solid malignant tumors. (bmj.com)
In terms of other side effects, there is a black box warning for medullary thyroid carcinoma , because in rodents there is an increase in C-cell tumors, both malignant and benign, with this agent. (medscape.com)

Importantly, intratumor delivery of miRNA-29a mimics induced regression of tumors in mouse xenograft model of MM and this effect synergized with PRIMA-1 Met . (oncotarget.com)
Shanghai Model Organisms Center provides multiple types of tumor-bearing mouse models for cancer research and drug efficacy testing, including cell line-derived xenograft model (CDX) and patient-derived xenograft model (PDX). (modelorg.com)
Furthermore, growth of subcutaneous WiDr tumors in a xenograft model was significantly lower in mice treated with oxaliplatin followed by intratumoral CVA11 injection compared with mice receiving either treatment alone. (elsevierpure.com)

These cells form tumors in syngeneic models, upon subcutaneous and systemic (i.v.) injection, in immunocompetent mice. (genoway.com)
Furthermore, sub-cutaneous injection of the antisense mRNA expressing transformed BALB/c-3T3 cells resulted in a significant reduction in the onset as well as the size of tumors in athymic nude mice. (cdc.gov)
In mice GFP expression was detected in splenic dectin-2(+) cells after intravenous injection and in CD11c(+) dendritic cells in the draining lymph node after subcutaneous injection. (ox.ac.uk)
And the viral particles containing small interfering RNA for CDC2 were subsequently injected into subcutaneous and intracranial xenogeneic graft tuomrs of nude mice. (biomedcentral.com)
Mabs capable of targeting the malignancies noted above were produced following immunization of BALBc mice with the Tumor Specific Antigens. (jcancer.org)
Testosterone was tested by subcutaneous injection and/or implantation in mice, rats and hamsters. (inchem.org)
The incidences of leukaemia and of liver-cell and breast tumours in untreated mice of some strains were decreased by testosterone treatment, but the incidence of mammary tumours was increased by neonatal treatment of females of a mammary-tumour-virus-bearing strain. (inchem.org)
We investigated mechanisms of resistance of liver tumors in mice to infiltrating T cells.Mice were given hydrodynamic tail vein injections of clustered regularly interspaced short palindromic repeats-Cas9 (CRISPR-Cas9) and transposon vectors to disrupt Trp53 and overexpress C-Myc (Trp53KO/C-MycOE mice). (stanford.edu)
some mice were given intraperitoneal injections of antibodies against PD1, T-cell immunoreceptor with Ig and ITIM domains (TIGIT), or CD8 before the cancer cells were injected. (stanford.edu)
Tumors from mice given anti-PD1 had larger numbers of memory CD8+ T cells (CD44+CD62L-KLRG1int) and T cells that expressed PD1, lymphocyte activating 3 (LAG3), and TIGIT compared with mice not given the antibody. (stanford.edu)
In Trp53KO/C-MycOE mice and mice with tumors grown from Hepa1-6 cells, injection of the combination of anti-PD1 and anti-TIGIT significantly reduced tumor growth, increased the ratio of cytotoxic to regulatory T cells in tumors, and prolonged survival.PVRL1, which is up-regulated by HCC cells, stabilizes cell surface PVR, which interacts with TIGIT, an inhibitory molecule on CD8+ effector memory T cells. (stanford.edu)
For prophylactic vaccination, mice were vaccinated three times in weekly intervals prior to tumor challenge with Panc02 cells. (uni-muenchen.de)
Combination of the two strategies significantly increased survival of tumor-bearing mice (50 % at day 58 after tumor challenge). (uni-muenchen.de)
A-B) Human colon cancer cells genetically engineered to express firefly luciferase gene were injected via carotid artery into nude mice. (modelorg.com)
Right) Subcutaneous tumor formed by HepG2 cells on nude mice. (modelorg.com)
Fig 3: A549-mediated subcutaneous tumor formation on NMG mice. (modelorg.com)
E) Immunohistological analysis of Vegf expression in tumors harvested from MSTO-211H -bearing nude mice either treated with anti-tumor drug or not. (modelorg.com)
The most prevalent (two studies) and CD1 mice (IARC, cifically including beryllium and source of human exposure to ar- 2012 ). (who.int)
100C (IARC, 2012 ) as carcinogenic and pentavalent methylated metab- male mice), and after weaning until to humans (Group 1). (who.int)
It is difficult to assess mice, which cannot repair certain In rodents, multiple studies showed the relevance to humans of rodent types of oxidative DNA damage, but that in utero exposure to arsenic via studies that use multiple agents, one not in Ogg+/+ mic e (IARC, 2012 ). (who.int)

Treatment of syngeneic tumors resulted in CD8 and PD-L1-dependent tumor rejection or growth inhibition and a reduction in myeloid cells endogenously expressing high levels of PD-L1. (elifesciences.org)
We have used this protocol to detect human and murine DTCs in xenograft, syngeneic, and genetically engineered mouse models. (oncotarget.com)
Because of its species-restricted activity, it has not been possible to demonstrate antitumor activity in immunologically intact syngeneic tumor model systems, where effects on the host immune system would be observable. (drugs.com)

Our approach serves as a platform for the development of immunotherapies that endow cancer cells with the capability to process and present endogenous tumor antigens. (lu.se)
NK cells contribute to cancer immune surveillance not only by their direct natural cytotoxicity which is triggered rapidly upon stimulation through germline-encoded cell surface receptors, but also by modulating T-cell mediated antitumor immune responses through maintaining the quality of dendritic cells and enhancing the presentation of tumor antigens. (frontiersin.org)
Monoclonal antibodies developed against immunogenic proteins (Tumor Specific Antigens/TSA's) that are expressed in human cancers, display a unique behavioral pattern. (jcancer.org)
These tumor proteins, when first defined, were referred to as tumor associated antigens. (jcancer.org)
Monoclonals developed from these tumor antigens are in the initial phases of investigation with regard to their specificity and antitumor activity. (jcancer.org)

Bleomycin for injection is provided as a sterile, white to off-white, lyophilized cake or powder in vials for intramuscular, intravenous, or subcutaneous administration. (nih.gov)
Systemic bioavailability of bleomycin is 100% and 70% following intramuscular and subcutaneous administrations, respectively, and 45% following both intraperitoneal and intrapleural administrations, compared to intravenous and bolus administration. (nih.gov)
Following intravenous bolus administration of 30 units of bleomycin to one patient with a primary germ cell tumor of the brain, a peak CSF level was 40% of the simultaneously-obtained plasma level and was attained in two hours after drug administration. (nih.gov)
Do not administer by intravenous or intramuscular injection as no data is available on the safety or efficacy via these routes. (pdr.net)
Intravenous Opdivo has helped transform the treatment of several solid tumor types over the past decade, but there remains a need for additional administration options to address treatment burden on patients and improve efficiencies in health care systems," said Gina Fusaro, VP global program lead, Bristol Myers Squibb. (pharmamanufacturing.com)
On the second day of hospitalization, we switched from intravenous to subcutaneous injection of insulin. (cdc.gov)

It was also under development for solid tumor. (pharmaceutical-technology.com)
However, solid tumor cells at rest are known to secrete either very low amounts of galectin-9 or, in most of the cases, do not secrete it at all. (bmj.com)

Here, we demonstrate that NK cells (haNKs) engineered to express a PD-L1 chimeric antigen receptor (CAR) haNKs killed a panel of human and murine head and neck cancer cells at low effector-to-target ratios in a PD-L1-dependent fashion. (elifesciences.org)
T cell-based immunotherapy, such as immune checkpoint blockade or adoptive T cell transfer, is limited by the ability of T cells to detect major histocompatibility complex (MHC)-presented antigen by tumor cells. (elifesciences.org)
We used the minimal gene regulatory network of type 1 conventional dendritic cells (cDC1) to reprogram cancer cells into professional antigen-presenting cells (tumor-APCs). (lu.se)
Reprogramming restored the expression of antigen presentation complexes and costimulatory molecules on the surfaces of tumor cells, allowing the. (lu.se)
Human primary tumor cells could also be reprogrammed to increase their capability to present antigen and to activate patient-specific tumor-infiltrating lymphocytes. (lu.se)
γδ T cells, specifically the Vγ9Vδ2 subset, which is the dominate subset among γδ T cells in human peripheral blood, recognize target cells in a human leukocyte antigen (HLA)-independent manner. (nature.com)
Immunization with a lentivector that targets tumor antigen expression to dendritic cells induces potent CD8+ and CD4+ T-cell responses. (ox.ac.uk)
Results: Prophylactic DC-based vaccination completely prevented subcutaneous and orthotopic tumor development and induced immunological memory as well as tumor antigen-specific CTL. (uni-muenchen.de)
Human leukocyte antigen typing identified no specific alleles, including DR4, known to be related to T1D ( Table ). (cdc.gov)

These results demonstrate that ChoK plays an essential role in both normal human mammary epithelial cell proliferation and breast tumor progression. (aacrjournals.org)
The introduction of biological agents such as tumor necrosis factor-α (TNF-α) inhibitors into the therapeutic strategy for rheumatoid arthritis (RA) resulted in a shift characterized by the sufficient inhibition of arthritic signs and symptoms, radio graphic progression, and functional disability 1 , 2 . (jrheum.org)
It has recently been demonstrated to inhibit tumor progression and metastasis in breast cancer models. (iiarjournals.org)
Abnormalities in cell cycle regulation are reported to be strongly associated with tumorigenesis and progression of tumors. (biomedcentral.com)
Tumor specimens were obtained with informed consent from a 37-year-old female patient who underwent initial surgical removal in January 1999 and subsequent recurrent resections of a right temporal tumor July 1999 and February 2001 at the 2nd Affiliated Hospital of Soochow University (Suzhou, China) and did not receive chemotherapy and radiation between these stages of progression. (biomedcentral.com)
Here at Stanford, I am using different genome editing tools and mouse models to investigate the role of macrophages in promoting tumor progression and immune tolerance in liver cancer. (stanford.edu)
Our lab's mission is to develop therapies for regenerating human tissues lost due to diseases or aging, and to build tissue engineered 3D models for understanding disease progression and informing drug discovery. (stanford.edu)

IDO is one of several immune checkpoints involved in tumor immune escape, and IDO-1 inhibitors are currently in clinical development, according to the company. (drugdiscoverynews.com)
According to Doody, preclinical studies using IMO-2125 either as a single-agent or in combination with several checkpoint inhibitors-such as anti-CTLA-4, anti-PD-1 and IDO-1 inhibitor-have shown robust tumor regression. (drugdiscoverynews.com)
Objectives To assess baricitinib on patient-reported outcomes (PROs) in patients with moderately to severely active rheumatoid arthritis, who had insufficient response or intolerance to ≥1 tumour necrosis factor inhibitors (TNFis) or other biological disease-modifying antirheumatic drugs (bDMARDs). (bmj.com)
Antitumor immunity elicited by tumor-APCs was synergistic with immune checkpoint inhibitors. (lu.se)
In this respect, the introduction of checkpoint inhibitors to unleash the activity of tumor-reactive T cells has been a milestone in cancer immunotherapy. (nature.com)
Immune checkpoint inhibitors are effective in the treatment of some hepatocellular carcinomas (HCCs), but these tumors do not always respond to inhibitors of programmed cell death 1 (PDCD1, also called PD1). (stanford.edu)

Myeloid immune cells, specifically tumor-associated macrophages (TAMs), may represent potential novel therapeutic targets in HCC, complementing current ablative or immune therapies. (cancerindex.org)
It operates as a developer of therapeutic products for the treatment of human diseases. (pharmaceutical-technology.com)
To compare the heterogeneities of human umbilical cord mesenchymal stem cells (HUCMSCs) derived from different donors and test their therapeutic variations in mouse liver fibrosis model. (researchsquare.com)
Arlen M, Arlen P, Tsang A, Wang X, Gupta R. The Therapeutic Value of Monoclonal Antibodies Directed Against Immunogenic Tumor Glycoproteins. (jcancer.org)
With the ability of the mAbs to demonstrate therapeutic antitumor activity in those patients with relatively advanced malignancies, the term tumor specific was introduced. (jcancer.org)
Our study indicates that miRNA-29a is a tumor suppressor that plays an important role during PRIMA-1 Met -induced apoptotic signaling by targeting c-Myc and provides the basis for novel therapeutic strategies using miRNA-29a mimics combined with PRIMA-1 Met in MM. (oncotarget.com)
Therapeutic vaccination was started when tumors formed a palpable nodule. (uni-muenchen.de)

This includes the early recognition of these immunogenic membrane proteins that can serve as diagnostic markers, and the targeting of such markers for the destruction of the tumor, primarily thru ADCC. (jcancer.org)
The monoclonals (mAbs) that we have developed against specific immunogenic tumor membrane proteins have been studied in detail. (jcancer.org)
Monoclonals that we were able to develop from tumor specific proteins derived from colon and pancreas cancer were found capable of targeting those tumors to induce apoptosis. (jcancer.org)
Background Galectin-9 is a member of the family of lectin proteins and crucially regulates human immune responses, particularly because of its ability to suppress the anticancer activities of T lymphocytes and natural killer cells. (bmj.com)
As an example, we studied the cooperation of galectin-9 and V-domain Ig-containing suppressor of T cell activation (VISTA) proteins in human cancer cells. (bmj.com)
Thus, various aspects of the disclosure provide tumor-targeting viral-like nanoparticles that comprise photosensitive molecules conjugated to capsid proteins. (justia.com)

To investigate the effect of gambogic acid (GA) on apoptosis in the HT-29 human colon cancer cell line. (wjgnet.com)
Here we provide evidence of a novel mechanism for PRIMA-1 Met , a small molecule with anti-tumor activity in phase I/II clinical trial, showing that PRIMA-1 Met induces apoptosis in MM cells by suppressing c-Myc and upregulating miRNA-29a. (oncotarget.com)
PRIMA-1 is a low-molecular weight compound that can restore wild-type conformation and specific DNA binding of mutant p53, consequently triggering apoptosis in tumour cells carrying mutant p53 [ 4 - 8 ]. (oncotarget.com)

Glioblastoma (GBM) is the most common primary brain tumor, which is prone to recurrence and metastasis with poor prognosis. (bvsalud.org)
Positron emission tomography-computed tomography showed no metastasis or recurrence of the tumor 1 month before admission. (cdc.gov)

Patients not currently receiving octreotide acetate should begin therapy with Sandostatin Injection given subcutaneously in an initial dose of 50 mcg three times daily which may be titrated. (guidelinecentral.com)

This suppresses the ant-tumor immune response. (stanford.edu)
However, it is believed that direct antiproliferative action against tumor cells, inhibition of virus replication and modulation of the host immune response play important roles in antitumor and antiviral activity. (drugs.com)
Also tell your doctor if you have or have ever had diabetes, human immunodeficiency virus (HIV) , acquired immunodeficiency syndrome (AIDS), or any other condition that affects your immune system. (medlineplus.gov)
Background: A more effective immune response against glioblastoma is needed in order to achieve better tumor control. (lu.se)
Radiotherapy can induce anti-tumor mediated immune reactions, in addition to its dose response effects. (lu.se)

The underlying molecular mechanism of this anti-tumor effect was found to be by the specific inhibition of activity of oncogenic BRAFV600E in tumors that harbored the mutation. (wikipedia.org)

Immunohistochemistry indicated that CDC2 are negative and TUNEL are positive in tumors treated with recombinant retrovirus. (biomedcentral.com)
The technology is based on Halozyme's proprietary recombinant human hyaluronidase PH20 enzyme that degrades hyaluronan. (pharmamanufacturing.com)
Roferon-A (Interferon alfa-2a, recombinant) is a sterile protein product for use by injection. (drugs.com)
Roferon-A is manufactured by recombinant DNA technology that employs a genetically engineered Escherichia coli bacterium containing DNA that codes for the human protein. (drugs.com)
The biological activities of Interferon alfa-2a, recombinant are species-restricted, i.e., they are expressed in a very limited number of species other than humans. (drugs.com)
1 Using human cells in culture, Interferon alfa-2a, recombinant has been shown to have antiproliferative and immunomodulatory activities that are very similar to those of the mixture of interferon alfa subtypes produced by human leukocytes. (drugs.com)

Intratumoral injection of IMO-2125 leads to interferon-alpha production and activation of dendritic cells. (drugdiscoverynews.com)
Human CD19 expression was assessed in EL4 parental cell line (left), human control cells - PBMC (center), and EL4-hCD19-LZ cell line (right). (genoway.com)
Indole-3-carbinol induces a G1 growth arrest of human reproductive cancer cells. (wikipedia.org)
Here, we have investigated the role of ChoK in the development of breast cancer and found that ChoK is both necessary and sufficient for growth factor-induced proliferation in primary human mammary epithelial cells and an absolute requirement for the specific mitogenic response to heregulin in breast tumor-derived cells. (aacrjournals.org)
Within 9 days of reprogramming, tumor-APCs acquired transcriptional and epigenetic programs associated with cDC1 cells. (lu.se)
Despite the existence of a highly immunosuppressive tumor environment, adenovirus-infected cells can nonetheless be efficiently cleared by infiltrating cytotoxic T lymphocytes (CTL) without compromising tumor burden. (aacrjournals.org)
In this study, we tested the hypothesis that tumor-infiltrating T cells could be more effectively activated and redirected by oncolytic adenoviruses that were armed with bispecific T-cell-engager (BiTE) antibodies. (aacrjournals.org)
Vγ9Vδ2 T cells are promising candidates for cellular tumor immunotherapy. (nature.com)
This lentivector expressed a green fluorescent protein (GFP) transgene in mouse bone marrow-derived dendritic cell cultures and in human skin-derived Langerhans and dermal dendritic cells. (ox.ac.uk)
HPV is present in the tumour cells. (sv40.org)
SV40 is a powerful carcinogen that, in vitro , transforms human mesothelial cells. (sv40.org)
Due to the difficulty in sampling and detection, few techniques exist to efficiently and consistently detect and quantify disseminated tumor cells (DTCs) in the bone marrow of cancer patients. (oncotarget.com)
DAbR1 was subcloned together with green fluorescent protein into an SFG-retroviral vector and used to transduce CD3/CD28-activated primary human T cells and second-generation 1928z (CAR) T cells. (snmjournals.org)
Methods A wide range of human cancer cell lines derived from solid tumours, keratinocytes and primary embryonic cells were employed, together with helper and cytotoxic T cell lines and human as well as mouse primary T cells. (bmj.com)
Our findings indicate that tumor associated macrophages including Kupffer cells, have a profound impact on liver cancer and I am studying the molecular basis for these effects. (stanford.edu)
tumors were analyzed by mass cytometry using markers to detect T cells and other lymphocytes. (stanford.edu)
We have previously shown that gemcitabine sensitizes human pancreatic carcinoma cells against CTL-mediated lysis. (uni-muenchen.de)
DC-based vaccination also prevented death from pulmonary metastatization after i.v.-injection of Panc02 cells. (uni-muenchen.de)
The present disclosure provides, at least in in part, methods and compositions for detecting and/or selectively targeting tumor cells, for example, for the diagnosis and/or treatment of cancer (e.g., ocular cancer). (justia.com)
In some instances, the methods and compositions provided herein can be used to selectively kill cancerous tumor cells without damaging healthy cells. (justia.com)
For example, viral-like nanoparticles that comprise (e.g., are conjugated to) photosensitive molecules may be selectively delivered to tumor cells and photoactivated by exposure to light. (justia.com)
In vitro experimental models to study the efficiency of the placental barrier for environmental toxicants: tumor cell lines versus trophoblast primary cells. (biomedicineandprevention.com)
In humans the placental barriers are composed by the endothelium of the fetal capillaries, and two layers of trophoblast cells, the syncytiotrophoblast, composed of syncytia forming a continuous lining of the villous tree, and the cytotrophoblast, composed of single cells forming a discontinuous layer in the mature placenta (Figure 1). (biomedicineandprevention.com)
Some children, teenagers, and young adults who received golimumab injection and similar medications developed severe or life-threatening cancers including lymphoma (cancer that begins in the cells that fight infection). (medlineplus.gov)

Conclusion: DC-based immunotherapy may not only be successfully combined with gemcitabine for the treatment of advanced pancreatic carcinoma, but may also be effective in preventing local recurrence or metastatization in tumor-free patients. (uni-muenchen.de)
In animals with subcutaneous tumors, combined radio-immunotherapy with anti-C1-INH and irradiation at 8 Gy × 2 significantly prolonged survival compared to control animals, whereas irradiation or anti-C1-INH treatment as single therapies did not lead to significantly increased survival compared to control animals. (lu.se)

The only adverse events that occurred significantly more often in the etanercept group were injection-site reactions, accidental injuries, and upper respiratory tract infections. (nih.gov)
For subcutaneous tumors, injection of CDC2-shRNA retroviruses significantly decreased tumor weight and volume compared with control. (biomedcentral.com)
The rate of pediatric brain tumors is increasing and cytotoxic therapy (i.e. chemotherapy and radiation) is seldom successful in significantly prolonging life or curing the patient. (sv40.org)

Enforced expression of the transcription factors PU.1, IRF8, and BATF3 (PIB) was sufficient to induce the cDC1 phenotype in 36 cell lines derived from human and mouse hematological and solid tumors. (lu.se)

Tumor growth was measured every 2 to 4 days. (genoway.com)
Treatment of xenograft tumors resulted in PD-L1-dependent tumor growth inhibition. (elifesciences.org)
In patients with carcinoid syndrome and VIPomas, the effect of Sandostatin Injection and SANDOSTATIN LAR DEPOT on tumor size, rate of growth and development of metastases, has not been determined. (guidelinecentral.com)
The monoclonals, so produced, were not only more efficient in controlling tumor growth but minimized the development of a HAMA response. (jcancer.org)
Tumor growth was evaluated at multiple time points post inoculation. (modelorg.com)
Pancreatic cancer with cachexia and elevated human growth differentiation factor 15 (GDF15). (medscape.com)

However, we are also very excited to further understand what other areas we can apply the technology to, such as in tumors that may not be immunogenic and perhaps unresponsive to checkpoint inhibition. (drugdiscoverynews.com)
The concept of checkpoint inhibition or other methods of resistance modulation have emerged, as well as, importantly, the concept of intratumoral injections of therapies. (drugdiscoverynews.com)

Testosterone cypionate injection, for intramuscular injection, contains testosterone cypionate which is the oil-soluble 17 (beta)-cyclopentylpropionate ester of the androgenic hormone testosterone. (nih.gov)
Recently, first vaccines have been approved for people over 60 years of age applied by intramuscular injection. (bvsalud.org)

Anti-C1-INH was delivered as intratumoral injections. (lu.se)

Choline kinase (ChoK) is increased in human mammary tumors with high incidence, and this activation is associated with clinical variable indicators of greater malignancy. (aacrjournals.org)
Increasingly numerous results have demonstrated overexpression of CDC2/Cyclin B1 in various tumors however there is still no report of CDC2/Cyclin B1 expression in clinical samples from patients with gliomas. (biomedcentral.com)
While PDX models better reflect the heterogeneity and diversity of human cancers, CDX models allow researchers to advance their pre-clinical drug development in a cost- and time-efficient manner. (modelorg.com)

Glioblastoma (GB) is the most common and aggressive primary brain tumor in adults and currently incurable. (frontiersin.org)
Fully immunocompetent Fischer 344 rats with NS1 glioblastoma tumors were treated. (lu.se)

Mounjaro™ (tirzepatide) injection is FDA-approved as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. (therecover.com)
Five months after discharge, the patient still requires multiple daily insulin injections for glycemic control. (cdc.gov)

IMO-2125 was developed several years ago and clinically tested in several human studies, including hepatitis C and a number of different cancers. (drugdiscoverynews.com)
This Table supports the position that the SV40 association with some human mesothelioma cancers is causative. (sv40.org)
Recent evidence demonstrated that galectin-9 is highly expressed in a wide range of human malignancies including the most aggressive tumors, such as high-grade glioblastomas and pancreatic ductal adenocarcinomas, as well as common malignancies such as breast, lung and colorectal cancers. (bmj.com)

The suggested dosage for DEPO-Testosterone Injection varies depending on the age, sex, and diagnosis of the individual patient. (pfizermedicalinformation.com)

As Doody explained, "Tumor regression was not only observed in the injected tumor but also in the uninjected tumor, essentially creating a systemic response. (drugdiscoverynews.com)
At that time, IMO-2125 was being delivered in a systemic fashion via subcutaneous injections. (drugdiscoverynews.com)

Bleomycin is rapidly absorbed following either intramuscular, subcutaneous, intraperitoneal or intrapleural administration reaching peak plasma concentrations in 30 to 60 minutes. (nih.gov)
A mouse model of primary liver cancer can be established in about 6 months after intraperitoneal injection of DEN. (modelorg.com)

Tissue microarrays were utilized to investigate the expression of genes in a large number of tumor samples and to identify overexpressed genes which could be potentially causing tumorigenesis. (biomedcentral.com)
Human glioma tissue microarrays indicated the positive expression rates of CDC2/CyclinB1 with a positive correlation with pathologic grades (r = 0.982, r = 0.959, respectively). (biomedcentral.com)
Surprisingly, conjugation of photosensitive molecules to viral-like nanoparticles does not interfere with the tissue/tumor tropism of the nanoparticles (e.g., the specificity of the viral-like nanoparticles for a particular host tumor tissue or tumor cell). (justia.com)

CDC2 gene plays an important role in the proliferation of human gliomas. (biomedcentral.com)

It is required by FDA that the potential effects of tumor control and toxicity be defined using the naked antibodies produced under GMP conditions, In those situations where patients with recurrent malignancies are to be studied we have come to realize that a number of factors can influence the response to monoclonal therapy. (jcancer.org)

However, such antitumor activity has been repeatedly demonstrated with, for example, mouse interferon-alfa in transplantable mouse tumor systems. (drugs.com)

Bristol Myers Squibb announced that a phase 3 trial of a subcutaneous formulation of its blockbuster Opdivo met co-primary endpoints in kidney cancer. (pharmamanufacturing.com)
The safety profile of subcutaneous nivolumab was consistent with the IV formulation. (pharmamanufacturing.com)
The injection formulation of Opdivo used in the CheckMate -67T trial was formulated using Halozyme Therapeutics' primary technology, Enhanze. (pharmamanufacturing.com)
Earlier this month , Genentech shared data from a phase 3 trial demonstrating that a subcutaneous injection formulation of multiple sclerosis blockbuster Ocrevus performed just as well as the original IV formulation. (pharmamanufacturing.com)

Models with either intracranial or subcutaneous tumors were evaluated separately. (lu.se)

SV40 is present in a highly specific group of human tumours. (sv40.org)

No studies were located in humans or animals regarding the effects on the respiratory, hematological, musculoskeletal, hepatic, renal, and dermal/ocular systems after inhalation exposure to thallium. (cdc.gov)

It is not known if this occurs in humans, but because of the rodent data, there is a black box warning. (medscape.com)

Fig 4: Evaluation of efficacy and toxicity of anti-tumor drug candidates D1 and D2 on A549 (A&B)- and MSTO-211H (C&D)-bearing mouse models. (modelorg.com)

SANDOSTATIN LAR DEPOT 10 mg, 20 mg, and 30 mg is indicated in patients in whom initial treatment with Sandostatin Injection has been shown to be effective and tolerated. (guidelinecentral.com)
Long-term treatment of the profuse watery diarrhea associated with VIP-secreting tumors. (guidelinecentral.com)
Following the last treatment, tumors were excised and measured. (iiarjournals.org)
Results: Docetaxel treatment resulted in a significant reduction in tumor volume compared to control. (iiarjournals.org)
Gliomas are the most common and aggressive primary brain tumors for which unfortunately no effective treatment modalities exist despite advances in molecular biology as the knowledge base to unravel the extremely complex molecular mechanisms of tumorigenesis is limited. (biomedcentral.com)
However, the success of CAR T-cell therapy for solid tumors has been limited so far, and the mechanisms for the tumor's treatment resistance are not well understood. (snmjournals.org)
The present disclosure is directed to methods and compositions for the diagnosis and/or treatment of tumors, such as ocular tumors, using virus-like particles conjugated to photosensitive molecules. (justia.com)
Taken together, these findings identify a novel potential chemovirotherapeutic modality for the treatment of oxaliplatin-resistant human CRC. (elsevierpure.com)
At the beginning of last century, the only treatment available for patients with solid tumors was surgery, associated with high morbidity and mortality. (bvsalud.org)

Persons who have other diseases associated with immunosuppression (e.g., human immunodeficiency virus {HIV} and Streptococcus pneumoniae) may be at higher risk for some other encapsulated bacteria. (cdc.gov)

Our study further demonstrates that miRNA-29a functions as a tumor suppressor which targets c-Myc. (oncotarget.com)

SV40 also expresses the oncogenic protein T Ag in human mesotheliomas, which inactivates p53 and RB. (sv40.org)

Anatomy18

Organisms11

Diseases80

Chemicals and Drugs50

Analytical, Diagnostic and Therapeutic Techniques and Equipment54

Phenomena and Processes47

Disciplines and Occupations1

Information Science4

Health Care6

Microenvironment8

Delayed tumor growth1

Vivo20

Melanoma6

Metastatic8

Circulating tumor cells1

Malignant7

Xenograft model3

Mice20

Syngeneic3

Antigens5

Intravenous6

Solid tumor2

Antigen9

Progression7

Inhibitors6

Therapeutic7

Proteins6

Apoptosis3

Metastasis2

Subcutaneously1

Immune5

Anti-tumor effect1

Recombinant6

Cells24

Immunotherapy2

Significantly3

Induce1

Growth6

Inhibition2

Intramuscular injection2

Intratumoral injections1

Clinical3

Glioblastoma2

Glycemic control2

Cancers3

Dosage1

Systemic2

Intraperitoneal2

Tissue3

Proliferation1

Malignancies1

Antitumor1

Formulation4

Intracranial1

Tumours1

Hematological1

Rodent1

Toxicity1

Treatment9

Immunodeficiency Virus1

Targets1

Oncogenic1