Human tumor necrosis factor. Medical search. Frequent questions

Expression system for standard: Tumor necrosis factor receptor superfamily member 18(TNFRSF18), also called GITR or AITR is a protein that in humans is encoded by the TNFRSF18 gene. (innov-research.com)

16-membered) on MUC5AC and MUC2 gene expression and secretion from human airway epithelial cells. (karger.com)
Kim YD, Cho JS, Kim HS, Song SH: Effect of macrolide on the interleukin-1 β-mediated MUC2/5AC genes expression and mucin secretion in human airway epithelial cells. (karger.com)
This study has demonstrated that a subset of mononuclear phagocytes, mature macrophages, are responsible for tumour necrosis factor secretion and this could have implications for targeted management in sarcoidosis in the future. (ersjournals.com)

Tumour necrosis factor (TNF)-α is thought to be a key early cytokine in the pathogenesis of sarcoidosis, despite conflicting data. (ersjournals.com)
Tumour necrosis factor (TNF)-α is a key early cytokine in a variety of chronic inflammatory responses, including fibrosing alveolitis and granulomatous disease 6 - 8 . (ersjournals.com)
formerly known as tumor necrosis factor alpha or TNF-α) is an adipokine and a cytokine. (wikipedia.org)
Tumor necrosis factor (TNF), the first pro-inflammatory cytokine to be released by an inflammatory response, suppresses the translation of the key enzyme of melatonin synthesis (arylalkylamine- N -acetyltransferase, Aanat ). (frontiersin.org)
Cytokine control in human endometrium. (aaem.pl)
Tumor necrosis element α (TNFα) is the prototype of a proinflammatory cytokine that is primarily secreted by triggered macrophages but also by keratinocytes fibroblasts and endothelial cells. (biomedigs.org)
These mice constitutively communicate the human being TNFα cytokine and 10 weeks after birth develop a severe form of RA that affects primarily ankle bones. (biomedigs.org)
PMNs were added either unactivated or after f-met-leu-phe (fMLP) activation (10 −8 M), into tissue chambers containing human umbilical vein segments under either control or cytokine-treated conditions. (aspetjournals.org)

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. (joplink.net)
These effects of diabetic plasma on enzyme activity and cell adhesion, mediated by PKCβ2-dependent phosphorylation of the core 2 GlcNAc-T protein, were found to be triggered by increased plasma levels of tumor necrosis factor (TNF)-α. (diabetesjournals.org)
We also show that the TNF signaling reduces the level of inhibitory nuclear factor kappa B protein subtype A (NFKBIA), leading to the nuclear translocation of two NFKB dimers, p50/p50, and p50/RelA. (frontiersin.org)
In healthy individuals, cryopyrin and apoptosis-associated speck-like protein (ASC) interact via the oligomerization of ASC to induce both apoptosis and activate nuclear factor (NF)-kappa B. (medscape.com)
Finally, by successful identification of TNF-induced genes, including MCP-1 (monocyte chemoattractant protein-1), in human monocyrtic leukemia cells ML-1a using a modified differential display technique, we showed that this new technique is a powerful tool in identifying TNF-regulated genes involved in different biological activities. (jefferson.edu)
Full length native protein (purified) corresponding to Human TNF alpha. (abcam.com)

Distinct roles of the two tumor necrosis factor (TNF) receptors in modulating TNF and lymphotoxin alpha effects. (aaem.pl)
Aderka D, Engelmann H, Maor Y, Brakebusch C, Wallach D. Stabilization of the bioactivity of tumor necrosis factor by its soluble receptors. (aaem.pl)
Onsrud M, Shabana A, Austgulen R, Nustad K. Comparison between soluble tumor necrosis factor receptors and CA125 in peritoneal fluids as a marker for epithelial ovarian cancer. (aaem.pl)
Opala T, Rzymski P, Wilczak M, Woźniak J. Evaluation of soluble tumour necrosis factor alpha receptors p55 and p75 in ovarian cancer patients. (aaem.pl)

Adalimumab is a recombinant human anti-TNF-alpha IgG1 monoclonal antibody that blocks inflammatory activity of TNF-alpha. (medscape.com)

Regardless of the tumor heterogeneity, cotreatment with the proteasome inhibitor bortezomib efficiently sensitized all primary glioma samples for TRAIL-induced apoptosis and tremendously reduced their clonogenic survival. (aacrjournals.org)
WALTHAM, MA, June 24, 2021 / B3C newswire / -- Scipher Medicine , a precision immunology company matching patients with the most effective therapy, today announced positive results from a multicenter, blinded prospective observational clinical study assessing the ability of the PrismRA test to predict which patients with rheumatoid arthritis are unlikely to respond to tumor necrosis factor-alpha inhibitor (TNFi) therapies either when prescribing initial targeted therapy or when modifying treatment. (b3cnewswire.com)

The human TNF gene was cloned in 1985. (wikipedia.org)
This transgenic mouse contains the total genomic sequence of the human being TNFα gene. (biomedigs.org)
Only the 3′-noncoding region was replaced from the 3′-untranslated region (3′-UTR) of the human being β-globin gene. (biomedigs.org)
To conquer this problem we generated a doxycycline-inducible human being TNFα-transgenic mouse (also called an ihTNFtg mouse) in which the expression of the human being TNFα gene is definitely under the control of a tetracycline (Tet)-responsive promoter. (biomedigs.org)
100.000 cCREs in total), dispersed within the genome and present in cis-regulatory regions of ~81% of human genes, as calculated following gene enrichment analysis. (mdpi.com)

Subsequently, in 1975 Lloyd J. Old from Memorial Sloan Kettering Cancer Center, New York, reported another cytotoxic factor produced by macrophages and named it tumor necrosis factor (TNF). (wikipedia.org)
On the other hand, phagosomes are formed when the pathogen is engulfed by macrophages and fuse with lysosomes to release enzymes and toxic substances, resulting in killing or having cytotoxic effects on bacteria and tumor cells. (frontiersin.org)
Macrophages play a significant role in many processes, such as the human immune function, parasite infection, and tissue remodeling by secreting cytokines and producing reactive oxygen and nitrogen intermediates. (frontiersin.org)
In vitro, ivacaftor does not alter LPS-induced CD80 and tumor necrosis factor alpha mRNA increases in BV2 microglial cells, while augmenting mRNA levels of these markers in mouse macrophages and differentiated human THP-1-derived macrophages. (lu.se)

Growing evidence suggests that proinflammatory cytokines (PICs), such as interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNFα), are induced in the spinal cord under various injury conditions and contribute to pain hypersensitivity. (jneurosci.org)
Cytokines secreted by adipocytes, such as tumor necrosis factor-α, transforming growth factor-β, and interleukin-6, are implicated in NAFLD. (wjgnet.com)

Infliximab, an antibody to human tumor necrosis factor alpha, has proved successful in the treatment of severe refractory disease and generally causes only mild side effects. (aafp.org)
Adalimumab is a fully human antibody and therefore thought to be less immunogenic than chimeric antibodies. (bmj.com)
Infliximab is a chimeric mouse-human monoclonal antibody to TNF. (medscape.com)
Golimumab is a human anti-TNF-alpha monoclonal antibody that blocks the inflammatory activity of TNF-alpha. (medscape.com)

We report pulmonary M . haemophilum infection in a woman who had been immunosuppressed by tumor necrosis factor-α antagonist (TNF-αA) (adalimumab) treatment for rheumatoid arthritis. (cdc.gov)
Hadlima (adalimumab-bwwd) is a tumor necrosis factor (TNF) blocker indicated for treatment of rheumatoid Arthritis ( RA ), juvenile idiopathic arthritis (JIA), psoriatic arthritis (PsA), ankylosing spondylitis (AS), adult Crohn's disease (CD), ulcerative colitis (UC), and plaque psoriasis (Ps). (rxlist.com)
To compare tumor necrosis factor-α (TNF-α) inhibitors to nonbiological disease-modifying antirheumatic drugs (DMARD) for the risk of serious infection in Japanese patients with rheumatoid arthritis (RA). (jrheum.org)
The introduction of tumor necrosis factor-α (TNF) inhibitors for treatment of rheumatoid arthritis (RA) is a major therapeutic breakthrough 1 . (jrheum.org)
A substantial proportion of patients with rheumatoid arthritis (RA) still have persistent disease activity or flare of disease activity despite tumour necrosis factor (TNF)α blocking therapy. (bmj.com)
The majority of rheumatoid arthritis patients prescribed the world's largest selling drug class, tumor necrosis factor inhibitors (TNFi) therapy, don't respond to treatment at a per-patient cost of over $65,000 per year, even though alternative effective drugs are available in the market. (b3cnewswire.com)

To assess the role of shark cartilage as an immune modulator, acid, salt-soluble, and phosphate-buffered saline extracts were prepared from three different commercial sources (SL, TL, FDC) of cartilage and used to stimulate human leukocytes in vitro. (fiu.edu)
Olsson I, Gatanaga T, Gullberg U, Lantz M, Granger GA. Tumour necrosis factor (TNF) binding proteins (soluble TNF receptor forms) with possible roles in inflammation and malignancy. (aaem.pl)
Engelmann H, Holtmann H, Brakebusch C, Avni YS, Sarov I, Nophar Y, Hadas E, Leitner O, Wallach D. Antibodies to a soluble form of a tumor necrosis factor (TNF) receptor have TNF-like activity. (aaem.pl)
It reacts with free soluble (17 kDa) and membrane (26 kDa) human TNF-alpha. (abcam.com)
Crystal structure of the soluble human 55 kd TNF receptor-human TNF complex: implications for TNF receptor activation. (lu.se)

In patients with RA or Crohn's disease, human anti-chimeric antibodies (HACAs) to infliximab have been reported. (bmj.com)

The levels of tumor-necrosis factor -α (TNF-α) and interleukin 6 (IL-6) in monocytes were detected by ELISA and the expression of miR-155 was measured by real-time quantitative PCR (qRT-PCR) in monocytes before and after the treatment of TPT at different concentrations. (curehunter.com)
Increased levels of tumor necrosis factor, interferon-gamma, and interleukin 1 have been demonstrated. (medscape.com)

NIEHS research uses state-of-the-art science and technology to investigate the interplay between environmental exposures, human biology, genetics, and common diseases to help prevent disease and improve human health. (nih.gov)

Human leukocyte antigen-DQB1 polymorphisms and haplotype patterns in Guillain-Barré syndrome. (cdc.gov)

The antitumor effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in gliomas has thus far only been thoroughly established in tumor cell lines. (aacrjournals.org)
We isolated primary tumor cells from 13 astrocytoma and oligoastrocytoma patients of all four WHO grades of malignancy and compared the levels of TRAIL-induced apoptosis induction, long-term tumor cell survival, caspase, and caspase target cleavage. (aacrjournals.org)
Research in the laboratory led by Mark Mattson has shown that TNF can prevent the death/apoptosis of neurons by a mechanism involving activation of the transcription factor NF-κB which induces the expression of antioxidant enzymes and Bcl-2. (wikipedia.org)
Depending on the cell context, ligation of DR3 by TL1A can trigger one of two signaling pathways, activation of the transcription factor NF-kB, or activation of caspases and apoptosis. (novusbio.com)

However, the activity of factor V or factor X, proteins that function in blood coagulation was not inhibited by parmodulin. (news-medical.net)

In the present study, we demonstrate that following exposure to plasma from diabetic patients, the human promonocytic cell line U937 exhibits a significant elevation in core 2 GlcNAc-T activity and increased adherence to cultured retinal capillary endothelial cells. (diabetesjournals.org)
Intracellular metal ion chelators inhibit TNFalpha-induced SP-1 activation and adhesion molecule expression in human aortic endothelial cells. (oregonstate.edu)
Albumin selectively inhibits TNF alpha-induced expression of vascular cell adhesion molecule-1 in human aortic endothelial cells. (oregonstate.edu)
Lack of inhibitory effect of HDL on TNFalpha-induced adhesion molecule expression in human aortic endothelial cells. (oregonstate.edu)
Dietary flavonoids attenuate tumor necrosis factor alpha-induced adhesion molecule expression in human aortic endothelial cells. (oregonstate.edu)
Human endothelial cells were incubated with parmodulin 2 in vitro for 4 hours in order to examine the activity of parmodulins on the endothelium. (news-medical.net)
A blood-vessel-on-a-chip developed at Wyss institute that consisted of microfluidic channels embedded in a clear polymer chip, coated with collagen, and lined by human endothelial cells was used to validate this theory. (news-medical.net)

Administering TNF to malaria-infected mice did not cause cerebral symptoms nor breakdown of the blood-brain barrier, which is the hallmark of P. berghei ANKA cerebral malaria and is generally absent in human cerebral malaria. (ox.ac.uk)
Objective To generate doxycycline-inducible human being tumor necrosis factor α (TNFα)-transgenic mice to overcome a major disadvantage of existing transgenic mice with constitutive expression of TNFα which is the limitation in crossing them with numerous knockout or transgenic mice. (biomedigs.org)
Furthermore unlimited crossing of doxycycline-inducible human being TNFα-transgenic mice with numerous knockout or transgenic mice opens new options for unraveling the part of various signaling molecules acting in concert with TNFα. (biomedigs.org)
Mice deficient in tumor necrosis factor (TNF) activity, i.e. (cdc.gov)

In the present study, we investigated the therapeutic potential of TRAIL in primary human glioma cells. (aacrjournals.org)

5 Nevertheless, it has previously been suggested that human anti-human antibodies against adalimumab may develop as well, although the data are limited. (bmj.com)

Cigana C, Assael BM, Melotti P: Azithromycin selectively reduces tumor necrosis factor alpha levels in cystic fibrosis airway epithelial cells. (karger.com)
Endometrial cancer invasion depends on cancer-derived tumor necrosis factor-alpha and stromal derived hepatocyte growth factor. (aaem.pl)
Chegini N. An inverse relation between the expression of tumor necrosis factor alpha (TNF-alpha) and TNF-alpha receptor in human endometrium. (aaem.pl)
The functional roles of the two TNFRs in mediating NF-$\kappa$B activation, and inducing IL-2R$\alpha$ chain (CD25) and ICAM-1 (CD54) expression, were examined using receptor-specific antisera and TNF mutants, Northern blot analysis, gel shift assay and flow cytometry on human NK-like YT cells. (jefferson.edu)
Tumor necrosis factor-alpha -863C/A polymorphism is associated with Guillain-Barré syndrome in Bangladesh. (cdc.gov)
Tumor necrosis factor alpha -863C/A polymorphism and Guillain-Barré Syndrome. (cdc.gov)
Regarding the potential for promotion of synthesis and the bad things that upregulate cancers and inflammation, we know that vitamin D actually inhibits the response of tumor necrosis factor-alpha. (medscape.com)

If you see this knockout in humans, they really don't respond well to any therapy other than stem cell transplant. (medscape.com)

Haider S, Knofler M. Human tumour necrosis factor: physiological and pathological roles in placenta and endometrium. (aaem.pl)
This review summarizes the major pathological factors linking obesity to diabetes, focussing on current epidemiological data related to obese diabetic patients in the Arab world, the etiology of the disease and the genetic determinants of diabetes and obesity. (who.int)

In contrast to cell lines, isolated primary tumor cells from all investigated glioma patients were highly TRAIL resistant. (aacrjournals.org)
Eleven of the patients had at least one risk factor for LTBI (e.g., born in countries where TB is prevalent or contact with a person with TB disease). (cdc.gov)
Three patients underwent a medical history for TB risk factors before beginning therapy with a TNF-α antagonist. (cdc.gov)
Evaluate patients for tuberculosis risk factors and test for latent tuberculosis infection prior to initiating CIMZIA and during therapy. (theodora.com)
Human papillomavirus type 6 or type 16 has not been detected in patients with BXO, which strongly suggests that genital papillomaviruses do not have a strong association with BXO. (medscape.com)
Ils ont été répartis en deux groupes : 12 patients souffrant d'une thrombocytopénie à médiation immunitaire (groupe 1) et 12 patients atteints d'une thrombocytopénie à médiation non immunitaire (groupe 2). (who.int)
La présente analyse récapitule les facteurs pathologiques majeurs liant l'obésité au diabète, en se concentrant sur les données épidémiologiques actuelles relatives aux patients diabétiques obèses dans le monde arabe, l'étiologie de la maladie et les déterminants génétiques du diabète et de l'obésité. (who.int)

In 1968, Gale A Granger from the University of California, Irvine, reported a cytotoxic factor produced by lymphocytes and named it lymphotoxin (LT). Credit for this discovery is shared by Nancy H. Ruddle from Yale University, who reported the same activity in a series of back-to-back articles published in the same month. (wikipedia.org)

Tumor necrosis factor did, however, induce hypoglycemia and liver injury, pathology that is seen in terminal P. vinckei and falciparum malaria, but is absent in terminal P. berghei ANKA malaria. (ox.ac.uk)

The present study demonstrates that AZM and MDM suppress the synthesis of mucin and TNF-α from human airway epithelial cells. (karger.com)

CIMZIA is a medicine called a Tumor Necrosis Factor (TNF) blocker. (theodora.com)

A multivariate analysis revealed that the use of TNF inhibitors is a significant independent risk factor for serious infection (relative risk 2.37, 95% CI 1.11-5.05, p = 0.026). (jrheum.org)
Human Immunodeficiency Virus (HIV) Infection Human immunodeficiency virus (HIV) infection is a viral infection that progressively destroys certain white blood cells and is treated with antiretroviral medications. (msdmanuals.com)

In human studies, sera from 200 automobile painters were evaluated for hexamethylene diisocyanate (HDI)-specific antibodies. (cdc.gov)
These results indicate the lack of association of antibodies with symptoms of asthma in an animal model and in humans. (cdc.gov)

NLRP3 ( CIAS1 ) mutations are gain-of-function mutations that cause constitutive activation of the inflammasome, a complex with pro-IL-1-processing activity, and macrophage necrosis. (medscape.com)

Because both of these murine models and the human disease have now been defined in terms of excess tumor necrosis factor (TNF) production, the authors have more closely examined the two murine models in this light to see which provides the better overall model for falciparum malaria. (ox.ac.uk)
In comparing the factors that contribute to the buildup of excess calories in obesity, an imbalance of energy homeostasis can be considered as the basis. (wjgnet.com)

Malignant gliomas are the most aggressive human brain tumors without any curative treatment. (aacrjournals.org)
Taken together, these findings suggest that these algae extracts may be potential phytotherapeutics against HSVs and may be useful for the treatment and reduction of common herpetic manifestations in humans. (frontiersin.org)
These guidelines update previous CDC recommendations for the diagnosis, treatment, and prevention of tuberculosis (TB) among adults and children coinfected with human immunodeficiency virus (HIV) in the United States. (cdc.gov)
Agency is provided by the study of of carcinogenesis associated with the treatment of invasive cervical cancer the role of cutaneous HPV types in important risk factors for two common by decreasing recurrences of cancerous skin carcinogenesis, carried out by the human cancers. (who.int)

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. (mcw.edu)
There are many microorganisms colonized in the human intestine, and more than 1000 bacterial species in the intestinal ecosystem of a single individual. (frontiersin.org)
We have publications tested in 1 confirmed species: Human. (novusbio.com)

Confluent NCI-H292 human mucoepidermoid airways epithelial cells were pretreated with AZM or MDM for 2 h and then stimulated with 200 nmol/l phorbol 12-myristate 13-acetate (PMA) for 8 h. (karger.com)
We find that fibroblast-derived TNF-α stimulates epithelial LOX expression through activation of nuclear factor κB and TGF-β-mediated signaling. (nih.gov)

These guidelines update previous CDC recommendations for treating and preventing active tuberculosis (TB) among adults and children coinfected with human immunodeficiency virus (HIV) (1-3). (cdc.gov)

Our products are intended for in-vitro use only for manufacturing and research and are not suitable for human or animal use. (innov-research.com)

Koontongkaew S, Monthanapisut P, Saensuk T: Inhibition of arachidonic acid metabolism decreases tumor cell invasion and matrix metalloproteinase expression. (karger.com)

Leptin and adiponectin can augment the oxidation of fatty acid in liver by activating the nuclear receptor super-family of transcription factors, namely peroxisome proliferator-activated receptor (PPAR)-α. (wjgnet.com)

Crystal structure of human RANKL complexed with its decoy receptor osteoprotegerin. (joplink.net)

Human endogenous retroviruses (HERVs) are a family of endogenous retroviruses that comprise the ~8.93% of the human genome sequence, with a high proportion being human specific. (mdpi.com)

Dysregulation of TNF production has been implicated in a variety of human diseases including Alzheimer's disease, cancer, major depression, psoriasis and inflammatory bowel disease (IBD). (wikipedia.org)

This human TNFRSF18 ELISA Kit was based on standard sandwich enzyme-linked immune-sorbent assay technology. (innov-research.com)

To investigate the role of anitbodies in the pathogenesis of the disease we used both animal and human data. (cdc.gov)
It has been proposed that postmicturation drippling could be a a contributing factor in the pathogenesis of BXO. (medscape.com)

Both unactivated and activated PMNs induced a cell number-dependent (1.5 × 10 5 to 2 × 10 6 cells/ml) vasoconstriction in human umbilical vein segments. (aspetjournals.org)
CD137L is also expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interactions. (fishersci.com)

It is hypothesised that mononuclear phagocyte TNF-α production early in the pathophysiology of granuloma formation is a pivotal factor in the initiation of disease. (ersjournals.com)
It lacks, however, many of the systemic changes seen in the human disease. (ox.ac.uk)
The authors therefore conclude that P. vinckei malaria, although lacking a cerebral component, is the better model for the human disease. (ox.ac.uk)
The abrogation of human being TNFα manifestation by the removal of doxycycline 6 weeks after beginning stimulation resulted in fast resolution of the most advanced macroscopic and histologic disorders and 3-6 weeks later on only minimal indications of disease were visible. (biomedigs.org)
3 Environmental factors must play a role in the development of Crohn's disease, because while the disease is uncommon in African blacks, U.S. blacks have an incidence similar to that of whites. (aafp.org)
While etiologic evidence suggests a complex interplay between many factors, pathophysiologically, Crohn's disease involves an immune system dysfunction. (aafp.org)
Although a small percentage of microorganisms are harmful to certain plants and animals and may cause serious disease in humans, the vast majority of microorganisms provide beneficial services, such as assisting in water purification and the production of certain foods, and many are essential for the proper functioning of Earth's ecosystems. (researchgate.net)

We investigated the contractile effects of both activated and unactivated polymorphonuclear leukocytes (PMNs) on human vascular tissue to characterize the influence of human PMNs on vascular tone. (aspetjournals.org)

Evidence suggests that obesity and insulin resistance are the major factors that contribute to the development of NAFLD. (wjgnet.com)

We established a stable culture model for isolated primary human glioma cells. (aacrjournals.org)
Both factors were described based on their ability to kill mouse fibrosarcoma L-929 cells. (wikipedia.org)

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