DNA Topoisomerases, Type IDNA Topoisomerases, Type IITopoisomerase II InhibitorsTopoisomerase I InhibitorsDNA CleavageAmsacrineRazoxaneDNA, SuperhelicalAntigens, NeoplasmTeniposideCamptothecinDNATopoisomerase InhibitorsEtoposideDNA Topoisomerase IVDNA-Binding ProteinsIntercalating AgentsPodophyllotoxinSubtilisinAntineoplastic Agents, PhytogenicEnzyme InhibitorsCatalysisMolecular Sequence DataNucleic Acid ConformationBase SequenceIsoenzymesDNA DamagePlasmidsRecombinant ProteinsDrug ResistanceAntineoplastic AgentsSaccharomyces cerevisiaeBinding SitesModels, MolecularSubstrate SpecificityDNA TopoisomerasesProtein Structure, TertiaryProtein BindingHeLa CellsOligodeoxyribonucleotidesAmino Acid SequenceMutationDNA, CatenatedKineticsNovobiocinTumor Cells, CulturedEllipticinesHydrolysisCatalytic DomainDNA ReplicationOligonucleotidesAdenosine TriphosphatePiperazinesProtein ConformationAmino Acid SubstitutionDNA GyraseCloning, MolecularRecombinant Fusion ProteinsTopotecanPoint MutationStructure-Activity RelationshipMutagenesis, Site-DirectedSequence Homology, Amino AcidDNA PrimersNuclear ProteinsHydrogen BondingDNA, KinetoplastAminoacridinesTransfectionThiobarbituratesQuinolonesProtein Structure, SecondaryAnti-Infective AgentsFluoroquinolonesAminocoumarinsEscherichia coliDrug Screening Assays, AntitumorIndenesLeukemia P388DoxorubicinCrithidia fasciculataAclarubicinCell CycleMitoxantroneDNA, NeoplasmNorfloxacinCell NucleusNaphthyridinesDrug Resistance, NeoplasmDNA, CircularRecQ HelicasesNucleic Acid Synthesis InhibitorsLeukemia L1210MitosisLeishmania donovaniCell LineCell SurvivalAntibiotics, AntineoplasticDNA RepairCell Line, Tumor