• Telomerase synthesizes chromosome-capping telomeric repeats using an active site in telomerase reverse transcriptase (TERT) and an integral RNA subunit template. (elifesciences.org)
  • The fundamental question of whether human telomerase catalytic activity requires cooperation across two TERT subunits remains under debate. (elifesciences.org)
  • Surprisingly, telomerase reconstitutions yielded heterogeneous DNA-bound TERT monomer and dimer complexes in relative amounts that varied with assembly and purification method. (elifesciences.org)
  • The center of telomerase has a protein called TERT that forms complexes with other proteins. (elifesciences.org)
  • The molecular composition of the human telomerase complex was determined by Scott Cohen and his team at the Children's Medical Research Institute (Sydney Australia) and consists of two molecules each of human telomerase reverse transcriptase (TERT), telomerase RNA (TR or TERC), and dyskerin (DKC1). (wikipedia.org)
  • The human TERT gene (hTERT) is translated into a protein of 1132 amino acids. (wikipedia.org)
  • Rare loss of function mutations in the gene that encodes the protein component of telomerase (TERT) have been described in patients with idiopathic pulmonary fibrosis (IPF). (nih.gov)
  • The TERT mutations compromised telomerase catalytic activity, and mutation carriers had short telomeres. (jci.org)
  • This is significant because some other telomerase activators may work only indirectly, through reactivation of a gene (the telomerase reverse transcriptase -TERT gene) which then affects telomerase. (antiaging-systems.com)
  • The promoter region of the telomerase reverse transcriptase (TERT) gene is a regulatory element capable of affecting TERT expression, telomerase activity, and telomerase length. (bvsalud.org)
  • all genes associated with this syndrome (ie, DKC1 , TERT, TERC, NOP10 ) encode proteins in the telomerase complex responsible for maintaining telomeres at the ends of chromosomes regarding shortening length, protection, and replication. (medscape.com)
  • In the autosomal dominant form, mutations in the RNA component of telomerase ( TERC ) or telomerase reverse transcriptase ( TERT ) are responsible for disease phenotype. (medscape.com)
  • In humans, mRNA expression of hTERT ( hEST2 ), the candidate telomerase catalytic subunit gene, appears to parallel the levels of telomerase enzyme activity, suggesting that induction of hTERT is necessary and perhaps sufficient for expression of telomerase activity in tumor cells. (nature.com)
  • To test this model directly, we ectopically expressed an epitope-tagged version of hTERT in telomerase-negative cells and show that telomerase activity was induced to levels comparable to those seen in immortal telomerase-positive cells and that the expressed hTERT protein was physically associated with the cellular telomerase activity. (nature.com)
  • We conclude that synthesis of the hTERT telomerase subunit represents the rate-limiting determinant of telomerase activity in these cells and that this protein, once expressed, becomes part of the functional telomerase holoenzyme. (nature.com)
  • Differential splicing of hTERT mRNA may be involved in faster loss of telomerase activity in normal cells with respect to malignant cells. (muni.cz)
  • Transfection of cells with expression vectors containing the human telomerase reverse transcriptase (hTERT) maintains telomere length and effectively gives normal cells an unlimited life span in culture. (elsevierpure.com)
  • To study the DNA methylation of human telomerase reverse transcriptase (hTERT) promoter in ameloblastoma (AB) and investigate its clinical biological significance. (neb.com)
  • In a time and dose dependent manner, EPA and DHA suppressed cellular telomerase activity and the mRNAs encoding hTERT (human telomerase reverse transcriptase) and c-myc. (elsevierpure.com)
  • Based on these observations, we suggest that PUFAs inhibit telomerase activity through dual mechanisms: direct inhibition of enzymatic activity and down regulation of hTERT, one of the telomerase components. (elsevierpure.com)
  • Telomerase activity, hTERT transcription level and p- p70 S6k was demonstrated by the telomeric repeat amplification protocol and silver staining assay, Dual-Luciferase Reporter Assay and Western blot analysis respectively. (biomedcentral.com)
  • The 5-Fu treatment nearly abolishes transcription of hTERT (the major component of telomerase) mRNA. (biomedcentral.com)
  • Human telomerase reverse transcriptase (hTERT) and epidermal growth factor receptor (EGFR) play an important role in many cancers including gynecological cancers. (qxmd.com)
  • We tested whether multi-walled carbon nanotubes (MWCNTs) induce oxidative stress and a pro-inflammatory response in human N-hTERT telomerase-immortalized keratinocytes, in human SZ95 SV-40 immortalized sebocytes and in in vitro reconstructed epidermises. (unamur.be)
  • STAT3 was bound to the promoter region of human telomerase reverse transcriptase (hTERT). (bvsalud.org)
  • The binding of STAT3 to the hTERT promoter region and telomerase activity showed reduction with withaferin A treatments. (bvsalud.org)
  • Hu LH, Chen FH, Li YR, Wang L. Real-time determination of human telomerase reverse transcriptase mRNA in gastric cancer. (wjgnet.com)
  • Telomerase-expressing cells contained mRNA for α smooth muscle actin, smoothelin, oxytocin receptor, and estrogen receptor α, but the estrogen receptor β receptor was lost. (elsevierpure.com)
  • A diagnostic evaluation of serum human telomerase reverse transcriptase mRNA as a novel tumor marker for gynecologic malignancies. (qxmd.com)
  • Interestingly, telomerase upregulation to lengthen telomere length may turn out to be a decent match for the capabilities of lipid nanoparticle (LNP) delivery of messenger RNA (mRNA) as an implementation of gene therapy . (fightaging.org)
  • Rejuvenation's products are optimized telomerase mRNA encapsulated in a custom tissue targeted lipid nanoparticle. (fightaging.org)
  • A single dose of our telomerase mRNA reverses years of telomere shortening in hours. (fightaging.org)
  • I was definitely waiting for an mRNA 'vaccine' that expresses telomerase. (fightaging.org)
  • In cultured human coronary artery endothelial cells, ANG 1-7 significantly increased telomerase activity. (mcw.edu)
  • The role of telomeres and telomerase in cell aging and cancer was established by scientists at biotechnology company Geron with the cloning of the RNA and catalytic components of human telomerase and the development of a polymerase chain reaction (PCR) based assay for telomerase activity called the TRAP assay, which surveys telomerase activity in multiple types of cancer. (wikipedia.org)
  • It is true to say that telomeres and telomerase are one of the hottest areas of anti-aging research, but it is also true that the misconceptions and confusion in this area are significant. (antiaging-systems.com)
  • However, the impact of shortened telomeres and telomerase dysfunction on the ability of lung cells to respond to significant challenge is still largely unknown. (ca.gov)
  • Mutations in the TERC template sequence can be incorporated into the telomeres of human tumors. (nih.gov)
  • A subset of pulmonary fibrosis, like dyskeratosis congenita, bone marrow failure, and liver disease, represents a "telomeropathy" caused by germline mutations in telomerase and characterized by short telomere lengths. (nih.gov)
  • Here, we tested whether telomerase mutations are a risk factor for human emphysema by examining their frequency in smokers with chronic obstructive pulmonary disease (COPD). (jci.org)
  • Our findings identify germline mutations in telomerase as a Mendelian risk factor for COPD susceptibility that clusters in autosomal dominant families with telomere-mediated disease including pulmonary fibrosis. (jci.org)
  • Telomerase mutations and significantly shortened chromosomal telomeres have recently been implicated in human lung pathologies. (ca.gov)
  • Telomerase Reverse Transcriptase Promoter Mutations in Human Hepatobiliary, Pancreatic and Gastrointestinal Cancer Cell Lines. (bvsalud.org)
  • [ 21 ] Mutations in either HuR or TERC can weaken the HuR- TERC binding and reduce TERC methylation, resulting in decreased telomerase activity. (medscape.com)
  • Objective : We examined the hypothesis that telomerase activity modulates microvascular ow-mediated dilation, and loss of telomerase activity contributes to the change of mediator from nitric oxide to mitochondrial hydrogen peroxide in patients with coronary artery disease (CAD). (hypertension.qc.ca)
  • Overall, this work defines human telomerase DNA binding and synthesis properties at single-molecule level and establishes conserved telomerase subunit architecture from single-celled organisms to humans. (elifesciences.org)
  • Cells were isolated from myometrial tissue obtained from women undergoing hysterectomy, and retroviral infection was used to express the catalytic subunit of telomerase in myometrial cells. (elsevierpure.com)
  • The focus of most research on telomerase in protozoa (gloriously), fungi, and plant and animal metazoa has been on the enzyme's molecular components-once thought to consist of just a subunit of RNA and another one of protein, but now probably several of the latter. (rupress.org)
  • Therefore, a future challenge will be to refine the method to allow experiments to use much less protein, which would more closely reflect how telomerase is produced in cells. (elifesciences.org)
  • Recent work on the ribonucleoprotein enzyme telomerase has indicated an unanticipated degree of intranuclear dynamics of both its RNA and protein subunits. (rupress.org)
  • Evidence exists for telomerase dysfunction, ribosome deficiency, and protein synthesis dysfunction in this disorder. (medscape.com)
  • Vascular Actions of Angiotensin 1-7 in the Human Microcirculation: Novel Role for Telomerase. (mcw.edu)
  • Conclusions : We have identi ed a novel role for telomerase in re-establishing a physiological mechanism of vasodilation in arterioles from subjects with CAD. (hypertension.qc.ca)
  • thus, we also tested whether telomerase activity was necessary for ANG 1-7-mediated vasoprotection by treating separate arterioles with ANG 1-7±the telomerase inhibitor 2-[[(2E)-3-(2-naphthalenyl)-1-oxo-2-butenyl1-yl]amino]benzoic acid. (mcw.edu)
  • Telomerase inhibitor. (abcam.com)
  • Flow-mediated dilation was measured in vessels pretreated with the telomerase inhibitor BIBR-1532 or vehicle. (hypertension.qc.ca)
  • Costunolide is an Inhibitor of human telomerase activity (IC50 = 65 μM in MCF-7 breast cancer cells). (adooq.com)
  • RHPS4 is a potent inhibitor of Telomerase at submicromolar. (adooq.com)
  • TMPyP4 tosylate (TMP 1363) is a telomerase inhibitor with antitumor effects in osteosarcoma cell lines. (adooq.com)
  • Telomerase RNA TERC and the PI3K-AKT pathway form a positive feedback loop to regulate cell proliferation independent of telomerase activity. (nih.gov)
  • We have previously shown that lungs of late generation, telomerase null B6.Cg-Terc(tm1Rdp) mice feature alveolar simplification and chronic stress signaling at baseline, a phenocopy of aged lung. (ca.gov)
  • To determine the role telomerase plays when the lung is challenged, B6.Cg-Terc(tm1Rdp) mice carrying shortened telomeres and wild-type controls were subjected to partial pneumonectomy. (ca.gov)
  • However, increased levels of telomerase activity were detected in alpha-particle survivors while robust telomerase activity was seen in the tumorigenic cell lines. (duke.edu)
  • The botanicals in Telomere Plus have been shown to increase the activity of telomerase, a naturally-occurring enzyme that lengthens telomeres and protects them from shortening. (enzymedica.com)
  • Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. (nih.gov)
  • These findings suggest that telomerase assembly, trafficking and extension occur with normal efficiency in Cajal bodies deficient human cells. (telomerescience.com)
  • Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. (nih.gov)
  • Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. (nih.gov)
  • Telomerase activity was monitored in cells with a polymerase chain reaction-based telomerase activity assay. (elsevierpure.com)
  • 100000 nM for human telomerase, human RNA polymerase I and human RNA polymerase II + III respectively). (adooq.com)
  • Telomerase is mechanistically a reverse transcriptase but to the grateful genomes on which it operates it is a chromosome end-specific DNA polymerase. (rupress.org)
  • The question is whether or not lengthening of telomeres via telomerase gene therapy is a good idea in humans. (fightaging.org)
  • In mice, telomerase gene therapy is quite beneficial, both extending life and reducing cancer risk . (fightaging.org)
  • Our gene expression analysis of human melanoma cell lines and patient tumors revealed that melanoma follows a two-dimensional differentiation trajectory that can be subclassified into four progressive subtypes. (bvsalud.org)
  • Recent studies have demonstrated that cell culture life span is related to chromosomal telomere length, and cellular senescence results from progressive telomere shortening and the lack of telomerase expression. (elsevierpure.com)
  • Because telomeres function to maintain chromosomal stability, telomerase has a critical role in preventing cellular senescence and cancer progression. (medscape.com)
  • Embryonic stem cells express telomerase, which allows them to divide repeatedly and form the individual. (wikipedia.org)
  • In adults, telomerase is highly expressed only in cells that need to divide regularly, especially in male sperm cells, but also in epidermal cells, in activated T cell and B cell lymphocytes, as well as in certain adult stem cells, but in the great majority of cases somatic cells do not express telomerase. (wikipedia.org)
  • Normal somatic cells, however, usually do not express telomerase. (nih.gov)
  • We conclude that functional telomerase and properly maintained telomeres play key roles in both long-term survival and the early phase of compensatory lung growth following partial pneumonectomy. (ca.gov)
  • The naturally-occurring enzyme telomerase lengthens telomeres and keeps them from shortening, and the botanicals in Telomere Plus activate the telomerase in our bodies so that it can give us the whole-body benefits. (enzymedica.com)
  • Furthermore, the feasibility of detecting gain of the telomerase genes with the HPV MLPA assay was evaluated. (dundee.ac.uk)
  • Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. (nih.gov)
  • The expression of telomerase, the enzyme that synthesizes telomeric DNA de novo , is suppressed in normal somatic human cells but is reactivated during tumorigenesis. (nature.com)
  • Telomerase is active in gametes and most cancer cells, but is normally absent in most somatic cells. (wikipedia.org)
  • In the somatic tissues, the stem cells expressed telomerase-associated RNA, but no proliferation activity. (nih.gov)
  • Allelic distribution of human leucocyte antigen in historical and recently diagnosed tuberculosis patients in Southern Italy. (cdc.gov)
  • Reference: [DNA methylation of human telomerase reverse transcriptase promoter region in human ameloblastoma]. (neb.com)
  • Telomerase, also called terminal transferase, is a ribonucleoprotein that adds a species-dependent telomere repeat sequence to the 3' end of telomeres. (wikipedia.org)
  • This reactivation appears to arrest the normal loss of telomeric DNA incurred as human cells divide. (nature.com)
  • Since continual loss of telomeric DNA is predicted to eventually limit cell proliferation, activation of telomerase in cancer cells may represent an important step in the acquisition of the cell immortalization which occurs during tumor progression. (nature.com)
  • Telomerase, an enzyme associated with cellular immortality, is expressed by malignant tumor and stem cells, especially germ cells. (nih.gov)
  • In the malignant tumor, deregulation of telomerase is thought to facilitate tumorigenesis and cellular immortality by providing cancer cells unlimited proliferation capacity. (nih.gov)
  • When the proliferation activity of the stem cells increased, however, the telomerase-associated expressions decreased. (nih.gov)
  • Changes in Telomerase Activity, Expression and Splicing in Response to Differentiation of Normal and Carcinoma Colon Cells. (muni.cz)
  • Several strategies have been described for the primary culture of human myometrial cells. (elsevierpure.com)
  • The expression of various smooth muscle/myometrium cell markers suggests that these cells may be an appropriate model system to study certain aspects of human myometrial function. (elsevierpure.com)
  • CIL:49951, Primary human small airway epithelial cells immortalized with telomerase. (ucsd.edu)
  • Primary human small airway epithelial cells in interphase state were fixed with 2.5% glutaraldehyde, 5mM CaCl 2 in 0.1 M sodium cacodylate buffer (pH 7.4). (ucsd.edu)
  • GRN510, through a mechanism of telomerase activation, also suppressed the accumulation of senescent cells in the lung. (antiaging-systems.com)
  • We found that telomerase activity was strongly induced in alveolar epithelial type 2 cells (AEC2) of the remaining lung immediately following surgery. (ca.gov)
  • Human cells lacking coilin and Cajal bodies are proficient in telomerase assembly, trafficking and telomere maintenance. (telomerescience.com)
  • Here, the role of Cajal bodies was examined in Human cells deficient of coilin (i.e. coilin-knockout (KO) cells), in which no Cajal bodies are detected. (telomerescience.com)
  • Therefore, telomerase adds similar numbers of TTAGGG repeats to telomeres in coilin-KO and controls cells. (telomerescience.com)
  • In this study, we investigated Zscan4 expression and interactions with Rap1 in telomerase positive (HeLa, MCF7) and ALT pathway (SaOS2, U2OS) cancer cells. (ttu.edu)
  • Using bimolecular fluorescence complementation, we further validate this functional interaction in human cancer cells. (ttu.edu)
  • In this study, we have tested whether telomerase might be a target for the antitumor effect of fatty acids using DLD-1 colorectal adenocarcinoma cells. (elsevierpure.com)
  • Eitsuka, T , Nakagawa, K & Miyazawa, T 2004, ' Dual mechanisms for telomerase inhibition in DLD-1 human colorectal adenocarcinoma cells by polyunsaturated fatty acids ', BioFactors , vol. 21, no. 1-4, pp. 19-21. (elsevierpure.com)
  • Treating SMMC-7721 cells with 5-Fu leads to apoptosis of the cells, and reduction in telomerase activity, as well as a dramatic reduction in the activated form of p70 S6 kinase, a mTOR substrate. (biomedcentral.com)
  • 5-Fu and rapamycin were synergistic in regards to down-regulation of telomerase activity in hepatocarcinoma cells. (biomedcentral.com)
  • Human aging is the result of the aging of the body's trillions of cells. (politics-prose.com)
  • Sex cells and stem cells can reproduce indefinitely, without aging, because they create telomerase. (politics-prose.com)
  • Telomerase re-lengthens the telomeres, keeping these cells young. (politics-prose.com)
  • In 2004, he authored the magisterial academic textbook, Cells, Aging, and Human Disease , and in 2011, he coauthored The Immortality Edge , a bestselling discussion of the potential for extending the human lifespan. (politics-prose.com)
  • Scholars@Duke publication: Chromosome end-to-end associations and telomerase activity during cancer progression in human cells after treatment with alpha-particles simulating radon progeny. (duke.edu)
  • Chromosome end-to-end associations seen at metaphase involve telomeres and are commonly observed in cells derived from individuals with ataxia telangiectasia and most types of human tumors. (duke.edu)
  • In the present study we evaluated chromosome end-to-end associations, telomere length and telomerase activity with the tumorigenic status of human bronchial epithelial cells immortalized with human papillomavirus. (duke.edu)
  • The fewest chromosome end associations and lowest telomerase activity were observed in the parental immortalized cells. (duke.edu)
  • The tumorigenic cells that were telomerase positive and had the highest frequency of cells with chromosome end-to-end associations were also metastatic. (duke.edu)
  • The acclaimed role of telomerase in the growth properties of some cells has given it tabloid status on both the oncology and biotechnology industry radar screens, but only time will tell if that rush has been warranted. (rupress.org)
  • This finding is a new twist on the intranuclear location and dynamics of telomerase in mammalian cells, but we still have much to learn about how telomerase and its subunits roam around in the nucleus as related to the enzyme's on- and off-duty work cycles. (rupress.org)
  • To complete the 5′ end of the product DNA strand, evolution came up with telomerase (as well as a different, recombination-based mechanism that is very important in many cells and creatures but does not figure in the work we are looking at here). (rupress.org)
  • As SARS-CoV-2 spreads across the planet, we explored the range of human cells that can be infected by this virus. (cdc.gov)
  • We also tested a wide range of human immune cells for productive infection with SARS-CoV-2. (cdc.gov)
  • We confirm that human primary peripheral blood mononuclear cells are not permissive for SARS-CoV-2. (cdc.gov)
  • It is critical to isolate SARS-CoV-2 viruses to characterize their ability to infect and replicate in multiple human cell types and to determine if the virus is evolving in its ability to infect human cells and cause severe disease. (cdc.gov)
  • In addition, we studied the replication kinetics of SARS-CoV-2/SB3-TYAGNC in human fibroblast, epithelial, and immune cells. (cdc.gov)
  • ATCC) were cultured as previously mentioned ( 4 ), as were THF cells (human telomerase life-extended cells) ( 5 ). (cdc.gov)
  • Laboratory studies suggest that ginger can protect brain cells from the plaques that cause Alzheimer's disease, but this effect has not been studied in humans. (mskcc.org)
  • Germ cells (eggs and sperm) and stem cells contain an enzyme, telomerase, that restores telomere length. (cdc.gov)
  • Although it is normally inactive in most other cells in the body, telomerase is activated in cancer cells, making them "immortal. (cdc.gov)
  • Although activating telomerase to immortalize normal cells is a theoretical possibility, its feasibility isn't known. (cdc.gov)
  • 5. Gronthos S, Mankani M, Brahim J, Robey PG, Shi S. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. (bvsalud.org)
  • Stem cell properties of human dental pulp stem cells. (bvsalud.org)
  • SHED: stem cells from human exfoliated deciduous teeth. (bvsalud.org)
  • 9. Chen SC, Marino V, Gronthos S, Bartold PM. Location of putative stem cells in human periodontal ligament. (bvsalud.org)
  • 10. Kamata N, Fujimoto R, Tomonari M, Taki M, Nagayama M, Yasumoto S. Immortalization of human dental papilla, dental pulp, periodontal ligament cells and gingival fibroblasts by telomerase reverse transcriptase. (bvsalud.org)
  • By activating the enzyme telomerase to lengthen telomeres, we can support cellular health and age gracefully. (enzymedica.com)
  • The essence of this theory is that human aging is the result of cellular aging. (politics-prose.com)
  • We evaluated the reliability of a novel multiplex ligation-dependent probe amplification (MLPA) assay in detecting integration of human papillomavirus (HPV) based on the viral E2/E6 copy number ratio in formalin-fixed and paraffin-embedded cervical lesions. (dundee.ac.uk)
  • however, in telomerase-null mice, short telomeres predispose to emphysema after chronic cigarette smoke exposure. (jci.org)
  • Rationale : Telomerase is a nuclear regulator of telomere elongation with recent reports suggesting a role in regulation of mitochondrial reactive oxygen species. (hypertension.qc.ca)
  • Our results indicate that Zscan4 functions as a mediator of telomere length through its direct interaction with Rap1, possibly regulating shelterin complex-controlled telomere elongation in both telomerase positive and alternative lengthening of telomere pathways. (ttu.edu)
  • Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. (nih.gov)
  • Up-regulation of telomerase activity is thought to be a critical step leading to cell transformation. (biomedcentral.com)
  • Patients with DKC have reduced telomerase activity and abnormally short tracts of telomeric DNA compared with normal controls. (medscape.com)
  • Deregulation of telomerase, in addition to proliferation activity, is associated with tumorigenesis. (nih.gov)
  • These results suggest that chemotherapeutic agent 5-Fu may down-regulate telomerase activity at both transcriptional level and PI3K/Akt/mTOR pathway-dependent post-transcriptional level to facilitate hepatocellular carcinoma cell apoptosis. (biomedcentral.com)
  • Telomerase can bind the first few nucleotides of the template to the last telomere sequence on the chromosome, add a new telomere repeat (5'-GGTTAG-3') sequence, let go, realign the new 3'-end of telomere to the template, and repeat the process. (wikipedia.org)
  • Telomerase restores short bits of DNA known as telomeres, which are otherwise shortened after repeated division of a cell via mitosis. (wikipedia.org)
  • Telomerase in the ciliate Tetrahymena was discovered by Carol W. Greider and Elizabeth Blackburn in 1984. (wikipedia.org)
  • The negative stain electron microscopy (EM) structures of human and Tetrahymena telomerases were characterized in 2013. (wikipedia.org)
  • Multi-tilt EM tomogram of primary human small airway epithelial cell (SAEC) in interphase state. (ucsd.edu)
  • In vivo loss of telomeric repeats with age in humans. (enzymedica.com)
  • Evidence for each hypothesis and its associated change having occurred are reviewed, and the hypotheses are combined in a synthetic theory for the origin of human menopause. (frontiersin.org)
  • This study investigated changes in mTOR pathway and telomerase activity in hepatocarcinoma cell line SMMC-7721 treated with chemotherapeutic agent 5-fluorouracil (5-Fu). (biomedcentral.com)
  • Prevalence of human papillomavirus types in head and neck cancer sub-sites in the Indian population. (who.int)
  • In addition, almost 80 experiments have been conducted with mammals, including humans, that confirm that interventions in the aging process can prevent, delay, and even avoid age-related diseases such as cancer. (medscape.com)
  • María A. Blasco, MD, scientific director of the National Cancer Research Center, an international leader in telomere research and co-author of the study, noted on the institution's website, "The spectacular advances in recent years to increase the longevity of model organisms, including in mammals, indicate that it will be important to develop rational strategies to intervene in human aging. (medscape.com)
  • One of the most well-known telomerase activators is the compound cycloastragenol. (antiaging-systems.com)
  • Teas and extracts of this plant have been used in traditional medicine as health supplements and it is known that cycloastragenol has several other effects apart from the telomerase activities (6). (antiaging-systems.com)
  • An interesting study has shown that cycloastragenol not only promotes telomerase activity, but it may also be useful in reducing depressive symptoms (7). (antiaging-systems.com)
  • In another project, it was shown that a direct derivative of cycloastragenol, a compound called GRN510 which is a small proprietary molecule, also has telomerase enhancing activities. (antiaging-systems.com)