Human sterol carrier protein proteins known carrier proteins. Medical search. Frequent questions

The human sterol carrier protein 2 (SCP2) is a basic protein that is believed to participate in the intracellular transport of cholesterol and various other lipids. (wikipedia.org)
Before entering lipid synthesis pathways, different kinds of acyl-CoA transporters which acts as the major carrier of acyl-CoAs, such as fatty acid binding protein (FABP), sterol carrier protein 2 (SCP2) and acyl-CoA-binding protein (ACBP), would activate and convert fatty acids to fatty acyl-CoA esters via a reaction catalyzed by fatty acyl-CoA synthetase and transported to various metabolic locations [ 11 ]. (biomedcentral.com)
This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2) , as a result of transcription initiation from 2 independently regulated promoters. (fn-test.com)
The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. (fn-test.com)
Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. (fn-test.com)

Sterol carrier proteins (also known as nonspecific lipid transfer proteins) is a family of proteins that transfer steroids and probably also phospholipids and gangliosides between cellular membranes. (wikipedia.org)
These proteins are different from plant nonspecific lipid transfer proteins but structurally similar to small proteins of unknown function from Thermus thermophilus. (wikipedia.org)
The genes encoding non-specific lipid transfer proteins (nsLTPs), members of a small multigene family, show a complex pattern of expressional regulation, suggesting that some diversification may have resulted from changes in their expression after duplication. (korea.ac.kr)

HSD17B4, SCPX, HSDL2, and STOML1 encode fusion proteins with SCP-2 downstream of another protein domain, whereas C20orf79 encodes an unfused SCP-2. (slu.se)

Does not convert to estrogen Muscle growth No water cardiovascular diseases as well as cancer and 1 weekend day in the the level of expression of apoE, sterol carrier protein-2, or caveolin. (smashingbuzz.com)
Hippocampal lipids were not significantly affected by APOE genotype, however levels of myelin-enriched sulfatides and hexosylceramides were significantly lower, and polyunsaturated phospholipids were higher, in rs1990622-A carriers after controlling for APOE genotype. (biomedcentral.com)

As such, if we consume a balanced meal prior to training but is usually only heaved of with and safety of longer-term heat shock proteins. (smashingbuzz.com)
In contrast, the thermally sensitive population exhibited higher basal levels of heat shock proteins and had three times fewer changes in gene expression overall. (frontiersin.org)

This domain occurred 5 times on human genes ( 6 proteins). (umbc.edu)
In the case of genes that are used to produce proteins, the RNA polymerase II holoenzyme that actually performs the transcription from the template strand needs to find chemical cues for attachment to the DNA and where to begin transcription. (wikiversity.org)
The "upstream regions of the human CYP11A and bovine CYP11B genes [have] a distal promoter in each gene. (wikiversity.org)
retained genes for the last three steps of the pathway, allowing The most abundant group of heme proteins are cytochromes them to synthesize heme from their host-derived precursors (20). (medicinelakex1.com)

We have identified a cytosolic acyl-CoA binding protein, with highly conserved amino acid residues and a typical acyl-CoA binding domain in N. caninum . (biomedcentral.com)
The sequence encoded a novel protein rich in alanine (25%) and proline (20%), which contained regions similar to proteins of comparable amino acid composition such as extracellular matrix components or the membrane-cytoskeletal linker synapsin. (lookformedical.com)

In this sense, besides the triglycerides, the term would include several other types of compounds like mono- and diglycerides, phospholipids (such as lecithin), sterols (such as cholesterol), waxes (such as beeswax), and free fatty acids, which are usually present in human diet in smaller amounts. (mathisfunforum.com)

Sterol carrier protein-2 ( SCP-2) is an intracellular, small, basic protein domain that in vitro enhances the transfer of lipids between membranes. (slu.se)

Parasitic ecule because it reversibly binds to certain proteins, such as kinetoplastid ﬂagellates represent a rare example of organisms transcription factors and ion channels, and thus modulates their that depend on oxidative metabolism but are heme auxotrophs. (medicinelakex1.com)
The p53 protein, to exert its function, binds in a sequence-specific manner to the DNA-binding sites by forming a tetramer, via four self-assembling p53 molecules, which are stabilized by protein-protein and base-stacking interactions [ 3 ] . (encyclopedia.pub)

The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-Coa thiolase specific for branched-chain acyl CoAs, which is proteolytically cleaved from the sterol carrier protein. (umbc.edu)

Continuous delivery of a portion of cellular cholesterol to mitochondria ensures synthesis of cholesterol-derived sterols, like oxysterols and steroid hormones via mitochondria-localized oxidoreductases. (nature.com)
Lipid synthesis requires bulk carbon skeleton acyl-CoAs, the transport of which depends on the acyl-CoA binding protein (ACBP). (biomedcentral.com)
ANADROL Tablets the usual administration protocols among male should be carried out, including how 400-600 mg per Increases the synthesis of protein, boldenone 300 dosage. (smashingbuzz.com)
Measuring muscle protein synthesis in humans and the influence of nutritional state. (tamu.edu)

The recombinant NcACBP protein was expressed to verify the binding activities of NcACBP in vitro , and the heterologous expression of NcACBP in Δacbp yeast in vivo . (biomedcentral.com)
The NcACBP recombinant protein was able to specifically bind acyl-CoA esters in vitro . (biomedcentral.com)
The patterns of N-glycosylation within the recombinant ectodomain and S1 subunit of the SARS-CoV-2 spike protein were characterized using this approach. (cdc.gov)
In addition, we compared N-glycan profiles of the recombinant spike proteins produced from different expression systems, including human embryonic kidney (HEK 293) cells and Spodoptera frugiperda (SF9) insect cells. (cdc.gov)

alpha polypeptide, also known as FCER1A, is a protein which in humans is encoded by the FCER1A gene. (wikiversity.org)
The Atg12 protein in yeast is an indispensable polypeptide in the highly conserved ubiquitin-like conjugation system operating in the macroautophagy/autophagy pathway. (bvsalud.org)

Distal protein-protein interactions in vitro may be favored on supercoiled DNA because of topological constraints. (wikiversity.org)

Defects in MFE2 are a cause of D-bifunctional protein deficiency (DBPD) [ MIM:261515 ]. (mitosciences.com)

The human FCER1A may be regulated using its distal promoter. (wikiversity.org)
A distal promoter in the S-phase has a role in the control of the human H1.2 histone gene transcription. (wikiversity.org)

The import of membrane proteins into peroxisomes needs PEX19 for recognition, targeting and insertion via docking at PEX3. (genome.jp)
Matrix proteins in the cytosol are recognized by peroxisomal targeting signals (PTS) and transported to the docking complex at the peroxisomal membrane. (genome.jp)
discussed in this article, showed that the N terminus of lipidated human ATG8s adopts the "closed" conformation when it interacts with the membrane in cis-membrane association, i.e. with the same membrane ATG8 is anchored to. (bvsalud.org)
A 210 kDa protein is located in a membrane-microtubule linker at the distal end of mature and nascent basal bodies. (lookformedical.com)
The protein was part of the Y-shaped fibrous linkers between the doublet microtubules and the flagellar membrane, as indicated by statistical analysis of post-labeled sections using anti-centrin and anti-tubulin as controls. (lookformedical.com)
One membrane component that is often subverted by vacuolar bacteria is cholesterol - an abundant lipid that mammalian cells produce de novo at the endoplasmic reticulum (ER) or acquire exogenously from serum-derived lipoprotein carriers. (microbialcell.com)
Western Blot: SR-BI Antibody [NB400-104] - Detection of SR-BI in rat H4IIE total cell lysates and plasma membrane proteins. (novusbio.com)

Pair their versions of Anvarol Anavar, Clenbutrol Clenbuterol and Winsol Winstrol, with a healthy diet of protein, carbohydrates, fats and regular exercise, and you CAN achieve the results you want, but safely. (awachimie.com)
It is obvious that the seeds of different variety of cotton vary as grown in diverse agroclimatic conditions with respect to oil, fats and protein contents. (scielo.br)
Fats are one of the three main macronutrient groups in human diet, along with carbohydrates and proteins, and the main components of common food products like milk, butter, tallow, lard, salt pork, and cooking oils. (mathisfunforum.com)

Fatty acid-binding proteins are low molecular weight (100-130 aa) chaperones for long chain fatty acids, fatty acyl CoA esters, eicosanoids, retinols, retinoic acids and related metabolites and are usually regarded as being responsible for allowing the otherwise hydrophobic ligands to be mobile in aqueous media. (guidetoimmunopharmacology.org)
The ABC transporter proteins Pat1 and Pat2 are required for import of long-chain fatty acids into peroxisomes of Saccharomyces cerevisiae. (research.com)

Using the intrinsically fluorescent cholesterol analog, cholestatrienol, we directly observe sterol transport to mitochondria in fibroblasts upon treating NPC2 deficient human fibroblasts with NPC2 protein. (nature.com)
Cholesterol trafficking between sterol-rich organelles, such as the PM and endosomes and metabolically active but sterol-poor organelles, like ER and mitochondria, is very important, as the two latter harbor the molecular machinery to sense cellular cholesterol abundance and to convert cholesterol into essential sterol metabolites, respectively 4 . (nature.com)

A multifunctional role of Atg8-family proteins (Atg8 from yeast and human LC3 and GABARAP subfamilies, all referred to here as ATG8s) in macroautophagy/autophagy is carried out by two protein domains, the N-terminal helical domain (NHD) and ubiquitin-like (UBL) domain. (bvsalud.org)

metabolism of this heme-free eukaryote, we searched for heme- There are only a few examples of facultatively anaerobic or containing proteins in its de novo sequenced genome and exam-ined several cellular processes for which heme has so far been con- pathogenic bacteria that do not require heme (10-12), but no sidered indispensable. (medicinelakex1.com)
The free-living nematode Caenorhabditis eleganslacks the capacity to synthesize heme but is able to take it from the cytochromes respiration sterols protist bacteria it feeds on (15). (medicinelakex1.com)
Often starting as a phagosome in the endocytic compartment, these bacteria-occupied vacuoles transition into organelles with novel molecular features via remodeling of host proteins and lipids through the highly coordinated actions of bacterial factors [3] [5] . (microbialcell.com)

Lasting MCSs between endo-lysosomes containing NPC2 and mitochondria move by slow anomalous sub-diffusion, providing location and time for sterol transport between both organelles. (nature.com)

Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation. (tamu.edu)

These in vitro, and their expression in these human tumour virus. (who.int)

HSD17B4 which encodes a D-bifunctional protein ( DBP) with domains for D-3-hydroxyacyl-CoA dehydrogenase, enoyl-CoA hydratase, and SCP-2 are found in animals from insects to mammals and also in fungi. (slu.se)

A monoclonal antibody raised against purified flagellar basal apparatuses from the green flagellate Spermatozopsis similis reacted with a protein of 210 kDa (p210) in western blots. (lookformedical.com)
Using a polyclonal antibody (anti-p210) raised against the C-terminal part of p210, it was shown that the protein was highly enriched in the basal apparatuses. (lookformedical.com)
During deflagellation the protein remained at the basal body but we observed changes in its distribution, indicating that p210 partially moved to the tip of the basal body. (lookformedical.com)

Atg12 is comprised of a ubiquitin-like (UBL) domain preceded at the N terminus by an intrinsically disordered protein region (IDPR), a domain that comprises a major portion of the protein but remains elusive in its conformation and function. (bvsalud.org)

The relative abundance of sialylated glycans in the S1 subunit compared to the full-length protein could indicate differences in the global structure and function of these two species. (cdc.gov)

In soluble guanylyl cyclase, heme serves as a protein cofactor for fundamental cellular processes, such as as the nitric oxide sensor, and thus plays an important role in electron transport in the respiratory chain, oxidative stress re- signal transduction. (medicinelakex1.com)
We conducted a comprehensive mass spectrometric analysis of the N-glycosylation profiles of the SARS-CoV-2 spike proteins using signature ions-triggered electron-transfer/higher-energy collision dissociation (EThcD) mass spectrometry. (cdc.gov)

In the poster section, Joanna Shisler (University of Illinois at Urbana-Champaign [UIUC], Urbana) reported that the modified virus, Ankara, activates nuclear factor κB through the mitogen-activated protein kinase, extracellular signal-regulated kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway, possibly facilitating the host immune response. (cdc.gov)
In the poster section, Joanna Shisler (University of Illinois at Urbana-Champaign [UIUC], Urbana) reported that the modified virus, Ankara, activates nuclear factor κB through the mitogen-activated protein kinase, extracellular signal–regulated kinase (MEK)/extracellular signal–regulated kinase (ERK) pathway, possibly facilitating the host immune response. (cdc.gov)

We devise a protocol to determine the surface fraction of endo-lysosomes in contact with mitochondria and show that this fraction does not depend on functional NPC1 or NPC2 proteins. (nature.com)
Here, we show that the IDPR in unconjugated Atg12 is positioned in proximity to the UBL domain, a configuration that is important for the functional structure of the protein. (bvsalud.org)
The basic unit of the p53 protein consists of three major functional domains such as an N-terminal transactivation domain (TAD), a core DNA-binding domain (DBD)-the main target for mutations, and a C-terminal regulatory domain (CTD) ( Figure 1 A) [ 2 ] . (encyclopedia.pub)

The protein is around 70kDa and made up of 3 domains, a short chain alcohol dehydrogenase reductase, a central hydratase domain and a C terminal sterol carrier protein 2 domain. (mitosciences.com)

Our study demonstrates that TMEM106B protein abundance is increased with brain ageing in humans, establishes that dementia risk allele rs1990622-A predisposes to TMEM106B fibril formation in the hippocampus, and provides the first evidence that rs1990622-A affects brain lipid homeostasis, particularly myelin lipids. (biomedcentral.com)

Conserved residues that modulate protein trans-splicing of Npu DnaE split intein. (tamu.edu)

Proteins found in any species of algae. (lookformedical.com)
One exception is hu- humanized SCID mice, the use of al oncogenic viruses that are strictly man T-cell lymphotropic virus type 1 surrogate hosts has not proven very species-specific, causing cancer in (HTLV-1): in addition to its ability to useful for defining tumour site con- humans only. (who.int)
For this reason, the infect humans, this virus can infect cordance between humans and ex- question about tumour site concor- several other species - including perimental animals. (who.int)
For other human tumour virus- primate species are related to the hu- tween data in humans and in experi- es, the use of humanized severe man tumour viruses, the incidence of mental animals is not obvious. (who.int)
In this combined immunodeficiency (SCID) cancer is low in these species (as it chapter, some aspects of this issue mice, in which the human target is in humans), which renders cancer are discussed. (who.int)

For instance, mice are able to reconstitute most lymphomas in monkeys and humans woodchuck hepatitis virus induces major components of the human provides strong support for a direct hepatocellular carcinoma (HCC) haematolymphoid system including oncogenic role of EBV in vivo. (who.int)

Hemoglobin subunit epsilon is a protein that in humans is encoded by the HBE1 gene. (wikiversity.org)
Significant variations were observed in the distribution of glycan types as well as the specific individual glycans on the modification sites of the ectodomain and subunit proteins. (cdc.gov)

This domain is involved in binding sterols. (wikipedia.org)
If you've navigated here from a protein, hovering over a position on the weblogo will display the corresponding protein position for that domain position. (umbc.edu)
A major deletion in the IDPR disrupts intactness of the UBL domain at the unconjugated C terminus, and a mutation in the predicted α0 helix in the IDPR prevents Atg12 from binding to Atg7 and Atg10, which ultimately affects the protein function in the ubiquitin-like conjugation cascade. (bvsalud.org)
A cysteine-rich metal-binding domain from rubella virus non-structural protein is essential for viral protease activity and virus replication. (tamu.edu)
A ) Simplified representation of the secondary structure showing domain organization of the human p53 protein (Uniprot #P04637). (encyclopedia.pub)

This process depends on the endo-lysosomal sterol transfer protein Niemann Pick C2 (NPC2). (nature.com)
Sec14-like phosphatidylinositol-transfer proteins and diversification of phosphoinositide signalling outcomes. (tamu.edu)

Immunohistochemistry-Paraffin: SR-BI Antibody [NB400-104] - Staining of human adrenal cortex. (novusbio.com)

This study tests sampled migratory and local wild birds to detect WNV and identify possible avian carriers. (cdc.gov)
Combining these data with information about avian migratory patterns, landscape characteristics, and weather conditions, over space and time, will provide the foundation for developing spatial analytical and forecasting models to assess the risk for human illness. (cdc.gov)

Using fluorescence microscopy, we localize endo-lysosomes containing NPC2 relative to mitochondria based on the Euclidian distance transform and use statistical inference to show that about 30% of such LE/LYSs are in contact to mitochondria in human fibroblasts. (nature.com)
that is histopathological y very simi- T cel s, B cel s, natural kil er cel s, LMP1 of EBV can transform ro- lar to that caused by hepatitis B vi- macrophages, and dendritic cells, dent fibroblasts and is expressed rus (HBV) in humans, but it does so and this humanized mouse model in most of the human cancers as- through a different mechanism. (who.int)

The oxidation state of the iron is important human parasites, depend on oxygen but are unable to produce for most biological roles of heme, but its exact function is ulti- heme. (medicinelakex1.com)

Vegetable oils have their specific physicochemical properties due to which they are playing vital role in human nutritional diet for health benefits. (scielo.br)
He also showed that double-stranded (ds)RNA- and ZDNA binding proteins had a role in poxvirus pathogenesis. (cdc.gov)
The spike protein expressed on the surface of this virus is highly glycosylated and plays an essential role during the process of infection. (cdc.gov)

Structure of the p53 protein. (encyclopedia.pub)

Decanoate is eliminated as urinary metabolites, however these situations can lead to longer exposure to the adult human kidney. (me-cabo.com)

This study aimed to determine how ageing and major genetic risk factors for dementia affect the hippocampal proteome and lipidome of neurologically-normal humans over the age of 65. (biomedcentral.com)

Although sequence homology is limited, crystallographic studies suggest conserved 3D structures across the group of binding proteins. (guidetoimmunopharmacology.org)

His study ties his expertise on Human genetics together with the subject of Endocrinology. (research.com)
Moreover, The use of animals as surrogate rine host, can provide a platform for animal models for tumour viruses in hosts for the study of human tu- in vivo infection. (who.int)

Western Blot: SR-BI Antibody [NB400-104] - SR-BI antibody was tested in human adrenal cell lysate. (novusbio.com)
Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)

Anatomy14

Organisms19

Chemicals and Drugs138

Analytical, Diagnostic and Therapeutic Techniques and Equipment30

Phenomena and Processes52

Technology, Industry, Agriculture3

Information Science4

Health Care3

SCP25

Lipid transfer3

SCPX1

ApoE2

Heat shock pr2

Genes4

Amino acid2

Phospholipids1

Membranes1

Binds2

Thiolase1

Synthesis4

Recombinant4

Polypeptide2

Interactions1

DEFICIENCY1

Distal promoter2

Membrane7

Fats3

Fatty acids2

Cholesterol2

Multifunctional1

Bacteria3

Organelles1

Mitochondrial1

Vitro1

Encodes1

Basal3

Intrinsically1

Full-length protein1

Electron2

Extracellular2

Functional3

Dehydrogenase1

Abundance1

Residues1

Species5

Induces1

Subunit2

Domain5

Transfer2

Immunohistochemistry1

Avian2

Fibroblasts2

Parasites1

Role3

Structure1

Kidney1

Major1

Group1

Study2

Cell2