• STAT (signal transducer and activator of transcription) proteins are latent cytoplasmic transcription factors that become activated by tyrosine phosphorylation in response to cytokine stimulation. (nih.gov)
  • The in vivo PIAS1-Stat1 interaction requires phosphorylation of Stat1 on Tyr-701. (nih.gov)
  • Our findings revealed that the protective induction of IDO1 is suppressed specifically within primary infected cells because Chlamydia attenuates the nuclear import of activated STAT1 following IFNγ exposure, without affecting STAT1 levels or phosphorylation. (duke.edu)
  • After phosphorylation by JAK tyrosine kinases, STAT1 enters the nucleus to regulate transcription of many different genes. (thermofisher.com)
  • When binding to the receptor complex, Jak1 and Tyk2 will be activated, and leads to subsequent tyrosine phosphorylation of the IFN-λR1 (intracellular domain, Tyr406 and Tyr343, Tyr517), and activation of STAT1 and STAT2. (medchemexpress.com)
  • In addition, interferon (IFN) regulatory factor 1 (IRF1) and signal transducer and activator of transcription 1 (STAT1) phosphorylation do not respond in NHDFs after IR. (elsevierpure.com)
  • In contrast, IFNγ treatment upregulates PD-L1 and IRF1 expressions and STAT1 phosphorylation. (elsevierpure.com)
  • As a consequence of incubation of cells with a variety of cytokines and growth factors the Stats are activated by tyrosine phosphorylation resulting in their nuclear translocation. (grantome.com)
  • In addition, apigenin and luteolin markedly inhibited IFN-γ-induced phosphorylation of STAT1 with little impact on cell survival. (alstuttu.org)
  • In addition, apigenin and luteolin markedly inhibited IFN-gamma-induced phosphorylation of STAT1 with little impact on cell survival. (alstuttu.org)
  • Further study demonstrated that the HBV polymerase protein inhibited the Stat1 nuclear translocation induced by IFN-alpha, but did not induce Stat1 degradation nor interfere with its phosphorylation. (edu.au)
  • STAT1 tyrosine phosphorylation was enhanced, while only the activation of GAS (IFN-gamma-activated site) but not ISRE (interferon-stimulated response element) was observed. (mpeg3.org)
  • Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. (antibodies-online.cn)
  • Coimmunoprecipitation analysis showed that PIAS1 was associated with Stat1 but not Stat2 or Stat3 after ligand stimulation. (nih.gov)
  • Furthermore, oxaliplatin decreased TLR-induced STAT1 and STAT3 expression, and NF-κB-mediated responses. (tue.nl)
  • Interestingly, ID-associated genes exhibit promoter-localized MER41 LTRs that harbor TF binding sites (TFBSs) for not only STAT1 but also other immune TFs such as, in particular, NFKB1 (Nuclear Factor Kappa B Subunit 1) and STAT3 (Signal Transducer And Activator Of Transcription 3). (biorxiv.org)
  • The IL-21/IL-21R interaction triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3. (egfie.com)
  • STAT3 protein belongs to a group of intracellular transcription factors that mediate a variety of functions such as cellular differentiation, proliferation, and apoptosis. (biolegend.com)
  • IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. (wikipedia.org)
  • Of note, functionally-relevant differences between humans and chimpanzees are observed regarding the 3 main components of this pathway: i) the protein sequences of immunes TFs binding MER41 LTRs, ii) the insertion sites of MER41 LTRs in the promoter regions of ID-associated genes and iii) the protein sequences of the targeted ID-associated genes. (biorxiv.org)
  • STAT1 is known to regulate several genes which are involved in cell growth, apoptosis, immune responses, and lipid metabolism. (thermofisher.com)
  • IFN-ECs were enriched in regenerative-stage mouse hearts and expressed genes encoding immune responsive transcription factors (Irf7, Batf2, and Stat1). (bvsalud.org)
  • Ingenuity Pathway Analysis indicated that this differentially expressed genes formed a network centered on STAT1, a grasp transcription factor of the IFN response (Physique 1B). (thetechnoant.info)
  • The higher expression of the STAT1 signature genes (signal transducer and activator of transcription 1), (immunity-related GTPase family M member 1), (colony-stimulating factor 1), (C-C motif chemokine receptorClike 2), (C-C motif chemokine ligand 5), and (C-X-C motif chemokine ligand 9) in B cells from the lungs of infected mice was confirmed by quantitative reverse transcriptaseCpolymerase chain reaction (Figures 1C and 1D). (thetechnoant.info)
  • 100.000 cCREs in total), dispersed within the genome and present in cis-regulatory regions of ~81% of human genes, as calculated following gene enrichment analysis. (mdpi.com)
  • Interferon tau (IFNtau) is the pregnancy recognition signal produced by the conceptus trophectoderm and acts in a paracine manner on the ovine endometrium to increase expression of IFN-stimulated genes primarily in the stroma and deep glandular epithelium, including IFN regulatory factor-1 (IRF-1). (tamu.edu)
  • Our in silico findings report that there is cross-regulation between both pathways at the level of gene transcription regulation, mediated by the presence of binding sites for both factors in promoters of genes essential for these pathways. (biomedcentral.com)
  • In this paper we examine evidence for a direct crosstalk of the NF-κB and IRF3 signaling pathways at the lowest level, between main transcription factors and genes coding for these transcription factors. (biomedcentral.com)
  • We analyzed respective gene promoters' sequences using in silico methods for identification of transcription binding sites, mainly in the NF-κB- and IRF-coding genes. (biomedcentral.com)
  • This domain occurred 99 times on human genes ( 217 proteins). (umbc.edu)
  • The Stat family of transcription factors are well known to control the expression of nuclear encoded cellular genes. (grantome.com)
  • Furthermore, we are able to demonstrate that Stat1 binds to the D-loop region of the mitochondrial genome where transcription of the mitochondrially encoded genes is initiated. (grantome.com)
  • In addition, HBV polymerase could inhibit the transcriptional activity of other IFN-stimulated response element-driven promoters and the expression of interferon-stimulated genes (ISGs), such as Stat1 and ISG15. (edu.au)
  • A small cluster of genes were identified whose expression was enhanced after co-treatment including BclG (Bcl-2 family protein G), XAF1 (X-linked inhibitor of apoptosis associated factor-1), TRAIL (TNF-related apoptosis inducing ligand) and TAP1 (transporter 1). (mpeg3.org)
  • Taken together, we postulate that IRF-1 hyper-activation and elevated STAT1 dimer formation associate with enhanced expression of a subset of interferon stimulated genes (ISGs) which may lead to even greater antiviral activity. (mpeg3.org)
  • Transcription factors are proteins that regulate the transcription of genes, or the production of mRNA from DNA. (biolegend.com)
  • The underphosphorylated, active form of Rb interacts directly with E2F1 , leading to cell cycle arrest, while the hyperphosphorylated form decouples from E2F1, thus promoting the transcription of genes promoting entry into the S phase. (biolegend.com)
  • Explore the normal functions of human genes and the health implications of genetic changes. (medlineplus.gov)
  • MEK and ERK inhibitors prevented OSM-driven transcription of select target genes and stem-like/mesenchymal reprogramming, resulting in reduced tumor growth and resensitization to gemcitabine. (bvsalud.org)
  • Activated STAT1 and STAT2 together with IRF-9 (p48) form a trimeric transcription factor complex (ISGF3). (medchemexpress.com)
  • Stat2, and interferon regulatory factor-9 (IRF-9) in interferon tau regulation of IRF-1. (tamu.edu)
  • The roles of Stat1, Stat2, and IRF-9 in IFNtau regulation of IRF-1 expression were determined using human stromal fibroblasts lacking specific IFN signaling components or complemented with specific Stat1 mutants. (tamu.edu)
  • In contrast, IFNtau did not affect IRF-1 expression in Stat1- and Stat2-deficient cells or in Stat1-deficient cells complemented with Stat1 Y701Q or Stat1 R602L mutants. (tamu.edu)
  • Interferon regulatory factor 2 is a protein that in humans is encoded by the IRF2 gene. (wikipedia.org)
  • Effects of EGCG on nuclear factor kappa B (NFκB) and activator protein-1 (AP-1) transcriptional activity were assessed by reporter gene assay. (molvis.org)
  • Treatment of HCEpiC with 1 ng/ml IL-1β for 18 h significantly increased release of the cytokines/chemokines granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-6 (IL-6), interleukin-8 (IL-8), and monocyte chemotactic protein-1 (MCP-1), while hyperosmolarity-induced release of IL-6 and MCP-1. (molvis.org)
  • Finally, a survey of the human proteome has allowed us to map a protein-protein network which links the identified immune/MER41/cognition pathway to FOXP2 (Forkhead Box P2), a key TF involved in the emergence of human speech. (biorxiv.org)
  • IFN-lambda 2/IL-28A Protein, Human (HEK293, His) is a recombinant human IFN-lambda 2 (V26-V200) with C-terminal 6*His tag, which is expressed in HEK293. (medchemexpress.com)
  • induced immunosuppressive properties of B7-H1 in human BM- and WJ-MSCs were mediated by STAT-1 signaling, and not by PI3K/RAC-a serine/threonine-protein kinase signaling. (korea.ac.kr)
  • Luteolin concentration-dependently abolished LPS/IFN-γ-induced NO, tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) production as well as inducible nitric oxide synthase (iNOS) protein and mRNA expression. (alstuttu.org)
  • Analysis of site mutants showed that the region targeted by the polymerase protein contained the signal transducer and activator of transcription (Stat) binding site. (edu.au)
  • Reagents The antibodies to IRF-1 (sc-497), IRF-2(sc-498) and IRF-9 Hydrocortisone buteprate (sc-496) were obtained from Santa Cruz, antibodies to STAT1 (#9172) and Phospho-STAT1 (Tyr 701) RELA (#9171) were from Cell Signaling, BclG antibody ("type":"entrez-protein","attrs":"text":"PAB10209″,"term_id":"1236622771″,"term_text":"PAB10209″PAB10209) was obtained from Orbigen. (mpeg3.org)
  • The encoded protein contains two different binding sites that are known to bind DNA and function as a regulator of gene transcription. (biolegend.com)
  • Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. (antibodies-online.cn)
  • The point mutant K350A in the STAT1 DNA-binding domain did not provide any further information about molecular mechanisms of signal-dependent target gene recognition, since the mutant did not differ from the wild type protein. (uni-goettingen.de)
  • E7 from human papil omavirus type 16 cooperate to cancer: the European prospective investigation into doi:10.1093/carcin/bgp321 PMID:20047954 target the PDZ protein Na/H exchange regulatory cancer and nutrition study. (who.int)
  • PIAS1, but not other PIAS proteins, blocked the DNA binding activity of Stat1 and inhibited Stat1-mediated gene activation in response to interferon. (nih.gov)
  • The rhoptry proteins ROP18 and ROP5 mediate Toxoplasma gondii evasion of the murine, but not the human, interferon-gamma response. (saeijlab.com)
  • DRAM2 overexpression also increased proteins CDK4, CyclinD3, and decreased p27 expression, all of which are cell cycle-related factors. (cancerindex.org)
  • In primary murine pro B cells and MEFs isolated from Stat1-null mice the expression of all RNAs that encode mitochondria synthesized proteins are elevated 3 to 8 fold compared to pro B cells or MEFs derived from wild type littermates. (grantome.com)
  • STAT proteins (signal transducers and activators of transcription) play an essential part in one of the oldest and highly conserved signal transduction pathways. (uni-goettingen.de)
  • Results showed that three critical amino acid residues in the STAT1 linker domain (E559, E563 and K567) are located in a homologous sequence pattern which is highly conserved among the seven STAT human proteins. (uni-goettingen.de)
  • This paper identified changes in STAT1, the primary transcription factor activated by interferons. (sciencedaily.com)
  • STAT1 is activated to regulate gene expression in response to extracellular signaling polypeptides including cytokines, interferons, and growth factors. (thermofisher.com)
  • The discovery of the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway arose from investigations of how cells respond to interferons (IFNs), revealing a paradigm in cell signaling conserved from slime molds to mammals. (bvsalud.org)
  • The analysis results establish the importance of interferons and the IRF-family of transcription factors, predicting that they are activated at 4 hours and maintained through 28 days in both blood and lung. (cdc.gov)
  • It has also been demonstrated that STAT1 (Signal Transducer And Activator Of Transcription 1), a transcription factor (TF) crucially involved in the IFNγ pathway, binds consensus sequences that, in humans, are located with a high frequency in the LTRs (Long Terminal Repeats) of the MER41 family of primate-specific HERVs (Human Endogenous Retrovirus). (biorxiv.org)
  • The present study demonstrated activation of B7-H1 by engaging signal transducer and activator of transcription (STAT)-1 signaling in MSCs. (korea.ac.kr)
  • This revealed a STAT1 (signal transducer and activator of transcription 1)-centered signature, which pointed to the ability of B cells to both produce and respond to type I IFN. (thetechnoant.info)
  • Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84). (lu.se)
  • Luteolin exerted an inhibitory effect on transcription factor activity including nuclear factor κB (NF-κB), signal transducer and activator of transcription 1 (STAT1) and interferon regulatory factor 1 (IRF-1) in LPS/IFN-γ-activated BV-2 microglial cells. (alstuttu.org)
  • For example, it is well known that the activation of the signal transducer and activator of transcription (STAT) signaling pathway plays a central role in interferon-gamma (IFN-gamma)-induced microglial CD40 expression. (alstuttu.org)
  • Subsequent promoter analysis of BclG showed that IRF-1 (interferon regulatory factor 1) and STAT1 (signal transducer and activator of transcription 1) were both essential for full enhancement of gene expression. (mpeg3.org)
  • Recent clinical trials of Janus kinase (JAK) inhibitors in treating COVID-19-induced ARDS have shown a positive outcome, which makes the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway a potential therapeutic target for treating ARDS. (bvsalud.org)
  • Gene sequencing identified mutations in signal transducer and activator of transcription 1 ( STAT1 ), leading to defective immune responses in type 1 and type 17 helper T cells. (medscape.com)
  • The new Mechanistic Network Analysis in IPA was used to computationally construct a plausible hypothesis that TRIM24 inactivation may lead to activation of IRF7 and STAT1 and other upstream regulators to drive the gene expression profile after the first exposure. (cdc.gov)
  • Their expression in tumour cells is modulated by a complex interplay of genomic, transcriptomic and post translational factors involving multiple intracellular antigen processing pathways. (portlandpress.com)
  • These results identify PIAS1 as a specific inhibitor of Stat1-mediated gene activation and suggest that there may exist a specific PIAS inhibitor in every STAT signaling pathway. (nih.gov)
  • However, the putative role of an IFNγ/STAT1/MER41 pathway in human cognition and/or behavior is still poorly documented. (biorxiv.org)
  • Our data further indicate that non-inherited forms of ID might result from alterations of the immune/MER41/cognition pathway induced notably by the untimely or quantitatively inappropriate exposure of human neurons to IL-6. (biorxiv.org)
  • Further analysis of two overlapping deficiency lines and mutant alleles led to identification of genetic interactions between the CDK8-CycC pair and the components of the Decapentaplegic (Dpp, the Drosophila homolog of TGFβ, or Transforming Growth Factor-β) signaling pathway. (sdbonline.org)
  • It was observed that CDK8-CycC positively regulates transcription activated by Mad (Mothers against dpp) , the primary transcription factor downstream of the Dpp/TGFβ signaling pathway . (sdbonline.org)
  • Biochemical and genetic analysis has demonstrated that Stat1 is essential for gene activation in response to interferon stimulation. (nih.gov)
  • Besides killing tumor cells, oxaliplatin bolsters immunosuppressive pathways, resulting in decreased activation of T cells by human plasmacytoid dendritic cells (pDCs). (tue.nl)
  • Stimulation of TLRs (Toll-Like Receptors) by a pathogen induces activation of signal transduction cascades, which leads to translocation of nuclear factor-κB (NF-κB) to the nucleus [ 1 ], activation of interferon regulatory factors 3/7 (IRF3/7) and/or activator protein-1 (AP-1), which cooperate to induce transcription of various cytokines such as alpha/beta interferon (IFN-α/β) to counteract infection [ 2 - 4 ]. (biomedcentral.com)
  • Apigenin and luteolin modulate microglial activation via inhibition of STAT1-induced CD40 expression. (alstuttu.org)
  • Transcriptomic analysis identified that OSM-mediated stemness requires MAPK activation and sustained, feed-forward transcription of OSMR. (bvsalud.org)
  • These discoveries revealed mechanisms underlying rapid gene expression mediated by a wide variety of extracellular polypeptides including cytokines, interleukins, and related factors. (bvsalud.org)
  • Once activated, p38 phosphorylates a number of targets, including the nuclear transcription factors ATF2 and Max. (rndsystems.com)
  • Once activated, p38 alpha phosphorylates a number of targets, including the cytoplasmic kinases MNK 4 and PRAK5 and the nuclear transcription factors ATF2 1 and STAT1. (rndsystems.com)
  • In summary, these results indicate that HBV polymerase is a general inhibitor of IFN signalling and can inhibit IFN-inducible MyD88 expression by inhibiting the activity of the MyD88 promoter through blocking the nuclear translocation of Stat1. (edu.au)
  • Our results suggest a major role of nuclear noncoding RNA networks in systemic antiviral responses to SARS-CoV-2 in humans. (bvsalud.org)
  • Several studies have clearly demonstrated that distinct cytokine activated signalling and transcription factors regulate the commitment of a naïve T cell along the Th1 or T helper cell type 2 (Th2) phenotype, as well as maintenance of the polarised phenotype. (bmj.com)
  • Programmed cell death-1 (PD-1) and its ligand (programmed death-ligand 1, PD-L1) are key factors that regulate a cytotoxic immune reaction. (elsevierpure.com)
  • Interferon γ (IFN-γ) and interleukin (IL)-4 RNA expression was examined in T lamina propria lymphocytes by quantitative reverse transcription-polymerase chain reaction. (bmj.com)
  • Once the transcription factor binds to an enhancer region, this can cause stimulation or repression of gene transcription. (biolegend.com)
  • RUNX1 regulates CD4 gene transcription during multiple stages of T cell development and represses the CD4 gene in CD4-CD8- (double negative) T cells. (biolegend.com)
  • RHAMM regulates MMTV-PyMT-induced lung metastasis by connecting STING-dependent DNA damage sensing to interferon/STAT1 pro-apoptosis signaling. (medscape.com)
  • Many important questions remain however regarding factors which induce and maintain Th1 cell polarisation in CD. (bmj.com)
  • Using a panel of PDAC cells driven through epithelial-mesenchymal transition (EMT) by OSM or the transcription factors ZEB1 or SNAI1, we find that OSM uniquely induces tumor initiation and gemcitabine resistance independently of its ability to induce a CD44HI/mesenchymal phenotype. (bvsalud.org)
  • Although long noncoding RNAs (lncRNAs) have been suggested as important regulators of transcription factor activity, their contributions to the systemic immunopathologies observed during SARS-CoV-2 infection have remained unknown. (bvsalud.org)
  • Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). (wikipedia.org)
  • Exposure to oxaliplatin markedly increased expression of the T-cell inhibitory molecule programmed death receptor-ligand 1 (PD-L1) on human pDCs and also TLR9-induced IFNα secretion. (tue.nl)
  • induced B7-H1 expression on human BM- and WJ-MSCs increased in a time-dependent manner. (korea.ac.kr)
  • To analyse expression of transcription factors which control the Th1 cell commitment in CD. (bmj.com)
  • Importantly, B cells purified from the pleural fluid of patients with TB displayed a massive type I IFN expression, and supernatants CXCR2-IN-1 of Mtb-stimulated human B cells also polarized human macrophages toward an antiinflammatory profile Table E1 in the online supplement) compared with naive controls. (thetechnoant.info)
  • The developmental regulation of HERV-H expression, the association of HERV-H with binding sites for pluripotency transcription factors, and the extremely high levels of HERV-H RNA in human ES cells suggest that HERV-H contributes to pluripotency in human cells. (biomedcentral.com)
  • NF-κB also controls expression of the downstream IFN auto-amplification loop through STAT1, IRF-1, −5, and −7 transcription factors. (biomedcentral.com)
  • In the present study, we aimed to investigate PD-L1 expression in primary normal human dermal fibroblasts (NHDFs) in response to DSBs. (elsevierpure.com)
  • We hypothesize that Stat1 plays an important role in the expression of mitochondrial encoded mRNAs and possibly other functions involved in electron transport. (grantome.com)
  • To test this hypothesis we will perform the following specific aims: 1) Determine whether decreased expression of mitochondria-encoded RNAs is mediated by Stat1 localized in the mitochondria and identify the domains in Stat1 required for its localization in the mitochondria. (grantome.com)
  • Stage identity and developmental progression in insects is controlled by sequential expression of temporal-specific transcription factors. (elifesciences.org)
  • We analyzed the expression and function of ChemR23 in monocytes and differently activated human primary macrophages. (aai.org)
  • The restricted expression of ChemR23 in naive and M1 macrophages supports the role of ChemR23 in the attraction of macrophages to inflamed tissue by chemerin and in the initiation of resolution of inflammation through RvE1-mediated repolarization of human M1 macrophages toward resolution-type macrophages. (aai.org)
  • In addition, two glutamic acid residues at position E559 and E563 are important for the dissociation of the STAT1 dimer from DNA. (uni-goettingen.de)
  • In conclusion, the data confirm the impact of the linker domain on signal-dependent GAS binding mediated by the steric arrangement of the glutamic acid residues E559 and E563 located on the inner surface of the STAT1 dimer. (uni-goettingen.de)
  • The two glutamic acid residues are aligned perpendicular to the DNA on the longitudinal axis of the STAT1 dimer. (uni-goettingen.de)
  • IRF1 Interferon regulatory factors IRF2 has been shown to interact with BRD7, EP300 and PCAF. (wikipedia.org)
  • In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. (antibodies-online.cn)
  • We treated Huh7 cells with recombinant human IFN-α2a (PBL Assay Science, https://www.pblassaysci.com ) or recombinant human IFN-γ (R&D Systems, https://www.rndsystems.com ) 16 h before and 2 h after infection. (cdc.gov)
  • Peripheral blood mononuclear cells (PBMC) were either left unstimulated (unshaded) or stimulated (shaded) with 100 ng/ml (final concentration) BD Pharmingen™ Recombinant Human IFNγ (Cat. (bdbiosciences.com)
  • Using 5′ RACE, we identified three transcription start sites and several splice variants of ChemR23 in both monocytes and macrophages. (aai.org)
  • Our results uncover the lncRNA PIRAT (PU.1-induced regulator of alarmin transcription) as a major PU.1 feedback-regulator in monocytes, governing the production of the alarmins S100A8/A9, key drivers of COVID-19 pathogenesis. (bvsalud.org)
  • Analysis of Stat1 (pY701) in human peripheral blood monocytes. (bdbiosciences.com)
  • Proximity of HERV-H to binding sites for pluripotency transcription factors within ES cells might be due to retention of the same chromatin features that determined the site of integration of the ancestral, exogenous, gamma-retrovirus that gave rise to HERV-H in the distant past. (biomedcentral.com)
  • Chromatin immunoprecipitation analysis showed that the IFN-induced DNA-binding activity of Stat1 was affected. (edu.au)
  • Further, STAT1 plays an important role in mediating cell viability in response to different cell stimuli and pathogen exposure. (thermofisher.com)
  • Luteolin, baicalein and quercetin inhibited the release of histamine, leukotrienes (LTs), prostaglandin D2 (PGD2), and granulocyte macrophage-colony stimulating factor (GM-CSF) from HCMC in a concentration-dependent manner. (alstuttu.org)
  • The presence of these signatures in human HF and murine MI models suggests a potential role for EC-mediated immune regulation in responding to stress induced by acute injury in MI and chronic adverse remodeling in HF. (bvsalud.org)
  • We conclude that members of the NF-κB family may directly impact regulation of IRF family, while IRF members impact regulation of NF-κB family rather indirectly, via other transcription factors such as AP-1 and SP1. (biomedcentral.com)
  • The ED 50 =1.0 -10 ng/ml, determined by the dose-dependant proliferation of human peripheral blood mononuclear cells. (egfie.com)
  • Research from the Buck Institute and Stanford University suggests that chronic viral infections have a profound and lasting impact on the human immune system in ways that are similar to those seen during aging. (sciencedaily.com)
  • STAT1 plays a major role in normal immune responses, particularly to viral, mycobacterial and fungal pathogens. (sciencedaily.com)
  • The systemic immune response to viral infection is shaped by master transcription factors, such as NF-κB, STAT1, or PU.1. (bvsalud.org)
  • Human endogenous retroviruses (HERVs) are a family of endogenous retroviruses that comprise the ~8.93% of the human genome sequence, with a high proportion being human specific. (mdpi.com)
  • Human endogenous retroviruses (HERVs) are not uncommon, and account for at least 8% of the total human DNA. (biomedcentral.com)
  • However, the role of DRAM2 in the progression of human neoplasms is still unknown. (cancerindex.org)
  • Transcription factors have an important role in the ability of a cell to self-renew and also differentiate into most cell types, also known as pluripotency 1 . (biolegend.com)
  • There are many shreds of evidence that suggest that the extrinsic antigens, environmental conditions, and genetic factors play a crucial role in the development of sarcoidosis through an exaggerated immune response. (ijpsr.com)
  • Our analyses highlight the role of ITGAM and STAT1 in T2DM-TB-associated pathways and advances our knowledge of the genetic processes driving this comorbidity. (springeropen.com)
  • The completion of the first human genome drafts (Yamey 2000 ) was just a start of the modern DNA sequencing era which resulted in further invention, improved development toward new advanced strategies of high-throughput DNA sequencing, so called the " high-throughput next generation sequencing " (HT-NGS). (springer.com)
  • For the future direction, we need the in-depth genome sequence information and analysis for most of the mammals, including human to fully understand genome variation of economic traits, genetic susceptibility to diseases, and pharmacogenomics of drug response. (springer.com)
  • The National Human Genome Research Institute (NHGRI) has echoed this need through its vision for genomics research (Collins et al. (springer.com)
  • Year 2011 is celebrated as the 10th anniversary since the human genome was first sequenced ( www.nature.com/natureconferences/hg10years/index.html ). (springer.com)
  • During this period, tremendous success has been achieved in the fields of decoding of human genome, technological advancement of new era of human genome applications, toward personalized genomes and discovery of rare variants, leveraging genome sequencing to impact on cancer researches and mammalian evolution and population structure. (springer.com)
  • pooled RNA was applied to Human Genome U133 Plus 2.0 Affymetrix GeneChips. (bmj.com)
  • We cultivated human lung epithelial A549 cells (ATCC CCL-185), human hepatoma Huh7 cells ( 13 ), human cervix carcinoma HeLa cells (ATCC CCL-2), African green monkey kidney Vero cells (ATCC CCL-81), and transformed human dermal fibroblast cultures ( 14 ) in Dulbecco modified eagle medium supplemented with 10% fetal calf serum at 37°C and 5% CO 2 . (cdc.gov)
  • Rb homeostasis is also essential for self-renewal and survival of human embryonic stem cells 10 . (biolegend.com)
  • The reference sequence was derived from Ensembl Human sequence AC067945.4.1.162471 . (lu.se)
  • Synthetic peptide within Human p38 aa 150-250 (internal sequence). (abcam.com)
  • Single-cell transcriptomic analysis of murine hearts subjected to MI uncovered an EC population (IFN-ECs) with immunologic gene signatures similar to those in human HF. (bvsalud.org)
  • Correction to: National and subnational burden of female and male breast cancer and risk factors in Iran from 1990 to 2019: results from the Global Burden of Disease study 2019. (medscape.com)
  • Although the promoters P1 and P3 are used equally in unpolarized macrophages, stimulation with LPS or IFN-γ leads to increased transcription from P3 in inflammatory M1 macrophages. (aai.org)
  • IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. (wikipedia.org)
  • Human interferon regulatory factor 2 gene. (wikipedia.org)
  • Dysregulation of CDK8 (Cyclin-Dependent Kinase 8) and its regulatory partner CycC (Cyclin C) , two subunits of the conserved Mediator (MED) complex, have been linked to diverse human diseases such as cancer. (sdbonline.org)
  • Homo sapiens transcription factor ISGF-3 mRNA, complete cds. (lu.se)
  • This antibody is a rabbit polyclonal antibody raised against residues near the N terminus of human STAT1. (thermofisher.com)
  • To determine the anti-inflammatory and anti-oxidant effects of epigallocatechin gallate (EGCG), the major polyphenol component of green tea, in human corneal epithelial cells (HCEpiC). (molvis.org)
  • In human beings, the depletion of B cells in sufferers treated with rituximab didn't increase the threat of TB reactivation (13, 14), and in macaques rituximab administration to Mtb-infected pets had limited results at the average person granuloma level (15). (thetechnoant.info)
  • Similar strong association was observed between HERV-H and the binding sites within ES cells for the pluripotency transcription factors NANOG, OCT4, and SOX2. (biomedcentral.com)
  • Either way, HERV-H RNA provides a specific marker for pluripotency in human cells. (biomedcentral.com)
  • In Stat1-deficient cells complemented with the Stat1 S727A mutant, Stat1alpha, or Stat1beta and treated with IFNtau, IRF-1 increased from 0 to 6 h, was maximal at 6 h, and decreased thereafter. (tamu.edu)
  • Preliminary data presented in this application indicates that Stat1 is constitutively present in the mitochondria of both human and mouse cells. (grantome.com)
  • Two alternatively spliced transcript variants encoding distinct isoforms of STAT1 have been described. (thermofisher.com)
  • One of our long-term goals is to understand how distinct Toxoplasma strains differ in their ability to cause disease in humans. (saeijlab.com)
  • Repolarization of ChemR23-expressing M1 macrophages with 10 nM RvE1 increases IL-10 transcription and phagocytosis of microbial particles, leading to a resolution-type macrophage distinct from the M2 phenotype. (aai.org)