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  • mice
  • Effect of RNA oligonucleotide targeting Foxo-1 on muscle growth in normal and cancer cachexia mice," Cancer Gene Therapy , vol. 14, no. 12, pp. 945-952, 2007. (hindawi.com)
  • Zerba E, Komoroski TE, Faulkner JA: Free radical injury to skeletal muscles of young, adult and old mice. (springer.com)
  • In diverse populations of normal healthy mice, the authors observed correlations between the abundance of mRNA transcripts related to mitochondrial biogenesis, the dystrophin-sarcoglycan complex, and nicotinamide adenine dinucleotide (NAD + ) synthesis, consistent with a potential role for the essential cofactor NAD + in protecting muscle from metabolic and structural degeneration. (musclecellnews.com)
  • Mutations in laminin 211 cause muscular dystrophy in mice and humans (Tome et al. (springer.com)
  • Exercise influences both the phase [ 15 ] and the amplitude [ 16 ] of circadian rhythms in mice, but this phenomenon is largely unexplored in human tissues. (biomedcentral.com)
  • In mdx mice, a model of human Duchenne muscular dystrophy (DMD), G-CSF mRNA and protein was down-regulated in limb and diaphragm muscle, but circulating G-CSF ligand levels were elevated. (frontiersin.org)
  • G-CSFR mRNA in the muscles of mdx mice was up-regulated however steady-state levels of the protein were down-regulated. (frontiersin.org)
  • Muscular Dystrophy
  • Chronic cardiac diseases are frequent findings in several forms of muscular dystrophy, including limb-girdle muscular dystrophies, caused by mutations in the sarcoglycan proteins that are involved in the maintenance of muscle integrity during contraction. (rupress.org)
  • Mutations in the Sgcb gene cause LMD2E (limb-girdle muscular dystrophy type 2E), often characterized by severe cardiomyopathy and mild muscle wasting. (rupress.org)
  • Mammalian
  • Mammalian skeletal muscle has the ability to regenerate and repair in response to exercise or injury. (asm.org)
  • Naguibneva I, Ameyar-Zazoua M, Polesskaya A, Ait-Si-Ali S, Groisman R, Souidi M, Cuvellier S, Harel-Bellan A (2006) The microRNA miR-181 targets the homeobox protein Hox-A11 during mammalian myoblast differentiation. (springer.com)
  • processes
  • J. G. Tidball, "Inflammatory processes in muscle injury and repair," American Journal of Physiology: Regulatory Integrative and Comparative Physiology , vol. 288, no. 2, pp. (hindawi.com)
  • proteins
  • Elevation of renal miR-196a/b expression by hydrodynamic-based delivery of a miR-196a/b-expressing plasmid before or shortly after UUO significantly downregulated profibrotic proteins, including collagen 1 and α -smooth muscle actin, and mitigated UUO-induced renal fibrosis. (asnjournals.org)
  • Adhesion proteins--an impact on skeletal myoblast differentiation. (abcam.com)
  • type 2 diabetic
  • Based on the presence of mitochondrial dysfunction in insulin-resistant conditions, we have examined whether Mfn2 expression is dysregulated in skeletal muscle from obese or nonobese type 2 diabetic subjects, whether muscle Mfn2 expression is regulated by body weight loss, and the potential regulatory role of tumor necrosis factor (TNF)α or interleukin-6. (diabetesjournals.org)
  • Muscle Mfn2 expression was also reduced in lean or in obese type 2 diabetic patients. (diabetesjournals.org)
  • A significant decrease in gene expression of subunits participating in complexes I-IV of the mitochondrial electron transport chain was observed in skeletal muscle of type 2 diabetic patients ( 3 , 4 ). (diabetesjournals.org)
  • modulate
  • The coordinated regulation of the circadian clock genes Cry1 , Per2 , and Bmal1 6 hours after RE and diurnal genes 18 hours after RE in the exercised leg suggest that RE may directly modulate circadian rhythms in human skeletal muscle. (biomedcentral.com)
  • gene
  • Even if the presence of gene amplification, activating point mutations, or ligand autocrine stimulation has been described, the most frequent alteration of the MET receptor in human tumors is, by far, overexpression ( 7, 8 ). (aacrjournals.org)
  • We then used quantitative PCR to validate the circadian expression of selected gene orthologs in mouse skeletal muscle. (biomedcentral.com)
  • stem
  • They further applied these devices to study drug responses, as well as the contractile development of human stem cell-derived laminar cardiac tissues over four weeks. (musclecellnews.com)
  • receptor
  • Immunoblotting of wild-type muscle lysates revealed that, not only were Id1 and Id3 highly upregulated within 24 h after injury, but other upstream components of the BMP pathway were as well, including the BMP receptor type II and phosphorylated Smad1/5/8 (pSmad1/5/8). (physiology.org)
  • The authors investigated the role of transient receptor potential channel-3 (TRPC3) in acetylcholine (ACh)-induced airway smooth muscle cell (ASMC) proliferation. (musclecellnews.com)
  • progression
  • Researchers evaluated the impact of miR-26b during the progression of cardiomyocyte differentiation from the P19 cell line. (musclecellnews.com)
  • After the incubation, each treatment group was evaluated for proliferation, cell cycle progression, and production of reactive oxygen species (ROS) using WST-1, flow cytometry, and CM-H2DCFDA, respectively. (sivb.org)
  • capacity
  • Human type 2 diabetes is associated with reduced capacity to oxidize glucose in the presence of insulin and, more importantly, to oxidize fatty acid in various conditions ( 1 , 2 ). (diabetesjournals.org)
  • mouse
  • Warren GL, Hayes DA, Lowe DA, Williams JH, Armstrong RB: Eccentric contraction-induced injury in normal and hindlimb-suspended mouse soleus and EDL muscles. (springer.com)
  • Confocal immunofluorescence microscopy revealed that activated Pax7 + myoblasts coexpressed nuclear pSmad1/5/8, Id1, and Id3 in injured mouse skeletal muscle sections. (physiology.org)
  • They utilized a conditional knockout mouse approach to examine the functional consequences of Dnmt1 depletion specifically in the developing muscle. (musclecellnews.com)
  • The additive effects of all four peptides gave the best results for both mouse cell lines tested, while primary human cell cultures differentiated equally well on most peptide surfaces tested. (springer.com)
  • These data show that a mixture of short biomimetic peptides can reliably promote differentiation in mouse and human myoblasts. (springer.com)
  • induce
  • Exercise causes structural changes in muscle and can induce phase shifts in circadian rhythms, fluctuations in physiology and behavior with a period of around 24 hours that are maintained by a core clock mechanism. (biomedcentral.com)