Human secretory. Medical search. Frequent questions

In ciliated cells, including bovine and Xenopus laevis rod photoreceptors, P/rds was robustly sensitive to endoglycosidase H, which is consistent with its bypassing the medial Golgi and traversing the unconventional secretory pathway. (jneurosci.org)
Most plasma membrane proteins are sorted by the trans -Golgi network (TGN) in the conventional secretory pathway. (jneurosci.org)
and is thus possibly a sign of P/rds trafficking through an unconventional secretory pathway. (jneurosci.org)
If unconventional secretion were to mediate the cilia trafficking of P/rds, then cooperation with the conventional secretory pathway that mediates the trafficking of rhodopsin would be required to ensure proper morphogenesis of the photoreceptive disk membranes. (jneurosci.org)
In order to elucidate the relationship between secretory pathway and processing for precursor molecule of peptide hormones, we performed immunoelectron microscopic studies to localize POMC-derived peptides in mouse cultured L cells (fibroblasts without secretory granules) and in mouse AtT20 cells (ACTH secreting pituitary tumor cells with secretory granules) which had been transformed with human POMC gene. (fujita-hu.ac.jp)
Using in vitro cell free systems, we demonstrated that apratoxin A prevents cotranslational translocation of proteins destined for the secretory pathway. (aspetjournals.org)
Our study indicates that apratoxins are new tools to study the secretory pathway and raises the possibility that inhibition of cotranslational translocation may be exploited for anticancer drug development. (aspetjournals.org)
In human cells, one-third of all polypeptides enter the secretory pathway at the endoplasmic reticulum (ER). (amrita.edu)
This Review summarizes the more recent biochemical, cellular and mouse model studies that underscore the importance of the ER acetylation process in maintaining protein homeostasis and autophagy within the secretory pathway, and its impact on developmental and age-associated diseases. (biologists.com)

However, as actual yields vary widely for individual proteins, GlycoFi is focusing on the improvement of protein yields in P. pastoris as part of the company's long term mission to develop yeast-based protein production technology for manufacturing therapeutic proteins with human glycosylation structures. (sbir.gov)
Full length native protein (purified) corresponding to Human IgA Secretory Component. (abcam.com)
Sera from residual specimens from NHANES 2001-2002 participants were tested for levels of human epididymal secretory protein E4 (HE4). (cdc.gov)
This research confirmed that deletion of some regions of the secretory signal sequence significantly improved the efficiency of HIP protein expression in P. pastoris . (springeropen.com)
Human CRISP-2, the ortholog of rodent testis specific protein 1 (Tpx1) is a secreted protein expressed in testis. (rndsystems.com)

sIgA (secretory immunoglobulin A). (bmj.com)

sIgA, secretory IgA. (nih.gov)

The senescence-associated secretory phenotype (SASP) is a hallmark of senescence with an important physiological impact, but how it is established is unclear. (rupress.org)
The altered secretory phenotype of infected astrocytes then impairs neuronal viability. (hindustantimes.com)
Moreover, human astrocyte infection elicits a secretory phenotype that reduces neuronal viability. (hindustantimes.com)

This gene product belongs to the SCAMP family of proteins, which are secretory carrier membrane proteins. (nih.gov)

It is now termed mammary secretory carcinoma because secretory carcinoma has sometimes been used to name tumors which develop in non-breast tissues but have the microscopic appearance of, and a critical gene abnormality found in, mammary secretory carcinoma. (wikipedia.org)
Their tumors' microscopic histopathology resembled that described in the pathology section of mammary secretory carcinoma and consisted of tumor cells that expressed the NTRK3-ETV6 fusion gene. (wikipedia.org)
Mutations in this gene are associated with susceptibility to obesity in humans. (nih.gov)
How do numerous non-coding variations in the human genome affect gene expression in the retina? (nih.gov)

In the absence of the region required for cilia targeting, P/rds was prohibited from entering the secretory pathways and was retained in the Golgi apparatus. (jneurosci.org)

As of 2021, 26 cases of secretory carcinoma of the skin had been reported. (wikipedia.org)

4 The proteins that occur in the mucus, including lactoferrin, lysozyme, and secretory IgA, are part of this defence system. (bmj.com)
Mature human CRISP-2 shares 86%, 73% and 71% amino acid sequence identity with the equine, mouse and rat proteins, respectively. (rndsystems.com)

The sialyltransferase ST6GAL1 that adds α2-6 linked sialic acids to N-glycans of cell surface and secreted glycoproteins is prominently associated with many human cancers. (nature.com)
Canonically, ST6GAL1 resides in the intracellular secretory apparatus and glycosylates nascent glycoproteins in biosynthetic transit. (nature.com)

Inhibition of SCAMP1 suppresses cell migration and invasion in human pancreatic and gallbladder cancer cells. (nih.gov)
Inhibition of human, ovine, and baboon neutrophil elastase with Eglin c and secretory leukocyte proteinase inhibitor. (docksci.com)
7 M'', These findings demonstrate marked differences in the inhibition kinetic properties of ovine and human elastase. (docksci.com)

The neutrophils from both species showed a significant increase in the production/release of prostaglandin E2 with exposure to 1.0 ppm, while the human cells also exhibited a significant increase at 0.4 ppm. (cdc.gov)

In short, this is a known list of sex organs that evolve from the same tissues in a human life. (wikibooks.org)

We conclude that the human pituitary gland secretes GH in volleys consisting of multiple secretory bursts, without measurable intervening tonic secretion. (elsevierpure.com)

Focusing on two individual healthy donors, whose milk was sampled longitudinally during the first 16 weeks of lactation, we demonstrate that the total repertoire of milk sIgA1 is dominated by only 50-500 clones, even though the human body theoretically can generate several orders of magnitude more clones. (uu.nl)
The previous studies successfully expressed recombinant human insulin precursors (HIP) in Pichia pastoris truncated and full-length α-factor recombinant clones. (springeropen.com)
This study aimed to compare the HIP expression from full-length and truncated α-factor secretory signals clones that grown in two types of media, buffered methanol complex medium (BMMY) and methanol basal salt medium (BSMM). (springeropen.com)

Discrete responses correlated with chemotactic and secretory functions. (jci.org)
Twenty-four-hour profiles of serum GH concentrations were accounted for by an average of 12 ± 1.2 (SE) discrete GH secretory bursts having a mean half-duration (duration at half-maximal amplitude) of 25 ± 2.3 min, indicating that 95% of daily GH secretion occurred in 8.8 h. (elsevierpure.com)
The majority (96%) of GH was secreted in volleys composed of multiple (4.0 ± 0.4) discrete secretory bursts. (elsevierpure.com)

To date, yeast is the host cell of choice used for the production of recombinant human insulin because of its advantages over other cells [ 4 ]. (springeropen.com)

This Mouse Anti-Human IgA, Secretory (HP6141) is validated for use in ELISA for the detection of Human IgA, Secretory. (emdmillipore.com)
ABSTRACT Crude antigenic preparations from Setaria equina were used in ELISA and Western blotting to examine cross- reaction with human sera from areas endemic for bancroftian filariasis. (who.int)
ELISA et transfert Western afin d'étudier la réaction croisée avec des sérums humains en provenance de zones endémiques pour la filariose de Bancroft. (who.int)

Concerning a future clinical application of proteinase inhibitors, the baboon seems a more suitable model than sheep to evaluate the effects of Eglin c and SLPI, since both inhibitors block baboon and human elastase with comparable efficiency. (docksci.com)
Secretory Leukocyte Proteinase Inhibitor (SLPI) inhibiert die Elastasen aller drie Spezies mit großer Ef- fizienz. (docksci.com)
SLPI, Secretory leukocyte proteinase inhibitor. (docksci.com)
Two promising low molecular mass serine proteinase inhibitors, Eglin c and secretory leukocyte proteinase inhibitor (SLPI), have been produced in their recombinant forms and been demonstrated to effectively inhibit human leukocyte elastase in vitro13'51. (docksci.com)
In this brief contribution we compare the association rate constants of Eglin c and SLPI with human and ovine, as well as with baboon neutrophil elastase, since the baboon is increasingly used by our group and others for studies of elastase-induced tissue damage during shock'10"121. (docksci.com)

However, the metabolic role and possible consequences of adipose tissue as a secretory organ in critically ill patients has not been investigated to date. (europa.eu)
To test this obesity we will characterize adipose tissue as a secretory organ using interstitial fluid sampling techniques and advanced peptide analysis in critically ill patients and healthy controls. (europa.eu)
RNA-sequencing was used to investigate the expression of CHL1 in human adipose, liver, muscle, and human islets. (lu.se)

The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)

Rapid changes in light scattering from human polymorphonuclear leukocytes exposed to chemoattractants. (jci.org)

Human insulin was the first FDA-approved biopharmaceutical drug produced through recombinant DNA technology. (springeropen.com)
Human insulin (HI) was the first medical biotechnology drug produced with this technology and was classified as the first biopharmaceutical approved by the FDA [ 1 , 2 ]. (springeropen.com)
CHL1 expression was found to correlate positively with insulin secretory index, GLP1R but inversely with HbA 1c and BMI. (lu.se)

The time course of spontaneous growth hormone (GH) secretion was studied in 12 normal men by analyzing serum GH concentrations measured in blood collected at 5-min intervals over 24 h with a multiple-parameter deconvolution model to simultaneously resolve endogenous GH secretory and clearance rates. (elsevierpure.com)
Diagnosis is by measurement of serum testosterone , luteinizing hormone, and follicle-stimulating hormone and by stimulation tests with human chorionic gonadotropin or gonadotropin-releasing hormone. (msdmanuals.com)

The biphasic nature of the light-scattering responses to chemoattractants, moreover, correlates with the dual regulation of the chemotactic and secretory responses of leukocytes. (jci.org)
In contrast to vaccination, natural infection in humans and experimental infections in animals induce strong secretory IgA responses in the naso-pharynx and in the lungs. (frontiersin.org)

Several studies have shown that secretory IgA may be instrumental in the control of B. pertussis infection. (frontiersin.org)
Supporting the hypothesis of astrocyte infection, neural stem cell-derived human astrocytes in vitro are susceptible to SARS-CoV-2 infection through a noncanonical mechanism that involves spike-NRP1 interaction. (hindustantimes.com)
In the presence of active S. equina infection, antigens from the adult and microfilaraemic stages showed the highest degree of cross-reaction with human sera. (who.int)

In Western blots, no cross-reactivity with recombinant human CRISP-3 is observed. (rndsystems.com)

In particular, the dialogue between T cells and beta cells is far more complex in humans and recent evidence supports potential type 1 diabetes 'endotypes' based on age at onset [ 8 , 9 ]. (springer.com)
In the human reproductive process, two kinds of sex cells ( gametes), are involved: the male gamete (sperm), and the female gamete (egg or ovum). (wikibooks.org)
The main causative agent of whooping cough is Bordetella pertussis ( 2 ), a gram negative coccobacillus which is able to colonize the human upper respiratory tract by attaching to the ciliated cells. (frontiersin.org)
Our investigations utilize in vivo mouse retina and human retinal organoids derived from pluripotent stem cells as study systems. (nih.gov)
Neutrophil infiltration to sites of tissue injury occurs during an inflammatory response, and increased numbers of these cells within the pulmonary airspaces have been described in humans and laboratory animals following exposure to ozone (O3), a potent irritant present in photochemical smog. (cdc.gov)
Thromboxane B2 (TxB2) levels were significantly reduced in the NCM from both human and rabbit cells exposed at 1 ppm. (cdc.gov)
Rabbit neutrophils showed a significant increase in phagocytic uptake of latex spheres with exposure to 0.4 and 1.0 ppm O3, whereas the human cells exhibited no change in such activity at any ozone concentration. (cdc.gov)
The possible donor-host rejection of human ES cells is another concern 3 . (bvsalud.org)
To date, four types of human dental stem cells have been isolated and characterized: (i) dental pulp stem cells (DPSCs) 12 (ii) stem cells from exfoliated deciduous teeth (SHED) 21 (iii) stem cells from apical papilla (SCAP) 31 (iv) periodontal ligament stem cells (PDLSCs) 28 . (bvsalud.org)

Secretory carcinoma was once used exclusively as a term for rare, slowly growing breast tumors without reference to their location in the breast. (wikipedia.org)

Mammary analogue secretory carcinoma, also termed MASCSG, is a slow growing salivary gland neoplasm (the SG in MASCSG stands for salivary gland) that develops in adults and, in a significant number of cases, children. (wikipedia.org)
Salivary gland-type carcinoma of the thyroid, also termed intrathyroidal mammary analog secretory carcinoma, has been reported in 12 cases in the English language. (wikipedia.org)
Salivary gland-type carcinoma of the thyroid appears to be a more aggressive disease than mammary secretory carcinoma or MASCSG. (wikipedia.org)

AN - check the tag INFANT HN - 2008 FX - Child Nutrition FX - Infant Nutrition Physiology FX - Milk FX - Milk, Human DH - Adolescent Nutrition DI - 052508 MN - SP6.021.067 MS - Nutrition of persons 10 through 19 years of age. (bvsalud.org)

Effect of in vitro exposure to ozone on eicosanoid metabolism and phagocytic activity of human and rabbit neutrophils. (cdc.gov)
This study examined the effects of O3 on selected secretory and functional activities of human and rabbit neutrophils isolated from peripheral whole blood. (cdc.gov)

Summary: The association rate constants (kon) of human, ovine, and baboon neutrophil elastase with two recombinant serine proteinase inhibitors (Eglin c, secretory leukocyte proteinase inhibitor) were compared. (docksci.com)

In this study, we provide evidence that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is found in the human brain, where it infects astrocytes and to a lesser extent, neurons. (hindustantimes.com)

Members of the human herpesvirus (HHV) and human papillomavirus (HPV) families cause the most common primary viral infections of the oral cavity. (medscape.com)

Such volleys of GH secretion were separated by 171 ± 19 min, whereas their constituent individual secretory events occurred every 36 ± 1.7 min (P = 0.0001). (elsevierpure.com)

CL4 clone, which utilized a truncated α-factor in the P. pastoris HIP expression cassette, significantly expressed HIP 8.97 times (in BMMY) and 1.17 times (in BSMM) higher than HF7 clone, which used a full-length α-factor secretory signal. (springeropen.com)

Nonetheless, many other viral infections can affect the oral cavity in humans, either as localized or systemic infections. (medscape.com)

Sixty one plants reputed to have anti-fertility activity were tested on female Sprague-Dawley rats, in order to isolate active compounds with a potential for use in human fertility regulation. (who.int)

models to predict the kinetics in humans. (cdc.gov)

This work extended earlier real-time studies of the secretory process using the same techniques (P. Thomas et al. (the-scientist.com)
The process of vision begins in the retina, and in humans, the retina supplies almost 30% of the sensory input received by the brain. (nih.gov)

Human studies demonstrate measurements of s-SPSG under different conditions, from various regions of the body. (rsc.org)
Immunohistopathological studies of pancreases from individuals with type 1 diabetes are generally compatible with these observations made in mice (see references below) but have exposed additional phenomena peculiar to the natural history of the disease in humans. (springer.com)

The FQPA requires that the Administrator of the Environmental Protection Agency (EPA) consult with the Secretary of the Department of Health and Human Services (which includes ATSDR) in implementing some of the provisions of the act. (cdc.gov)

Nevertheless, I was a little surprised that in your discussion of the recovery of secretory vesicle membrane you failed to cite the first study to define, both quantitatively and kinetically, secretory vesicle membrane retrieval using these techniques (P. Thomas et al. (the-scientist.com)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. (novusbio.com)

This pattern of in vivo GH release in normal humans is consistent with a model of high-frequency GH-releasing hormone secretory events super-imposed on low-frequency episodes of somatostatin withdrawal. (elsevierpure.com)

Reappraisal of the secretory potency and disappearance rate of pure human minigastrin. (bmj.com)

Human CRISP-2 also shares 71% amino acid sequence homology with human CRISP-3. (rndsystems.com)

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes1

Health Care5

Pathway9

Protein5

Immunoglobulin1

SIgA1

Phenotype3

Membrane proteins1

Gene4

Pathways1

20211

Proteins2

Glycoproteins2

Inhibition3

Species1

Tissues1

Pituitary1

Clones3

Discrete3

Yeast1

ELISA3

SLPI5

Adipose3

Centers for Diseas1

Polymorphonuclear leukocytes1

Insulin3

Serum2

Responses2

Infection3

Reactivity1

Cells9

Tumors1

Salivary3

Milk1

Neutrophils2

Recombinant1

Respiratory1

Primary1

Secretion1

Significantly1

Infections1

Regulation1

Kinetics1

Process2

Studies2

Department of Healt1

Study1

Clinical1

Vivo1

Rate1

Amino Acid Seq1