• DNA-directed RNA polymerase II subunit RPB4 is an enzyme that in humans is encoded by the POLR2D gene. (wikipedia.org)
  • This gene encodes the fourth-largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. (wikipedia.org)
  • In yeast, this polymerase subunit is associated with the polymerase under suboptimal growth conditions and may have a stress protective role. (wikipedia.org)
  • hPaf1/PD2, a subunit of the human PAF-complex, involved in the regulation of transcriptional elongation has oncogenic potential. (nebraska.edu)
  • The product Assay kit for Guinea pig Mediator of RNA polymerase II transcription subunit 14(MED14) (ELISA) is intended to be used for research purposes only. (rnagrade.com)
  • The product Assay kit for Guinea pig Mediator of RNA polymerase II transcription subunit 14(MED14) (ELISA) should be kept between two and eight degrees Celsius to ensure the retention of the stability and reactivity of the reagents included in the kit. (rnagrade.com)
  • Polymerase (RNA) II (DNA directed) Polypeptide K, also known as POLR2K is am ember of the archaeal RpoP/eukaryotic RPC10 RNA polymerase subunit family. (prospecbio.com)
  • In addition, the other two DNA-directed RNA polymerases share this subunit. (prospecbio.com)
  • Mediator of RNA polymerase II transcription, subunit 28 homolog (yeast). (invivogen.com)
  • Here, we quantified Mediator-controlled Pol II kinetics by coupling rapid subunit degradation with orthogonal experimental readouts. (nih.gov)
  • Like its counterpart in yeast, this subunit may be shared by the other two DNA-directed RNA polymerases. (origene.com)
  • TGF-β1 binding to either subunit initiates their assembly into a heteromeric protein complex that consists of two type I and two type II subunits. (springer.com)
  • Co-transcriptional pre-mRNA processing relies on reversible phosphorylation of the carboxyl-terminal domain (CTD) of Rpb1, the largest subunit of RNA polymerase II (RNAP II). (cipsm.de)
  • Physique 2 The multi-subunit general transcription apparatus The same group has recently exhibited that p53 target promoters are structurally diverse and display pronounced differences in Poll II occupancy [9]. (opioid-receptors.com)
  • We mapped all estrogen receptor and RNA polymerase II binding sites on a genome-wide scale, identifying the authentic cis binding sites and target genes, in breast cancer cells. (nature.com)
  • Some miRNAs are hosted in pri-miRNAs annotated as long non-coding RNAs (lncRNAs) and defined as MIRHGs (for miRNA Host Genes). (mdpi.com)
  • Guinea pig ELISA kits for plasma and sera samples are used to study human genes through the guinea pig model (Cavia porcellus), also called the cavy rodent model. (rnagrade.com)
  • The Pre-Initiation Complex (PIC), which consists of Mediator, TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, and RNA polymerase II (pol II), governs the expression of all protein-coding and most non-coding RNA genes in the human genome and is over 4.0 MDa in size. (colorado.edu)
  • This was accompanied by a selective and pronounced disruption of cell type-specifying transcriptional circuits, whose constituent genes featured exceptionally high rates of Pol II turnover. (nih.gov)
  • Maintenance of transcriptional activity at these genes was linked to an unexpected, CDK9-dependent compensatory feedback loop that elevated Pol II pause release rates genome-wide. (nih.gov)
  • In the vast majority of eukaryotes, OXPHOS is operated by genes encoded by two genomes - most in the nuclear genome (nDNA) and 37 in the short circular mitochondrial genome (mtDNA). (biorxiv.org)
  • This bi-genomic division is accompanied by profoundly different transcription regulatory system: whereas nDNA-encoded genes are transcribed individually by RNA polymerase 2 and the general nuclear transcription machinery, mtDNA transcription is long known to be regulated mainly by a dedicated RNA polymerase (POLRMT) and mtDNA-specific transcription factors (TFAM and TFB2) ( Shutt and Shadel 2010 ). (biorxiv.org)
  • Mutations in two genes, CBP (CREBBP) and EP300 , have been identified in affected individuals. (medscape.com)
  • Both genes are highly conserved, and their proteins are thought to have 2 functions: (1) formation of a bridge or scaffold between the DNA-binding transcription factors and the RNA polymerase II complex and (2) serving as histone acetyltransferases that open the chromatin structure, a process essential for gene expression. (medscape.com)
  • With a kinetic modeling approach we ascribe function to the observed OCT4-SOX2-NANOG network by making plausible assumptions about the interactions between the transcription factors at the gene promoter binding sites and RNA polymerase (RNAP), at each of the three genes as well as the target genes. (lu.se)
  • Explore the normal functions of human genes and the health implications of genetic changes. (medlineplus.gov)
  • Mammalian RNA polymerase II (Pol II) transcription termination is an essential step in protein-coding gene expression that is mediated by pre-mRNA processing activities and DNA-encoded terminator elements. (ox.ac.uk)
  • The function of RNA Polymerase II (Pol2) is essential for eukaryotes as it transcribes all cellular mRNA. (uni-wuerzburg.de)
  • cDNAs of Guinea pigs are also very popular.The activation of transcription factor subunits is the first step of gene expression, in which a particular segment of DNA is copied into RNA (mRNA) by the enzyme RNA polymerases. (rnagrade.com)
  • These results suggest a similar contribution of PCIF1 to the fine regulation of RNA polymerase II activity in mammals, in addition to its mRNA methylation activity, whose role in mRNA translation efficiency is actively studied but still controversial. (cea.fr)
  • regulation by RNA polymerase II (RNA Pol II) is a highly regulated process involving the action of multiple transcription factors that collectively regulate synthesis of messenger RNA (mRNA). (opioid-receptors.com)
  • M2, matrix 2 protein. (cdc.gov)
  • Orthologous to human ZNF565 (zinc finger protein 565). (jax.org)
  • High-resolution mapping of the protein interaction network for the human transcription machinery and affinity purification of RNA polymerase II-associated complexes. (genscript.com)
  • The localization of the HKE2 gene to the class II region, its cytoplasmic expression and putative protein-binding domain suggest that HKE2 may function in adaptive immunity and cancer. (genscript.com)
  • Integrator and protein phosphatase 2A (PP2A) form a complex that dephosphorylates paused RNA polymerase II (Pol II), cleaves the nascent RNA, and terminates transcription. (rcsb.org)
  • Recombinant protein encompassing a sequence within the center region of human NDP52. (genetex.com)
  • Studies carried out by scientists at IRIG, in collaboration with the University of Geneva, on the fruit fly model Drosophila melanogaster have revealed the role of Pcif1 in the control of gene expression, despite the fact that this protein has completely lost its RNA methyltransferase activity compared to its mammalian counterpart PCIF1. (cea.fr)
  • Researchers at IRIG, in collaboration with the University of Geneva, focused on a RNA mammalian methyltransferase, the PCIF1 protein (homologous to the Drosophila Pcif1 protein), which adds an extra methyl group to m 6 A (m 6 adenosine) to form m 6 Am when the first transcribed nucleotide is an adenosine. (cea.fr)
  • During evolution, this protein naturally lost its catalytic activity in Drosophila where Pcif1 is, like its human counterpart, expressed in the nucleus and associated with the C-terminal domain of RNA polymerase (RNA Pol II). (cea.fr)
  • This protein binds to the phosphorylated form of serine 5 of RNA polymerase II ( Figure ) and may directly modulate its activity or promote the recruitment of chromatin components. (cea.fr)
  • Transcription in eukaryotes is carried out by three main RNA polymerases: Pol I, II, and III. (mdpi.com)
  • POLR2K is one of the smallest subunits of RNA polymerase II, the polymerase is responsible for synthesizing messenger RNA in eukaryotes. (prospecbio.com)
  • The Integrator endonuclease docks to the RNA exit site and opens to cleave nascent RNA about 20 nucleotides from the Pol II active site. (rcsb.org)
  • Initially, DNA is taken from the clinical specimen, as well as certain sequence-specific oligonucleotide primers, thermostable DNA polymerase, nucleotides, and buffer. (medscape.com)
  • Finally, nucleotides complementary to the target DNA are added extending each primer by the thermostable DNA polymerase. (medscape.com)
  • 1. Is electrophilic or can be metabolical y activated to electrophiles does not alter the linear sequence of nucleotides (or bases) in the DNA, 2. (who.int)
  • To this end we used deep sequencing (GRO-seq and PRO-seq) and analyzed nascent mtDNA-encoded RNA transcripts in diverse human cell lines and metazoan organisms. (biorxiv.org)
  • Mediator is a common target of DNA-binding transcription factors (TFs) and also interacts with various components within the Pre-Initiation Complex (PIC), which consists of TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, Mediator itself, and pol II. (colorado.edu)
  • The Mediator complex directs signals from DNA-binding transcription factors to RNA polymerase (Pol) II. (nih.gov)
  • Despite this pivotal position, mechanistic understanding of Mediator in human cells remains incomplete. (nih.gov)
  • Consistent with a model of condensate-driven transcription initiation, large clusters of hypo-phosphorylated Pol II rapidly disassembled upon Mediator degradation. (nih.gov)
  • Collectively, our work positions human Mediator as a globally acting coactivator that selectively safeguards the functionality of cell type-specifying transcriptional networks. (nih.gov)
  • Using a combination of techniques in cell and molecular biology, biochemistry, genomics, and super-resolution microscopy, he will continue his investigations of the behaviors of the enzyme involved in the transcription of DNA to RNA molecules. (mit.edu)
  • The enzyme, RNA polymerase II, has been well-studied in vitro, but Cissé's work looks at these transient biological interactions within living cells. (mit.edu)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Polymerase DNA Directed Delta 1 (POLd) in Tissue homogenates, cell lysates and other biological fluids. (myelisakit.com)
  • Quantification of influenza virus RNA in aerosols in patient rooms. (cdc.gov)
  • Background: The potential for human influenza viruses to spread through fine particle aerosols remains controversial. (cdc.gov)
  • We collected ten air samples each in the presence of at least one patient with confirmed influenza A virus infection, and tested the samples by reverse transcription polymerase chain reaction. (cdc.gov)
  • The polymerase of influenza is very mistake prone and causes the virus to mutate rapidly. (cdc.gov)
  • Both WHO's Global Outbreak Alert and Response Network and Global Influenza Network were on high alert after reports from Hong Kong, on 19 and 20 February, confirming two cases (one fatal) of infection with avian influenza virus A, subtype H5N1. (who.int)
  • Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. (jax.org)
  • During transcription, a DNA sequence is read by an RNA polymerase, which produces a complementary, anti-parallel RNA strand called a primary transcript. (rnagrade.com)
  • Analysis of non-human organisms enabled de novo mtDNA sequence assembly, as well as detection of previously unknown mtDNA TIS, pausing, and transcription termination sites with unprecedented accuracy. (biorxiv.org)
  • Reverse transcription is the synthesis of a complementary DNA sequence from an RNA template using reverse transcriptase, which is an RNA-dependent DNA polymerase. (medscape.com)
  • Herein we elaborated effects of TGF-β1 on TJs of primary human bronchial epithelial cells. (springer.com)
  • Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. (rnagrade.com)
  • Toward this objective, ChIP-Seq data of 14 S/MAR binding proteins were analyzed and the binding site coordinates of these proteins were used to prepare a non-redundant S/MAR dataset of human genome. (researchgate.net)
  • In disorders such as leukemia, increased expression of antiapoptotic proteins, such as Bcl-2, is required for disease maintenance ( 3 ), confers drug resistance ( 4 ), and is associated with poor clinical outcome ( 5 ). (aacrjournals.org)
  • ADP-ribosylation is a post-translational modification of proteins that occurs mostly in response to cellular stress and is catalysed by members of the diverse poly-ADP-ribose (PAR) polymerase (PARP/ARTD) family. (cipsm.de)
  • This expression is strictly dependent on the synthesis of messenger RNAs transcripts from the DNA molecule and their subsequent translation into proteins by the ribosomes. (cea.fr)
  • RNA, lipids, and proteins. (who.int)
  • The synthesis of this RNA in vitro and in vivo, and the close proximity of its 5′ end to the promoter of the α1 globin gene suggest a common mechanism regulating the transcriptional initiation of both the upstream and the major α1 globin RNAs. (tmu.edu.tw)
  • Surprisingly, accurate detection of human mtDNA transcription initiation sites (TIS) in the heavy and light strands revealed a novel conserved transcription pausing site near the light strand TIS, upstream to the transcription-replication transition region. (biorxiv.org)
  • Figure1) 1 are kinase inhibitors that impair transcription initiation by targeting components of the Pol II pre-initiation complex. (opioid-receptors.com)
  • This is achieved by the ability of p53 to establish markedly different affinities of Poll II on its diverse target promoters and recruit transcriptional initiation components in a stress-specific manner. (opioid-receptors.com)
  • PubMed] 3 Morachis J Huang R Emerson B. Id of Kinase Inhibitors the mark Transcription Initiation by RNA Polymerase II. (opioid-receptors.com)
  • Proper regulation of gene expression is fundamental to every major physiological process, and changes in gene expression patterns are hallmarks of human development and disease. (colorado.edu)
  • The role of RNA Polymerase II contiguity and long-range interactions in the regulation of gene expression in human pluripotent stem cells. (muni.cz)
  • Treatment Human immunodeficiency virus (HIV) infection results from 1 of 2 similar retroviruses (HIV-1 and HIV-2) that destroy CD4+ lymphocytes and impair cell-mediated immunity, increasing risk of certain. (msdmanuals.com)
  • in Human Immunodeficiency Virus (HIV) Infection. (msdmanuals.com)
  • Recommended infant laboratory evaluation includes both molecular (real-time reverse transcription-polymerase chain reaction [rRT-PCR]) and serologic (immunoglobulin M [IgM]) testing. (cdc.gov)
  • The diagnosis of many infectious diseases, both viral and bacterial, may include the use of reverse transcriptase-polymerase chain reaction (RT-PCR). (medscape.com)
  • [ 1 ] The resultant complementary DNA is amplified by polymerase chain reaction (PCR). (medscape.com)
  • Among 20 laboratories testing Module A, 17 (85%) correctly detected DENV RNA by reverse transcription polymerase chain reaction (RT-PCR), 18 (90%) correctly determined serotype and 19 (95%) correctly identified CHIKV by RT-PCR. (who.int)
  • Participants positive for Hepatitis C (HCV) antibody are eligible only if polymerase chain reaction is negative for HCV RNA. (who.int)
  • MicroRNAs (miRNAs) are small regulatory non-coding RNAs, resulting from the cleavage of long primary transcripts (pri-miRNAs) in the nucleus by the Microprocessor complex generating precursors (pre-miRNAs) that are then exported to the cytoplasm and processed into mature miRNAs. (mdpi.com)
  • Two receptor subunits are known, receptor type I and type II subunits. (springer.com)
  • Within this complex, type II subunits phosphorylate type I subunits at their N-terminal domain. (springer.com)
  • analyzed the impact of multiple kinase inhibitors on RNA transcriptional activity along three p53 target gene core regulatory elements using transcription and electrophoretic mobility shift (EMSA) assays. (opioid-receptors.com)
  • Diagnostic kits/assays tested for the molecular diagnosis of SARS-CoV-2 infection in São Paulo, Brazil. (bvsalud.org)
  • Twenty-four national-level public health laboratories performed routine diagnostic assays on a proficiency testing panel consisting of two modules. (who.int)
  • Entrez Gene: POLR2D polymerase (RNA) II (DNA directed) polypeptide D". Jeang KT (1998). (wikipedia.org)
  • POLR2K Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 81 amino acids (1-58 a.a) and having a molecular mass of 9.4kDa. (prospecbio.com)
  • However, a comprehensive genome-wide map of human S/MARs is yet not available. (researchgate.net)
  • Whereas promoter databases list up to 40,000 known and potential Pol II promoter sequences, fewer than ten Pol II terminator sequences have been described. (ox.ac.uk)
  • Near-atomic resolution visualization of human transcription promoter opening. (expasy.org)
  • The RNA polymerase II primary promoter - the gateway to transcription. (opioid-receptors.com)
  • Integrator does not bind the DNA clamps formed by Pol II and DSIF, enabling release of DNA and transcription termination. (rcsb.org)
  • Overall, we define cellular mechanisms of how a translocating pathobiont induces human T- and B-cell-dependent autoimmune responses, providing a framework for developing host- and microbiota-derived biomarkers and targeted therapies in extraintestinal autoimmune diseases. (bvsalud.org)
  • Using our knowledge of the human β-globin terminator mechanism, we have developed a selection strategy for mapping mammalian Pol II terminator elements. (ox.ac.uk)
  • Mammalian cell lines were subjected to extensive safety testing to establish a cell line that is human pathogens free, while maintaining sufficient vaccine yield. (cdc.gov)
  • Biological assembly 2 assigned by authors. (rcsb.org)
  • As a graduate student at Cornell University, she employed the invertebrate model organism C. elegans, and made significant contributions to the discovery of RNA interference (RNAi) as well as understanding of asymmetric cell divisions. (ucsf.edu)
  • The results of this analysis pave the way for the full understanding of Pol II termination pathways and their roles in gene expression. (ox.ac.uk)
  • We show here that the translocating pathobiont Enterococcus gallinarum induces human IFNγ + Th17 differentiation and IgG3 subclass switch of anti- E. gallinarum RNA and correlating anti-human RNA autoantibody responses in patients with systemic lupus erythematosus and autoimmune hepatitis. (bvsalud.org)
  • These findings provide a mechanistic basis for simultaneously targeting Mcl-1 and Bcl-2/Bcl-xL in leukemia. (aacrjournals.org)
  • Human isolates from the second outbreak. (cdc.gov)
  • Of the 120 isolates analysed, 118 (98.3%) were identified as M. tuberculosis complex and 2 (1.7%) were identified as mycobacteria other than M. tuberculosis. (who.int)
  • The results showed that those 2 isolates were multi-drug resistant and the DNA sequencing analysis showed that the alignment of nucleic acid of DNA in isolates of mycobacteria other than M. tuberculosis was different from that of M. tuberculosis complex. (who.int)
  • Costunolide is an Inhibitor of human telomerase activity (IC50 = 65 μM in MCF-7 breast cancer cells). (adooq.com)
  • Lurbinectedin is under clinical development by Jazz Pharmaceuticals and currently in Phase II for Human Epidermal Growth Factor Receptor 2 Negative Breast Cancer (HER2- Breast Cancer). (pharmaceutical-technology.com)
  • According to GlobalData, Phase II drugs for Human Epidermal Growth Factor Receptor 2 Negative Breast Cancer (HER2- Breast Cancer) have a 49% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. (pharmaceutical-technology.com)
  • It will be important to determine how p53 directs the recruitment of Poll II and specific cofactors to its different focus on promoters before and after tension to generate the correct transcriptional response and exactly how this technique fails in individual cancers. (opioid-receptors.com)
  • Laboratory testing is recommended for 1) infants born to mothers with laboratory evidence of Zika virus infection during pregnancy and 2) infants who have abnormal clinical or neuroimaging findings suggestive of congenital Zika syndrome and a maternal epidemiologic link suggesting possible transmission, regardless of maternal Zika virus test results. (cdc.gov)
  • Congenital Zika syndrome is a recently recognized pattern of congenital anomalies associated with Zika virus infection during pregnancy that includes microcephaly, intracranial calcifications or other brain anomalies, or eye anomalies, among others ( 2 ). (cdc.gov)
  • A wide range of neurologic abnormalities, in addition to microcephaly, has been observed among infants with presumed or confirmed congenital Zika virus infection ( 2 , 4 ). (cdc.gov)
  • Consistent with increased transcriptional activity of retrotransposons in cancer cells we found significantly higher levels of L1 retrotransposon RNA expression in prostate tumors compared to normal-matched controls. (nih.gov)
  • Recent ChIP experiments of human and mouse embryonic stem cells have elucidated the architecture of the transcriptional regulatory circuitry responsible for cell determination, which involves the transcription factors OCT4, SOX2 and NANOG. (lu.se)
  • Collectively, these findings suggest down-regulation of Mcl-1 by either CDK inhibitors or genetic approaches dramatically potentiate ABT-737 lethality through cooperative interactions at two distinct levels: unleashing of Bak from both Bcl-xL and Mcl-1 and simultaneous induction of Bak activation and Bax translocation. (aacrjournals.org)
  • These observations have prompted the development of small-molecule Bcl-2 inhibitors (refs. (aacrjournals.org)
  • Integrase inhibitors prevent HIV DNA from being integrated into human DNA. (msdmanuals.com)
  • Chemical conversion of human conventional Pluripotent Stem Cells to Trophoblast Stem Cells. (axonmedchem.com)
  • Revealing cell populations catching the early stages of the human embryo development in naïve pluripotent stem cells. (axonmedchem.com)
  • The aim of this workshop was to assess the progress that has been made over the past 2 years in bringing effective therapeutic protocols that use agents capable of reverting pathologic epigenetic changes into the clinic. (aacrjournals.org)
  • Not for any clinical, therapeutic, or diagnostic use in humans or animals. (genetex.com)
  • Therapeutic approaches based on these principles include 1) reduction of reinoculation, 2) combination antiviral therapy, 3) immunomodulation, 4) antiplatelet/antithrombotic therapy, and 5) administration of oxygen, monitoring, and telemedicine. (rumormillnews.com)
  • These mobile genetic elements play important roles in shaping genomes during evolution, and have been implicated in the etiology of many human diseases. (nih.gov)
  • In wake of paper describing genetic modification of human embryos, scientists disagree about ethics. (natureasia.com)
  • Also, the repertoire of Cryptococcus neoformans may represent a better model fungal system within which to study the functions of the PPIases as its genome size and genetic tractability are equal to those of Saccharomyces cerevisiae , whilst its repertoires exhibits greater orthology to that of humans. (biomedcentral.com)
  • 3 classes inhibit reverse transcriptase by blocking its RNA-dependent and DNA-dependent DNA polymerase activity. (msdmanuals.com)
  • Ectopic Mcl-1 expression attenuates Bak activation and apoptosis by ABT-737 + roscovitine, whereas cells overexpressing Bcl-2 or Bcl-xL remain fully sensitive. (aacrjournals.org)
  • Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and transcription cis-regulatory region binding activity. (jax.org)
  • However, the role of DRAM2 in the progression of human neoplasms is still unknown. (cancerindex.org)
  • Some fungi have been used as model systems to investigate the role of PPIases within the cell, however how representative these repertoires are of other fungi or humans has not been fully investigated. (biomedcentral.com)
  • Molecular portraits of human breast tumours. (nature.com)
  • The Taatjes lab investigates the molecular mechanisms by which the human transcription machinery functions and is regulated. (colorado.edu)
  • Whereas mammals (chimpanzee, rhesus macaque, rat, and mouse) showed a human-like mtDNA transcription pattern, the invertebrate pattern (Drosophila and C. elegans) profoundly diverged. (biorxiv.org)
  • Approximately 9 months of the severe acute respiratory syndrome coronavius-2 (SARS-CoV-2 [COVID-19]) spreading across the globe has led to widespread COVID-19 acute hospitalizations and death. (rumormillnews.com)
  • Tracking SARS-CoV-2 mutations and variants through the COG-UK-Mutation Explorer. (cdc.gov)
  • Mutations in the SARS-CoV-2 RNA dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms. (cdc.gov)
  • SARS-CoV-2 Point Mutation and Deletion Spectra and Their Association with Different Disease Outcomes. (cdc.gov)
  • SARS-CoV-2 variant Delta rapidly displaced variant Alpha in the United States and led to higher viral loads. (cdc.gov)
  • SARS-CoV-2 for the use of kits available during this emergency, without an accurate evaluation of their performance. (bvsalud.org)
  • This rate is patterns, gene sequencing, immuno- Centre for Disease Prevention and higher than that of severe acute respira- genicity and the animal-human and hu- Control (ECDC) and the National In- tory syndrome coronavirus (SARS), man-human interfaces. (who.int)
  • Severe acute respiratory syndrome (SARS) is a new infectious disease in human beings, first recognized in late February 2003, when cases of atypical pneumonia of unknown cause began appearing among staff at a hospital in Hanoi (Viet Nam). (who.int)
  • As we recently reported, analysis of 77 FHWT by whole genome sequencing (WGS, 58 patients) or whole exomic sequencing (WES,19 patients) identified 825 high-quality somatic, non-synonymous variants, with an average of 11 candidate mutations/case (range 2-42) (ref. 6 ). (nature.com)
  • Disruption of the human CBP gene, either by gross chromosomal rearrangements or by point mutations, leads to Rubinstein-Taybi syndrome. (medscape.com)
  • Integrator binds Pol II and the pausing factors DSIF and NELF to exclude binding of the elongation factors SPT6 and PAF1 complex. (rcsb.org)
  • The PHD finger binds two zinc ions using the so-called 'cross-brace' motif and is thus structurally related to the RING finger and the FYVE finger . (embl-heidelberg.de)
  • The fly Pcif1 expressed in the nucleus and binds the phosphorylated C-terminal domain (CTD) of RNA Pol II (at the level of phosph orylated s erine 5). (cea.fr)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human Polymerase DNA Directed Gamma 1 (POLg1) in samples from tissue homogenates, cell lysates or other biological fluids. (myelisakit.com)
  • Depending on the epitopes used human ELISA kits can be cross reactive to many other species. (rnagrade.com)
  • There are thousands of species of mushrooms, but approximately 100 species of mushrooms casue the majority of cases of poisoning when eaten by humans, and only 15-20 mushroom species are potentially lethal when ingested. (medscape.com)
  • Each poisonous mushroom species contains 1 or more toxins, which may be classified on the basis of the mushroom's physiologic and clinical effects in humans, the target organ toxicity, and the time to symptom onset. (medscape.com)
  • Some porcine sapoviruses are genetically related to human caliciviruses, which has raised public health concerns over animal reservoirs and the potential cross-species transmission of sapoviruses. (lu.se)
  • The repertoires of Cryptococcus neoformans, Aspergillus fumigatus , and Aspergillus nidulans were found to exhibit the highest orthology to the human repertoire, and Saccharomyces cerevisiae one of the lowest. (biomedcentral.com)
  • Myosin-VI is encoded by gene MYO6, the human homolog of the gene responsible for deafness in Snell's waltzer mice. (nih.gov)
  • Is part of an RNA polymerase II-associated complex with possible chaperone activity. (genscript.com)
  • Lurbinectedin (Zepzelca) is a synthetic tetrahydropyrrolo [4, 3, 2-de] quinolin-8(1H)-one alkaloid analogue with potential anti-neoplastic activity. (pharmaceutical-technology.com)
  • In murine gnotobiotic lupus models, E. gallinarum translocation triggers IgG3 anti-RNA autoantibody titers that correlate with renal autoimmune pathophysiology and with disease activity in patients. (bvsalud.org)
  • One Sentence Summary: Translocating pathobiont Enterococcus gallinarum promotes human Th17 and IgG3 autoantibody responses linked to disease activity in autoimmune patients. (bvsalud.org)
  • There is a growing class of cyclic antibiotics, many of which are of bacterial origin, that exhibit activity against Gram-negative bacteria, which constitute an urgent problem in human health. (bvsalud.org)
  • We report the structure of the pretermination complex containing the human Integrator-PP2A complex bound to paused Pol II. (rcsb.org)
  • This model corresponds to the calmodulin (CaM) binding domain (CBD), which consists of three subdomains: a unique insert (Insert 2 or Ins2), an IQ motif, and a proximal tail domain (PTD, also known as lever arm extension or LAE). (nih.gov)
  • In similarity to the RING finger and the LIM domain, the PHD finger is thought to bind two zinc ions. (embl-heidelberg.de)
  • the E-value for the PHD domain shown below is 2.94e-2. (embl.de)