• The function of the protein is not completely understood, but WDCP has been identified in a fusion protein with anaplastic lymphoma kinase found in colorectal cancer. (wikipedia.org)
  • WDCP protein domains include two tryptophan-aspartic acid repeat sites, multiple phosphorylation sites, and a domain that interacts with the hemopoietic cell kinase. (wikipedia.org)
  • pronounced "sarc", as it is short for sarcoma), is a non-receptor tyrosine kinase protein that in humans is encoded by the SRC gene. (wikipedia.org)
  • This induces long-range allostery via protein domain dynamics, causing the structure to be destabilized, resulting in the opening up of the SH3, SH2 and kinase domains and the autophosphorylation of the residue tyrosine 416. (wikipedia.org)
  • A number of human cancer cell lines show over-expression of Lck, pointing to a possible role for this kinase in the initiation and maintenance of the transformed state in human cancers (2). (bio-techne.com)
  • Phosphorylation at Y419 of human Src up-regulates kinase activity, while phosphorylation at Y530 inactivates Src. (rndsystems.com)
  • and protein tyrosine kinase activity. (nih.gov)
  • and transmembrane receptor protein tyrosine kinase signaling pathway. (nih.gov)
  • Orthologous to human ABL2 (ABL proto-oncogene 2, non-receptor tyrosine kinase). (nih.gov)
  • Src was the first proto-oncogenic non-receptor tyrosine kinase characterized in human. (ningbobio.com)
  • c-Fgr is a human non-receptor tyrosine kinase family member that was discovered by using a probe toward the v-Fgr portion of the cell-derived domain of Gardner-Rasheed feline sarcoma virus. (ningbobio.com)
  • Catalytic domain of Src kinase-like Protein Tyrosine Kinases. (umbc.edu)
  • The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K). (umbc.edu)
  • Src (src proto-oncogene, non-receptor tyrosine kinase) is a protein coding gene. (anthonyvandarakis.org)
  • Src is a proto-oncogene encoding a non-receptor tyrosine kinase, similar to the v-src gene of the rous sarcoma virus (14), which was initially. (anthonyvandarakis.org)
  • src kinase (src) is a tyrosine protein kinase that regulates cellular metabolism, survival, and proliferation. (anthonyvandarakis.org)
  • death associated protein kinase 1 [Sou. (gsea-msigdb.org)
  • Violin plots show distribution of expression levels for Kinase-like domain-containing protein (SMED30026449) in cells (dots) of each of the 12 neoblast clusters. (stowers.org)
  • Expression of Kinase-like domain-containing protein (SMED30026449) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells. (stowers.org)
  • Violin plots show distribution of expression levels for Kinase-like domain-containing protein (SMED30026449) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells. (stowers.org)
  • A role of Src family kinase members in causing sterile inflammation and human disease is only recently recognized. (nature.com)
  • The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. (affbiotech.cn)
  • The tyrosine kinase Src is a member of a family of related kinases known as the Src family kinases (SFKs) that share a common structural organization and function as key regulators of signal transduction pathways triggered by a wide variety of surface receptors, including receptor tyrosine kinases, integrins, G-protein-coupled receptors, and antigen receptors (Thomas and Brugge 1997). (mdm2-receptor.com)
  • Receptor tyrosine-protein kinase erbB-2 , also known as CD340 (cluster of differentiation 340), proto-oncogene Neu , Erbb2 (rodent), or ERBB2 (human), is a protein that in humans is encoded by the ERBB2 gene. (iiab.me)
  • This domain occurred 423 times on human genes ( 970 proteins). (umbc.edu)
  • small molecule perturbations changing expression of HCK gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. (maayanlab.cloud)
  • We identified ten hub genes in the protein-protein interaction (PPI) network, but only three ( COLEC10, TGFBR3 , and FYN ) appeared closely related to the prognosis. (biomedcentral.com)
  • As one of the Src family proteins and tumor suppressor genes, FYN has been little researched on liver cancer. (biomedcentral.com)
  • Cellular proteins encoded by the H-ras, K-ras and N-ras genes. (uchicago.edu)
  • c-Src can be activated by many transmembrane proteins that include: adhesion receptors, receptor tyrosine kinases, G-protein coupled receptors and cytokine receptors. (wikipedia.org)
  • Substitution of a valine for a glutamic acid in the transmembrane domain can result in the constitutive dimerisation of this protein in the absence of a ligand. (iiab.me)
  • Src proteins are involved in signaling pathways that regulate cytokine and growth factor responses, cytoskeleton dynamics, cell proliferation, survival, and differentiation. (umbc.edu)
  • pathways involving HCK protein from the Biocarta Pathways dataset. (maayanlab.cloud)
  • After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. (genome.jp)
  • Click the + buttons to view associations for HCK from the datasets below. (maayanlab.cloud)
  • Src is the human homolog of the v-Src gene of the rous sarcoma virus, also designated avian sarcoma virus or ASV. (ningbobio.com)
  • Src and other Src family protein tyrosine kinases are proto-oncogenes that play key roles in regulating cell growth and differentiation. (rndsystems.com)
  • Src (or c-Src) proteins are cytoplasmic (or non-receptor) tyr kinases which are anchored to the plasma membrane. (umbc.edu)
  • Src kinases are overexpressed in a variety of human cancers, making them attractive targets for therapy. (umbc.edu)
  • These data demonstrate that the src family tyrosine kinases are direct effectors of g proteins. (anthonyvandarakis.org)
  • The protein encoded by this gene is a member of the Src family of tyrosine kinases. (maayanlab.cloud)
  • DnaJ heat shock protein family (Hsp40). (gsea-msigdb.org)
  • HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family. (iiab.me)
  • ERBB is abbreviated from erythroblastic oncogene B, a gene isolated from avian genome. (iiab.me)
  • ErbB-2 was named for its similarity to ErbB (avian erythroblastosis oncogene B), the oncogene later found to code for EGFR. (iiab.me)
  • WDCP protein isoform 1 is 721 amino acids in length. (wikipedia.org)
  • Eventually this normal gene mutated into an abnormally functioning oncogene within the Rous sarcoma virus. (wikipedia.org)
  • Src was originally identified as a transforming protein of the rous sarcoma virus (rsv) that had enzymatic. (anthonyvandarakis.org)
  • WDCP exhibits increased protein expression in endocrine tissues, and well as the kidney and urinary bladder. (wikipedia.org)
  • tissues with high or low expression of HCK gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. (maayanlab.cloud)
  • In the present study, the expression levels of zyxin protein in cancer tissues and adjacent noncancerous tissues from 73 gastric cancer patients with different clinical stages were analyzed by Western blot. (bvsalud.org)
  • The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. (genome.jp)
  • ACKR1 is one of more than 20 distinct chemokine receptors expressed in human leukocytes. (guidetomalariapharmacology.org)
  • PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. (umbc.edu)
  • The human c-Fgr gene encodes a 529 amino acid protein. (ningbobio.com)
  • Here, we systematically evaluated the immunological effects of a lipid nanoparticle (LNP)-encapsulated mRNA vaccine that encodes human papillomavirus E7 protein (HPV mRNA-LNP), a tumor-specific antigen of HPV-positive oropharyngeal squamous cell carcinoma (OPSCC). (bvsalud.org)
  • Two transcript variants encoding the same protein have been found for this gene. (wikipedia.org)
  • cellular components containing HCK protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. (maayanlab.cloud)
  • cellular components co-occuring with HCK protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. (maayanlab.cloud)
  • WDCP is located in chromosome 2, specifically locus 2p23.3 on the minus strand, in humans. (wikipedia.org)
  • ERBB2 , a known proto-oncogene , is located at the long arm of human chromosome 17 (17q12). (iiab.me)
  • They were identified as the first proto-oncogene products, and they regulate cell adhesion, invasion, and motility in cancer cells and tumor vasculature, contributing to cancer progression and metastasis. (umbc.edu)
  • NCBI GEO Records reveal that overall WDCP expression is in the 65-70th percentile according to the Universal Human Reference RNA. (wikipedia.org)
  • cell lines with high or low expression of HCK gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. (maayanlab.cloud)
  • Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer . (iiab.me)
  • Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. (affbiotech.cn)
  • cell lines with fitness changed by HCK gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset. (maayanlab.cloud)
  • transcription factor binding site profiles with transcription factor binding evidence at the promoter of HCK gene from the CHEA Transcription Factor Binding Site Profiles dataset. (maayanlab.cloud)
  • transcription factors binding the promoter of HCK gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. (maayanlab.cloud)
  • This proto-oncogene may play a role in the regulation of embryonic development and cell growth. (wikipedia.org)
  • In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. (bio-techne.com)
  • Lck behaves as a proto-oncogene and can lead to cell transformation upon activation. (bio-techne.com)
  • HER2 is colocalised and most of the time, coamplified with the gene GRB7, which is a proto-oncogene associated with breast, testicular germ cell, gastric, and esophageal tumours. (iiab.me)
  • In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere. (bio-techne.com)
  • The protein sequence for WDCP Protein Isoform 1 is shown below. (wikipedia.org)
  • Protein sequence of WDCP protein isoform 1. (wikipedia.org)
  • This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. (maayanlab.cloud)
  • The protein contains no positive, negative, or mixed charged clusters. (wikipedia.org)