Endothelial progenitor cellsNeural progenitor cellsCellsHematopoieticEPCsStrainsAstrocytesPathogenNeuronsBone marrowPreviouslySpeciesRodentsDiseasesReservoirRegenerationVitroInfectLungMiceInvestigateMarkersSwineTransplantationHealthPopulationEarlyDirectSupportDiseaseVirusesCentralBloodDevelopmentSystemRisk
Endothelial progenitor cells6
- Such myeloid angiogenic cells (MAC) [ 1 ] of bone marrow origin were known as endothelial progenitor cells (EPCs). (hindawi.com)
- However, the features initially ascribed to endothelial progenitor cells, i.e ., phenotype, expression of endothelial markers, and ability to form tube-like structures on Matrigel, can be mimicked by blood monocytes [ 3 ]. (hindawi.com)
- Cells previously known as endothelial progenitor cells are considered now to be rather myeloid angiogenic cells than endothelial precursors [ 4 ]. (hindawi.com)
- This study aimed to explore the effects of chemerin on the functions of human endothelial progenitor cells (EPCs) and to investigate its role in lipid accumulation in ApoE-knockout (ApoE−/−) mice. (biomedcentral.com)
- Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)
- Different phenotypes and subtypes of endothelial progenitor cells (EPCs), such as early and late EPCs, have been described according to their functionality. (intechopen.com)
Neural progenitor cells3
- In addition to its use for long term neuronal survival, it has also been validated for serum-free culture of mouse ES cells and human ES cell derived neural progenitor cells. (sigmaaldrich.com)
- In these regions, neural stem cells (NSCs) and neural progenitor cells (NPCs) have been reported to proliferate and produce postmitotic neurons. (jneurology.com)
- In the last decade, cortical adult neurogenesis and its neural stem cells (NSCs), which are self-renewing and can generate neurons, astrocytes and oligodendrocytes, and neural progenitor cells (NPCs), which have a tendency to differentiate into certain types of neurons, have been found in the cerebral cortex of adult mammals 3 . (jneurology.com)
Cells20
- Myeloid angiogenic cells (MAC) derive from hematopoietic stem/progenitor cells (HSPCs) that are mobilized from the bone marrow. (hindawi.com)
- Conditioned media from such cells were then used to stimulate human aortic endothelial cells (HAoECs) to enhance tube-like structure formation in a Matrigel assay. (hindawi.com)
- Concluding, high concentrations of atorvastatin stabilize tubes and enhance the paracrine angiogenic activity of human PAC cells in vitro . (hindawi.com)
- In our study, we worked on cells derived from the CD34 + hematopoietic stem and progenitor cells, enriched with CD133 + population, and used culture media promoting growth of hematopoietic progenitors. (hindawi.com)
- In a first-of-its-kind look at human kidney development, researchers at The Saban Research Institute of Children's Hospital Los Angeles have isolated human nephron progenitor (NP) cells. (biologynews.net)
- Their results, published online in the journal Stem Cell Translational Medicine , will help scientists understand how these progenitor cells become renal cells in the developing fetus, and possibly offer a future way to foster renal regeneration after chronic kidney failure or acute injury. (biologynews.net)
- In humans, about 500,000 to 1,000,000 nephrons are generated before week 34 to 36 of fetal gestation, a point at which NP cells are fully depleted and nephrogenesis ceases. (biologynews.net)
- Previously, nephron progenitors have primarily been studied in animal models or through the use of induced pluripotent stem cells (iPCs). (biologynews.net)
- It is an important tool that will allow scientists to study cell renewal and differentiation in human cells, perhaps offering clues to how to regulate such development," added first author Stefano Da Sacco. (biologynews.net)
- Chemerin is an adipocytokine involved in the recruitment of immune cells [ 11 ] and serves as a bridge between various immune cells from the initial stage of inflammatory diseases through the development process [ 12 ], and its receptor CMKLR1 (also named ChemR23 in humans) is a specific functional member of the G protein receptor family. (biomedcentral.com)
- B lood cell differentiation begins with multipotent hematopoietic progenitor cells (HPCs), which are located in the marrow spaces of the bone. (nationalacademies.org)
- As the cells reproduce, they commit to a particular task or cell line and become known as committed progenitor cells . (nationalacademies.org)
- These committed progenitor cells are difficult to discern from the original multipotent cells but can be cultured to form colonies of specific types of blood cells (Guyton and Hall, 2000). (nationalacademies.org)
- Umbilical cord blood is a rich source of these committed progenitor cells and, presumably, multipotent HPCs (Knudtzon, 1974). (nationalacademies.org)
- 2005). Notch1 and syndecan-1 potent human embryonic stem (ES) cells. (lu.se)
- 2002). In humans, SSEA4 is expressed by building the nervous system but also for their prospec- nonneural cells such as the erythrocytes (Kannagi et al. (lu.se)
- 1983) and the multipotent progenitor cells from fetal disease (Bjorklund and Lindvall, 2000). (lu.se)
- To reduce possible xenobiotic contamination from 3T3s, primary human adipose-derived stem cells (ASCs) were examined as feeder cells to support the expansion of LSCs in vitro . (drcremers.com)
- CC-ASC generated epithelial cells with undifferentiated morphology in all culture methods, among which CC-ASC in 3D culture supported the highest cell doubling (cells doubled 9.0 times compared to cells doubled 4.9 times in control) while maintained the percentage of putative limbal stem/progenitor cells compared to the control. (drcremers.com)
- Mei H, González S, Nakatsu MN, Baclagon ER, Chen FV, Deng SX (2017) Human adipose-derived stem cells support the growth of limbal stem/progenitor cells. (drcremers.com)
Hematopoietic1
- Endothelial progenitors should be devoid of hematopoietic markers and able to form vessels both in vitro and in vivo . (hindawi.com)
EPCs1
- In conclusion, chemerin can enhance the adhesion and migration abilities of human EPCs and reduce the apoptosis ratio. (biomedcentral.com)
Strains5
- We report the isolation, since 2010, of 21 new strains of M. canettii in Djibouti, of which 7 were associated with 2 lymph node TB outbreaks in children. (cdc.gov)
- If a variant virus is antigenically drifted from current human seasonal vaccine (HuVac) strains, it may be chosen as a candidate virus vaccine (CVV) for pandemic preparedness purposes. (cdc.gov)
- To prepare for the potential of a future swine-origin IAV pandemic in humans, public health laboratories selected candidate vaccine viruses (CVV) for use as vaccine seed strains. (cdc.gov)
- We then characterized the representative swine IAV against human seasonal vaccine and CVV strains using ferret antisera in hemagglutination inhibition assays (HI). (cdc.gov)
- Influenza A viruses (IAVs) in the swine reservoir constantly evolve, resulting in expanding genetic and antigenic diversity of strains that occasionally cause infections in humans and pose threat of emerging as a strain capable of human-to-human transmission. (cdc.gov)
Astrocytes6
- Therefore, a plausible regenerative therapeutic option is to coax the endogenous reactive astrocytes to a pre-neurogenic progenitor state and use them as an endogenous reservoir for repair. (frontiersin.org)
- However, the effects of GATA3 in human astrocytes after injury are not known. (frontiersin.org)
- Therefore, in this report, we investigated how overexpression of GATA3 in primary human astrocytes would affect the neurogenic potential before and after injury in 2D and 3D cultures. (frontiersin.org)
- We found that primary human astrocytes are unable to induce GATA3 after injury. (frontiersin.org)
- Lentivirus-mediated overexpression of GATA3 significantly increased the number of GFAP/SOX2 double positive astrocytes and expression of pro-neural factor ASCL1, but failed to induce neurogenesis, suggesting that GATA3 is required for enhancing the neurogenic potential of primary human astrocytes and is not sufficient to induce neurogenesis alone. (frontiersin.org)
- Primary human astrocytes do not induce GATA3 after injury. (frontiersin.org)
Pathogen2
- Mycobacterium canettii ," an opportunistic human pathogen living in an unknown environmental reservoir, is the progenitor species from which Mycobacterium tuberculosis emerged. (cdc.gov)
- Even adjusting for underreporting and difficulty in microbiological isolation, Y pseudotuberculosis appears to be a relatively rare pathogen in humans. (medscape.com)
Neurons3
- N21 Medium Supplement (50X) The N21 Medium Supplement is an optimized serum-free supplement developed for isolation & expansion of neurons from mouse & rat hippocampus. (sigmaaldrich.com)
- The N21 Medium Supplement is an optimized serum-free supplement developed for isolation & expansion of neurons from mouse & rat hippocampus. (sigmaaldrich.com)
- Furthermore, in the last decade, several studies have found NSCs and NPCs capable of generating new neurons in mammals, including mice, rats, and humans. (jneurology.com)
Bone marrow1
- Patients with severe acute radiation sickness receive reverse isolation, antimicrobial and anti-inflammatory agents, and bone marrow support. (msdmanuals.com)
Previously1
- Gata3 was previously found to be a mechanism that zebrafish brain uses to injury-dependent induction of neural progenitors. (frontiersin.org)
Species2
- M. canettii is the progenitor species from which M. tuberculosis emerged ( 3 - 5 ). (cdc.gov)
- Cat population diversity supports the migration patterns of humans and other symbiotic species. (bvsalud.org)
Rodents1
- As humans transitioned from hunter-gatherers to farmers ~12,000 years ago, bold wildcats likely capitalized on increased prey density (i.e., rodents). (bvsalud.org)
Diseases1
- A complex interplay of genetic and environmental factors underlies the development of common human diseases such as cardiovascular disease. (harvard.edu)
Reservoir1
- This observation and the absence of human-to-human transmission support the existence of an environmental reservoir. (cdc.gov)
Regeneration1
- In addition to defining the genetic profile of human NP, this system will facilitate studies of human kidney development, providing a novel tool for renal regeneration and bioengineering purposes," says principal investigator Laura Perin, PhD, co-director of CHLA's GOFARR Laboratory for Organ Regenerative Research and Cell Therapeutics in Urology. (biologynews.net)
Vitro1
- Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. (sigmaaldrich.com)
Infect1
- only the adeno-associated parvoviruses (members of the dependovirus genus) and B19 are known to infect humans. (cdc.gov)
Lung3
- Here we demonstrate that acutely injured human lungs declined for transplantation, including a lung that failed to recover on EVLP, can be recovered by cross-circulation of whole blood between explanted human lungs and a Yorkshire swine. (nature.com)
- Fig. 2: Human lung function over the course of 24 h of xenogeneic cross-circulation. (nature.com)
- Cell replacement in human lung bioengineering. (nature.com)
Mice1
- Immunohisto- have been used for positive selection of NSCs from em- chemistry on human embryonic central nervous system bryonic mice (Nagato et al. (lu.se)
Investigate1
Markers1
- CD133+), but are rarely codetected with the neural stem dents, very few human-specific NSC markers have been cell (NSC) marker CD15. (lu.se)
Swine4
- Swine-to-Ferret Transmission of Antigenically Drifted Contemporary Swine H3N2 Influenza A Virus Is an Indicator of Zoonotic Risk to Humans. (cdc.gov)
- Human-to-swine transmission of influenza A (H3N2) virus occurs repeatedly and plays a critical role in swine influenza A virus (IAV) evolution and diversity. (cdc.gov)
- During the last decade, endemic swine H1 influenza A viruses (IAV) from six different genetic clades of the hemagglutinin gene caused zoonotic infections in humans. (cdc.gov)
- However, repeated introduction of human-seasonal H1N1, continual reassortment between endemic swine IAV, and subsequent drift in the swine host resulted in highly diverse swine IAV with human-origin genes that may become a risk to the human population. (cdc.gov)
Transplantation1
- 2003). After the early success of transplantation of cord blood from related donors, cord blood banks were established to provide rapidly accessible, human leukocyte antigen (HLA)-typed units predominantly for transplantation of HPCs from unrelated donors. (nationalacademies.org)
Health3
- This report* was developed to assist physicians, public health officials, and other health-care professionals respond to public concerns about recently recognized, serious complications of human parvovirus B19 (B19) infection, including transient aplastic crisis (TAC), chronic anemia, and fetal death. (cdc.gov)
- Atlanta, GA: U.S. Department of Health and Human Services. (cdc.gov)
- Asso- human health. (cdc.gov)
Population2
- The overall cat population structure suggested a single worldwide population with significant isolation by the distance of peripheral subpopulations. (bvsalud.org)
- Prevalence of human papillomavirus types in head and neck cancer sub-sites in the Indian population. (who.int)
Early1
- Environmentally sensitive hotspots in the methylome of the early human embryo. (who.int)
Direct1
- The CHLA scientists utilized an efficient protocol for direct isolation of human NP using RNA-labeling probes to obtain NP-expressing SIX2 and CITED1 - the master genes regulating renal development. (biologynews.net)
Support1
- This xenogeneic platform provided explanted human lungs a supportive, physiologic milieu and systemic regulation that resulted in functional and histological recovery after 24 h of normothermic support. (nature.com)
Disease1
- The adeno-associated parvoviruses have not been associated with disease in humans. (cdc.gov)
Viruses1
- Human noroviruses (HuNoVs) are positive-sense RNA viruses that can cause severe, highly infectious gastroenteritis. (harvard.edu)
Central1
- The liver is a central organ in the human body, and first line of defense between host and external environment. (harvard.edu)
Blood1
- The development of the human blood-CSF-brain barrier. (cdc.gov)
Development1
- This technique provides a 'how to' of human tissue during development," Perin says. (biologynews.net)
System1
- system (CNS) of human fetuses (Uchida et al. (lu.se)
Risk1
- Human Papillomavirus and Risk of Head and Neck Squamous Cell Carcinoma in Iran. (who.int)