Human polyomavirus bk bk virus. Medical search. Frequent questions

Agnoprotein is expressed from a region of the circular viral genome called the agnogene, an open reading frame contained in a region of the polyomavirus genome that codes for the viral capsid proteins and is known as the "late region" because it is expressed late in the cycle of viral infection and replication. (wikipedia.org)
Infection with the BK virus (BKV): In 1971, a renal transplant recipient suffering from ureteric stenosis had the BK virus isolated from his urine. (openpr.com)
Incidence, clearance and predictors of human papillomavirus infection in women. (mcmaster.ca)
Prevalence of infection with carcinogenic human papillomavirus among older women. (mcmaster.ca)
Respiratory syncytial virus (RSV) is the most frequent cause of lower respiratory tract infection in infants and children and the second most common viral cause of pneumonia in adults. (medscape.com)
Influenza pneumonia: Amantadine hydrochloride and rimantadine hydrochloride are approved for the prevention and treatment of influenza A virus infection. (medscape.com)
After primary infection of urothelial cells, virus DNA will be integrated into the host's genome. (biomedcentral.com)
These include BK polyomavirus which causes severe urinary tract infection in immunocompromised patients and Merkel cell polyomavirus associated with aggressive cancers. (diamond.ac.uk)
Murine Models of Hepatitis A Virus Infection. (unc.edu)
Human pegivirus type 1 infection in Asia-A review of the literature. (uc.edu)
In silico analysis of mutations associated with occult hepatitis B virus (HBV) infection in South Africa. (uc.edu)
Adult X-linked immunodeficiency (XID) mice, IGM-/- single knockout and IGM-/- CD8-/- double knockout mice do not clear polyomavirus infection. (ictv.global)
It is noted that only a few tubules are showing cytopathic effects, which is common for JC virus infection as opposed to the more diffuse tubular cell changes related to BK virus infection. (cytopathology.ca)
A review on JC virus infection in kidney transplant recipients. (cytopathology.ca)
2017, Jul).Rhodiolae kirliowii radixet rhizoma and crataegus pinnatifida fructus extracts effectively inhibit BK virus and JC virus infection of host cells. (ccu.edu.tw)
x-linked immunodeficiency with magnesium defect, epstein-barr virus infection, and neoplasia: report of a family and literature review]. (liverpool.ac.uk)
objective: to investigate the clinical features and genetic characteristics of cases with x-linked immunodeficiency with magnesium defect, epstein-barr virus (ebv) infection, and neoplasia (xmen). (liverpool.ac.uk)
what is the impact of epstein-barr virus in peri-implant infection? (liverpool.ac.uk)
transcriptional profile and epstein-barr virus infection status of laser-cut immune infiltrates from the brain of patients with progressive multiple sclerosis. (liverpool.ac.uk)
it is debated whether multiple sclerosis (ms) might result from an immunopathological response toward an active epstein-barr virus (ebv) infection brought into the central nervous system (cns) by immigrating b cells. (liverpool.ac.uk)
epstein-barr virus infection and type i interferon signature in patients with systemic lupus erythematosus. (liverpool.ac.uk)
epstein-barr (eb) virus infection has long been speculated to evoke systemic lupus erythematosus (sle). (liverpool.ac.uk)
since a virus infection can induce interferon (ifn) system activation, we aimed to discover the relationship between the two in the progression of sle in a chinese inpatient cohort. (liverpool.ac.uk)
Favi E, Delbue S, Colico C, Signorini L, Clementoni L, Ferraresso M. Longitudinal Study Investigating Characteristics of Human Polyimaviruses Infection after Kidney Transplantation [abstract]. (atcmeetingabstracts.com)
Notch-a possible mediator between Epstein-Barr virus infection and bone resorption in apical periodontitis. (fakenews.rs)
Smoking, alcohol consumption and human papillomavirus infection as risk factors for oral cavity and oropharyngeal tumors in Serbia-A pilot study. (fakenews.rs)
At last follow-up, all patients were enjoying functioning grafts without recurrence of BK virus infection. (ectrx.org)
10,11 Only 1% to 10% affected patients change from reactivated infection to histologically confirmed BK virus nephropathy, usually at mean 10 to 13 months after transplant (range, 6 days to 5 years). (ectrx.org)
18 Although immunosuppressive agents are essential for therapy after organ transplant, these agents increase the incidence and deteriorate the severity of BK virus infection. (ectrx.org)
The primary infection of these viruses is usually asymptomatic and latent which is activated as a consequence of immunosuppression. (edu.au)
The ability of a pathogenic virus to lie dormant within a cell (latent infection). (lookformedical.com)
BACKGROUND: Infection with the human polyomaviruses BK (BKV) and JC (JCV) is almost ubiquitous, asymptomatic, and lifelong. (ox.ac.uk)
Nipah virus infection causes febrile encephalitis and aseptic meningitis. (stanford.edu)
A relativiely quick virus, clinical manifestations of Nipah infection occur shortly after handling infected pigs. (stanford.edu)

After transplantation, the patient tested positive for recurrent blood cytomegalovirus (CMV) and Epstein-Barr virus (EBV) infections, and on March 31, 2020, he underwent lung lavage because of bilateral pneumonia. (biomedcentral.com)
Hemorrhagic cystitis results from damage to the bladder's transitional epithelium and blood vessels by toxins, viruses, radiation, drugs (in particular, chemotherapeutic drugs), bacterial infections, or other disease processes. (medscape.com)
Las Vegas, Nevada, United States) As per DelveInsight's assessment, globally, BK virus infections pipeline constitutes 4+ key companies continuously working towards developing 4+ BK virus infections treatment therapies, analysis of Clinical Trials, Therapies, Mechanism of Action, Route of Administration, and Developments analyzes DelveInsight. (openpr.com)
BK virus infections Pipeline Insight, 2023" report by DelveInsight outlines comprehensive insights into the present clinical development scenario and growth prospects across the BK virus infections Market. (openpr.com)
The BK virus infections Pipeline report embraces in-depth commercial and clinical assessment of the pipeline products from the pre-clinical developmental phase to the marketed phase. (openpr.com)
Companies across the globe are diligently working toward developing novel BK virus infections treatment therapies with a considerable amount of success over the years. (openpr.com)
Emerging BK virus infections therapies in the different phases of clinical trials are- BK virus antiviral therapy, AIC 468, AntiBKV antibody, Brincidofovir, MAU868, ALVR 105, and others are expected to have a significant impact on the BK virus infections market in the coming years. (openpr.com)
BK virus infections pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. (openpr.com)
Viruses are also responsible for the common cold, childhood exanthems (such as chickenpox, measles, rubella), latent infections (such as herpes simplex), some cancers or lymphomas (such as Epstein-Barr virus), and diseases of all organ systems. (unboundmedicine.com)
The virus is harmless to macaques or may cause only a herpetic rash in macaques, but in humans it often produces fatal infections of the brain and meninges. (unboundmedicine.com)
Overview of JC polyomarvirus, BK polyomavirus and other polyomavirus infections. (cytopathology.ca)
Human Polyomaviruses (HPyV) infections are extremely common, ranging from 60% to 100% in the general population, depending on the virus. (atcmeetingabstracts.com)
At the completion of this project, INESSS had developed clinical recommendations for the optimal use of nonspecific human intravenous immunoglobulin (IVIg) in solid organ transplantation to prevent or treat eight different infections and to prevent or treat transplant rejection in pediatric or adult solid organ transplant recipients (kidney, heart, lung, liver, pancreas or small intestine). (inahta.org)
The data from the systematic reviews indicate that IVIg is only marginally effective or ineffective for four indications: the prevention of Epstein-Barr virus infections (low level of evidence), the treatment of norovirus infections (low level of evidence), and the prevention and the treatment of polyomavirus BK infections (moderate to low level of evidence). (inahta.org)
In addition, the systematic literature reviews did not yield any primary studies and have an insufficient level of evidence to draw any conclusions regarding the treatment of Epstein-Barr virus infections or the prevention of norovirus infections. (inahta.org)
The clinical practice guideline recommendations and the clinician perspective are consistent in not recommending the use of IVIg to prevent Epstein-Barr virus, norovirus or BK polyomavirus infections, or to treat Epstein-Barr virus or norovirus infections. (inahta.org)
the Institut national d'excellence en santé et en services sociaux does not recommend the use of IVIg to prevent Epstein-Barr virus, norovirus, HHV-6, parvovirus B19, polyomavirus BK, adenovirus, or West Nile virus infections or to treat of Epstein-Barr virus, norovirus or HHV-6 infections in solid organ transplant recipients. (inahta.org)
Because of insufficient data, the Institut national d'excellence en santé et en services sociaux could not make recommendations concerning the use of IVIg to prevent transplant rejection in hyperimmunized individuals who have received a liver transplant, to treat chronic humoral rejection in solid organ transplant recipients, to prevent respiratory syncytial virus infections or to treat respiratory syncytial virus, adenovirus or West Nile virus infections in solid organ transplant recipients. (inahta.org)
A slow virus, BK establishes latent infections in B-lymphocytes and attacks an immunosuppressed host upon reactivation. (stanford.edu)

Identification of an overprinting gene in Merkel cell polyomavirus provides evolutionary insight into the birth of viral genes. (ictv.global)
Association of Merkel cell polyomavirus-specific antibodies with Merkel cell carcinoma. (ictv.global)
Specimens were tested for BK Polyomavirus (BKPyV), JC Polyomavirus (JCPyV), Merkel Cell Polyomavirus (MCPyV), Human Polyomavirus 7 (HPyV7), and Human Polyomavirus 9 (HPyV9) genome by virus-specific duplex TaqMan Real Time PCR. (atcmeetingabstracts.com)
Reactivation and mutation of newly discovered WU, KI, and Merkel cell carcinoma polyomaviruses in immunosuppressed individuals. (ox.ac.uk)
In this study, we investigated whether the recently discovered WU and KI polyomaviruses (WUPyV and KIPyV) and Merkel cell polyomavirus (MCPyV) could, like BKV and JCV, persist, mutate, and reactivate in immunodeficient subjects. (ox.ac.uk)

Routine immunohistochemistry study for polyomavirus BK nephropathy in transplanted kidney biopsies, is it recommended? (biomedcentral.com)
Early diagnosis and treatment of Polyomavirus BK Nephropathy (PVBKN) is a challenging issue in the management of patients with kidney transplantation. (biomedcentral.com)
Polyomavirus BK nephropathy (PVBKN) is an important cause of allograft dysfunction in patients with kidney transplantation [ 1 ]. (biomedcentral.com)
The John Cunningham virus (JCV) is the established etiological agent of the polyomavirus-associated nephropathy among renal transplant recipients. (biomedcentral.com)
Despite the high incidence of reactivation of the JC virus in recipients of renal transplantation, a small fraction of patients eventually show JC virus-associated nephropathy, which may lead to rejection of the transplant [ 11 ]. (biomedcentral.com)
BK virus is associated with nephropathy and ureteral stenosis in kidney transplant patients. (cytopathology.ca)
Although both BK and JC viruses can cause nephropathy in kidney transplant patients, there are many differences between the two. (cytopathology.ca)
Firstly, JC virus nephropathy is not as frequent and not as well studied as the BK virus-related nephropathy in the literature. (cytopathology.ca)
Secondly, JC virus nephropathy seems to be associated with a less aggressive and more protracted clinical course when compared with BK virus with lower rate of graft rejection and better survival. (cytopathology.ca)
A third difference is the lower level of viremia in JC virus nephropathy in comparison to BK virus. (cytopathology.ca)
In addition, the extent of the histological changes in JC-virus nephropathy is lower with more patchy tubular involvement and more focal cytopathologic changes. (cytopathology.ca)
Given the results of qPCR performed on the patient's blood, a diagnosis of JC virus nephropathy was established. (cytopathology.ca)
After being diagnosed with JC virus-associated nephropathy, one of the patient's immunosuppressive agents was changed and the patient's creatinine returned to the baseline. (cytopathology.ca)
Polyomavirus BK versus JC replication and nephropathy in renal transplant recipients: a prospective evaluation. (cytopathology.ca)
Several studies have shown that BK viral load in plasma and urine are reliable markers for the detection of BK virus associated nephropathy (BKVAN) in renal transplant patients. (lifchem.com)
Nephropathy from BK virus is an increasing problem in renal transplant recipients and has been correlated with newer immuno-suppressive agents and the decline in acute rejection rates. (ectrx.org)
9,12-17 In other reports, it has been concluded that the median time to detect BK virus nephropathy after kidney transplant is 9.5 months, but the duration until graft failure is only 4 months after incidence of BK virus nephropathy. (ectrx.org)
Diagnosis of BK virus nephropathy is based on histologic appearance characterized by lymphocytic interstitial infiltrates, nuclear reaction to the anti-SV-40T antibody as evidence of viral replication, and positive PCR for BK virus DNA. (ectrx.org)
It is difficult to make a clear differential diagnosis between BK virus nephropathy and acute cellular rejection. (ectrx.org)
Therefore, a decrease or discontinuation of immunosuppressive agents is essential as initial treatment for BK virus nephropathy. (ectrx.org)
Factors that may be associated with the risk of BK virus nephropathy include older age, male sex, white ethnicity, diabetes, renal tissue injury from ischemia, presence of cytomegalovirus, acute rejection, and treatment with high-dose steroid pulses. (ectrx.org)
The BK virus nephropathy is 1 of the major causes of allograft dysfunction or graft loss in patients in an overly immunosuppressed state. (ectrx.org)
It has been showed that 45% patients with BK virus nephropathy progressed to irreversible graft failure with tubular atrophy and interstitial fibrosis. (ectrx.org)
Activated BKPyV and JCPyV viruses lead to the development of BK Virus Associated Nephropathy and Progressive Multifocal Leukoencephalopathy, respectively. (edu.au)
Nevertheless, the experts consulted indicated that IVIg may be considered a treatment option for treating confirmed polyomavirus BK nephropathy in solid organ transplant recipients, particularly if concurrent transplant rejection is suspected in a kidney transplant recipient. (inahta.org)

Founded in August of 2021 with the in-licensing of antiviral programs from Novartis, Via Nova Therapeutics' programs target influenza A virus, human rhinovirus, BK polyomavirus, and adenovirus. (swasthsamachar.com)

Polyomaviruses in which it occurs include two human polyomaviruses associated with disease, BK virus and JC virus, as well as the simian polyomavirus SV40. (wikipedia.org)
Agnoprotein is typically quite short: examples from BK virus, JC virus, and SV40 are 62, 71, and 66 amino acid residues long, respectively. (wikipedia.org)
The BK, JC, and SV40 agnoproteins have all been experimentally demonstrated to be phosphorylated in vivo, which appears to improve both protein stability and viral propagation, but no other post-translational modifications have been detected. (wikipedia.org)
the BK, JC, and SV40 examples are by far the best-studied and have fairly high sequence conservation. (wikipedia.org)
All these biopsy samples were evaluated with routine renal biopsy stains as well as IHC for SV40 (Simvian Virus 40) antigen. (biomedcentral.com)
In most of the clinics, antibody for the anti-large T antigen of Simian virus 40 (SV40) is used. (biomedcentral.com)
These tubular cells also stained positive by an antibody against SV40 large T antigen, confirming the presence of polyomavirus cytopathic effects. (cytopathology.ca)

This disease occurs mainly in the context of immunodeficiency, usually from human immunodeficiency virus.We report a case of 67 years old patient, treated for metastatic nasopharyngeal epidermoid carcinoma with three lines of chemotherapy, admitted for deterioration of performance status and neurological symptoms represented by agitation, cognitive decline complicated by loss of consciousness, after receiving three cycles of carboplatin-docetaxel. (bjmo.be)
Since the onset of the AIDS epidemic in 1981, the incidence of PML has increased significantly and now human immunodeficiency virus (HIV) associated cases account for up to 85% of all cases of PML. (bmj.com)

Detection of Epstein Barr Virus in Renal Transplant Recipients: Two Centers Study. (edu.iq)
Serostatus of HHV-6A and Epstein-Barr virus (EBV) was analysed with a bead-based multiplex assay. (bvsalud.org)
BK virus (BKV) is a polyomavirus and Epstein-Barr Virus (EBV) is a gamma herpesvirus, both viruses can cause disease in humans. (novacyt.com)
achieving a cure for hiv, hepatitis b virus, epstein barr-virus, and others, requires novel approaches to facilitate the clearance of infected cells from the host. (liverpool.ac.uk)
a novel epstein-barr virus-latent membrane protein-1-specific t-cell receptor for tcr gene therapy. (liverpool.ac.uk)
adoptive transfer of genetically engineered t-cells to express antigen-specific t-cell receptor (tcr) is a feasible and effective therapeutic approach for numerous types of cancers, including epstein-barr virus (ebv)-associated malignancies. (liverpool.ac.uk)
long-term follow up of post renal transplantation epstein-barr virus-associated smooth muscle tumors: report of two cases and review of the literature. (liverpool.ac.uk)
epstein-barr virus (ebv)-associated smooth muscle tumors (smts) following solid organ transplantation are very rare slow growing neoplasms. (liverpool.ac.uk)
murid herpesvirus-4 (muhv-4), epstein-barr virus and the kaposi's sarcoma-associated herpesvirus all infect b cells. (liverpool.ac.uk)
to compare the qualitative and quantitative profile of epstein-barr virus (ebv) at external and internal implant surfaces between participants with peri-implantitis and healthy peri-implant tissues and to quantitatively assess the relation between ebv and periopathogens inside the microbiologic profile associated with peri-implantitis. (liverpool.ac.uk)
The sequence analysis of Epstein-Barr virus EBNA1 gene: could viral screening markers for nasopharyngeal carcinoma be identified? (fakenews.rs)
Levels of oxidative stress biomarkers and bone resorption regulators in apical periodontitis lesions infected by Epstein-Barr virus. (fakenews.rs)

Human herpesvirus 6A (HHV-6A) is associated with an increased risk of developing multiple sclerosis. (bvsalud.org)
Furthermore, there are some studies showing antiviral effects of ivermectin against DNA viruses such as Equine herpes type 1, BK polyomavirus, pseudorabies, porcine circovirus 2, and bovine herpesvirus 1. (jdfor2020.com)
Nuclear antigens encoded by VIRAL GENES found in HUMAN HERPESVIRUS 4. (lookformedical.com)
The type species is HERPESVIRUS 1, HUMAN . (lookformedical.com)

The virus remains latent in the body throughout life and can be reactivated under certain circumstances. (nih.gov)
The mechanism by which latent viruses, such as genetically transmitted tumor viruses ( PROVIRUSES ) or PROPHAGES of lysogenic bacteria, are induced to replicate and then released as infectious viruses. (lookformedical.com)

BK polyomavirus (BKPyV) is a member of the Polyomaviridae family, and it was first identified in 1971 by electron microscopy of the urine and uroepithelial cells of a renal transplant recipient [ 1 ]. (biomedcentral.com)
Comparison of self-collected vaginal, vulvar and urine samples with physician-collected cervical samples for human papillomavirus testing to detect high-grade squamous intraepithelial lesions. (mcmaster.ca)
Optimized amplification of BK polyomavirus in urine. (uc.edu)
Zeptometrix developed a quantitative real time PCR assay based on TaqMan technology for the measurement of BK viral load in plasma and urine. (lifchem.com)
The limit of detection of the assay is 300 copies per milliliter in both plasma and urine and the limit of quantitation is 1000 copies per milliliter using the Zeptometrix NATtrol BK Virus Linearity Panel (Gentaur Poland). (lifchem.com)
Among 18 kidney donors with BK virus in blood and urine, 5 donors were fit for donation. (ectrx.org)
We report here the complete genome sequence of polyomavirus BK subtype Ib-1, isolate AR11, identified in urine from a human kidney transplant recipient with a clinical diagnosis of BK viremia. (johnshopkins.edu)

The BK polyomavirus role in promoting urothelial neoplasia in transplant recipients may be partly indirect, based on the demonstration by polymerase chain reaction in both tumors of BK polyomavirus with intact open reading frames and close phylogenetic clustering with known replication- competent strains, and viral capsid protein VP1 messenger RNA and intranuclear virions by electron microscopy in 1 tumor. (northwestern.edu)
METHODS: Autopsy samples of lymphoid tissue from 42 AIDS-immunosuppressed subjects and 55 control samples were screened by polymerase chain reaction for all 5 polyomaviruses. (ox.ac.uk)

We have also implemented commercial tests for HIV RNA, hepatitis C RNA, hepatitis C genotyping, hepatitis B DNA, and have developed molecular tests for the detection of resistance of human cytomegalovirus and hepatitis B virus to antiviral drugs. (wustl.edu)

In immunocompromised populations, such as patients with AIDS and recipients of solid organ and hematopoietic stem cell transplants, BK polyomavirus (BKPyV) can reactivate and cause several diseases, which can lead to death in their severe forms. (biomedcentral.com)
Out of the 14 human polyomaviruses described so far, BKPyV and JCPyV have been studied extensively since their discovery in 1971. (edu.au)

We report 2 cases of kidney ± pancreas transplant recipients with evidence of BK polyomavirus reactivation, who developed aggressive urinary bladder urothelial carcinomas with adenocarcinomatous and/or micropapillary differentiation. (northwestern.edu)
Clinical vigilance is warranted for early diagnosis of BK polyomavirus-related urothelial malignancies in transplant recipients. (northwestern.edu)
Urological manifestations of BK polyomavirus in renal transplant recipients. (mcmaster.ca)
BK Polyomavirus Subtypes II and IV in Hematopoietic Cell Transplant Recipients. (uc.edu)
Human polyomavirus 7: associated with a pruritic rash and viremia in lung transplant recipients. (cytopathology.ca)
Systematic screening for HPyV replication after KTx could help discriminate recipients at increased risk of virus-related complications. (atcmeetingabstracts.com)
We aimed to evaluate the effect of BK virus-positive kidney donors on the outcome of kidney transplant recipients after mean follow-up 21 months. (ectrx.org)
Human leukocyte antigen Cw7 was detected in 4 of 5 recipients, and the fifth case, the antigen was detected in the donor. (ectrx.org)

This variant has been associated with a disease recently described from case reports called JC virus encephalopathy, distinct from progressive multifocal leukoencephalopathy (PML), which has long been associated with JC in immunocompromised individuals. (wikipedia.org)
The John Cunningham virus (JCV) is an ubiquitous human polyomavirus that was first discovered in 1971 from patients with progressive multifocal leukoencephalopathy (PML) [ 1 ]. (biomedcentral.com)
JC virus is associated with progressive multifocal leukoencephalopathy in immunocompromised patients. (cytopathology.ca)
Progressive multifocal leukoencephalopathy is a rare demyelinating condition caused by reactivated JC polyomavirus. (bjmo.be)

Identification of a polyomavirus microRNA highly expressed in tumors. (ictv.global)
Novel polyomavirus associated with brain tumors in free-ranging raccoons, western United States. (ictv.global)

Polyomaviruses are a family of ubiquitous double-stranded DNA viruses many of which are human pathogens. (diamond.ac.uk)
Due to high and ubiquitous distribution of these viruses, frequent studies are required to develop a better understanding regarding the epidemiology and pathobiology of these viruses in Asia. (edu.au)

Divergent MicroRNA targetomes of closely related circulating strains of a polyomavirus. (ictv.global)
Analysis of variability of urinary excreted JC virus strains in patients infected with HIV and healthy donors. (fakenews.rs)
Polyoma BK viruses are widespread, double-stranded, nonencapsulated DNA viruses comprising BK and JC strains that are pathogenic in humans. (ectrx.org)
A local-scale One Health genomic surveillance of Clostridioides difficile demonstrates highly related strains from humans, canines, and the environment. (cdc.gov)

BK Polyomavirus Genomic Integration and Large T Antigen Expression: Evolving Paradigms in Human Oncogenesis. (unc.edu)
A truncated T antigen expressed from an alternatively spliced BK virus early mRNA. (ictv.global)
Polyoma BK virus-positive people can be accepted safely for kidney donation, especially with a possible protective role of human leukocyte antigen Cw7. (ectrx.org)

The 400 known viruses are classified in several ways: by genome core (RNA or DNA), host (animals, plants, or bacteria), method of reproduction (such as retrovirus), mode of transmission (such as enterovirus), and disease produced (such as hepatitis virus). (unboundmedicine.com)

In October 2021, Posoleucel (ViralymM, ALVR105) was given Orphan Drug Designation (ODD) by the US Food and Drug Administration (FDA) to treat virus-associated hemorrhagic cystitis (HC). (openpr.com)
In March 2021, In order to assess ALVR105 (Viralym-M), an allogeneic, commercially available multi-virus specific T cell treatment, AlloVir started a Phase III trial. (openpr.com)
2021) Suppression of bone metastatic castration-resistant prostate cancer cell growth by a suicide gene delivered by JC polyomavirus-like particles. (ccu.edu.tw)
2021). Peptide-guided JC polyomavirus-like particles specifically target bladder cancer cells for gene therapy. (ccu.edu.tw)

After DNA extraction, the simultaneous detection and quantification of JCV and BK polyomavirus (BKV) were conducted using a Real-time quantitative PCR method. (biomedcentral.com)

This assay is linear over a 7 log range (10 to 1 × 10(7) copies per reaction), no cross-reactivity was detected with the closest-related polyomavirus JCV, as well as other viruses that may be found in immunocompromised patients, and human genomic DNA. (lifchem.com)

ABBR: AAV A genus in the parvovirus family whose members cannot replicate without the presence of another virus. (unboundmedicine.com)

Agnoprotein is a protein expressed by some members of the polyomavirus family from a gene called the agnogene. (wikipedia.org)
Agnoprotein is a regulatory protein required for efficient proliferation of the viruses in which it is present, although many polyomaviruses do not have the gene. (wikipedia.org)
This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. (cancerindex.org)
Integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS. (unc.edu)
AAVs are nonenveloped single-stranded DNA viruses used in gene therapy to insert copies of missing genes into host cells. (unboundmedicine.com)
Gene therapy for castration-resistant prostate cancer cells using JC polyomavirus-like particles packaged with a PSA promoter driven-suicide gene. (ccu.edu.tw)
Gene therapy for human lung adenocarcinoma using a suicide gene driven by a lung-specific promoter delivered by JC virus-like particles. (ccu.edu.tw)
Any of the processes by which cytoplasmic factors influence the differential control of gene action in viruses. (lookformedical.com)

It was evaluated as possibly carcinogenic comprises a reassessment and Volume 92 (853 pp) to humans (Group 2B). (who.int)

A species of POLYOMAVIRUS apparently infecting over 90% of children but not clearly associated with any clinical illness in childhood. (nih.gov)
Despite progress in the field, clinical implementation is still delayed, mainly due to insurmountable rejection, but also due to critical functional differences between xenografts and human tissue. (msdmanuals.com)
At the suggestion of the Comité consultatif national de médecine transfusionnelle, the Ministère de la Santé et des Services sociaux asked the Institut national d'excellence en santé et en services sociaux to develop clinical recommendations concerning the use of nonspecific human immunoglobulins in solid organ transplantation, in the form of an optimal use guide. (inahta.org)
In healthy individuals BK produces no clinical outcome or mild respiratory disease. (stanford.edu)

Polyomavirus is a non-enveloped double stranded DNA virus which exists latently in the human body. (biomedcentral.com)

High-risk human papilloma virus genotypes in cervical carcinoma of Serbian women: Distribution and association with pathohistological findings. (fakenews.rs)

After immunosuppression, following transplantation, the virus activates, replicates, and damages urothelial cells as well as renal parenchymal tubules. (biomedcentral.com)
Both BK and JC viruses can infect urothelial cells and renal tubular cells and give rise to characteristic cytopathic effects (DeCoy cells) that can sometimes exhibit overlapping features with high-grade urothelial carcinoma. (cytopathology.ca)

Immunosuppression reactivates BK virus replication and is linked to hemorrhagic cystis in bone marrow transplants. (stanford.edu)

In immunosuppressed individuals the virus can lead to hemorrhagic cystis, ureteral stenosis and some urinary tract illnesses.ic meningitis. (stanford.edu)

Despite strong experimental evidence, BK polyomavirus involvement in human cancers has been controversial. (northwestern.edu)
Antibody levels against BK virus and prostate, kidney and bladder cancers in the EPIC-Oxford cohort. (ox.ac.uk)

In this study, we aimed to characterize the TRL compartment in human kidney transplant nephrectomies and examine its potential role in antiviral immunity. (jci.org)
Potent immunosuppression is believed to be the cause of the resurgence of BK virus in kidney transplant patients. (ectrx.org)

Pizzato M, McCauley SM, Neagu MR, Pertel T, Firrito C, Ziglio S, Dauphin A, Zufferey M, Berthoux L, Luban J. Lv4 Is a Capsid-Specific Antiviral Activity in Human Blood Cells That Restricts Viruses of the SIVMAC/SIVSM/HIV-2 Lineage Prior to Integration. (umassmed.edu)

Lin, M.-C., C.-H. Shen, D.C. Chang and M. Wang (2019, Nov). Inhibition of human lung adenocarcinoma growth and metastasis by JC polyomavirus-like particles packaged with an SP-B promoter-driven CD59-specific shRNA. (ccu.edu.tw)

5 This DNA virus, so labelled after the initials of the patient whose tissue was used to isolate it, is a member of the genus Polyomavirus in the family Papovaviridae , which also includes BK virus and SV 40 virus. (bmj.com)

A longitudinal study on avian polyomavirus-specific antibodies in captive Spix's macaws ( Cyanopsitta spixii ). (ictv.global)

Hepatitis B virus genotypes and drug resistance mutations circulating in blood donors in Beira, Mozambique. (uc.edu)
BK Polyomavirus Genotypes in Two Patients after Hematopoietic Cell Transplant. (uc.edu)

However, virus-infected cells were identified just after IHC study in 4 (22.2%) of patients. (biomedcentral.com)
There was a statistically significant coexistence between BK and JC viruses among our patients ( P = 0.029). (biomedcentral.com)
To prevent the post-transplantation diseases caused by both viruses there is increasing monitoring for BKV and EBV DNAemia after transplantation and in patients undergoing immunosuppression. (novacyt.com)

Parainfluenza virus (PIV) is second in importance only to RSV as a cause of lower respiratory tract disease in children and pneumonia and bronchiolitis in infants younger than 6 months. (medscape.com)
TCR sequences from reactivated WUPyV and KIPyV variants showed a number of point mutations and insertions that were absent in viruses recovered from respiratory tract specimens obtained from nonimmunosuppressed subjects. (ox.ac.uk)

In a case-control study nested within the EPIC-Oxford cohort, there were no statistically significant differences in the prevalence or titre of antibodies against BK virus measured in plasma taken prior to diagnosis between cases with cancer of the prostate (n=31), kidney (n=5) or bladder (n=9) and controls (n=45). (ox.ac.uk)
Hepatitis B virus prevalence and vaccine antibody titers in children HIV exposed but uninfected in Botswana. (uc.edu)

Infectious causes of hemorrhagic cystitis include bacteria and viruses. (medscape.com)
Some of the most virulent diseases are caused by viruses, e.g., the hemorrhagic fever caused by Ebola virus. (unboundmedicine.com)

Although agnoprotein is critical for proliferation in the polyomaviruses in which it occurs, its distribution among polyomaviruses whose genomes have been sequenced is patchy. (wikipedia.org)

The BK polyomavirus-induced profound effects on cell activation, cell cycle shift to proliferation, and apoptosis inhibition, in the context of marked immunosuppression, constitute a potentially ideal background for malignant transformation. (northwestern.edu)

An identical miRNA of the human JC and BK polyoma viruses targets the stress-induced ligand ULBP3 to escape immune elimination. (ictv.global)
Polyoma tumor development in neonatally polyoma-virus-infected CD4-/- and CD8-/- single knockout and CD4-/-8-/- double knockout mice. (ictv.global)
Variations in polyoma virus genotype in relation to tumor induction in mice. (ictv.global)

Development and validation of a quantitative real time PCR assay for BK virus. (lifchem.com)
Plasmid for JC virus real time PCR. (european-virus-archive.com)

In this article, we have presented a compendium of latest advances in the molecular understanding of polyomaviruses and their pathobiology. (edu.au)

Polyomaviridae family consists of small circular dsDNA viruses. (edu.au)

Epidemiology of polyomaviruses has also been studied extensively. (edu.au)
Long-Term Epidemiology and Evolution of Swine Influenza Viruses, Vietnam. (cdc.gov)

Quantification Standards in the kits are calibrated against the First World Health Organization International Standards for Virus Nucleic Acid Amplification Techniques (NIBSC code 14/212), and demonstrate the kits have strong levels of sensitivity and specificity performance as well as reproducibility. (novacyt.com)
Quantification Standards (QS) are included in the kits which are calibrated against the First World Health Organization International Standards for Virus Nucleic Acid Amplification Techniques (NIBSC code 14/212). (novacyt.com)
PCR performed on his blood sample is negative for BK virus DNA amplification twice in a row. (cytopathology.ca)

It has also been suggested that agnoprotein functions as a viroporin - that is, a viral protein that alters membrane permeability to facilitate the virus particles' exit from the cell. (wikipedia.org)

Anatomy5

Organisms10

Diseases14

Chemicals and Drugs8

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes7

Information Science2

Infection34

Infections19

Merkel5

Nephropathy25

Adenovirus1

SV407

Immunodeficiency Virus2

Epstein Barr12

Herpesvirus4

Latent2

Urine7

Polymerase chain re2

Cytomegalovirus1

BKPyV2

Recipients8

Progressive multifocal leukoenc4

Tumors2

Ubiquitous2

Strains4

Antigen3

HEPATITIS VIRUS1

20214

Detection1

Cross Reactivity1

Parvovirus1

Gene8

Carcinogenic1

Clinical4

Double stranded1

Papilloma virus1

Urothelial2

Transplants1

Urinary1

Cancers2

Kidney transplant2

Antiviral1

20191

Papovaviridae1

AVIAN1

Genotypes2

Patients3

Respiratory2

Prevalence2

Hemorrhagic2

Occurs1

Immunosuppression1

Polyoma3

Real Tim2

Pathobiology1

DsDNA1

Epidemiology2

Amplification3

Viral protein1