Human pluripotent stem cells embryonic. Medical search. Frequent questions

Directed differentiation of human embryonic stem cells (hESCs) has generated much interest in the field of regenerative medicine. (ca.gov)
Detailed characterization of cell type transitions is essential for cell biology in general and particularly for the development of stem cell-based therapies in regenerative medicine. (nature.com)
Induced pluripotent stem (iPS) cells have great potential for regenerative medicine and gene therapy. (stemcell.com)
Human induced pluripotent stem cells (hiPSCs) and human embryonic stem cells (hESCs) are promising candidate cell sources for regenerative medicine. (jci.org)
Our results suggest that caution should be exercised before assuming that hiPSCs occupy a pluripotent state equivalent to that of hESCs, particularly when producing differentiated cells for regenerative medicine aims. (jci.org)
To exploit the full potential of human pluripotent stem cells for regenerative medicine, developmental biology and drug discovery, defined culture conditions are needed. (nih.gov)
Pluripotent stem cells can provide a truly unlimited source for deriving therapeutically relevant cell types for applications in human disease modeling or regenerative medicine. (mskcc.org)
The Studer laboratory investigates human stem cells as tools to understand normal and pathological development in the nervous system and to develop cell-based strategies for regenerative medicine. (mskcc.org)
Oct. 10, 2023 Generating specific cell lineages from induced pluripotent stem cells and embryonic stem cells is the holy grail of regenerative medicine. (sciencedaily.com)
Stem cells and regenerative medicine - future perspectives. (springer.com)
Stem cells in regenerative medicine: introduction. (springer.com)
Stem cell-based regenerative medicine shows much promise. (selectbiosciences.com)
Author Dr Gabriella Ficz, commented: "This study brings us one step closer to the ultimate aim in regenerative medicine of using patient-derived cells to avoid immune rejection in cell and organ replacement therapies. (epigenie.com)
They may also serve as an unlimited source of therapeutically active cells for regenerative medi- cine. (lu.se)
Evidence the fate of stem cells has broad ramifications for biomedical suggests that during development or differentiation, cells make science from elucidating the causes of cancer to the use of very precise transitions between apparently stable ``network stem cells in regenerative medicine. (lu.se)

Feb. 21, 2022 Embryonic stem cells and other pluripotent cells divide rapidly and have the capacity to become nearly any cell type in the body. (sciencedaily.com)

Nanotopography Promotes Pancreatic Differentiation of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells. (bioscience.co.uk)
Directing differentiation of human pluripotent stem cells into different endodermal lineages such that we may generate tissue for replacement therapies and discover novel in vitro methods to model and study human development and disease. (aiche.org)
Many existing protocols for neuronal differentiation of human pluripotent cells result in heterogeneous cell populations and unsynchronized differentiation, necessitating the development of methods for labeling specific cell populations. (lu.se)

We studied human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) measuring the SNPs and CNVs with Affymetrix SNP 6 microarrays and expression values with Affymetrix Exon microarrays. (biomedcentral.com)
They are 3-dimensional, complex, multicellular structures that can be derived from patient specific human induced pluripotent stem cells (hiPSCs). (nature.com)
While human induced pluripotent stem cells (hiPSCs) provide novel prospects for disease-modeling, the high phenotypic variability seen across different lines demands usage of large hiPSC cohorts to decipher the impact of individual genetic variants. (frontiersin.org)
Thus, a much higher grade of parallelization, and throughput in the production of hiPSCs is needed, which can only be achieved by implementing automated solutions for cell reprogramming, and hiPSC expansion. (frontiersin.org)
We have developed a feeder-free, Sendai virus-mediated reprogramming protocol suitable for cell culture processing via a robotic liquid handling unit that delivers footprint-free hiPSCs within 3 weeks with state-of-the-art efficiencies. (frontiersin.org)
Automatically expanded hiPSCs exhibit normal growth characteristics, and show sustained expression of the pluripotency associated stem cell marker TRA-1-60 over at least 5 weeks (10 passages). (frontiersin.org)
The advent of the human induced pluripotent stem cells (hiPSCs) technology offers unprecedented opportunities for disease modeling, personalized medicine, and the development of new therapeutic interventions. (frontiersin.org)
However, despite the common ability of hiPSCs and hESCs to differentiate into all 3 germ layers, their functional equivalence at the single cell level remains to be demonstrated. (jci.org)
Here, we used single cell analysis to resolve the gene expression profiles of 362 hiPSCs and hESCs for an array of 42 genes that characterize the pluripotent and differentiated states. (jci.org)
Comparison between single hESCs and single hiPSCs revealed markedly more heterogeneity in gene expression levels in the hiPSCs, suggesting that hiPSCs occupy an alternate, less stable pluripotent state. (jci.org)
We found that reprogramming of differentiated cells induces T-circle and single-stranded C-rich telomeric DNA accumulation, indicating the activation of telomere trimming pathways that compensate telomerase-dependent telomere elongation in hiPSCs. (sens.org)
Kussauer S, David R, Lemcke H ( 2019 ) hiPSCs Derived Cardiac Cells for Drug and Toxicity Screening and Disease Modeling: What Micro- Electrode-Array Analyses Can Tell Us. (multichannelsystems.com)
Given this, human pluripotent stem cells, such as human embryonic stem cells (hESCs) and induced pluripo- tent stem cells (hiPSCs), have become a unique cell source for study- ing early human brain development. (lu.se)

The attached embryos robustly generated outgrowths comprising Oct4-positive cells indicating the presence of Sera progenitor cells (Supplementary info Data S1 Number 1C). (researchhunt.com)
Until now, several progenitor cells derived from dental tissues have been isolated and characterized ( table I ). (bvsalud.org)
To varying degrees, these fates also extend to the Such state stability is required in stem and progenitor cells to immediate progeny of stem cells, known as progenitor or support self-renewal and maintenance of the uncommitted transit-amplifying cells. (lu.se)
The first part of the thesis (Paper I, II, III) shows the development and improvement of a hESC-based system of for virus-mediated direct reprogramming of human glial progenitor cells into both induced dopaminergic neurons (iDANs) and GABAergic interneurons. (lu.se)

We provide detailed protocols for lentiviral transduction, neural differentiation, and subsequent analysis of human embryonic stem cells. (lu.se)

Direct neuronal reprogramming of a somatic cell into therapeutic neurons, without a transient pluripotent state, provides new promise for the large number of individuals afflicted by neurodegenerative diseases or brain injury. (lu.se)
Direct neuronal conversion of resident glial cells is advantageous since they are ubiquitously distributed brain cells able to self-renew and replenish their number, making them ideal candidates for endogenous repair. (lu.se)
We are currently generating neurons by iPS and iN cell technology aiming to produce cortical neurons and after intracerebral transplantation or direct in vivo reprogramming of non-neuonal cells restore damaged neuronal network. (lu.se)
For gene therapy, a combinatorial approach with multiple target genes, as well as more complex optogenetic approaches are studied, while for cell-therapy human induced pluripotent stem cells and human induced neuronal cells are investigated. (lu.se)
Intracerebral grafting of neuronal cell suspensions II. (lu.se)

These new types of cells are called induced pluripotent stem cells (iPSCs). (healthline.com)

The cytotoxic and immunogenic hurdles associated with non-viral mRNA-mediated reprogramming of human fibroblasts. (mpg.de)
Activation of pluripotency-associated genes in mouse embryonic fibroblasts by non-viral transfection with in vitro-derived mRNAs encoding Oct4, Sox2, Klf4 and cMyc. (mpg.de)
Dr. Daniel Besser, Prof. Walter Birchmeier and Torben Redmer from the MDC, a member of the Helmholtz Association, used mouse embryonic fibroblasts (MEFs) in their stem cell experiments. (sciencedaily.com)
2008). Historically, this concept is highlighted by the experi- factors are key intrinsic regulators of these fate decisions and mental phenomenon of lineage reprogramming, for example, that fate choice involves modulating networks of transcription by the conversion of fibroblasts to muscles cells following trans- factors. (lu.se)
One way we did this was by converting adult fibroblasts, or skin cells, into interneurons. (lu.se)

Our results revealed altogether 217 genes and 584 SNPs whose genomic alterations affect the transcriptome in the same cells. (biomedcentral.com)
Our results revealed that in the human pluripotent stem cells, the expression values of several genes, transcripts and exons were affected due to the genomic variation. (biomedcentral.com)
The human leukocyte antigen (HLA) system or complex is a complex of genes on chromosome 6 in humans which encode cell-surface proteins responsible for regulation of the immune system. (wikipedia.org)
The RUNX1 protein turns on (activates) genes that help control the development of blood cells (hematopoiesis). (medlineplus.gov)
While t(8;21) is important for leukemia development, a mutation in one or more additional genes is typically needed for the myeloid blasts to develop into cancerous leukemia cells. (medlineplus.gov)
By looking at which genes were expressed in these human gastruloids at 72 hours of development, the researchers found a clear signature of the event that gives rise to important body structures such as thoracic muscles, bone, and cartilage, but they do not develop brain cells. (scitechdaily.com)
Found within Wharton's jelly - which is easily harvested from what would otherwise be post-natal medical waste - are several distinct stem cell genes. (articlecity.com)
Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD. (springer.com)
explosion further, consider that a fictitious small genome with 2002) More recently and more dramatically, the potential for 260 genes would host the same number of combinations as cell state conversions is exemplified by the reprogramming of the number of atoms in the visible universe! (lu.se)

Surfactant is produced by alveolar type II cells which can be differentiated in vitro from patient specific induced pluripotent stem cell (iPSC)-derived lung organoids. (nature.com)
These findings suggest that a lethal lung disease can be targeted and corrected in a human lung organoid model in vitro . (nature.com)
Gene therapy has been utilized successfully to repair or inactivate mutations in animal models of monogenic human diseases 19 as well as human in vitro cells 12 . (nature.com)
We detect alterations of protein properties in numerous cellular pathways and components including ribosome biogenesis and demonstrate that modulation of ribosome maturation through SBDS protein can be helpful for manipulating cell stemness in vitro. (nature.com)
Using our integrative proteomics approach and the web-based tool, we uncover a molecular basis for the uncoupling of robust transcription from parsimonious translation in stem cells and propose a method for maintaining pluripotency in vitro. (nature.com)
The stem cell field witnessed a genuine breakthrough when a combination of solely four transcription factors ( Oct3 / 4 , Sox2 , Klf4 and c-Myc, OSKM ) proved enough to revert, in vitro, the differentiated status of a variety of cell types back to pluripotency, giving rise to so-called induced pluripotent stem (iPS) cells. (springer.com)
This protocol describes a detailed procedure for resuspending and culturing human stem cell derived neurons that were previously differentiated from neural progenitors in vitro for multiple weeks. (jove.com)
We are working to generate red blood cells in vitro from pluripotent stem cells, however the extremely large cell numbers involved pose unique challenges to culture technology and scale-up. (selectbiosciences.com)
Oleaga C, Jalilvand G, Legters G, Martin C, Ekman G, McAleer CW, Long CJ, Hickman JJ ( 2019 ) A human in vitro platform for the evaluation of pharmacology strategies in cardiac ischemia. (multichannelsystems.com)
We combine these in vitro models with gain and loss of gene function approaches (Crispr/Cas9 system), single cell genomics (RNA-seq), spatial transcriptomics as well as live cell imaging techniques. (mdc-berlin.de)
Owing to their manifold roles in health and disease, there have been intense efforts to synthetically generate blood vessels in vitro from human pluripotent stem cells (hPSCs). (bvsalud.org)
How can we specifically generate either arterial or venous endothelial cells (ECs) from hPSCs in vitro? (bvsalud.org)
In this thesis, human glia-to-neuron direct conversion and engineered viral vectors are explored using pre-clinical in vitro and ex vivo models. (lu.se)
In vitro experiments using NV virus-like particles (VLPs) directly showed NV VLP attachment to HBGA, resulting in VLP internalization into the cell ( 19 ). (cdc.gov)
From these critical studies, putative NV receptors were identified, and thus it was hypothesized that a successful in vitro cell culture system would most likely possess these receptors to support NV replication. (cdc.gov)

Editor Embryonic stem cells (ESCs) are pluripotent cells established from early stage embryos that maintain the capability to differentiate into three-germ level cells. (researchhunt.com)
The immune system uses the HLAs to differentiate self cells and non-self cells. (wikipedia.org)
Eventually, the cells begin to differentiate, taking on a certain function in a part of the body. (healthline.com)
Adult stem cells can't differentiate into as many other types of cells as embryonic stem cells can. (healthline.com)
They can differentiate into all types of specialized cells in the body. (healthline.com)
The breakthrough has created a way to "de-differentiate" the stem cells. (healthline.com)
Human pluripotent stem cells, with their ability to proliferate indefinitely and to differentiate into virtually all cell types of the human body, provide a novel resource to study human development and to implement relevant disease models. (mdpi.com)
Published on June 11, 2020, in the journal Nature , the report describes a method of using human embryonic stem cells to generate a three-dimensional assembly of cells, called gastruloids, which differentiate into three layers organized in a manner that resembles the early human body plan. (scitechdaily.com)
However, these models may behave differently from human embryos when the cells start to differentiate. (scitechdaily.com)
They are able to differentiate into any cell of an organism and have the ability of self-renewal. (articlecity.com)
Researchers have discovered what enables embryonic stem cells to differentiate into diverse cell types and thus to be pluripotent. (sciencedaily.com)
Researchers of the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch have discovered what enables embryonic stem cells to differentiate into diverse cell types and thus to be pluripotent. (sciencedaily.com)
Human embryonic stem cells are blank-slate, or pluripotent, cells that have the capacity to differentiate into any of the more than 220 cell types in the human body. (wisc.edu)

Human induced pluripotent stem cells (iPSCs) have been recently found to harbor genomic alterations. (mdc-berlin.de)
Massively parallel pyrosequencing of mtDNA revealed that human iPSCs derived from young healthy donors harbored single base mtDNA mutations (substitutions, insertions, and deletions), both homoplasmic (in all mtDNA molecules) and heteroplasmic (in a fraction of mtDNAs), not present in the parental cells. (mdc-berlin.de)
Here we show the differentiation of patient specific iPSCs derived from a patient with SFTPB deficiency into lung organoids with mesenchymal and epithelial cell populations from both the proximal and distal portions of the human lung. (nature.com)
Infection of iPSCs with lentiviral inserts is a highly efficient process since stem cells grow quickly, remain undifferentiated in specific cell culture conditions and can establish fully infected clones within 2-3 passages. (nature.com)
To create iPSCs, scientists genetically reprogram the adult stem cells so they behave like embryonic stem cells. (healthline.com)
In this reprogramming technique, somatic cells are converted into induced pluripotent stem cells (iPSCs). (sciencedaily.com)
In addition to human iPSCs, it can be used to replate culture of primary neurons or to resuspend them for fact sorting or single cell sequencing. (jove.com)
These progenitors which are derived from either embryonic stem cells (ESCs) or healthy induced pluripotent stem cells (iPSCs) express wild-type levels of a-syn, thus making them equally susceptible to developing Lewy bodies over time. (lu.se)
The advent of iPSCs has opened up the possibility to graft patient-specific cells which most likely would circumvent the need for immunosuppression. (lu.se)

While subpopulations of hESCs within pluripotent cultures have been identified based on expression of specific surface antigens, their significance and fates are not well understood. (ca.gov)
In contrast, CD135(+)GFP(+) hESCs gave rise to tissues representing all three embryonic germ layers, and were virtually indistinguishable from CD135(-)-derived tissues. (ca.gov)
These data establish that subpopulations of proliferating hESCs whose tissue fate is predetermined exist, and challenge the notion that all cells within proliferating hESC cultures are truly 'pluripotent. (ca.gov)
Excessive telomere elongation compromises telomere stability and promotes the formation of partially single-stranded telomeric DNA circles (C-circles) in hESCs, suggesting heightened sensitivity of stem cells to replication stress at overly long telomeres. (sens.org)

During this time, he pioneered efforts to generate 3-dimensional intestinal organoids from human pluripotent stem cells using an approach know as directed differentiation. (aiche.org)

Promotes differentiation of neurons from human and mouse embryonic stem (ES) cells (Crawford and Roelink, Elkabetz et al. (stemcell.com)
However, current protocols for deriving neurons from human pluripotent stem cells give rise to heterogeneous cell populations both in regard to the temporal aspects and the cellular composition. (lu.se)

In the beginning preimplantation blastocysts (embryonic day time 4.5) from an outbred strain of CD:VRL1 rats (also called Sprague-Dawley (SD)) and inbred strains of Fischer 344 and Brown-Norway (BN) rats were individually seeded onto mitomycin C-treated mouse embryonic fibroblast cells in N2B27 medium supplemented with 2i-LIF (Supplementary info Data S1 Number 1A and ?and1B).1B). (researchhunt.com)
Here, we describe the StemCellFactory, an automated, modular platform covering the entire process of hiPSC production, ranging from adult human fibroblast expansion, Sendai virus-based reprogramming to automated isolation, and parallel expansion of hiPSC clones. (frontiersin.org)
Preparation of mouse embryonic fibroblast cells suitable for culturing human embryonic and induced pluripotent stem cells. (mpg.de)

Pluripotent teratocarcinoma-thymus somatic cell hybrids. (springer.com)

Understanding transitions from one cell type or state to another is in the focus of modern molecular biology. (nature.com)
Our laboratory aims at exploiting recent advances in stem cell biology to develop radically new therapies for degenerative disease and cancer. (mskcc.org)
The main focus in the lab is on the biology and application of human embryonic stem (ES) and human induced pluripotent (iPS) cells. (mskcc.org)
Cell Biology and Toxicology, 34(1), pp.51-64. (bioscience.co.uk)
Understanding cell-fate decisions in stem cell populations is a major goal of modern biology. (lu.se)
Lund center for Stem Cell Biology and Cell Therapy is one of six Swedish strategic centers of excellence in life sciences, supported by the Swedish Foundation for Strategic Research. (lu.se)
Combining cell biology and electrophysiology, his work has the potential to create personalized disease models for future research. (lu.se)

These cells have been described as embryonic stem cells (ESCs) and. (scitizen.com)

The use of stem cell-derived dopamine neurons or deep brain stimulation (DBS) represents two alternative approaches to treat Parkinson's Disease. (lu.se)
The results obtained in the Lund transplantation program have provided proof-of-principle that human fetal midbrain dopamine neurons can survive and function for many years (more than a decade) after transplantation to the striatum in patients with advanced Parkinson´s disease ( publications 4 below ). (lu.se)
Current efforts in the Lund PD transplantation program are focused on the use of dopamine neurons derived from pluripotent stem cells, using a protocol that has been devloped here in Lund ( publications 9 below ). (lu.se)

Blue marks DNA, magenta marks neural cells, green marks mesodermal cells. (scitechdaily.com)
Similarly, the transplantation of other tissue-specific stem cells, such as stem cells isolated from epithelial and neural tissues, can treat mouse disease models and human patients in which epithelial and neural cells are damaged. (articlecity.com)
NSCs are derived from the embryonic stem (ES) cells or fetal and adult nervous system, and can generate different type of neural cells. (lu.se)

NZBIndex is forever born in our download Human Embryonic of different Usenet family scientists for different issues are sure. (idealnaja.pl)
Since stem cells have the ability to turn into various other types of cells, scientists believe that they can be useful for treating and understanding diseases. (healthline.com)
Scientists have recently discovered how to turn adult stem cells into pluripotent stem cells. (healthline.com)
Scientists are hoping that the cells can be made from someone's own skin to treat a disease. (healthline.com)
Scientists from the University of Cambridge, in collaboration with the Hubrecht Institute in The Netherlands, have developed a new model to study an early stage of human development using human embryonic stem cells. (scitechdaily.com)
Model organisms including mice and zebrafish have previously enabled scientists to gain some insights into human gastrulation. (scitechdaily.com)
Levine reasons this could be a result of the fact that there are many incentives for scientists to work with existing human embryonic stem cell lines rather than creating new ones. (scienceblog.com)
An interesting question going forward is how committed these scientists are to stem cell research or if they are relating their work to stem cells now simply to be eligible for state funding - that's unknown right now. (scienceblog.com)
For decades scientists have been trying to reproduce cell culture environment for the closest mimicry of the natural cellular "embedding" within a living organism. (selectbiosciences.com)
Wisconsin scientists also are pioneering the use of stem cells to help develop better and safer medicines. (wisc.edu)
Current human pluripotent stem cells lack the transcription factor circuitry that regulates the ground state of mouse embryonic stem cells (ESC), the scientists found that short-term expression of two components, NANOG and KLF2, is sufficient to ignite other elements of the network and reset the human pluripotent state. (epigenie.com)
Scientists have found a way to possibly avoid using embryonic stem. (scitizen.com)

Following his Ph.D., he performed a research fellowship in the lab of Jim Wells at Cincinnati Children's Hospital , where he turned his focus to understanding mechanisms that regulate embryonic development of endoderm-derived tissue (pancreas, liver, intestine) and utilizing human pluripotent stem cells (hPSCs) to understand human differentiation and development. (aiche.org)
Human pluripotent stem cells (hPSCs)-derived brain organ. (springeropen.com)
Generating primordial germ cell-like cells (PGCLCs) from human pluripotent stem cells (hPSCs) advances studies of human reproduction and development of infertility treatments, but often entails complex 3D aggregates. (bvsalud.org)

Adult stem cells have a misleading name, because they are also found in infants and children. (healthline.com)
Adult stem cells don't present any ethical problems. (healthline.com)
Adult stem cells, which are present in small amounts in adult tissue but less adaptable than embryonic stem cells, making their use in medical treatments more challenging. (articlecity.com)
Comparison of adult stem cells derived from multiple stem cell niches. (bioscience.co.uk)
https://pubmed.ncbi.nlm.nih.gov/26857609-comparison-of-adult-stem-cells-derived-from-multiple-stem-cell-niches/ [Accessed 28 Feb. 2020]. (bioscience.co.uk)
Adult Stem Cells: The New Plastic Surgery? (scitizen.com)
27 Jun, 2008 05:23 pm A new article in Live Science predicts that adult stem cells may replace silicone breast implants and other contemporary plastic surgery techniques. (scitizen.com)
Stem cells are classified into two main: embryonic stem cells, which are found in the embryos and adult stem cells, found in adult tissues. (bvsalud.org)
Adult stem cells are found in differentiated tissues and are able to generate specialized cells in some types of tissues (Multipotent Stem Cells). (bvsalud.org)

Moreover, iPSC lines bearing different mtDNA mutational loads maintained a consistent human embryonic stem cell-like reprogramming of energy metabolism. (mdc-berlin.de)
The LARGE principle of cellular reprogramming: lost, acquired and retained gene expression in foreskin and amniotic fluid-derived human iPS cells. (mpg.de)
Induced pluripotent stem cells, which harness the power of genetic reprogramming - basically, the altering of a cell's DNA - to change the course of cellular development. (articlecity.com)
The molecule also plays a crucial role in the reprogramming of body cells into pluripotent stem cells. (sciencedaily.com)
E-Cadherin is necessary for maintaining pluripotent stem cells and also for inducing the pluripotent state in the reprogramming of somatic cells," Dr. Besser said. (sciencedaily.com)
Reprogramming of differentiated cells can be efficiently induced in oocytes. (selectbiosciences.com)
Professor Wolf Reik, who oversaw the work, added: "We can liken this reprogramming to giving cells amnesia so they forget any previous developmental decisions they have made. (epigenie.com)
Reprogramming of somatic (e.g., skin or blood) cells is an emerging technology which gives the possibility to develop any cell type avoiding the ethical concerns with the use of human embryonic stem (ES) cells. (lu.se)

Doctors have been performing stem cell transplants, also known as bone marrow transplants, for decades using hematopoietic stem cells in order to treat certain types of cancer. (healthline.com)
Hematopoietic stem cell transplantation (HSCT) involves the intravenous infusion of hematopoietic stem cells in order to reestablish blood cell production in patients whose bone marrow or immune system is damaged or defective. (medscape.com)

Subpopulations of human embryonic stem cells with distinct tissue-specific fates can be selected from pluripotent cultures. (ca.gov)
This co-culture approach also will enable identification of other distinct hESC subpopulations, and selection for these should prove valuable in generating tissue-specific reagents for cell-based therapy. (ca.gov)
Several genome-wide studies have reported genomic variants that correlate with gene expression levels in various tissue and cell types. (biomedcentral.com)
This means they can potentially produce new cells for any organ or tissue. (healthline.com)
Multi-omic profiles of human non-alcoholic fatty liver disease tissue highlight heterogenic phenotypes. (mpg.de)
With this raw material, biomedical firms can create stem cell lines that, among other things, aid recuperation via the regeneration of tissue that has been lost or damaged. (articlecity.com)
Current research is focused on growing a wide range of new tissue from stem cells, including muscle, blood, brain, and cartilage cells. (articlecity.com)
They have many of the positive characteristics of embryonic stem cells while sourcing material is far less challenging, since postpartum tissue can be used. (articlecity.com)
The MDC researchers found that in contrast to the original cells, the new pluripotent cells derived from mouse connective tissue contained E-cadherin. (sciencedaily.com)
It's all about finding out what the cell needs in order to survive and multiply while making sure that they have lost the memory of the tissue they came from. (epigenie.com)
Both conditions need to be fulfilled for successful use of embryonic stem cells in tissue generation. (epigenie.com)
Organoids are cultured cellular structures that consist of the major cell types of a tissue including tissue stem cells and other differentiated cells, resemble the basic features and possess the functions of the tissue. (springeropen.com)
Preclinical models that can accurately predict the toxicity and efficacy of candidate drugs to human liver tissue are in urgent need. (springeropen.com)
8 Jun, 2007 04:13 pm Stem cells provide the starting material for the development and repair of every organ and tissue in the body and they are present in all stages of life. (scitizen.com)
As a result of being capable of differentiating into a variety of cell types, it can be presumed that stem cell therapy has an advantage when compared to other tissue repair methods. (bvsalud.org)
The aim of this paper is to provide a review about current and future materials for scaffolds to carry stem cells in tissue engineering in Dentistry, especially for bone tissue repair. (bvsalud.org)
The ability to restore cells and tissue function without the need of immunosuppressive drugs and without the concern for tissue compatibility makes Mesenchymal Stem Cells (MSCs, usual acronym) a strong promise for the future. (bvsalud.org)
For stem cells to be used in tissue engineering a scaffold is essential to provide the necessary support for the transport of nutrients, oxygen and the elimination of metabolic waste 30 , promoting a conducive environment for cell growth and differentiation. (bvsalud.org)
The high regeneration potential has aroused a great interest in the scientific community 3 , due to its many clinical applications in cell therapy or tissue engineering. (bvsalud.org)
Cell therapy is a therapy where cellular material is injected systemically or directly into the injured tissue, to promote local repair or to restore systemic health. (bvsalud.org)
Transplantations of fetal tissue in the 1980s and 1990s provided proof-of-concept for the potential of cell replacement therapy for PD and some patients benefitted greatly from their transplants. (lu.se)
However, post-mortem analysis of transplanted tissue revealed accumulation of pathological Lewy bodies in a small subset of transplanted cells over time, revealing a host-to-graft disease propagation. (lu.se)

However, more research is needed to help understand the potential uses of amniotic fluid stem cells. (healthline.com)
Valproic acid confers functional pluripotency to human amniotic fluid stem cells in a transgene-free approach. (mpg.de)

This brings as oral dopamine therapies with the advantage that with it continued infective risks for the patients the cells can be targeted to the site where dopamine with DBS which is not so for patients with trans- is most needed, namely the striatum. (lu.se)
Stem cells from dental tissues have a real potential in Advanced Therapies. (bvsalud.org)
The data presented in this thesis may serve as valuable resources to help optimize future cell replacement therapies for patients suffering from PD. (lu.se)
Our laboratory for the first time combines transplantation of stem cells, stimulation of endogenous neurogenesis and modulation of inflammatory responses in order to develop clinically effective cell replacement therapies for human neurodegenerative diseases. (lu.se)

A balance between elongation and trimming regulates telomere stability in stem cells. (sens.org)
Next, the MDC researchers want to find out to what extent E-cadherin also regulates human embryonic stem cells. (sciencedaily.com)

Stem cells exist both in embryos and adult cells. (articlecity.com)

Although many differentiation protocols in the literature have been successful in mimicking lung development from stem cells, there has not been an examination of how a specific mutation impacts the differentiation process including its effects on the early endoderm, as well as the proximal and distal lung epithelial cell populations in the lung organoids. (nature.com)
Here, we employed a human pancreatic differentiation platform complemented with an shRNA screen in human pluripotent stem cells (PSCs) to identify potential drivers of early endoderm and pancreatic development. (mdpi.com)
In particular, it plays an important role in development of hematopoietic stem cells, early blood cells that have the potential to develop into all types of mature blood cells such as white blood cells, red blood cells, and platelets. (medlineplus.gov)
Gastrulation is often referred to as the 'black box' period of human development, because legal restrictions prevent the culture of human embryos in the lab beyond day 14, when the process starts. (scitechdaily.com)
For this reason it is important to develop better models of human development. (scitechdaily.com)
This is a hugely exciting new model system, which will allow us to reveal and probe the processes of early human embryonic development in the lab for the first time. (scitechdaily.com)
Experiments with zebrafish and human pluripotent stem cells reveal the necessary ingredients, besides genetic mutations, that fuel the development of melanoma. (mskcc.org)
Embryonic stem cells, which must be extracted from embryos three to five days old (known as blastocysts, which contain only about 150 cells at this point of development). (articlecity.com)
Human pluripotent stem cell-derived neurons are increasingly relevant in the areas of basic research, drug development, and degenerative medicine. (jove.com)
One reason for these differences may be the development of induced pluripotent stem cells, which are derived from adult body cells rather than from embryos. (scienceblog.com)
The opportunities and challenges of development of stem cell-based therapeutic interventions for joint surface repair for the treatment and prevention of osteoarthritis will be discussed. (selectbiosciences.com)
This presentation describes the current state of the stem cells marketplace as it relates to their utilization for pharmaceutical screening as well as their development for cellular therapy. (selectbiosciences.com)
Induced pluripotent stem cells derived from reprogrammed skin cells show some differences from human embryonic stem cells and also are the focus of much promising research for human health and pharmaceutical development. (wisc.edu)
The strengths and focus of the Spence lab include using mouse models to study embryonic development of GI and associated organs, and in using 3-dimensional human models to study human development and disease. (aiche.org)
The lab is currently pursuing projects aiming to understand intestinal development and function and also studies lung development, using mice and a new 3-dimensional human lung organoid model the Spence lab has recently described. (aiche.org)
We use human pluripotent stem cells and advanced organoid technologies to model and understand normal and pathological development of the neuromuscular system. (mdc-berlin.de)
Following the cues from mouse embryonic development we have recently succeeded in generating human neuromuscular organoids (NMOs) from a pluripotent stem cell derived neuromesodermal progenitor population (NMP). (mdc-berlin.de)
Our focus is understanding how specific types of spinal cord neurons and skeletal muscle cells are generated in space and time during development, how they interact and, intriguingly, how defects in early development of these tissues can lead to different predisposition to disease in the adult life. (mdc-berlin.de)
Therefore, organoids are great models for investigation of organ formation and regeneration, organ homeostasis, human development and disease mechanisms as well as for drug discovery and sensitivity test, having great potentials in personalized medicine. (springeropen.com)
Early human brain development can be affected by multiple prenatal factors that involve chemical exposures in utero, maternal health characteristics such as psychiatric disorders, and cancer. (springeropen.com)
Cell metabolism plays vital roles in organismal development, but it has been much less studied than transcriptional and epigenetic control of developmental programs. (springeropen.com)
Here, we summarize how arterial or venous ECs arise during embryonic development. (bvsalud.org)
Embryonic stem cells are present only in the early stages of development and are able to generate any cell type (Pluripotent Stem Cells). (bvsalud.org)
The development of the human blood-CSF-brain barrier. (cdc.gov)
The lack of an efficient cell culture system in which to study NoV infections has hindered development of antiviral drugs to control or limit NoV outbreaks ( 5 ). (cdc.gov)

For example, because hematopoietic stem cells can reconstitute the entire blood system, bone marrow transplantation has long been used in the clinic to treat various diseases. (articlecity.com)
Transplantation of living nuclei from blastula cells into enucleated frogs' eggs. (springer.com)
In addition, using iPS and iN cell technology patient-specific cells can be generated for transplantation, avoiding the need for immunosuppression and risk for rejection. (lu.se)
By linking together basic and clinical research, we aim to clarify cellular mechanisms of regeneration following damage to the brain and develop new therapeutic strategies to restore function in this organ (primarily in stroke and Parkinson's disease) by transplantation of stem cells or reprogrammed cells and optimization of endogenous repair mechanisms. (lu.se)
The clinical team from Lund headed by Prof. Olle Lindval in collaboration with Prof. Anders Björklund, were the first to show in patients the proof of principle that cell transplantation therapy is feasible approach to treat the patients with Parkinson's disease. (lu.se)

Here, we generate >90% pure human artery or vein endothelial cells from pluripotent stem cells within 3-4 days. (bvsalud.org)

Viable offspring derived from fetal and adult mammalian cells. (springer.com)

Blastocysts on embryonic time 4.5 were seeded on MEF NVP-AUY922 feeders individually. (researchhunt.com)
Embryonic stem cell lines derived from human blastocysts. (springer.com)

Novel culture and cryopreservation systems for human pluripotent stem cells and neural stem cells will be presented and their advantages and applicability in the production of high quality advanced therapeutic products or functional screening tools for preclinical research discussed. (selectbiosciences.com)
This presentation will describe the current status of strategies to generate induced pluripotent stem (iPS) cells from mouse and human somatic cells for patient-specific disease modeling and cell therapeutic applications. (selectbiosciences.com)
The evolution of pluripotent stem cell-derived retinal organoids (ROs) has brought remarkable opportunities for developmental studies while also presenting new therapeutic avenues for retinal diseases. (springeropen.com)
The potential therapeutic use of stem cells has been broadly researched in recent years. (bvsalud.org)
The stem cells from exfoliated deciduous teeth (SHEDs) have a great potential for therapeutic use because of its differentiation capability and its easy access, since the collection is performed at the physiological exfoliation stage of the deciduous teeth. (bvsalud.org)
5. In 2001, France and Germany requested the United Nations General Assembly to develop international conventions on human reproductive cloning, therapeutic cloning and research on stem cells. (who.int)

Alveolar type II (ATII) epithelial cells synthesize, secrete and recycle all components of surfactant and dysfunction in surfactant metabolism can result in a variety of pediatric lung diseases including respiratory distress syndrome and interstitial lung disease 3 . (nature.com)

Based on these results, it is possible to prevent the transition to clinical trials in humans. (israel-clinics.guru)
Animal models can respond differently to certain drugs: the anti-morning sickness drug thalidomide, for example, passed clinical trials after testing in mice but subsequently led to severe birth defects in humans. (scitechdaily.com)
Human induced pluripotent stem cells--from mechanisms to clinical applications. (mpg.de)
Details are provided about the quantitative market opportunity for various stem cell classes as well as the current state of the clinical trials space wherein stem cell-based therapeutics are being evaluated for therapy in various disease classes. (selectbiosciences.com)
Clinical use of human embryonic stem (hES) cells is already being explored in a several phase1 safety trials. (selectbiosciences.com)
Each of those cell sources has specific advantages and disadvantages, and each has found particular clinical applications. (medscape.com)
DBS is a widely used FDA-approved treatment and stem cell-derived dopamine neuron replacement has now evolved to the first in-human clinical trials. (lu.se)
The biological properties and clinical potential of stem cells elicit that are generated must not be unduly sensitive to small fluctu- continued scientific, commercial, and public interest. (lu.se)
Today, clinical trials using stem cell-derived dopaminergic progenitors have commenced. (lu.se)
Next, in order to study the potential of autologous cell replacement therapy we transplanted progenitors derived from a PD patient into a pre-clinical rat model. (lu.se)

These particular antigens stimulate multiplication of T-helper cells (also called CD4-positive T cells), which in turn stimulate antibody-producing B-cells to produce antibodies to that specific antigen. (wikipedia.org)
Submitter supplied) We show a recombinant lectin probe, rBC2LCN, is a new tool for fluorescence-based imaging and flow cytometry analysis of human pluripotent stem cells, as an alternative to conventional pluripotent maker antibodies. (nih.gov)

Returning them to this state means that we can then control their cellular decisions, allowing us to generate the particular types of cells needed. (epigenie.com)
Stem cell research endeavors to generate specific subtypes of classically defined "cell types. (bvsalud.org)

however, the mechanisms governing telomere length homeostasis in these cell types are unclear. (sens.org)
Prof. Lindvall and Dr. Kokaia were the first in the world to show that the brain produces new neurons in response to stroke which opened new possibilities for cell therapy by developing the way to modulate and direct brains this self-repair mechanisms. (lu.se)
Main emphasis of Epilepsy Center is to explore mechanisms underlying epileptogenesis, and develop gene- and cell-therapy based treatment strategies for epilepsy. (lu.se)

Human genomic variations, including single nucleotide polymorphisms (SNPs) and copy number variations (CNVs), are associated with several phenotypic traits varying from mild features to hereditary diseases. (biomedcentral.com)
After sequencing the human genome, numerous projects have focused on characterizing genomic alterations and associating them with the different diseases or functional elements of the genome. (biomedcentral.com)
Understanding these processes holds the potential to reveal the causes of human birth defects and diseases, and to develop tests for these in pregnant women. (scitechdaily.com)
Stem cells are defined by their capacity for self-renewal and multilineage differentiation, making them uniquely situated to treat a broad spectrum of human diseases. (articlecity.com)
Understanding the molecular relationships is essential for using human somatic cells to develop stem cell therapy for diseases such as heart attack, Alzheimer's or Parkinson's disease or diabetes," Dr. Besser said. (sciencedaily.com)
Today, Wisconsin researchers are considered leaders in developing an understanding of these cells as they search for treatments and cures for diseases such as diabetes, Parkinson's and heart disease. (wisc.edu)
Introducing the students to stem cells allows us to teach a variety of concepts including the genetic aspects of human diseases and important ethical considerations for researchers. (wisc.edu)
Studying the etiology of human neurodevelopmental diseases has long been a challenging task due to the brain's complexity and its limited accessibility. (springeropen.com)
The main objective of the Stem Cell Center´s Neuroscience Program is to study the properties of neural stem cells (NSCs) and explore the possibilities to use these cells for treatment of neurodegenerative diseases such as Parkinson's disease and stroke. (lu.se)

A transcriptional roadmap to the induction of pluripotency in somatic cells. (mpg.de)
It seems all that was needed for human stem cells to maintain their pluripotent state, was just a little transcriptional rewiring. (epigenie.com)
Finally, hPSC-derived PGCLCs can be easily purified by virtue of their CXCR4+PDGFRA-GARP- surface-marker profile and single-cell RNA-sequencing reveals that they harbor transcriptional similarities with fetal PGCs. (bvsalud.org)
In terminally differentiated cell fate is coupled to appropriate regulation of the alternative cells, transcriptional networks must be stable and irreversible, pathways. (lu.se)

This piece will focus on the medical technology being developed using Wharton's jelly as a source material for stem cells, but will also delve into broader aspects of stem cell research, one of the most fascinating current areas of scientific study. (articlecity.com)
This new technique may help researchers avoid the controversies that come with the use of human embryos to produce human embryonic stem cells for research purposes. (sciencedaily.com)
Evans MD, Kelley J. US attitudes toward human embryonic stem cell research. (springer.com)
States, not the federal government, now fund the majority of human embryonic stem cell research conducted in the United States, according to a recent study in the journal Nature Biotechnology . (scienceblog.com)
In addition, states varied substantially in the extent to which they prioritized human embryonic stem cell research, and much of the research performed in the states could likely have been funded by the National Institutes of Health under federal guidelines established by President Bush in 2001. (scienceblog.com)
While the federal government still contributes more to stem cell research overall, each year since 2007 these six states have funded more human embryonic stem cell research than the federal government," said Aaron Levine, assistant professor at Georgia Tech. (scienceblog.com)
Levine created an online searchable database ( http://www.stemcellstates.net/ ) that allows users to find detailed information about each grant given out by the six states that adopted programs specifically to fund stem cell research. (scienceblog.com)
From what I could tell, only a relatively small portion of the stem cell research supported by these states was clearly ineligible for federal funding," said Levine, who is on the faculty of the School of Public Policy in the Ivan Allen College of Liberal Arts. (scienceblog.com)
He said he was surprised at how great the difference was among states in the share of grants that supported human embryonic stem cell research. (scienceblog.com)
These cells continue to play a vital role in international research because of their flexibility and well-documented performance characteristics. (wisc.edu)
The students benefit from learning about the cutting-edge research that is going on while at the same time gaining hands-on experience with stem cells and other critically important research tools. (wisc.edu)
Such is the fate of two entire fields of academia intertwined in the current issue of human embryonic stem cell research. (lifeissues.net)
See Irving, "Human Embryonic Stem Cell Research: Are official positions based on scientific fraud? (lifeissues.net)
During her studies, she has invested herself in the intersection of technology and social impact by doing research with Stanford's Center for Human Rights, TAing a class on Human Trafficking, and taking her technical skills to a nonprofit that tackles the issue of domestic sex trafficking. (aaas.org)
8 Feb, 2008 06:09 pm Six years ago, biomedical engineer Michael King was exploring the strange rolling motion of white blood cells when his research took a radical turn. (scitizen.com)
27 Nov, 2007 10:41 am Tony Maciulis talks with Dr. Jon LaPook about a breakthrough in stem cell research. (scitizen.com)
21 Nov, 2007 10:54 am A huge advancement in stem cell research--and a stake in the heart of human cloning--was announced yesterday. (scitizen.com)
6 Sep, 2007 12:57 pm British authorities decided yesterday to permit research that uses animal eggs to create human stem cells because of the limited supply of human eggs. (scitizen.com)
25 Jun, 2007 04:43 pm On June 7, the House of Representatives voted 247-176 to pass a bill (S 5) that would allow federal funding for research using stem cells derived from. (scitizen.com)
Research groups are gathered within five main research clusters: MultiPark, Stem Cell Center and Epilepsy Center. (lu.se)
The possibility to isolate and propagate NSCs and their potential applications in cell therapy have attracted a lot of research interest in recent years. (lu.se)
Andreas' research focuses on generating brain cells, specifically interneurons, in the lab, which has significant implications for the study of neurodegenerative and neuropsychiatric disorders. (lu.se)

These stem cells come from developed organs and tissues in the body. (healthline.com)

For example, hematopoietic stem cells are a type of adult stem cell found in bone marrow. (healthline.com)
May 20, 2020 In the bone marrow, blood stem cells via precursor cells give rise to a variety of blood cell types with various functions: white blood cells, red blood cells, or blood platelets. (sciencedaily.com)
The National Marrow Donor Program (NMDP), founded in 1986, and the World Marrow Donor Association (WMDA), founded in 1988, were established to (1) locate and secure appropriate unrelated-donor HSCT sources for patients by promoting volunteer donation of bone marrow and peripheral blood stem cells in the community and (2) promote ethical practices of sharing stem cell sources by need, rather than by geographic location of the donor. (medscape.com)
Stem cells derived from dental tissues are isolated from specialized tissues and have a strong ability to give rise to other cell lines, but with a different potential of bone marrow stem cells 16 . (bvsalud.org)

After differentiating the mutant and corrected cells into lung organoids, we show expression of SFTPB mRNA during endodermal and organoid differentiation but the protein product only after organoid differentiation. (nature.com)
To address these questions we are developing advanced 2D cell culture and 3D organoid models that more closely resemble the in vivo systems from human pluripotent stem cells. (mdc-berlin.de)
Human liver organoid (HLO) derived from human pluripotent stem cells offers. (springeropen.com)

Milk Fat Globule-EGF Factor 8, Secreted by Mesenchymal Stem Cells, Protects Against Liver Fibrosis in Mice. (bioscience.co.uk)
Mesenchymal Stem Cells (MSCs) can be isolated from several body tissues, including dental tissues. (bvsalud.org)

We used an array of self-assembled monolayers to identify peptide surfaces that sustain pluripotent stem cell self-renewal. (nih.gov)

Islets organoids would have value in the cell replacement therapy for diabetes apart from usual personalized drug screening routes. (springeropen.com)
Because of this local degeneration of a relatively small population of dopaminergic neurons in the midbrain, PD has been considered an especially interesting candidate for cell-replacement therapy. (lu.se)
The overall aim of this thesis has been to assess the potential of autologous grafting in cell replacement therapy for PD. (lu.se)
The work with stem cell-based therapy in stroke is in initial phase and recently Dr. Zaal Kokaia started a consortium within EU to develop the preclinical protocol for cell therapy in stroke. (lu.se)

To distinguish and collect two morphologically unique cell populations for practical study in our work we suspended the dome-shaped colonies by softly pipetting up and down under a stereomicroscope. (researchhunt.com)
Moreover, single cell heterogeneity amongst stem cell populations may underlie important cell fate decisions. (jci.org)
Here we describe how microRNA-regulated lentiviral vectors can be used to visualize specific cell populations by exploiting endogenous microRNA expression patterns. (lu.se)
To track differentiating cell populations, reporter cell lines generated by homologous recombination (knock-in) or via BAC transgenes have been widely used in mouse cells (5-8 ). (lu.se)
Stem and progenitor cell populations are often heterogeneous, which may reflect stem cell subsets that express subtly different properties, including different propensities for lineage selection upon differentiation, yet remain able to interconvert. (lu.se)

The winners and finalists will be recognized at the October 2021 AAAS Science and Human Rights Virtual Conference . (aaas.org)
Kalyani Ramadurgam is a Computer Science major and Human Rights minor in the Stanford Class of 2021. (aaas.org)

https://pubmed.ncbi.nlm.nih.gov/23684459-phosphorylation-of-ezh2-activates-stat3-signaling-via-stat3-methylation-and-promotes-tumorigenicity-of-glioblastoma-stem-like-cells/ [Accessed 28 Feb. 2020]. (bioscience.co.uk)
https://pubmed.ncbi.nlm.nih.gov/26089346-enhanced-metabolizing-activity-of-human-es-cell-derived-hepatocytes-using-a-3d-culture-system-with-repeated-exposures-to-xenobiotics/ [Accessed 28 Feb. 2020]. (bioscience.co.uk)

The model resembles some key elements of an embryo at around 18-21 days old and allows the researchers to observe the processes underlying the formation of the human body plan never directly observed before. (scitechdaily.com)
The researchers judged the equivalent human embryonic age of the gastruloids by comparing them to the Carnegie Collection of Embryology. (scitechdaily.com)
Since the initial discovery of the self-renewing properties of stem cells in the early 1960s - pioneered by a small team of researchers at the Ontario Cancer Institute [3] - the understanding of the power and diversity of stem cells has increased rapidly. (articlecity.com)
In a second step the researchers investigated what happens when somatic cells that normally neither have E-cadherin nor are pluripotent are reprogrammed into a pluripotent stem cell state. (sciencedaily.com)
Eighteen top science students from northern Wisconsin high schools have earned the opportunity to hone their laboratory skills and work alongside leading researchers from the University of Wisconsin-Madison at a summer science camp focused on stem cells. (wisc.edu)
Such "guidelines" will ensure that stem cell researchers are not treated poorly as was Hwang when he was eventually found guilty of falsifying his data. (lifeissues.net)
18 Sep, 2007 12:13 pm Rice University researchers have engineered musculoskeletal cartilages with human embryonic stem cells, with the hope of eventually using the neotissue. (scitizen.com)
6 Jun, 2007 07:00 pm Researchers have reprogrammed skin cells into embryonic stem cells. (scitizen.com)
The National Cancer Institute (NCI) and ESTools consortium, a European group of human embryonic and induced pluripotent stem cell researchers, have purchased a site-wide license for Integromics' RT-qPCR (real time quantitative polymerase chain reaction) data analysis solution, RealTime StatMiner. (scientific-computing.com)

Activity assays were conducted using recombinant enzymes as well as human liver and intestinal microsomes. (helsinki.fi)
The developmental capacity of nuclei taken from intestinal epithelium cells of feeding tadpoles. (springer.com)
A previous study, which used a 3-dimensional (3-D) intestinal model derived from INT-407 cells reported NoV replication and extensive cytopathic effects (CPE). (cdc.gov)

Fluoresceinated rBC2LCN also separated live pluripotent stem cells from mixed cell population by flow cytometry. (nih.gov)
Finally, we provide protocols for analyzing these cells through flow cytometry and immunocytochemistry. (lu.se)

Thus, somatic cells (primitive streak) and PGCLCs are related-yet distinct-lineages segregated by temporally-dynamic signaling. (bvsalud.org)

The last mentioned had been similar to look at NVP-AUY922 to mouse epiblast stem cells (Amount 1B). (researchhunt.com)
Pluripotency factors including NANOG are continuously expressed during the transition from pluripotency to posterior epiblast to PGCs, thus bridging pluripotent and germline states. (bvsalud.org)

Viral and non-viral generation and characterization of induced pluripotent stem cells from human amniotic fluid cells. (mpg.de)

We apply our method to study differences between human pluripotent stem cells and several cell types including their parental cell line and differentiated progeny. (nature.com)
This strategy provides a useful tool for visualization and identification of neural progeny derived from human pluripotent stem cells. (lu.se)

Martin GR. Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. (springer.com)
Establishment in culture of pluripotential cells from mouse embryos. (springer.com)
Reduces colony-forming efficiency of mouse neural stem cells (Androutsellis-Theotokis et al. (stemcell.com)
Promotes differentiation of retinal pigment epithelium from mouse ES cells (Osakada et al. (stemcell.com)
66259-1-Ig targets Nestin in WB, FC, ELISA applications and shows reactivity with human, mouse, rat samples. (ptglab.com)

Comparative molecular portraits of human unfertilized oocytes and primordial germ cells at 10 weeks of gestation. (mpg.de)

During gastrulation, three distinct layers of cells are formed in the embryo that will later give rise to all the body's major systems: the ectoderm will make the nervous system, mesoderm the muscles, and endoderm the gut. (scitechdaily.com)
The developmental capacity of nuclei taken from differentiating endoderm cells of Xenopus laevis. (springer.com)

Moris added: "Our system is a first step towards modeling the emergence of the human body plan, and could prove useful for studying what happens when things go wrong, such as in birth defects. (scitechdaily.com)

A novel characterisation and separation technique for pluripotent human embryonic and hematopoietic stem cells. (ukri.org)

Anatomy35

Organisms8

Diseases2

Chemicals and Drugs30

Analytical, Diagnostic and Therapeutic Techniques and Equipment29

Phenomena and Processes28

Disciplines and Occupations4

Technology, Industry, Agriculture2

Regenerative15

20221

Differentiation of human3

HiPSCs13

Progenitor cells4

Analysis of human embryonic1

Neuronal5

Called induced pluri1

Fibroblasts5

Genes9

Vitro15

Differentiate13

IPSCs9

HESCs4

Organoids from human1

Neurons from human2

Fibroblast3

Somatic cell1

Biology7

ESCs1

Dopamine Neurons3

Neural cells3

Scientists12

HPSCs3

Adult stem9

Reprogramming8

Hematopoietic stem cells in2

Tissue22

Amniotic fluid stem cells2

Therapies4

Regulates2

Embryos and adult cells1

Development25

Transplantation5

Endothelial Cells1

Fetal and adult1

Blastocysts2

Therapeutic6

Metabolism1

Clinical10

Antibodies2

Generate2

Mechanisms3

Diseases9

Transcriptional4

Research22

Tissues in the body1

Bone marrow4

Organoid3

Mesenchymal Stem2

Self-renewal1

Therapy4

Populations5

20212

20202

Researchers9

Intestinal3

Flow cytometry2

Lineages1

Epiblast2

Characterization1

Progeny2

Mouse5

Molecular1

Endoderm2

Modeling1

Separation1